iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	9.60e-107	357.8	12	430

Active Site

Position(s)	Description	Evidence
175	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR039133-1, ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 11   eaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveaheesiteleeeivFfk 108
           + qe +k++kvl+vGagg+GcE+lKnLvl+G+  i+++D dt+++snlnrqFLf++e+vgksKA va e++  +npd +++a+++s+t +++ + Ffk
   Q: 12   TLQELVKKSKVLVVGAGGIGCEVLKNLVLSGFTDIEIIDLDTIDLSNLNRQFLFHREHVGKSKARVARESALSFNPDAKITAYHDSVTSTDYGVNFFK 109
           67999****************************************************************************************99*** PP
   S: 109  kfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketpnaaehtiewa.vlfnklleeeageee 205
           kfd+V++aldnr+ar++vnr+clna+vpliesgt G+ Gqv+ i +glt cy+c+++++q+++P+ct+++tp+++ h+i+wa +lfn+l++e+ ++e+
   Q: 110  KFDLVLSALDNRAARNHVNRMCLNADVPLIESGTAGYNGQVELIKRGLTQCYECTPKDKQRSFPGCTIRNTPSEPIHCIVWAkHLFNQLFGESLEDED 207
           ***********************************************************************************899999988888888 PP
   S: 206  vlekldseekeegkdkvkselks................edeenfeeaieiavkafakttins.ikqllksfecdivtkskspfwv............ 274
            +++ +  + +e +    +++ +                ++     ++++i ++++ak  +++  k + k f+ di +   ++ ++            
   Q: 208  ISPDAADPDAKEKDGGDGNGEPKgdgkekgeeskeekeaKEDTANGNIMRINTRQWAKDCNYDaGKLFNKFFNEDITYLLRMSNLWktrkapvpvqwd 305
           8887766555554443333333345555555555555434444456789**************99999999***************888888888888 PP
   S: 275  .........sfcsnaealqvpekvekdeevvkasaplylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiepkldddlikeiag 363
                      + +a+++   +++e+  +v++ s     l++   +f k +g +  +l ++kdd+ a+d+v+a+an r + ++ie   +++ ik++ag
   Q: 306  tllpegssgDQKDVAKQHHKVWSIEECAQVFANS-----LKELSANFLKLEGDD--TLAWDKDDQPAMDFVAACANVRSHIFDIER-KSRFEIKSMAG 395
           8888887777777777777778888888888777.....567777888888886..69****************************.*********** PP
   S: 364  niipaiattnavvgGlaaqEviKvvsgkfeplknf 398
           niipaiattna+ +G+ ++ ++Kv+++k e++k +
   Q: 396  NIIPAIATTNAITAGISVMRAFKVLEAKWEQCKAV 430
           ********************************975 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MAAAINGVFP PTLQELVKKS KVLVVGAGGI GCEVLKNLVL SGFTDIEIID LDTIDLSNLN 60
RQFLFHREHV GKSKARVARE SALSFNPDAK ITAYHDSVTS TDYGVNFFKK FDLVLSALDN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTATACGTT TCCCAACACC TGCACCGGCG GCGTCACTTT TCTCGGCTTT TCCGTATCGC 60
AATTTTGCAA TTTTCTCGCC AAAAATAAGA AAAAGGAAAA CGTAAATTCA GAAAATGGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR016040--NAD(P)-bd_dom
IPR030661--SAE2/Uba2
IPR000594--ThiF_NAD_FAD-bd
IPR028077--UAE_UbL_dom
IPR019572--UBA_E1_Cys
IPR033127--UBQ-activ_enz_E1_Cys_AS

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF00899--ThiF
PF14732--UAE_UbL
PF10585--UBA_e1_thiolCys

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0031510--C:SUMO activating enzyme complex
GO:0019948--F:SUMO activating enzyme activity
GO:0033134--F:ubiquitin activating enzyme binding
GO:0006959--P:humoral immune response
GO:0034126--P:positive regulation of MyD88-dependent toll-like receptor signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0016925--P:protein sumoylation

KEGG

dme:Dmel_CG7528

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000112	Aegilops tauschii	36.27	2.00e-101	362.00
IUUC-Aml-001662	Ailuropoda melanoleuca	49.67	2.00e-164	571.00
IUUC-Atr-002636	Amborella trichopoda	38.37	9.00e-103	367.00
IUUC-Apl-003369	Anas platyrhynchos	48.14	2.00e-146	511.00
IUUC-Aca-004490	Anolis carolinensis	52.12	1.00e-143	502.00
IUUC-Aly-006359	Arabidopsis lyrata	37.43	8.00e-88	317.00
IUUC-Ath-007667	Arabidopsis thaliana	38.30	2.00e-92	332.00
IUUC-Ago-007844	Ashbya gossypii	33.23	1.00e-78	286.00
IUUC-Acl-008270	Aspergillus clavatus	45.27	1.00e-102	366.00
IUUC-Afl-008674	Aspergillus flavus	39.88	3.00e-112	398.00
IUUC-Afu-008883	Aspergillus fumigatus	45.14	7.00e-106	377.00
IUUC-Ani-009500	Aspergillus nidulans	42.91	9.00e-110	390.00
IUUC-Ang-009535	Aspergillus niger	63.68	4.00e-72	265.00
IUUC-Aor-010223	Aspergillus oryzae	40.12	2.00e-113	402.00
IUUC-Ate-010282	Aspergillus terreus	44.14	1.00e-91	330.00
IUUC-Ame-011736	Astyanax mexicanus	49.29	2.00e-171	594.00
IUUC-Bgr-012166	Blumeria graminis	44.26	6.00e-103	367.00
IUUC-Bta-012589	Bos taurus	49.42	5.00e-166	577.00
IUUC-Bci-013802	Botrytis cinerea	42.51	2.00e-101	362.00
IUUC-Bdi-014697	Brachypodium distachyon	35.03	1.00e-99	356.00
IUUC-Bol-016315	Brassica oleracea	35.93	1.00e-94	340.00
IUUC-Bra-017009	Brassica rapa	35.82	6.00e-94	337.00
IUUC-Cel-018708	Caenorhabditis elegans	60.85	5.00e-69	254.00
IUUC-Cja-019120	Callithrix jacchus	48.85	5.00e-163	566.00
IUUC-Cfa-021061	Canis familiaris	49.42	4.00e-165	573.00
IUUC-Cpo-021842	Cavia porcellus	48.76	1.00e-161	562.00
IUUC-Csa-024104	Chlorocebus sabaeus	50.00	1.00e-160	559.00
IUUC-Cho-024332	Choloepus hoffmanni	46.37	7.00e-130	456.00
IUUC-Cin-025363	Ciona intestinalis	51.28	5.00e-160	556.00
IUUC-Cgl-026419	Colletotrichum gloeosporioides	61.58	3.00e-72	265.00
IUUC-Cne-026888	Cryptococcus neoformans	39.27	4.00e-70	258.00
IUUC-Cme-027315	Cyanidioschyzon merolae	47.00	8.00e-49	187.00
IUUC-Dre-028420	Danio rerio	51.05	2.00e-165	575.00
IUUC-Dno-030041	Dasypus novemcinctus	48.93	7.00e-162	563.00
IUUC-Dor-031039	Dipodomys ordii	38.03	7.00e-59	221.00
IUUC-Dse-031504	Dothistroma septosporum	40.61	4.00e-95	341.00
IUUC-Ete-033037	Echinops telfairi	45.96	7.00e-144	503.00
IUUC-Eca-033774	Equus caballus	48.81	1.00e-157	548.00
IUUC-Eeu-035074	Erinaceus europaeus	42.42	1.00e-109	389.00
IUUC-Fca-036508	Felis catus	49.32	7.00e-159	553.00
IUUC-Fal-036813	Ficedula albicollis	48.81	1.00e-152	532.00
IUUC-Fox-038056	Fusarium oxysporum	41.61	2.00e-109	389.00
IUUC-Fso-038223	Fusarium solani	42.29	2.00e-107	382.00
IUUC-Gmo-038526	Gadus morhua	51.68	3.00e-156	544.00
IUUC-Ggr-039767	Gaeumannomyces graminis	42.07	3.00e-96	345.00
IUUC-Gga-040981	Gallus gallus	48.44	5.00e-151	527.00
IUUC-Gac-041437	Gasterosteus aculeatus	49.75	5.00e-162	563.00
IUUC-Gma-043041	Glycine max	37.54	6.00e-102	363.00
IUUC-Ggo-045358	Gorilla gorilla	48.59	8.00e-152	529.00
IUUC-Hsa-046068	Homo sapiens	49.83	1.00e-160	559.00
IUUC-Hvu-047646	Hordeum vulgare	34.98	2.00e-100	358.00
IUUC-Itr-047887	Ictidomys tridecemlineatus	49.18	2.00e-161	561.00
IUUC-Lch-049565	Latimeria chalumnae	53.36	1.00e-170	592.00
IUUC-Lpe-050884	Leersia perrieri	39.71	2.00e-101	362.00
IUUC-Loc-052493	Lepisosteus oculatus	50.97	7.00e-171	593.00
IUUC-Lma-053117	Leptosphaeria maculans	45.71	2.00e-103	369.00
IUUC-Laf-054518	Loxodonta africana	48.85	4.00e-163	567.00
IUUC-Mcc-055334	Macaca mulatta	49.83	2.00e-160	558.00
IUUC-Mor-057137	Magnaporthe oryzae	43.76	2.00e-91	329.00
IUUC-Mpo-057449	Magnaporthe poae	41.44	5.00e-97	347.00
IUUC-Mtr-058045	Medicago truncatula	39.09	1.00e-104	373.00
IUUC-Mla-058864	Melampsora laricipopulina	41.24	1.00e-81	296.00
IUUC-Mga-059422	Meleagris gallopavo	46.23	6.00e-128	450.00
IUUC-Mvi-060536	Microbotryum violaceum	38.98	9.00e-81	293.00
IUUC-Mmr-061161	Microcebus murinus	48.30	1.00e-159	555.00
IUUC-Mdo-061802	Monodelphis domestica	49.17	1.00e-161	562.00
IUUC-Mmu-064357	Mus musculus	48.66	1.00e-168	585.00
IUUC-Mac-065475	Musa acuminata	36.94	2.00e-95	342.00
IUUC-Mpu-066895	Mustela putorius furo	49.59	1.00e-165	575.00
IUUC-Mlu-067862	Myotis lucifugus	49.75	5.00e-167	580.00
IUUC-Nfi-068385	Neosartorya fischeri	46.50	4.00e-110	391.00
IUUC-Ncr-068885	Neurospora crassa	46.02	1.00e-106	379.00
IUUC-Nle-069524	Nomascus leucogenys	50.34	3.00e-160	557.00
IUUC-Opr-071038	Ochotona princeps	48.98	1.00e-169	588.00
IUUC-Ont-071719	Oreochromis niloticus	50.75	9.00e-172	596.00
IUUC-Oan-072877	Ornithorhynchus anatinus	49.74	3.00e-146	511.00
IUUC-Ocu-074080	Oryctolagus cuniculus	48.68	4.00e-162	564.00
IUUC-Oba-075936	Oryza barthii	37.94	2.00e-99	355.00
IUUC-Obr-076841	Oryza brachyantha	38.12	1.00e-101	362.00
IUUC-Ogl-077686	Oryza glaberrima	38.07	3.00e-101	361.00
IUUC-Ogu-078597	Oryza glumaepatula	36.79	1.00e-96	346.00
IUUC-Oin-079791	Oryza indica	37.94	2.00e-99	355.00
IUUC-Olo-081009	Oryza longistaminata	37.94	2.00e-99	355.00
IUUC-Ome-081327	Oryza meridionalis	34.87	8.00e-92	330.00
IUUC-Oni-082334	Oryza nivara	37.15	4.00e-97	348.00
IUUC-Opu-083447	Oryza punctata	38.48	6.00e-100	357.00
IUUC-Oru-084977	Oryza rufipogon	37.94	2.00e-99	355.00
IUUC-Osa-086160	Oryza sativa	40.94	5.00e-88	317.00
IUUC-Ola-087415	Oryzias latipes	48.40	1.00e-168	585.00
IUUC-Olu-087850	Ostreococcus lucimarinus	38.98	3.00e-96	344.00
IUUC-Oga-088434	Otolemur garnettii	49.09	2.00e-162	565.00
IUUC-Oar-089872	Ovis aries	49.32	2.00e-158	551.00
IUUC-Ptr-091212	Pan troglodytes	49.83	1.00e-160	559.00
IUUC-Pan-092708	Papio anubis	60.89	2.00e-86	311.00
IUUC-Psi-093703	Pelodiscus sinensis	50.26	5.00e-152	530.00
IUUC-Pno-094953	Phaeosphaeria nodorum	44.92	8.00e-113	400.00
IUUC-Ppa-095963	Physcomitrella patens	37.88	4.00e-97	347.00
IUUC-Pfo-097515	Poecilia formosa	50.00	5.00e-160	556.00
IUUC-Pab-097951	Pongo abelii	47.52	6.00e-130	456.00
IUUC-Pop-100079	Populus trichocarpa	32.09	2.00e-85	309.00
IUUC-Pca-100426	Procavia capensis	49.51	3.00e-167	580.00
IUUC-Ppe-101152	Prunus persica	36.49	9.00e-103	366.00
IUUC-Pva-102792	Pteropus vampyrus	46.11	2.00e-153	535.00
IUUC-Pgr-103592	Puccinia graminis	34.23	2.00e-91	329.00
IUUC-Ptt-103805	Puccinia triticina	34.63	8.00e-74	270.00
IUUC-Pte-104215	Pyrenophora teres	43.14	3.00e-120	424.00
IUUC-Pyt-104634	Pyrenophora triticirepentis	45.26	3.00e-119	421.00
IUUC-Rno-106117	Rattus norvegicus	48.81	4.00e-168	583.00
IUUC-Sce-106177	Saccharomyces cerevisiae	35.40	7.00e-72	264.00
IUUC-Sha-107006	Sarcophilus harrisii	48.93	6.00e-162	563.00
IUUC-Sja-107967	Schizosaccharomyces japonicus	41.83	3.00e-90	325.00
IUUC-Spo-108020	Schizosaccharomyces pombe	41.23	5.00e-93	334.00
IUUC-Ssl-108509	Sclerotinia sclerotiorum	42.29	3.00e-100	358.00
IUUC-Smo-109264	Selaginella moellendorffii	37.33	1.00e-96	346.00
IUUC-Sit-110581	Setaria italica	36.47	8.00e-102	363.00
IUUC-Sly-111870	Solanum lycopersicum	35.93	6.00e-102	363.00
IUUC-Stu-112283	Solanum tuberosum	36.24	3.00e-102	365.00
IUUC-Sar-113432	Sorex araneus	67.18	1.00e-50	193.00
IUUC-Sbi-114075	Sorghum bicolor	36.16	6.00e-103	367.00
IUUC-Sre-114926	Sporisorium reilianum	38.85	1.00e-99	356.00
IUUC-Ssc-116281	Sus scrofa	73.12	8.00e-84	301.00
IUUC-Tgu-117247	Taeniopygia guttata	46.76	2.00e-152	531.00
IUUC-Tru-118075	Takifugu rubripes	50.91	4.00e-159	553.00
IUUC-Tsy-119398	Tarsius syrichta	38.29	3.00e-110	391.00
IUUC-Tni-120771	Tetraodon nigroviridis	47.16	1.00e-137	482.00
IUUC-Tca-121651	Theobroma cacao	38.07	1.00e-98	353.00
IUUC-Tre-122224	Trichoderma reesei	44.40	2.00e-102	365.00
IUUC-Tvi-122634	Trichoderma virens	43.82	2.00e-101	362.00
IUUC-Tae-123607	Triticum aestivum	35.49	7.00e-101	360.00
IUUC-Tur-126417	Triticum urartu	35.82	1.00e-100	360.00
IUUC-Tme-127016	Tuber melanosporum	44.68	1.00e-93	336.00
IUUC-Tbe-127678	Tupaia belangeri	43.22	3.00e-54	205.00
IUUC-Ttr-128598	Tursiops truncatus	47.45	3.00e-154	537.00
IUUC-Uma-129612	Ustilago maydis	37.41	3.00e-85	308.00
IUUC-Vda-129811	Verticillium dahliae	42.69	1.00e-95	343.00
IUUC-Vpa-130732	Vicugna pacos	38.71	2.00e-112	399.00
IUUC-Vvi-130832	Vitis vinifera	36.36	1.00e-94	339.00
IUUC-Xtr-132823	Xenopus tropicalis	45.74	4.00e-145	507.00
IUUC-Xma-133552	Xiphophorus maculatus	50.33	3.00e-160	557.00
IUUC-Yli-134666	Yarrowia lipolytica	39.57	9.00e-78	283.00
IUUC-Zma-135547	Zea mays	36.06	2.00e-102	365.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence