iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071646

Ensembl Protein ID

ENSONIP00000016600.1

UniProt Accession

I3K655; I3K655_ORENI

Genbank Protein ID

ENSONIP00000016600

Protein Name

Ribosome biogenesis protein WDR12; WD repeat-containing protein 12

Genbank Nucleotide ID

AERX01065581

Gene Name

wdr12; WDR12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000013200.1	ENSONIT00000016615.1	ENSONIP00000016600.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.50e-42	142.1	341	376
UBD/Beta-Prp	7.50e-47	160.3	246	412

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWDlrtgv 34
           Ht++vt++++  s  + lvsGs D+ ik+WD+r+++
   Q: 341  HTGWVTAVKWapSHeHQLVSGSLDNLIKLWDTRSCK 376
           ***********754688**************99876 PP

UBD/Beta-Prp

   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkl 171
           t+++++tl+gh++ v s+ ++  ++ + s+s+d tir+wd++tg     tl+g + v nc++++p ++ l+sGs+Dr +rlWd +t++ 
   Q: 246  TRTPLMTLSGHSEAVSSVLWCD-SEEVCSASWDHTIRIWDVDTGGMKT-TLTGSK-VFNCISYSPLCRRLASGSTDRHIRLWDPRTKDG 331
           67899*****************.8999*******************98.999987.99**************************88764 PP
   S: 172  lrtl...tgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
              l   t+ ht+ v+ +++ ++   +lvsgsld+ +klwd +  +  ++ l +h+d v +v+ + ++ +++sg++D+ ++ +
   Q: 332  SLVLlslTS-HTGWVTAVKWAPSHeHQLVSGSLDNLIKLWDTRsCKAPLYDLAAHEDKVFCVDWT-ESGLMLSGGADNKLYTY 412
           444444387.**********9988788****************54566****************9.99*********998876 PP

Organism

Oreochromis niloticus

Functional Description
(View)

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Protein Sequence
(Fasta)

MSQIQARFFT EDKRYVVDDV PFSIPAASEV QELSNVINKL LEAKNASHSK VEFDFLVRGQ 60
FLRTSLSAHM ETESILTEEV VEIEYVERIT APEPEECMMH DDWISSADAD AEWILTGSYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTCAGA TACAGGCAAG ATTCTTCACA GAAGACAAAA GGTGAGGTTT AAAAGAAAAA 60
AAAAAACCTC AACAGAAAAT GACAAACAAG CAAGCGAGCT AGCTAACTTG CTAGCTGTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0030687--C:preribosome, large subunit precursor
GO:0043021--F:ribonucleoprotein complex binding
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000532	Aegilops tauschii	31.59	6.00e-55	208.00
IUUC-Aml-001997	Ailuropoda melanoleuca	78.36	8.00e-180	623.00
IUUC-Atr-002544	Amborella trichopoda	33.33	3.00e-55	209.00
IUUC-Apl-003981	Anas platyrhynchos	77.39	4.00e-171	593.00
IUUC-Aca-004370	Anolis carolinensis	77.03	0.00e+00	651.00
IUUC-Aly-006455	Arabidopsis lyrata	33.25	4.00e-55	208.00
IUUC-Ath-006669	Arabidopsis thaliana	34.47	1.00e-50	194.00
IUUC-Ago-007864	Ashbya gossypii	31.36	3.00e-41	162.00
IUUC-Acl-008177	Aspergillus clavatus	29.15	2.00e-34	140.00
IUUC-Afl-008617	Aspergillus flavus	28.63	4.00e-36	145.00
IUUC-Afu-008752	Aspergillus fumigatus	27.27	9.00e-32	131.00
IUUC-Ani-009136	Aspergillus nidulans	29.82	5.00e-34	139.00
IUUC-Ang-009701	Aspergillus niger	27.05	9.00e-33	134.00
IUUC-Aor-009884	Aspergillus oryzae	28.19	5.00e-35	142.00
IUUC-Ame-011432	Astyanax mexicanus	82.90	0.00e+00	684.00
IUUC-Bgr-012218	Blumeria graminis	28.34	1.00e-34	140.00
IUUC-Bta-012829	Bos taurus	77.59	0.00e+00	644.00
IUUC-Bci-013953	Botrytis cinerea	28.08	4.00e-33	135.00
IUUC-Bdi-014351	Brachypodium distachyon	33.89	1.00e-52	200.00
IUUC-Bol-016190	Brassica oleracea	33.16	2.00e-54	206.00
IUUC-Bra-018095	Brassica rapa	33.42	2.00e-55	209.00
IUUC-Cel-018569	Caenorhabditis elegans	32.78	1.00e-52	200.00
IUUC-Cja-019468	Callithrix jacchus	76.87	0.00e+00	627.00
IUUC-Cfa-020471	Canis familiaris	77.83	3.00e-180	624.00
IUUC-Cpo-022260	Cavia porcellus	76.63	0.00e+00	633.00
IUUC-Cre-022614	Chlamydomonas reinhardtii	32.16	2.00e-39	156.00
IUUC-Csa-023989	Chlorocebus sabaeus	76.87	0.00e+00	628.00
IUUC-Cho-024426	Choloepus hoffmanni	75.87	1.00e-137	483.00
IUUC-Cin-025789	Ciona intestinalis	43.41	8.00e-97	347.00
IUUC-Cne-027063	Cryptococcus neoformans	23.97	5.00e-20	92.40
IUUC-Dre-027907	Danio rerio	84.32	0.00e+00	699.00
IUUC-Dno-029225	Dasypus novemcinctus	76.63	0.00e+00	639.00
IUUC-Dor-031082	Dipodomys ordii	64.34	2.00e-137	482.00
IUUC-Dse-031308	Dothistroma septosporum	26.34	8.00e-35	141.00
IUUC-Dme-032189	Drosophila melanogaster	41.63	8.00e-94	337.00
IUUC-Ete-032247	Echinops telfairi	73.73	2.00e-171	595.00
IUUC-Eca-034285	Equus caballus	77.35	0.00e+00	642.00
IUUC-Eeu-035322	Erinaceus europaeus	70.35	3.00e-159	554.00
IUUC-Fca-036114	Felis catus	77.83	0.00e+00	645.00
IUUC-Fal-036891	Ficedula albicollis	78.63	4.00e-161	560.00
IUUC-Fox-037965	Fusarium oxysporum	24.95	2.00e-34	140.00
IUUC-Fso-038244	Fusarium solani	25.98	4.00e-32	132.00
IUUC-Gmo-039040	Gadus morhua	84.32	0.00e+00	717.00
IUUC-Ggr-040093	Gaeumannomyces graminis	23.97	3.00e-15	77.00
IUUC-Gga-040610	Gallus gallus	75.95	0.00e+00	658.00
IUUC-Gac-042117	Gasterosteus aculeatus	89.79	0.00e+00	733.00
IUUC-Gma-043146	Glycine max	35.89	3.00e-63	236.00
IUUC-Ggo-045179	Gorilla gorilla	76.87	0.00e+00	627.00
IUUC-Hsa-046114	Homo sapiens	77.35	0.00e+00	628.00
IUUC-Hvu-047331	Hordeum vulgare	31.62	1.00e-50	193.00
IUUC-Itr-048275	Ictidomys tridecemlineatus	77.35	0.00e+00	645.00
IUUC-Kpa-049304	Komagataella pastoris	30.89	2.00e-43	169.00
IUUC-Lch-050655	Latimeria chalumnae	72.27	4.00e-137	481.00
IUUC-Lpe-051675	Leersia perrieri	33.73	7.00e-57	215.00
IUUC-Loc-052868	Lepisosteus oculatus	80.00	0.00e+00	657.00
IUUC-Lma-053258	Leptosphaeria maculans	25.70	1.00e-33	139.00
IUUC-Laf-053993	Loxodonta africana	77.59	0.00e+00	642.00
IUUC-Mcc-055128	Macaca mulatta	62.41	3.00e-138	484.00
IUUC-Meu-056501	Macropus eugenii	66.49	2.00e-142	498.00
IUUC-Mor-057114	Magnaporthe oryzae	25.80	3.00e-26	112.00
IUUC-Mtr-058367	Medicago truncatula	34.93	3.00e-58	219.00
IUUC-Mla-059107	Melampsora laricipopulina	27.16	4.00e-31	129.00
IUUC-Mga-059745	Meleagris gallopavo	75.42	0.00e+00	636.00
IUUC-Mvi-060362	Microbotryum violaceum	27.78	8.00e-31	128.00
IUUC-Mdo-062257	Monodelphis domestica	74.35	0.00e+00	659.00
IUUC-Mmu-063546	Mus musculus	77.35	0.00e+00	641.00
IUUC-Mac-065540	Musa acuminata	32.92	2.00e-54	206.00
IUUC-Mpu-066284	Mustela putorius furo	77.35	0.00e+00	642.00
IUUC-Mlu-067241	Myotis lucifugus	77.59	0.00e+00	641.00
IUUC-Nfi-068260	Neosartorya fischeri	27.53	4.00e-33	135.00
IUUC-Ncr-068719	Neurospora crassa	25.10	6.00e-25	108.00
IUUC-Nle-068981	Nomascus leucogenys	77.11	2.00e-176	612.00
IUUC-Opr-071218	Ochotona princeps	69.60	4.00e-162	564.00
IUUC-Oan-073453	Ornithorhynchus anatinus	76.96	0.00e+00	685.00
IUUC-Ocu-074008	Oryctolagus cuniculus	77.11	0.00e+00	642.00
IUUC-Oba-075712	Oryza barthii	29.29	1.00e-39	157.00
IUUC-Obr-076721	Oryza brachyantha	34.05	5.00e-57	215.00
IUUC-Ogl-077229	Oryza glaberrima	33.57	2.00e-56	213.00
IUUC-Ogu-078977	Oryza glumaepatula	29.16	7.00e-40	158.00
IUUC-Oin-079683	Oryza indica	33.97	6.00e-57	214.00
IUUC-Olo-080291	Oryza longistaminata	30.74	1.00e-25	110.00
IUUC-Ome-081834	Oryza meridionalis	33.73	1.00e-57	217.00
IUUC-Oni-082507	Oryza nivara	32.13	4.00e-52	199.00
IUUC-Opu-083396	Oryza punctata	33.25	1.00e-56	214.00
IUUC-Oru-085220	Oryza rufipogon	32.37	6.00e-52	198.00
IUUC-Osa-085767	Oryza sativa	33.97	6.00e-57	214.00
IUUC-Ola-087420	Oryzias latipes	88.36	0.00e+00	720.00
IUUC-Olu-087740	Ostreococcus lucimarinus	28.81	8.00e-36	144.00
IUUC-Oga-088264	Otolemur garnettii	76.14	4.00e-179	620.00
IUUC-Oar-089335	Ovis aries	77.11	0.00e+00	641.00
IUUC-Ptr-091320	Pan troglodytes	77.35	0.00e+00	628.00
IUUC-Pan-092833	Papio anubis	76.63	2.00e-180	624.00
IUUC-Psi-093504	Pelodiscus sinensis	78.15	0.00e+00	672.00
IUUC-Pma-094189	Petromyzon marinus	65.14	3.00e-163	568.00
IUUC-Pno-094929	Phaeosphaeria nodorum	25.70	1.00e-33	137.00
IUUC-Ppa-095429	Physcomitrella patens	34.99	2.00e-63	236.00
IUUC-Pfo-096337	Poecilia formosa	88.36	0.00e+00	748.00
IUUC-Pab-097571	Pongo abelii	77.11	0.00e+00	627.00
IUUC-Pop-099977	Populus trichocarpa	34.13	9.00e-61	227.00
IUUC-Pca-100394	Procavia capensis	74.81	1.00e-162	565.00
IUUC-Ppe-101848	Prunus persica	34.86	4.00e-60	225.00
IUUC-Pva-102921	Pteropus vampyrus	73.68	8.00e-90	324.00
IUUC-Pgr-103637	Puccinia graminis	29.27	6.00e-36	145.00
IUUC-Ptt-103781	Puccinia triticina	30.19	1.00e-36	147.00
IUUC-Pte-104135	Pyrenophora teres	27.19	5.00e-33	137.00
IUUC-Pyt-104609	Pyrenophora triticirepentis	26.15	3.00e-33	136.00
IUUC-Rno-105114	Rattus norvegicus	77.83	0.00e+00	644.00
IUUC-Sce-106401	Saccharomyces cerevisiae	29.74	2.00e-41	163.00
IUUC-Sha-107122	Sarcophilus harrisii	74.45	0.00e+00	626.00
IUUC-Sja-107766	Schizosaccharomyces japonicus	32.33	2.00e-48	186.00
IUUC-Spo-108134	Schizosaccharomyces pombe	28.74	4.00e-38	152.00
IUUC-Ssl-108398	Sclerotinia sclerotiorum	28.92	4.00e-35	142.00
IUUC-Smo-108720	Selaginella moellendorffii	34.51	4.00e-58	218.00
IUUC-Sit-110311	Setaria italica	35.04	4.00e-55	208.00
IUUC-Sly-111178	Solanum lycopersicum	33.83	3.00e-57	216.00
IUUC-Stu-112778	Solanum tuberosum	34.61	2.00e-60	226.00
IUUC-Sar-113596	Sorex araneus	64.10	2.00e-143	502.00
IUUC-Sbi-114193	Sorghum bicolor	35.48	6.00e-58	218.00
IUUC-Sre-115002	Sporisorium reilianum	26.29	2.00e-12	67.40
IUUC-Ssc-116066	Sus scrofa	77.11	0.00e+00	642.00
IUUC-Tgu-117048	Taeniopygia guttata	76.86	1.00e-169	589.00
IUUC-Tsy-119573	Tarsius syrichta	49.27	9.00e-104	370.00
IUUC-Tni-119820	Tetraodon nigroviridis	88.84	0.00e+00	744.00
IUUC-Tca-121605	Theobroma cacao	34.62	9.00e-59	221.00
IUUC-Tre-121947	Trichoderma reesei	27.14	2.00e-33	136.00
IUUC-Tvi-122481	Trichoderma virens	27.35	1.00e-34	140.00
IUUC-Tae-125861	Triticum aestivum	31.19	3.00e-55	209.00
IUUC-Tur-126586	Triticum urartu	31.62	2.00e-52	200.00
IUUC-Tme-126900	Tuber melanosporum	31.68	3.00e-46	179.00
IUUC-Tbe-127736	Tupaia belangeri	57.04	2.00e-121	429.00
IUUC-Ttr-129041	Tursiops truncatus	66.75	5.00e-155	540.00
IUUC-Uma-129628	Ustilago maydis	25.05	2.00e-15	77.00
IUUC-Vpa-130260	Vicugna pacos	77.59	0.00e+00	644.00
IUUC-Vvi-131009	Vitis vinifera	34.29	9.00e-59	221.00
IUUC-Xtr-132083	Xenopus tropicalis	74.58	0.00e+00	630.00
IUUC-Xma-133094	Xiphophorus maculatus	87.65	0.00e+00	743.00
IUUC-Yli-134531	Yarrowia lipolytica	24.69	6.00e-19	89.00
IUUC-Zma-135509	Zea mays	34.20	6.00e-58	218.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence