iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tae-125316

Ensembl Protein ID

TRIAE_CS42_5AL_TGACv1_375676_AA1225400.1

UniProt Accession

A0A1D5YJT1; A0A1D5YJT1_WHEAT

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
TRIAE_CS42_5AL_TGACv1_375676_AA1225400	TRIAE_CS42_5AL_TGACv1_375676_AA1225400.1	TRIAE_CS42_5AL_TGACv1_375676_AA1225400.1
TRIAE_CS42_5AL_TGACv1_375676_AA1225400	TRIAE_CS42_5AL_TGACv1_375676_AA1225400.2	TRIAE_CS42_5AL_TGACv1_375676_AA1225400.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	2.70e-105	355.6	15	521

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedv 69
           YDRQ+r+wG+++q++l++a+++l+++g++G+E lKnLvl+G+gs+tvvD+++ve+s+l+++FL+++   
   Q: 15   YDRQLRIWGDQGQAALEKASICLLNCGPTGTEALKNLVLGGIGSVTVVDGSKVEQSDLGNNFLLDEGCL 83
           ********************************************************************* PP
   S: 70   gksKAevaaealkelnpdvnveaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpl 137
           g+s+A++ + +l+eln+ v+++ +ees+ +  ++++ Ff++f++V++++ ++++ +k++++c++a++ l
   Q: 84   GQSRAKSICSFLQELNDAVKAKYVEESPATMIDTNPsFFSQFTIVLATQLPESSLLKLDSICRSANIVL 152
           **********************************99********************************* PP
   S: 138  iesgtlGllGqvrviikgltecyscsd...dppqktiPfctlketpn.........aaehtiewavlfn 194
           + ++++Gl G vrv+ik++ +++s++d   d++++ +P+++lk++           +++++++++v++ 
   Q: 153  VAARSYGLTGLVRVSIKEHCVIESKPDhslDDLRLHNPWPELKQFAKsidicdkdpVVHKHTPYIVILV 221
           *********************************************99999999999************* PP
   S: 195  klleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfec 262
            l+e++a +++++ +++++ek+e+kd++++ + + de+n++ea+e + k   +  i++ i+q++++ + 
   Q: 222  RLAEKWADAHDGQLPSTRQEKREFKDLIRAHMLNVDEDNYKEAVESSYKVSVTPGISDeIRQIIDD-SS 289
           ******************************************************************.55 PP
   S: 263  divtkskspfwv......................................................... 274
            +v+ s+s+fwv                                                         
   Q: 290  SEVNLSSSDFWVlvaslkefianegngelplegtipdmtslteyyvslqkiyqakaesdclaiehrvks 358
           599****************************************************************** PP
   S: 275  ..................sfcsnaealq..............vpekvekdeevvkasap.....lylll 306
                             +fc+n+++l+              v     + +++++++++     +y+ll
   Q: 359  ilkrigrdpdsisracikTFCKNTRKLKvcryrsmeeefsspV---LSEVKKYFADEDScfamnFYVLL 424
           ****************************666665555543221...223333333333367788***** PP
   S: 307  ralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiep.kldddlikeiagniipaiattna 374
           ra++r++++++r pg ++ e  +d +++l++aa +   +++g+++  l++dli+e+++++ ++i++++a
   Q: 425  RAVDRLAANYSRLPGIFDSEIGED-VPRLKEAAVSVL-SDMGLKGsSLSEDLIAEVCRFAGAEIHPVAA 491
           **************9999999999.999999888877.******************************* PP
   S: 375  vvgGlaaqEviKvvsgkfeplknfflfdae 404
           ++gG+a+qEviK+v+++f+pl+ +f+f+++
   Q: 492  FIGGVASQEVIKLVTKQFVPLNGTFIFNGI 521
           ***************************986 PP

Organism

Triticum aestivum

Functional Description
(View)

Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.

Protein Sequence
(Fasta)

MAAAAAAVAE PKTKYDRQLR IWGDQGQAAL EKASICLLNC GPTGTEALKN LVLGGIGSVT 60
VVDGSKVEQS DLGNNFLLDE GCLGQSRAKS ICSFLQELND AVKAKYVEES PATMIDTNPS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCCCATAAG GCCAGGTTTG CTTTGAGACA GGCTGAGAGA TACGCGTGAT CCGGCGGCCG 60
TTCCTTGGAA CTGGATGCAC GCACGAGCTG GTGCAAAACG CCTGCACCCA CCTCCGCATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002333	Ailuropoda melanoleuca	43.37	9.00e-129	454.00
IUUC-Atr-002644	Amborella trichopoda	70.06	0.00e+00	739.00
IUUC-Aly-005466	Arabidopsis lyrata	65.33	0.00e+00	737.00
IUUC-Ath-006692	Arabidopsis thaliana	66.48	0.00e+00	742.00
IUUC-Ago-007900	Ashbya gossypii	27.55	1.00e-40	161.00
IUUC-Bol-016399	Brassica oleracea	66.79	0.00e+00	749.00
IUUC-Cho-024537	Choloepus hoffmanni	35.34	5.00e-86	312.00
IUUC-Dse-031536	Dothistroma septosporum	30.80	7.00e-68	252.00
IUUC-Dme-031683	Drosophila melanogaster	38.31	2.00e-97	350.00
IUUC-Ete-032420	Echinops telfairi	38.46	2.00e-110	393.00
IUUC-Eeu-034713	Erinaceus europaeus	32.33	3.00e-34	140.00
IUUC-Fca-036548	Felis catus	42.94	1.00e-129	457.00
IUUC-Fox-038037	Fusarium oxysporum	31.99	2.00e-70	260.00
IUUC-Fso-038387	Fusarium solani	32.12	1.00e-70	261.00
IUUC-Ggr-040005	Gaeumannomyces graminis	33.03	4.00e-65	243.00
IUUC-Gac-042558	Gasterosteus aculeatus	41.67	1.00e-123	437.00
IUUC-Gma-043610	Glycine max	68.71	0.00e+00	744.00
IUUC-Hvu-047790	Hordeum vulgare	98.20	0.00e+00	757.00
IUUC-Lpe-051535	Leersia perrieri	84.21	0.00e+00	822.00
IUUC-Laf-053690	Loxodonta africana	44.11	4.00e-131	462.00
IUUC-Mor-057230	Magnaporthe oryzae	32.36	5.00e-69	255.00
IUUC-Mpo-057514	Magnaporthe poae	33.21	3.00e-64	240.00
IUUC-Mtr-058551	Medicago truncatula	66.29	0.00e+00	718.00
IUUC-Mla-059183	Melampsora laricipopulina	36.04	3.00e-88	320.00
IUUC-Mmu-063956	Mus musculus	42.75	4.00e-128	452.00
IUUC-Ncr-068910	Neurospora crassa	32.42	7.00e-69	255.00
IUUC-Oba-075437	Oryza barthii	88.87	0.00e+00	898.00
IUUC-Obr-076684	Oryza brachyantha	87.28	0.00e+00	831.00
IUUC-Ogl-077170	Oryza glaberrima	88.87	0.00e+00	898.00
IUUC-Ogu-078844	Oryza glumaepatula	87.93	0.00e+00	847.00
IUUC-Oin-079105	Oryza indica	88.87	0.00e+00	896.00
IUUC-Olo-080943	Oryza longistaminata	85.63	0.00e+00	816.00
IUUC-Oni-082891	Oryza nivara	85.99	0.00e+00	862.00
IUUC-Opu-083457	Oryza punctata	88.68	0.00e+00	894.00
IUUC-Oru-084960	Oryza rufipogon	85.63	0.00e+00	817.00
IUUC-Osa-085358	Oryza sativa	88.48	0.00e+00	890.00
IUUC-Oga-088810	Otolemur garnettii	43.51	2.00e-129	456.00
IUUC-Ppa-095798	Physcomitrella patens	55.81	5.00e-176	611.00
IUUC-Pfo-096467	Poecilia formosa	41.40	1.00e-120	427.00
IUUC-Pop-099722	Populus trichocarpa	70.25	0.00e+00	780.00
IUUC-Ppe-101280	Prunus persica	68.91	0.00e+00	766.00
IUUC-Pva-102333	Pteropus vampyrus	42.34	3.00e-123	436.00
IUUC-Pgr-103401	Puccinia graminis	30.71	2.00e-70	260.00
IUUC-Rno-105810	Rattus norvegicus	42.37	3.00e-126	446.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	33.33	5.00e-78	285.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	32.60	1.00e-60	228.00
IUUC-Smo-109296	Selaginella moellendorffii	53.46	3.00e-165	575.00
IUUC-Sit-110157	Setaria italica	88.29	0.00e+00	953.00
IUUC-Sly-111105	Solanum lycopersicum	65.98	0.00e+00	741.00
IUUC-Stu-112469	Solanum tuberosum	66.54	0.00e+00	750.00
IUUC-Sbi-113813	Sorghum bicolor	88.10	0.00e+00	950.00
IUUC-Sre-115058	Sporisorium reilianum	34.31	9.00e-65	241.00
IUUC-Tni-120231	Tetraodon nigroviridis	38.46	1.00e-107	384.00
IUUC-Tca-121491	Theobroma cacao	68.91	0.00e+00	731.00
IUUC-Tme-127097	Tuber melanosporum	35.10	2.00e-80	293.00
IUUC-Uma-129645	Ustilago maydis	33.03	1.00e-62	235.00
IUUC-Vda-129989	Verticillium dahliae	29.89	1.00e-50	194.00
IUUC-Vvi-131059	Vitis vinifera	70.63	0.00e+00	781.00
IUUC-Xtr-132002	Xenopus tropicalis	43.18	9.00e-128	451.00
IUUC-Yli-134505	Yarrowia lipolytica	35.26	1.00e-82	301.00
IUUC-Zma-135619	Zea mays	87.72	0.00e+00	902.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence