iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Acl-008307

Ensembl Protein ID

CADACLAP00008295

UniProt Accession

A1CF18; LIS12_ASPCL

Genbank Protein ID

EAW11467.1

Protein Name

Nuclear distribution protein nudF 2; Lissencephaly-1 homolog 2

Genbank Nucleotide ID

DS027052

Gene Name

ACLA_091650; nudF-2; lis1-2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADACLAG00008505	CADACLAT00008505	CADACLAP00008295

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.60e-44	146.9	87	118
UBD/Beta-Prp	7.50e-63	211.4	85	433

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlr 31
           H d ++c+af +    ++sGsdD+tik+WD+ 
   Q: 87   HRDTINCIAFhPKySSIASGSDDCTIKIWDWE 118
           9*********976678**************85 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk....ilvtgseDrtikvwdls.tgkcvhtlkghe 94
           ++h + i+c++f+p++s +a+gs+d tik+wd++ g l  +l+gh+ +v+++++ +       +l+++s+D tik+wd+   +k ++tl+gh+
   Q: 85   HSHRDTINCIAFHPKYSSIASGSDDCTIKIWDWELGELEVTLKGHTRAVRDLDYGSPPGavgvLLASCSSDLTIKLWDPAdGYKNIRTLQGHD 177
           578899************************************************766555889**************765489********** PP
   S: 95   dsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl..............ktgkllr 173
           + v +++f p+g+ l+s+s+d  +r+wd+ +g+c++ t +gh+g+v+ v+ + dg+ + s ++D tvrlWd+              +      
   Q: 178  HIVSAVRFIPNGSLLASASRDMDVRLWDVTNGYCVK-TIQGHTGWVRDVCASLDGRFILSTGDDMTVRLWDIsakpenkltmvgheN------ 263
           ************************************.***********************************655444444444444...... PP
   S: 174  tltgghtdsvysls..................fdsng...kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgs 245
                     ++ +                  +++ g   +++++gs+d+t+klwd  +g+c++tl+gh+++v+ + f+p + +l+s+s+D++
   Q: 264  --------FNECCAiapptsyqylaplarlakVSRAGstaEFMATGSRDKTIKLWDA-RGTCLMTLTGHDNWVRAIVFHPGGRYLLSVSDDKT 347
           ........44444433333322222333333444444888****************9.899******************************** PP
   S: 246  iriWdl.rsgdllktlqlhn..........................................ssvisvavlsfgdnvlvlgsedskvniw 292
           +r+Wdl + g+++kt+  ++                                          +s++ v+     + v+++gs d+k++i+
   Q: 348  LRCWDLsQEGKCVKTIRDTHggfitclrwapailkdtptdaaralvrqipdvaeimknatfeESFSDVQI----RCVVATGSVDKKLQIF 433
           ****973679********9976666666666666655555555555555555555554444444444444....5555666666666665 PP

Organism

Aspergillus clavatus

Functional Description
(View)

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.

Protein Sequence
(Fasta)

MARLLTNSQA EELHKSIIAY LSANGLPETT AILRKELGVT EHDFNATAVK KYETLLEKNG 60
PLLFAYRESR DSKAWLPQRP RYSLHSHRDT INCIAFHPKY SSIASGSDDC TIKIWDWELG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTCGCT TATTAACTAA TAGTCAAGCT GAAGAGCTGT AAGTCTAGGC CTTGGTGTGC 60
AAACTCTGAG GATCTCTCAA AGACTGATGC TGGGCACAAT CCAAGGCACA AATCCATTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0000922--C:spindle pole
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0006810--P:transport

KEGG

act:ACLA_091650

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ath-006686	Arabidopsis thaliana	34.35	6.00e-29	121.00
IUUC-Aor-009973	Aspergillus oryzae	64.27	6.00e-167	578.00
IUUC-Bdi-014652	Brachypodium distachyon	31.27	8.00e-29	120.00
IUUC-Bol-015355	Brassica oleracea	33.59	3.00e-28	119.00
IUUC-Hvu-047649	Hordeum vulgare	31.66	3.00e-29	122.00
IUUC-Lpe-051554	Leersia perrieri	31.91	3.00e-30	125.00
IUUC-Mtr-058053	Medicago truncatula	30.63	2.00e-29	122.00
IUUC-Oba-075448	Oryza barthii	32.82	1.00e-30	126.00
IUUC-Obr-076385	Oryza brachyantha	32.43	8.00e-30	124.00
IUUC-Ogl-077427	Oryza glaberrima	32.82	1.00e-30	127.00
IUUC-Oin-079811	Oryza indica	32.82	1.00e-30	127.00
IUUC-Olo-080245	Oryza longistaminata	32.82	1.00e-30	127.00
IUUC-Ome-081239	Oryza meridionalis	32.82	1.00e-30	126.00
IUUC-Oni-082640	Oryza nivara	32.82	1.00e-30	126.00
IUUC-Opu-083748	Oryza punctata	32.43	3.00e-30	125.00
IUUC-Oru-084609	Oryza rufipogon	32.82	1.00e-30	126.00
IUUC-Osa-085988	Oryza sativa	32.82	7.00e-31	127.00
IUUC-Pop-099149	Populus trichocarpa	31.66	9.00e-29	120.00
IUUC-Ppe-101237	Prunus persica	32.05	1.00e-29	123.00
IUUC-Sit-110360	Setaria italica	32.82	2.00e-30	126.00
IUUC-Tca-121185	Theobroma cacao	30.50	3.00e-27	115.00
IUUC-Tur-126411	Triticum urartu	31.66	2.00e-29	122.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence