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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106371
Ensembl Protein ID YHR193C
UniProt Accession P38879; D3DLE1; NACA_YEAST
Genbank Protein ID AAA92080.1; AAB68367.1; AAS56614.1; AAC15849.1; DAA06885.1
Protein Name Nascent polypeptide-associated complex subunit alpha; Alpha-NAC; GAL4 DNA-binding enhancer protein 2
Genbank Nucleotide ID U17134; U00030; AY558288; L12222; BK006934
Gene Name EGD2; YHR193C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YHR193C YHR193C YHR193C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
PHOSIDABioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 16926149; 12672455; 19087962
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 2.60e-06 25.9 137 173
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 4    edkleqlve.MGFdreealqaLraannnleaAveyLl 39
           +d +e  v  ++ ++++a++aL a+n++l  A++ L 
   Q: 137  KDDIELVVQqTNVSKNQAIKALKAHNGDLVNAIMSLS 173
           566777777799*********************9986 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation.
 Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation.
Protein Sequence
(Fasta)
MSAIPENANV TVLNKNEKKA RELIGKLGLK QIPGIIRVTF RKKDNQIYAI EKPEVFRSAG 60
GNYVVFGEAK VDNFTQKLAA AQQQAQASGI MPSNEDVATK SPEDIQADMQ AAAEGSVNAA 120
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Protein Fasta Sequence


>IUUC-Sce-106371|UBD,UBA|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGTCTGCTA TCCCAGAAAA CGCCAACGTT ACCGTCTTAA ACAAGAACGA AAAGAAAGCC 60
AGAGAATTGA TTGGCAAATT GGGTTTGAAG CAAATCCCAG GTATCATCAG AGTCACTTTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106371|UBD,UBA|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation
Interpro

IPR016641--EGD2/NACA
IPR002715--Nas_poly-pep-assoc_cplx_dom
IPR009060--UBA-like
PROSITE

PS51151--NAC_AB
Pfam

PF01849--NAC
SMART

SM01407--NAC
Gene Ontology

GO:0005854--C:nascent polypeptide-associated complex
GO:0005634--C:nucleus
GO:0070300--F:phosphatidic acid binding
GO:0080025--F:phosphatidylinositol-3,5-bisphosphate binding
GO:0032266--F:phosphatidylinositol-3-phosphate binding
GO:0070273--F:phosphatidylinositol-4-phosphate binding
GO:0051082--F:unfolded protein binding
GO:0051083--P:'de novo' cotranslational protein folding
GO:0006620--P:posttranslational protein targeting to membrane
KEGG sce:YHR193C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000480 Aegilops tauschii 33.77 2.00e-17 80.10
IUUC-Aml-002185 Ailuropoda melanoleuca 39.39 5.00e-20 92.00
IUUC-Atr-002586 Amborella trichopoda 29.70 2.00e-09 53.50
IUUC-Apl-003190 Anas platyrhynchos 38.04 2.00e-20 89.00
IUUC-Aca-005265 Anolis carolinensis 37.27 1.00e-20 90.50
IUUC-Aly-006397 Arabidopsis lyrata 35.33 7.00e-17 77.80
IUUC-Ath-007378 Arabidopsis thaliana 36.24 4.00e-16 75.90
IUUC-Ago-007936 Ashbya gossypii 55.62 1.00e-40 156.00
IUUC-Acl-008036 Aspergillus clavatus 52.86 1.00e-18 84.00
IUUC-Afl-008462 Aspergillus flavus 51.39 5.00e-19 85.50
IUUC-Afu-008832 Aspergillus fumigatus 53.12 3.00e-17 79.70
IUUC-Ani-009246 Aspergillus nidulans 50.68 1.00e-18 84.30
IUUC-Ang-009808 Aspergillus niger 52.86 2.00e-18 83.60
IUUC-Aor-009972 Aspergillus oryzae 51.39 5.00e-19 85.50
IUUC-Ame-011674 Astyanax mexicanus 38.41 5.00e-21 92.00
IUUC-Bgr-012162 Blumeria graminis 37.42 1.00e-20 90.90
IUUC-Bta-012508 Bos taurus 38.51 4.00e-20 89.40
IUUC-Bci-013643 Botrytis cinerea 48.61 8.00e-16 74.70
IUUC-Bdi-014874 Brachypodium distachyon 36.24 5.00e-14 68.60
IUUC-Bol-015681 Brassica oleracea 38.93 3.00e-17 79.30
IUUC-Bra-017630 Brassica rapa 50.00 9.00e-12 61.20
IUUC-Cel-018111 Caenorhabditis elegans 40.99 7.00e-24 101.00
IUUC-Cja-019846 Callithrix jacchus 37.42 4.00e-20 92.40
IUUC-Cfa-020429 Canis familiaris 38.51 3.00e-20 89.40
IUUC-Cpo-021659 Cavia porcellus 37.89 7.00e-20 90.90
IUUC-Cre-022679 Chlamydomonas reinhardtii 32.93 5.00e-19 84.70
IUUC-Csa-023260 Chlorocebus sabaeus 39.13 1.00e-19 90.50
IUUC-Cho-024869 Choloepus hoffmanni 57.14 1.00e-06 43.90
IUUC-Cin-025166 Ciona intestinalis 35.40 2.00e-19 87.00
IUUC-Csv-026284 Ciona savignyi 37.75 2.00e-18 82.40
IUUC-Cgl-026520 Colletotrichum gloeosporioides 41.67 1.00e-13 67.80
IUUC-Cne-026920 Cryptococcus neoformans 32.96 5.00e-17 78.60
IUUC-Cme-027301 Cyanidioschyzon merolae 32.56 2.00e-13 67.00
IUUC-Dre-027840 Danio rerio 34.68 5.00e-22 95.50
IUUC-Dno-029367 Dasypus novemcinctus 36.02 9.00e-19 87.80
IUUC-Dor-030962 Dipodomys ordii 38.51 5.00e-20 89.00
IUUC-Dme-032061 Drosophila melanogaster 35.40 7.00e-14 68.60
IUUC-Ete-033075 Echinops telfairi 37.09 2.00e-18 85.90
IUUC-Eca-034049 Equus caballus 37.89 2.00e-19 87.00
IUUC-Eeu-034673 Erinaceus europaeus 38.51 4.00e-20 89.40
IUUC-Fca-035429 Felis catus 39.75 5.00e-20 92.00
IUUC-Fal-037006 Ficedula albicollis 38.51 8.00e-20 88.20
IUUC-Fox-037704 Fusarium oxysporum 39.88 3.00e-21 92.80
IUUC-Fso-038247 Fusarium solani 38.73 6.00e-20 88.60
IUUC-Gmo-039002 Gadus morhua 39.66 4.00e-22 95.90
IUUC-Ggr-039888 Gaeumannomyces graminis 40.54 1.00e-13 67.40
IUUC-Gga-040237 Gallus gallus 38.51 4.00e-20 89.00
IUUC-Gac-041800 Gasterosteus aculeatus 39.13 2.00e-20 91.30
IUUC-Gma-043275 Glycine max 33.54 2.00e-18 83.60
IUUC-Ggo-045163 Gorilla gorilla 36.02 2.00e-21 93.20
IUUC-Hsa-045795 Homo sapiens 47.69 4.00e-15 76.30
IUUC-Hvu-047114 Hordeum vulgare 31.37 2.00e-17 79.70
IUUC-Itr-048152 Ictidomys tridecemlineatus 38.51 4.00e-20 89.40
IUUC-Kpa-049166 Komagataella pastoris 49.72 2.00e-34 136.00
IUUC-Lch-050076 Latimeria chalumnae 39.13 9.00e-21 91.30
IUUC-Lpe-051258 Leersia perrieri 36.67 2.00e-18 83.20
IUUC-Loc-052292 Lepisosteus oculatus 39.24 4.00e-20 89.40
IUUC-Lma-053293 Leptosphaeria maculans 39.18 7.00e-22 94.70
IUUC-Laf-054393 Loxodonta africana 36.65 1.00e-20 90.90
IUUC-Mcc-054632 Macaca mulatta 47.69 5.00e-15 75.90
IUUC-Meu-056242 Macropus eugenii 47.69 2.00e-15 73.60
IUUC-Mor-057099 Magnaporthe oryzae 43.06 1.00e-13 67.40
IUUC-Mpo-057543 Magnaporthe poae 36.36 4.00e-10 55.50
IUUC-Mtr-058769 Medicago truncatula 48.98 2.00e-09 53.50
IUUC-Mla-059166 Melampsora laricipopulina 37.65 2.00e-21 93.20
IUUC-Mga-060195 Meleagris gallopavo 34.78 1.00e-20 90.90
IUUC-Mvi-060390 Microbotryum violaceum 31.06 1.00e-14 70.10
IUUC-Mmr-061475 Microcebus murinus 36.14 3.00e-21 95.90
IUUC-Mdo-062474 Monodelphis domestica 36.02 1.00e-20 94.40
IUUC-Mmu-063984 Mus musculus 47.69 2.00e-15 77.00
IUUC-Mac-065175 Musa acuminata 36.18 3.00e-19 85.90
IUUC-Mpu-066751 Mustela putorius furo 40.00 6.00e-20 92.00
IUUC-Mlu-068234 Myotis lucifugus 38.51 4.00e-20 89.40
IUUC-Nfi-068541 Neosartorya fischeri 53.12 3.00e-17 79.70
IUUC-Ncr-068830 Neurospora crassa 44.59 6.00e-16 75.10
IUUC-Nle-069126 Nomascus leucogenys 38.51 6.00e-20 88.60
IUUC-Opr-070742 Ochotona princeps 38.51 3.00e-20 89.40
IUUC-Ont-071828 Oreochromis niloticus 39.13 3.00e-21 93.20
IUUC-Oan-073462 Ornithorhynchus anatinus 47.69 1.00e-14 74.30
IUUC-Ocu-074890 Oryctolagus cuniculus 37.04 4.00e-19 89.40
IUUC-Oba-075995 Oryza barthii 35.53 2.00e-19 87.00
IUUC-Obr-076073 Oryza brachyantha 35.53 1.00e-18 84.00
IUUC-Ogl-077445 Oryza glaberrima 35.53 2.00e-19 87.00
IUUC-Ogu-078606 Oryza glumaepatula 35.53 2.00e-19 87.00
IUUC-Oin-079287 Oryza indica 35.53 2.00e-19 87.00
IUUC-Olo-080686 Oryza longistaminata 31.95 2.00e-15 73.20
IUUC-Ome-081567 Oryza meridionalis 38.26 4.00e-19 85.10
IUUC-Oni-082873 Oryza nivara 35.53 2.00e-19 87.00
IUUC-Opu-083488 Oryza punctata 35.57 5.00e-18 82.00
IUUC-Oru-084592 Oryza rufipogon 35.53 2.00e-19 87.00
IUUC-Osa-086102 Oryza sativa 35.53 2.00e-19 87.00
IUUC-Ola-087531 Oryzias latipes 35.80 3.00e-21 92.80
IUUC-Olu-087895 Ostreococcus lucimarinus 32.47 4.00e-15 71.20
IUUC-Oga-088239 Otolemur garnettii 38.51 4.00e-20 89.40
IUUC-Oar-090371 Ovis aries 39.39 2.00e-19 89.70
IUUC-Ptr-090481 Pan troglodytes 38.89 2.00e-18 86.70
IUUC-Pan-092210 Papio anubis 39.13 3.00e-19 89.70
IUUC-Psi-093905 Pelodiscus sinensis 36.65 9.00e-21 91.30
IUUC-Pma-094702 Petromyzon marinus 39.13 4.00e-20 89.40
IUUC-Pno-094927 Phaeosphaeria nodorum 48.61 1.00e-16 77.40
IUUC-Ppa-095389 Physcomitrella patens 44.26 8.00e-13 64.70
IUUC-Pfo-096744 Poecilia formosa 37.65 1.00e-20 90.50
IUUC-Pab-098044 Pongo abelii 38.51 4.00e-20 89.40
IUUC-Pop-099938 Populus trichocarpa 36.42 8.00e-19 84.70
IUUC-Pca-100355 Procavia capensis 39.51 1.00e-20 93.60
IUUC-Ppe-101786 Prunus persica 36.42 2.00e-18 83.20
IUUC-Pva-102494 Pteropus vampyrus 38.51 3.00e-20 89.40
IUUC-Pgr-103303 Puccinia graminis 34.36 1.00e-18 84.00
IUUC-Ptt-103748 Puccinia triticina 35.21 1.00e-08 50.80
IUUC-Pte-104368 Pyrenophora teres 40.59 6.00e-21 91.70
IUUC-Pyt-104542 Pyrenophora triticirepentis 40.59 4.00e-21 92.40
IUUC-Rno-105387 Rattus norvegicus 47.69 3.00e-15 77.00
IUUC-Sha-107189 Sarcophilus harrisii 38.51 4.00e-20 89.40
IUUC-Sja-107942 Schizosaccharomyces japonicus 60.00 8.00e-07 44.70
IUUC-Spo-108121 Schizosaccharomyces pombe 32.37 2.00e-15 73.60
IUUC-Ssl-108595 Sclerotinia sclerotiorum 50.00 8.00e-17 78.20
IUUC-Smo-108783 Selaginella moellendorffii 36.42 9.00e-17 78.20
IUUC-Sit-110180 Setaria italica 36.67 1.00e-16 77.80
IUUC-Sly-110957 Solanum lycopersicum 36.00 3.00e-17 79.30
IUUC-Stu-112873 Solanum tuberosum 36.00 3.00e-17 79.30
IUUC-Sar-113668 Sorex araneus 57.14 2.00e-06 43.90
IUUC-Sbi-114328 Sorghum bicolor 37.33 1.00e-17 80.90
IUUC-Sre-115220 Sporisorium reilianum 39.71 6.00e-12 61.60
IUUC-Ssc-116119 Sus scrofa 38.51 4.00e-20 89.40
IUUC-Tgu-116528 Taeniopygia guttata 38.61 3.00e-19 85.90
IUUC-Tru-117538 Takifugu rubripes 38.27 4.00e-21 92.40
IUUC-Tsy-118855 Tarsius syrichta 57.14 1.00e-06 44.30
IUUC-Tni-120134 Tetraodon nigroviridis 37.65 3.00e-21 92.80
IUUC-Tca-121524 Theobroma cacao 36.84 8.00e-19 84.70
IUUC-Tre-121915 Trichoderma reesei 43.84 2.00e-12 63.50
IUUC-Tvi-122411 Trichoderma virens 44.93 2.00e-11 60.50
IUUC-Tae-123448 Triticum aestivum 34.21 1.00e-15 73.90
IUUC-Tur-126728 Triticum urartu 35.57 2.00e-17 80.50
IUUC-Tme-126875 Tuber melanosporum 48.48 6.00e-16 74.70
IUUC-Tbe-127759 Tupaia belangeri 34.44 2.00e-15 73.20
IUUC-Ttr-129124 Tursiops truncatus 34.97 2.00e-18 86.70
IUUC-Uma-129551 Ustilago maydis 38.57 3.00e-12 62.80
IUUC-Vda-129992 Verticillium dahliae 41.86 1.00e-21 94.40
IUUC-Vpa-130096 Vicugna pacos 38.51 2.00e-18 83.20
IUUC-Vvi-130940 Vitis vinifera 39.60 6.00e-18 82.00
IUUC-Xtr-132904 Xenopus tropicalis 37.89 8.00e-21 91.70
IUUC-Xma-133842 Xiphophorus maculatus 47.69 2.00e-15 73.90
IUUC-Yli-134485 Yarrowia lipolytica 36.56 1.00e-19 87.00
IUUC-Zma-135748 Zea mays 36.91 3.00e-17 79.70
Created Date 25-Jun-2017

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