iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT4G05320	AT4G05320.4	AT4G05320.4
AT4G05320	AT4G05320.8	AT4G05320.8
AT4G05320	AT4G05320.3	AT4G05320.3
AT4G05320	AT4G05320.7	AT4G05320.7

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
PINA	HINT	Mentha
Post-translational Modifications (PTMs)
dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UBL/NEDD8	2.90e-247	800.5	381	456
ULD/UDP/UBQ/UBQ_PIM	2.30e-168	547.4	381	453

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/NEDD8

   S: 1    mlikvktLtgkeieieieesdtierikerveekeGiPPsqqrliyaGkqleddktaadynlekgsvLhLvLaLrGG 76
           m+i+vktLtgk+i++e+e+sdti+++k+++++keGiPP+qqrli+aGkqled++t+adyn++k+s+LhLvL+LrGG
   Q: 381  MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGG 456
           89*************************************************************************9 PP

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkk 73
           m+++vktl+gk+++lev+++dt+ ++K+ki+++ g+pp+qq+LI+aGk+L+D +tL +++i+++s++hlv++ 
   Q: 381  MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRL 453
           99********************************************************************986 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).

Protein Sequence
(Fasta)

MQIFVKTLTG KTITLEVESS DTIDNVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLADYN 60
IQKESTLHLV LRLRGGMQIF VKTLTGKTIT LEVESSDTID NVKAKIQDKE GIPPDQQRLI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAATCTTAAA AACTTTCTCT CAATTCTCTC TACCGTGATC AAGGTAAATT TCTGTGTTCC 60
TTATTCTCTC AAAATCTTCG ATTTTGTTTT CGTTCGATCC CAATTTCGTA TATGTTCTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR019956--Ubiquitin
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2

Pfam

PF00240--ubiquitin

PRINTS

PR00348--UBIQUITIN

SMART

SM00213--UBQ

Gene Ontology

GO:0005634--C:nucleus
GO:0005773--C:vacuole
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT4G02890; ath:AT4G05050

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000772	Aegilops tauschii	48.18	4.00e-49	189.00
IUUC-Aly-005969	Arabidopsis lyrata	100.00	0.00e+00	903.00
IUUC-Acl-008108	Aspergillus clavatus	97.37	3.00e-171	593.00
IUUC-Bci-013832	Botrytis cinerea	98.68	9.00e-173	598.00
IUUC-Bol-015598	Brassica oleracea	100.00	0.00e+00	903.00
IUUC-Cel-018571	Caenorhabditis elegans	95.83	0.00e+00	876.00
IUUC-Cfa-020579	Canis familiaris	95.80	0.00e+00	727.00
IUUC-Cin-025600	Ciona intestinalis	96.06	0.00e+00	737.00
IUUC-Csv-026265	Ciona savignyi	94.53	0.00e+00	871.00
IUUC-Cne-026938	Cryptococcus neoformans	98.68	0.00e+00	893.00
IUUC-Dre-028552	Danio rerio	96.05	0.00e+00	871.00
IUUC-Dno-029812	Dasypus novemcinctus	95.80	0.00e+00	727.00
IUUC-Dme-031690	Drosophila melanogaster	95.84	0.00e+00	871.00
IUUC-Fal-036678	Ficedula albicollis	96.07	1.00e-168	584.00
IUUC-Gga-041058	Gallus gallus	95.74	2.00e-168	583.00
IUUC-Gac-042568	Gasterosteus aculeatus	95.42	0.00e+00	867.00
IUUC-Gma-043345	Glycine max	100.00	0.00e+00	904.00
IUUC-Ggo-044799	Gorilla gorilla	95.79	0.00e+00	725.00
IUUC-Hsa-046405	Homo sapiens	96.05	0.00e+00	870.00
IUUC-Hvu-047805	Hordeum vulgare	33.96	3.00e-39	155.00
IUUC-Laf-053548	Loxodonta africana	95.80	0.00e+00	727.00
IUUC-Mcc-055561	Macaca mulatta	96.05	0.00e+00	871.00
IUUC-Mtr-058615	Medicago truncatula	100.00	0.00e+00	903.00
IUUC-Mla-058957	Melampsora laricipopulina	99.78	0.00e+00	899.00
IUUC-Mdo-062630	Monodelphis domestica	96.05	0.00e+00	870.00
IUUC-Mmu-063593	Mus musculus	95.84	0.00e+00	873.00
IUUC-Nfi-068475	Neosartorya fischeri	97.37	3.00e-171	593.00
IUUC-Obr-076236	Oryza brachyantha	100.00	0.00e+00	900.00
IUUC-Oin-079920	Oryza indica	99.78	0.00e+00	901.00
IUUC-Olo-080418	Oryza longistaminata	33.62	2.00e-30	125.00
IUUC-Opu-083917	Oryza punctata	29.23	2.00e-29	123.00
IUUC-Osa-085789	Oryza sativa	100.00	0.00e+00	902.00
IUUC-Ola-087192	Oryzias latipes	95.74	0.00e+00	843.00
IUUC-Oar-089386	Ovis aries	90.37	0.00e+00	811.00
IUUC-Ptr-091261	Pan troglodytes	95.80	0.00e+00	727.00
IUUC-Pan-092134	Papio anubis	96.05	0.00e+00	870.00
IUUC-Psi-093239	Pelodiscus sinensis	74.12	2.00e-179	620.00
IUUC-Pma-094556	Petromyzon marinus	95.29	0.00e+00	763.00
IUUC-Ppa-095548	Physcomitrella patens	98.47	0.00e+00	890.00
IUUC-Pab-097884	Pongo abelii	95.84	0.00e+00	870.00
IUUC-Pop-099637	Populus trichocarpa	100.00	0.00e+00	753.00
IUUC-Pca-100992	Procavia capensis	95.98	0.00e+00	662.00
IUUC-Ppe-101604	Prunus persica	100.00	0.00e+00	903.00
IUUC-Pgr-103301	Puccinia graminis	99.78	0.00e+00	901.00
IUUC-Rno-105199	Rattus norvegicus	95.84	0.00e+00	873.00
IUUC-Sja-107825	Schizosaccharomyces japonicus	97.11	0.00e+00	741.00
IUUC-Smo-109245	Selaginella moellendorffii	98.47	0.00e+00	889.00
IUUC-Sit-110644	Setaria italica	100.00	0.00e+00	888.00
IUUC-Sly-111036	Solanum lycopersicum	100.00	0.00e+00	903.00
IUUC-Stu-112104	Solanum tuberosum	100.00	0.00e+00	903.00
IUUC-Sbi-114776	Sorghum bicolor	100.00	0.00e+00	886.00
IUUC-Ssc-115672	Sus scrofa	96.06	0.00e+00	873.00
IUUC-Tsy-119558	Tarsius syrichta	87.50	8.00e-72	261.00
IUUC-Tca-120959	Theobroma cacao	99.78	0.00e+00	901.00
IUUC-Tae-123654	Triticum aestivum	100.00	0.00e+00	900.00
IUUC-Tur-126025	Triticum urartu	99.78	0.00e+00	905.00
IUUC-Ttr-128311	Tursiops truncatus	95.61	0.00e+00	867.00
IUUC-Uma-129417	Ustilago maydis	98.68	0.00e+00	893.00
IUUC-Vvi-131563	Vitis vinifera	100.00	0.00e+00	903.00
IUUC-Xtr-132052	Xenopus tropicalis	95.61	0.00e+00	865.00
IUUC-Yli-134420	Yarrowia lipolytica	97.37	0.00e+00	886.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence