iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Kpa-049112

Ensembl Protein ID

CAY70908

UniProt Accession

C4R5S2; C4R5S2_KOMPG

Genbank Protein ID

CAY70908.1

Protein Name

Ubiquitin activating enzyme (E1), involved in ubiquitin-mediated protein degradation

Genbank Nucleotide ID

FN392321

Gene Name

PAS_chr3_0856

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
PAS_chr3_0856	CAY70908	CAY70908

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	2.40e-178	591.6	422	907

Active Site

Position(s)	Description	Evidence
605	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdv..nveahe 94
           YD Qi+++G    +k+ + kv+lvGag++GcE+lKn +++G+     g+i ++D+d +e+snlnrqFLfr++dvg++K+evaa+a+ e+npd   ++ea  
   Q: 422  YDNQIAVFGLSHIQKIANLKVFLVGAGAIGCEMLKNWAMMGLgsgpnGKIVLTDNDSIEKSNLNRQFLFRPKDVGQNKSEVAARAVVEMNPDLagKIEAKV 522
           9*******************************************************************************************955577889 PP
   S: 95   esiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketpnaaehtiewa.. 190
           +++ +++e+i+   F + +dvV +aldn+ear +v+r+c+  ++pl+esgtlG++G+++v+i+ lte+ys+s+dpp+k+iP+ctl+++pn+++hti wa  
   Q: 523  DKVGPETENIFdnsFWQGLDVVTNALDNIEARAYVDRRCVFFKKPLLESGTLGTKGNTQVVIPRLTESYSSSQDPPEKSIPLCTLRSFPNKIDHTIAWAks 623
           9********99*****************************************************************************************5 PP
   S: 191  ..........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqllksfecdivtkskspfwv....... 274
                     + +n +l++ +  e+ l+   ++   +g  ++ s+  +e++ +fe++i++a+ +f++ ++++i+qll +f++d vt+ ++pfw+       
   Q: 624  lfqgyfseapENVNLYLSQPNYVENILK---QSGDAKGTLETISQYLNERPYTFEDCIKWARLQFETKFNHEIQQLLYNFPKDSVTSTGAPFWSgpkrapt 721
           5555555555555555544444444444...2333344444445555699*************************************************** PP
   S: 275  ..................................................sfcsnaealqvpekvekdeevvkasap..............lylllraler 311
                                                                          k  +d ++++++++              ++ l  +l  
   Q: 722  plefdidnedhfnfvvgganllafiyglkgdqgepdkahykavldtlkieP-----------FKPRSDVKIQADDNDpdpnangndlnddvIQKLSDSLPP 811
           *******************************99999995555554444442...........333333333333333333555556667899999****** PP
   S: 312  fekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
            ++  g   +  +fekddd   ++++++aa+n ra +++ie+ +d++++k iag+i+paiatt+a v Gl+ +E++Kvv g  k e +kn f+++a+
   Q: 812  PSSLAGYRLTPAEFEKDDDTnhHIQFIAAASNCRALNYSIET-ADKQKTKFIAGRIVPAIATTTALVTGLITLELYKVVFGkeKIEDYKNGFVNLAL 907
           *999999999999999999999********************.************************************99888999*****99875 PP

Organism

Komagataella pastoris

Protein Sequence
(Fasta)

MAIRHTNEVQ ENKMQIDKPE EGKIDEDLYS RQLYVLGKEA MLKMQNSNVL IIGLKGLGVE 60
IAKNVALAGV KSLSLYDPEP VTLQDLSSQF FLSEKDIGEQ RAFATSSKLS ELNHYVPISI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAATTC GACACACTAA CGAGGTTCAG GAAAACAAAA TGCAAATTGA TAAGCCCGAA 60
GAGGGCAAAA TTGATGAAGA TTTGTACTCT CGTCAATTAT ATGTGCTAGG GAAAGAAGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0004839--F:ubiquitin activating enzyme activity

KEGG

ppa:PAS_chr3_0856

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000367	Aegilops tauschii	46.87	0.00e+00	826.00
IUUC-Aml-001311	Ailuropoda melanoleuca	52.01	0.00e+00	1035.00
IUUC-Atr-002684	Amborella trichopoda	46.20	0.00e+00	884.00
IUUC-Apl-004158	Anas platyrhynchos	41.65	0.00e+00	687.00
IUUC-Aca-004620	Anolis carolinensis	51.57	0.00e+00	1026.00
IUUC-Aly-005515	Arabidopsis lyrata	46.80	0.00e+00	898.00
IUUC-Ath-006891	Arabidopsis thaliana	46.46	0.00e+00	898.00
IUUC-Ago-007873	Ashbya gossypii	69.28	0.00e+00	1418.00
IUUC-Acl-008181	Aspergillus clavatus	60.90	0.00e+00	1224.00
IUUC-Afl-008455	Aspergillus flavus	60.98	0.00e+00	1179.00
IUUC-Afu-009065	Aspergillus fumigatus	61.20	0.00e+00	1243.00
IUUC-Ani-009371	Aspergillus nidulans	61.31	0.00e+00	1199.00
IUUC-Ang-009737	Aspergillus niger	60.14	0.00e+00	1206.00
IUUC-Aor-010007	Aspergillus oryzae	61.04	0.00e+00	1179.00
IUUC-Ate-010466	Aspergillus terreus	60.53	0.00e+00	1248.00
IUUC-Ame-010933	Astyanax mexicanus	51.77	0.00e+00	967.00
IUUC-Bgr-012281	Blumeria graminis	58.02	0.00e+00	1157.00
IUUC-Bta-012767	Bos taurus	51.96	0.00e+00	1041.00
IUUC-Bci-013721	Botrytis cinerea	60.23	0.00e+00	1161.00
IUUC-Bdi-014009	Brachypodium distachyon	45.03	0.00e+00	861.00
IUUC-Bol-015665	Brassica oleracea	47.02	0.00e+00	885.00
IUUC-Bra-017685	Brassica rapa	46.27	0.00e+00	895.00
IUUC-Cel-018260	Caenorhabditis elegans	43.36	0.00e+00	776.00
IUUC-Cja-019152	Callithrix jacchus	52.21	0.00e+00	1040.00
IUUC-Cfa-020622	Canis familiaris	51.43	0.00e+00	992.00
IUUC-Cpo-022526	Cavia porcellus	52.16	0.00e+00	1023.00
IUUC-Cre-022702	Chlamydomonas reinhardtii	45.30	0.00e+00	805.00
IUUC-Csa-023780	Chlorocebus sabaeus	51.87	0.00e+00	1033.00
IUUC-Cho-024682	Choloepus hoffmanni	40.44	1.00e-92	332.00
IUUC-Cin-025790	Ciona intestinalis	49.66	0.00e+00	1004.00
IUUC-Csv-026084	Ciona savignyi	49.33	0.00e+00	1001.00
IUUC-Cgl-026512	Colletotrichum gloeosporioides	59.48	0.00e+00	1213.00
IUUC-Cne-026960	Cryptococcus neoformans	55.09	0.00e+00	1082.00
IUUC-Cme-027290	Cyanidioschyzon merolae	40.90	0.00e+00	761.00
IUUC-Dre-028149	Danio rerio	52.21	0.00e+00	996.00
IUUC-Dno-028884	Dasypus novemcinctus	51.96	0.00e+00	1038.00
IUUC-Dor-030229	Dipodomys ordii	50.10	0.00e+00	976.00
IUUC-Dse-031524	Dothistroma septosporum	58.52	0.00e+00	1177.00
IUUC-Dme-032045	Drosophila melanogaster	49.36	0.00e+00	976.00
IUUC-Ete-033124	Echinops telfairi	40.23	1.00e-138	484.00
IUUC-Eca-033330	Equus caballus	51.96	0.00e+00	1034.00
IUUC-Eeu-035323	Erinaceus europaeus	41.97	1.00e-157	548.00
IUUC-Fca-036255	Felis catus	52.21	0.00e+00	1032.00
IUUC-Fal-036848	Ficedula albicollis	41.15	0.00e+00	694.00
IUUC-Fox-038007	Fusarium oxysporum	63.53	0.00e+00	675.00
IUUC-Fso-038339	Fusarium solani	59.30	0.00e+00	1138.00
IUUC-Gmo-039338	Gadus morhua	49.90	0.00e+00	962.00
IUUC-Ggr-039823	Gaeumannomyces graminis	59.96	0.00e+00	1234.00
IUUC-Gga-040747	Gallus gallus	41.95	0.00e+00	692.00
IUUC-Gac-041773	Gasterosteus aculeatus	50.64	0.00e+00	973.00
IUUC-Gma-043198	Glycine max	46.12	0.00e+00	873.00
IUUC-Ggo-045336	Gorilla gorilla	52.06	0.00e+00	1022.00
IUUC-Hsa-045982	Homo sapiens	52.06	0.00e+00	1022.00
IUUC-Hvu-047418	Hordeum vulgare	46.97	0.00e+00	866.00
IUUC-Itr-048460	Ictidomys tridecemlineatus	51.77	0.00e+00	1035.00
IUUC-Lch-050371	Latimeria chalumnae	52.99	0.00e+00	1033.00
IUUC-Lpe-051299	Leersia perrieri	45.01	0.00e+00	870.00
IUUC-Loc-052936	Lepisosteus oculatus	53.05	0.00e+00	1033.00
IUUC-Lma-053315	Leptosphaeria maculans	59.49	0.00e+00	1257.00
IUUC-Laf-053948	Loxodonta africana	51.28	0.00e+00	1003.00
IUUC-Mcc-055843	Macaca mulatta	51.87	0.00e+00	1033.00
IUUC-Meu-056258	Macropus eugenii	51.57	0.00e+00	1020.00
IUUC-Mor-057269	Magnaporthe oryzae	59.86	0.00e+00	1191.00
IUUC-Mpo-057435	Magnaporthe poae	59.26	0.00e+00	1194.00
IUUC-Mtr-058572	Medicago truncatula	46.84	0.00e+00	880.00
IUUC-Mla-059176	Melampsora laricipopulina	56.56	0.00e+00	1097.00
IUUC-Mga-059721	Meleagris gallopavo	41.91	0.00e+00	675.00
IUUC-Mvi-060437	Microbotryum violaceum	55.49	0.00e+00	1095.00
IUUC-Mmr-061405	Microcebus murinus	50.79	0.00e+00	996.00
IUUC-Mdo-062032	Monodelphis domestica	50.00	0.00e+00	981.00
IUUC-Mmu-063280	Mus musculus	51.54	0.00e+00	1027.00
IUUC-Mac-065505	Musa acuminata	46.63	0.00e+00	895.00
IUUC-Mpu-066409	Mustela putorius furo	52.21	0.00e+00	1041.00
IUUC-Mlu-067217	Myotis lucifugus	51.87	0.00e+00	1023.00
IUUC-Nfi-068407	Neosartorya fischeri	61.05	0.00e+00	1210.00
IUUC-Ncr-068698	Neurospora crassa	60.73	0.00e+00	1227.00
IUUC-Nle-070072	Nomascus leucogenys	50.00	0.00e+00	953.00
IUUC-Opr-070715	Ochotona princeps	36.07	2.00e-167	581.00
IUUC-Ont-071671	Oreochromis niloticus	52.50	0.00e+00	1009.00
IUUC-Oan-073268	Ornithorhynchus anatinus	41.67	0.00e+00	649.00
IUUC-Ocu-074544	Oryctolagus cuniculus	51.72	0.00e+00	1035.00
IUUC-Oba-075120	Oryza barthii	46.75	0.00e+00	862.00
IUUC-Obr-076557	Oryza brachyantha	47.15	0.00e+00	865.00
IUUC-Ogl-077887	Oryza glaberrima	46.45	0.00e+00	861.00
IUUC-Ogu-078305	Oryza glumaepatula	44.91	0.00e+00	871.00
IUUC-Oin-080154	Oryza indica	44.81	0.00e+00	868.00
IUUC-Olo-081089	Oryza longistaminata	44.91	0.00e+00	873.00
IUUC-Ome-081942	Oryza meridionalis	46.45	0.00e+00	863.00
IUUC-Oni-082365	Oryza nivara	46.55	0.00e+00	864.00
IUUC-Opu-083977	Oryza punctata	46.75	0.00e+00	866.00
IUUC-Oru-084469	Oryza rufipogon	44.91	0.00e+00	871.00
IUUC-Osa-085949	Oryza sativa	46.75	0.00e+00	876.00
IUUC-Ola-087002	Oryzias latipes	51.61	0.00e+00	1004.00
IUUC-Olu-087687	Ostreococcus lucimarinus	45.86	0.00e+00	813.00
IUUC-Oga-088594	Otolemur garnettii	51.77	0.00e+00	1015.00
IUUC-Oar-090068	Ovis aries	51.92	0.00e+00	1040.00
IUUC-Ptr-090609	Pan troglodytes	41.32	0.00e+00	682.00
IUUC-Pan-092114	Papio anubis	51.87	0.00e+00	1033.00
IUUC-Psi-093489	Pelodiscus sinensis	41.73	0.00e+00	700.00
IUUC-Pma-094214	Petromyzon marinus	49.09	2.00e-39	152.00
IUUC-Pno-095154	Phaeosphaeria nodorum	59.35	0.00e+00	1241.00
IUUC-Ppa-095227	Physcomitrella patens	46.56	0.00e+00	876.00
IUUC-Pfo-097184	Poecilia formosa	50.88	0.00e+00	987.00
IUUC-Pab-097861	Pongo abelii	51.87	0.00e+00	1004.00
IUUC-Pop-098934	Populus trichocarpa	46.85	0.00e+00	906.00
IUUC-Pca-100347	Procavia capensis	50.17	0.00e+00	859.00
IUUC-Ppe-102012	Prunus persica	45.30	0.00e+00	890.00
IUUC-Pva-102584	Pteropus vampyrus	52.26	0.00e+00	1065.00
IUUC-Pgr-103336	Puccinia graminis	54.07	0.00e+00	1029.00
IUUC-Ptt-103939	Puccinia triticina	54.28	0.00e+00	1024.00
IUUC-Pte-104200	Pyrenophora teres	59.69	0.00e+00	1245.00
IUUC-Pyt-104441	Pyrenophora triticirepentis	58.85	0.00e+00	1235.00
IUUC-Rno-105462	Rattus norvegicus	51.82	0.00e+00	1022.00
IUUC-Sce-106245	Saccharomyces cerevisiae	70.12	0.00e+00	1470.00
IUUC-Sha-107142	Sarcophilus harrisii	51.03	0.00e+00	1015.00
IUUC-Sja-107841	Schizosaccharomyces japonicus	59.49	0.00e+00	1236.00
IUUC-Spo-108034	Schizosaccharomyces pombe	60.16	0.00e+00	1229.00
IUUC-Ssl-108497	Sclerotinia sclerotiorum	60.25	0.00e+00	1186.00
IUUC-Smo-108912	Selaginella moellendorffii	48.14	0.00e+00	873.00
IUUC-Sit-110281	Setaria italica	46.55	0.00e+00	878.00
IUUC-Sly-110914	Solanum lycopersicum	46.32	0.00e+00	897.00
IUUC-Stu-112109	Solanum tuberosum	46.32	0.00e+00	901.00
IUUC-Sar-113737	Sorex araneus	52.06	0.00e+00	1036.00
IUUC-Sbi-114520	Sorghum bicolor	46.65	0.00e+00	884.00
IUUC-Sre-115148	Sporisorium reilianum	55.19	0.00e+00	1068.00
IUUC-Ssc-115777	Sus scrofa	52.02	0.00e+00	1036.00
IUUC-Tgu-116565	Taeniopygia guttata	41.65	0.00e+00	698.00
IUUC-Tru-118742	Takifugu rubripes	51.27	0.00e+00	972.00
IUUC-Tsy-119436	Tarsius syrichta	36.53	1.00e-161	561.00
IUUC-Tni-120401	Tetraodon nigroviridis	51.57	0.00e+00	980.00
IUUC-Tca-121672	Theobroma cacao	47.21	0.00e+00	893.00
IUUC-Tre-122009	Trichoderma reesei	59.26	0.00e+00	1141.00
IUUC-Tvi-122259	Trichoderma virens	59.65	0.00e+00	1134.00
IUUC-Tae-125676	Triticum aestivum	45.40	0.00e+00	877.00
IUUC-Tur-126189	Triticum urartu	47.22	0.00e+00	829.00
IUUC-Tme-127055	Tuber melanosporum	59.32	0.00e+00	1159.00
IUUC-Tbe-127714	Tupaia belangeri	39.27	9.00e-148	515.00
IUUC-Ttr-128331	Tursiops truncatus	52.16	0.00e+00	1028.00
IUUC-Uma-129387	Ustilago maydis	55.50	0.00e+00	1074.00
IUUC-Vda-129977	Verticillium dahliae	59.65	0.00e+00	1117.00
IUUC-Vpa-130716	Vicugna pacos	40.51	0.00e+00	668.00
IUUC-Vvi-130857	Vitis vinifera	46.44	0.00e+00	906.00
IUUC-Xtr-132026	Xenopus tropicalis	44.00	0.00e+00	756.00
IUUC-Xma-133805	Xiphophorus maculatus	51.37	0.00e+00	981.00
IUUC-Yli-134547	Yarrowia lipolytica	61.85	0.00e+00	1310.00
IUUC-Zma-135052	Zea mays	46.48	0.00e+00	886.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence