iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Opu-083457

Ensembl Protein ID

OPUNC03G36140.1

UniProt Accession

A0A0E0KKT1; A0A0E0KKT1_ORYPU

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
OPUNC03G36140	OPUNC03G36140.1	OPUNC03G36140.1
OPUNC03G36140	OPUNC03G36140.3	OPUNC03G36140.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	3.10e-110	370.2	19	525

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveahe 94
           YDRQ+r+wG+++q++l++a+++l+ +g++G+E  KnLvl+Gvgs+tvvD+++ve+s+l+++FL++a   g+s+A++++ +l+eln+ vn++++e
   Q: 19   YDRQLRIWGDQGQAALEKASICLLTCGPTGTEAMKNLVLGGVGSVTVVDGSKVELSDLGNNFLLDAGCLGQSRAKSVCSFLQELNDAVNAKFVE 112
           ********************************************************************************************** PP
   S: 95   esiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlketpn... 181
           es+ +l ++++ Ff++f+vV++++ ++ + +k++++c++a++ l+ ++++Gl G vr+++k++ +++s++d   d++++ +P+++lk++     
   Q: 113  ESPLALIDTNPsFFSQFTVVIATQLPERSLLKLDDICRKANIVLVAARSYGLTGLVRISVKEHNVIESKPDhflDDLRLHNPWVELKQFAKsid 206
           *****************************************************************************************88899 PP
   S: 182  ......aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfecdivtks 268
                 +++++++++v++  l+e++a +++++ +++++ek e+k ++++ + + deen++ea+e + k   +  i++ i+q++++ + ++v++s
   Q: 207  indkdpVVHKHTPYIVILVRLAEKWADAHDGRLPSTRQEKNEFKALIREHMLNLDEENYKEAVESSYKVSVTPGISDeIRQIIDD-SSAEVNSS 299
           999999******************************************************************************9.78899*** PP
   S: 269  kspfwv...........................................................................sfcsnaealq... 284
           +s+fwv                                                                            fc+na++l+   
   Q: 300  SSDFWVlvaalkefianegnselplegtipdmtslteyyvslqkiyqakaesdclalehhvkdilkridrdpdsisrayikAFCKNARKLRvcr 393
           *******************************************************************************************666 PP
   S: 285  ........vpekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiep.kldddlikeiagn 364
                   + +   + +++++++++     +y+llra++r++++++r+pg ++ e d+d +++l+taa +  ++++g+++ +l++dli+e++++
   Q: 394  yrsmeeefSSPVLSEVQKYFTDEDYcfamnFYVLLRAVDRLAANYNRYPGIFESEIDED-VPRLKTAAVSV-MSEMGMNGaPLSEDLITEMCRF 485
           666655553355666666667777788888*******************9999999999.*****988875.6********************* PP
   S: 365  iipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           + ++i++++a++gG+a+qEviK+v+++f+pl  +f+f+++
   Q: 486  GGAEIHPVAAFIGGVASQEVIKLVTKQFVPLLGTFIFNGI 525
           *************************************986 PP

Organism

Oryza punctata

Functional Description
(View)

Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.

Protein Sequence
(Fasta)

MAAAAAAAAA AFAEPKTKYD RQLRIWGDQG QAALEKASIC LLTCGPTGTE AMKNLVLGGV 60
GSVTVVDGSK VELSDLGNNF LLDAGCLGQS RAKSVCSFLQ ELNDAVNAKF VEESPLALID 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCCTTCTCC TTGCTTCCAC TTCAGCTTGA GACCGCTTTA TTCCTCGCCC AGGGAGGAGA 60
AGGAGAAGGA GAAGGCGAAG GCGAAGCAAG CAAAACCTCG GAAAAGCGGC AGAGCTCCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	87.83	0.00e+00	925.00
IUUC-Aml-002333	Ailuropoda melanoleuca	42.97	3.00e-128	451.00
IUUC-Atr-002644	Amborella trichopoda	71.40	0.00e+00	758.00
IUUC-Apl-003446	Anas platyrhynchos	41.92	7.00e-119	420.00
IUUC-Aca-004450	Anolis carolinensis	41.63	1.00e-122	432.00
IUUC-Aly-005466	Arabidopsis lyrata	67.62	0.00e+00	754.00
IUUC-Ath-006692	Arabidopsis thaliana	68.20	0.00e+00	754.00
IUUC-Ago-007900	Ashbya gossypii	27.68	4.00e-40	158.00
IUUC-Acl-008333	Aspergillus clavatus	32.24	3.00e-66	245.00
IUUC-Afl-008529	Aspergillus flavus	32.49	8.00e-71	260.00
IUUC-Afu-009071	Aspergillus fumigatus	31.88	6.00e-65	241.00
IUUC-Ani-009443	Aspergillus nidulans	31.94	5.00e-60	224.00
IUUC-Ang-009669	Aspergillus niger	31.52	2.00e-68	252.00
IUUC-Aor-009914	Aspergillus oryzae	32.19	8.00e-69	254.00
IUUC-Ate-010450	Aspergillus terreus	31.58	2.00e-66	246.00
IUUC-Ame-011183	Astyanax mexicanus	40.46	4.00e-121	427.00
IUUC-Bgr-012111	Blumeria graminis	32.52	2.00e-59	223.00
IUUC-Bta-012583	Bos taurus	43.32	1.00e-129	456.00
IUUC-Bci-013892	Botrytis cinerea	31.68	8.00e-57	214.00
IUUC-Bdi-014592	Brachypodium distachyon	88.29	0.00e+00	930.00
IUUC-Bol-016399	Brassica oleracea	67.56	0.00e+00	756.00
IUUC-Bra-017506	Brassica rapa	66.35	0.00e+00	733.00
IUUC-Cel-018456	Caenorhabditis elegans	30.61	9.00e-72	263.00
IUUC-Cja-020007	Callithrix jacchus	43.45	3.00e-128	451.00
IUUC-Cfa-020324	Canis familiaris	43.13	6.00e-130	457.00
IUUC-Cpo-022248	Cavia porcellus	39.88	2.00e-68	252.00
IUUC-Csa-023149	Chlorocebus sabaeus	40.73	2.00e-102	365.00
IUUC-Cho-024537	Choloepus hoffmanni	35.78	3.00e-87	315.00
IUUC-Cin-025763	Ciona intestinalis	41.71	1.00e-111	396.00
IUUC-Csv-026113	Ciona savignyi	39.55	8.00e-103	367.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	30.07	2.00e-56	212.00
IUUC-Cne-026884	Cryptococcus neoformans	31.07	2.00e-64	239.00
IUUC-Dre-028140	Danio rerio	41.57	2.00e-125	442.00
IUUC-Dno-030033	Dasypus novemcinctus	42.83	2.00e-111	395.00
IUUC-Dor-030513	Dipodomys ordii	36.21	9.00e-38	150.00
IUUC-Dse-031536	Dothistroma septosporum	30.13	9.00e-61	227.00
IUUC-Dme-031683	Drosophila melanogaster	38.90	7.00e-96	343.00
IUUC-Ete-032420	Echinops telfairi	38.27	2.00e-109	389.00
IUUC-Eca-033992	Equus caballus	41.22	3.00e-100	358.00
IUUC-Eeu-034713	Erinaceus europaeus	33.19	3.00e-36	145.00
IUUC-Fca-036548	Felis catus	42.75	4.00e-129	454.00
IUUC-Fal-037600	Ficedula albicollis	41.52	3.00e-116	411.00
IUUC-Fox-038037	Fusarium oxysporum	32.04	2.00e-67	249.00
IUUC-Fso-038387	Fusarium solani	32.43	2.00e-67	249.00
IUUC-Gmo-038562	Gadus morhua	40.72	4.00e-118	417.00
IUUC-Ggr-040005	Gaeumannomyces graminis	31.87	2.00e-63	235.00
IUUC-Gga-041129	Gallus gallus	41.98	2.00e-119	422.00
IUUC-Gac-042558	Gasterosteus aculeatus	41.25	2.00e-122	432.00
IUUC-Gma-043610	Glycine max	70.06	0.00e+00	753.00
IUUC-Ggo-045611	Gorilla gorilla	42.88	3.00e-127	448.00
IUUC-Hsa-046563	Homo sapiens	43.13	2.00e-128	452.00
IUUC-Hvu-047790	Hordeum vulgare	87.92	0.00e+00	680.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	43.51	2.00e-128	452.00
IUUC-Kpa-049309	Komagataella pastoris	35.32	1.00e-75	276.00
IUUC-Lch-050038	Latimeria chalumnae	42.13	3.00e-122	431.00
IUUC-Lpe-051535	Leersia perrieri	90.74	0.00e+00	880.00
IUUC-Loc-051917	Lepisosteus oculatus	38.42	1.00e-106	379.00
IUUC-Lma-053112	Leptosphaeria maculans	32.91	7.00e-69	254.00
IUUC-Laf-053690	Loxodonta africana	43.89	7.00e-131	460.00
IUUC-Mcc-055117	Macaca mulatta	42.80	4.00e-126	444.00
IUUC-Meu-056761	Macropus eugenii	35.55	8.00e-93	333.00
IUUC-Mor-057230	Magnaporthe oryzae	31.49	6.00e-67	247.00
IUUC-Mpo-057514	Magnaporthe poae	31.49	2.00e-59	222.00
IUUC-Mtr-058551	Medicago truncatula	66.85	0.00e+00	727.00
IUUC-Mla-059183	Melampsora laricipopulina	34.75	3.00e-87	315.00
IUUC-Mga-060144	Meleagris gallopavo	41.27	6.00e-116	410.00
IUUC-Mvi-060221	Microbotryum violaceum	33.50	3.00e-59	222.00
IUUC-Mmr-061325	Microcebus murinus	42.31	3.00e-125	441.00
IUUC-Mdo-062532	Monodelphis domestica	42.94	1.00e-127	449.00
IUUC-Mmu-063956	Mus musculus	42.56	1.00e-127	449.00
IUUC-Mac-064521	Musa acuminata	73.60	0.00e+00	804.00
IUUC-Mpu-066716	Mustela putorius furo	43.29	3.00e-120	424.00
IUUC-Mlu-067459	Myotis lucifugus	43.62	3.00e-130	457.00
IUUC-Nfi-068245	Neosartorya fischeri	32.42	2.00e-66	246.00
IUUC-Ncr-068910	Neurospora crassa	30.98	1.00e-62	233.00
IUUC-Nle-070034	Nomascus leucogenys	41.54	3.00e-121	427.00
IUUC-Opr-070552	Ochotona princeps	39.31	6.00e-98	350.00
IUUC-Ont-071426	Oreochromis niloticus	41.44	3.00e-124	437.00
IUUC-Oan-073389	Ornithorhynchus anatinus	38.74	5.00e-87	313.00
IUUC-Ocu-074911	Oryctolagus cuniculus	43.70	3.00e-130	458.00
IUUC-Oba-075437	Oryza barthii	98.85	0.00e+00	995.00
IUUC-Obr-076684	Oryza brachyantha	94.22	0.00e+00	900.00
IUUC-Ogl-077170	Oryza glaberrima	98.85	0.00e+00	995.00
IUUC-Ogu-078844	Oryza glumaepatula	97.79	0.00e+00	934.00
IUUC-Oin-079105	Oryza indica	98.85	0.00e+00	993.00
IUUC-Olo-080943	Oryza longistaminata	96.15	0.00e+00	913.00
IUUC-Oni-082891	Oryza nivara	96.16	0.00e+00	963.00
IUUC-Oru-084960	Oryza rufipogon	96.15	0.00e+00	913.00
IUUC-Osa-085358	Oryza sativa	98.46	0.00e+00	988.00
IUUC-Ola-086420	Oryzias latipes	39.36	2.00e-77	281.00
IUUC-Olu-087625	Ostreococcus lucimarinus	30.45	1.00e-58	219.00
IUUC-Oga-088810	Otolemur garnettii	43.32	6.00e-129	453.00
IUUC-Oar-089196	Ovis aries	43.07	8.00e-128	449.00
IUUC-Ptr-090617	Pan troglodytes	43.13	8.00e-129	453.00
IUUC-Pan-092761	Papio anubis	43.32	9.00e-130	456.00
IUUC-Psi-093191	Pelodiscus sinensis	40.00	2.00e-120	425.00
IUUC-Pma-094380	Petromyzon marinus	40.64	5.00e-109	387.00
IUUC-Pno-095084	Phaeosphaeria nodorum	31.48	2.00e-60	227.00
IUUC-Ppa-095798	Physcomitrella patens	55.15	9.00e-174	602.00
IUUC-Pfo-096467	Poecilia formosa	41.18	6.00e-120	424.00
IUUC-Pab-098255	Pongo abelii	44.80	2.00e-107	381.00
IUUC-Pop-099722	Populus trichocarpa	71.02	0.00e+00	786.00
IUUC-Pca-100807	Procavia capensis	52.41	4.00e-53	201.00
IUUC-Ppe-101280	Prunus persica	70.25	0.00e+00	776.00
IUUC-Pva-102333	Pteropus vampyrus	41.75	2.00e-122	432.00
IUUC-Pgr-103401	Puccinia graminis	29.83	3.00e-68	252.00
IUUC-Ptt-103889	Puccinia triticina	27.08	6.00e-60	224.00
IUUC-Pte-104355	Pyrenophora teres	32.31	2.00e-66	246.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	32.85	3.00e-67	248.00
IUUC-Rno-105810	Rattus norvegicus	42.37	2.00e-126	445.00
IUUC-Sce-106397	Saccharomyces cerevisiae	26.87	9.00e-33	134.00
IUUC-Sha-106770	Sarcophilus harrisii	48.85	4.00e-71	260.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.95	7.00e-77	280.00
IUUC-Spo-108276	Schizosaccharomyces pombe	33.84	3.00e-83	301.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	32.36	1.00e-58	220.00
IUUC-Smo-109296	Selaginella moellendorffii	54.34	3.00e-165	574.00
IUUC-Sit-110157	Setaria italica	88.48	0.00e+00	950.00
IUUC-Sly-111105	Solanum lycopersicum	67.29	0.00e+00	746.00
IUUC-Stu-112469	Solanum tuberosum	68.22	0.00e+00	761.00
IUUC-Sar-113083	Sorex araneus	33.85	5.00e-86	311.00
IUUC-Sbi-113813	Sorghum bicolor	89.25	0.00e+00	957.00
IUUC-Sre-115058	Sporisorium reilianum	34.31	1.00e-65	243.00
IUUC-Tgu-116772	Taeniopygia guttata	42.13	3.00e-116	411.00
IUUC-Tru-118686	Takifugu rubripes	40.11	1.00e-121	429.00
IUUC-Tsy-119111	Tarsius syrichta	45.25	2.00e-62	232.00
IUUC-Tni-120231	Tetraodon nigroviridis	39.32	7.00e-109	387.00
IUUC-Tca-121491	Theobroma cacao	70.44	0.00e+00	743.00
IUUC-Tre-122103	Trichoderma reesei	32.84	1.00e-71	263.00
IUUC-Tvi-122672	Trichoderma virens	31.77	6.00e-67	247.00
IUUC-Tae-125316	Triticum aestivum	88.68	0.00e+00	932.00
IUUC-Tur-126487	Triticum urartu	87.23	0.00e+00	902.00
IUUC-Tme-127097	Tuber melanosporum	34.24	2.00e-77	282.00
IUUC-Ttr-128465	Tursiops truncatus	40.04	3.00e-113	401.00
IUUC-Uma-129645	Ustilago maydis	32.81	5.00e-63	234.00
IUUC-Vda-129989	Verticillium dahliae	29.26	7.00e-49	187.00
IUUC-Vpa-130529	Vicugna pacos	40.99	3.00e-118	418.00
IUUC-Vvi-131059	Vitis vinifera	71.59	0.00e+00	787.00
IUUC-Xtr-132002	Xenopus tropicalis	42.97	3.00e-125	441.00
IUUC-Xma-133930	Xiphophorus maculatus	41.71	2.00e-123	435.00
IUUC-Yli-134505	Yarrowia lipolytica	34.36	4.00e-79	288.00
IUUC-Zma-135895	Zea mays	87.14	0.00e+00	939.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence