iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059252

UUCD1 version

UUC-MeG-00327

Ensembl Protein ID

ENSMGAP00000006848.1

UniProt Accession

G1N4Q4; G1N4Q4_MELGA

Protein Name

Uncharacterized protein

Gene Name

NLE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000006792.1	ENSMGAT00000007609.1	ENSMGAP00000006848.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.30e-62	202.5	77	119
UBD/Beta-Prp	1.60e-72	243.9	2	179

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf......sd.tllvsGsdDgtikvWDlrtgvll 36
           gH+ ++tcl++      ++ ++l+s+s Dg+i++WD+  g++ 
   Q: 77   GHSKWITCLCWeplhinPEcRYLASASKDGSIRIWDTLMGRCD 119
           8***************9889****************9988886 PP

UBD/Beta-Prp

   S: 60   fspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvv... 145
           fsp+gk+l++gs D t++ wdlst ++  t kgh + vls+++sp+g+kl+sG + + i +wd  tg  +  +l+gh+++++c+++   
   Q: 2    FSPTGKYLASGSGDTTVRFWDLSTETPQFTAKGHRHWVLSIAWSPDGKKLASGCKNSQIFLWDPATGNQIGRVLTGHSKWITCLCWepl 90
           99*********************************************************************************875222 PP
   S: 146  ..hpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfsp 232
             +p++++l+s+s+D+ +r+Wd  +g++ + lt+ ht+sv+++++  +g  l s s+d+t+k+w  q g   rtl+gh  +v+ +++s 
   Q: 91   hiNPECRYLASASKDGSIRIWDTLMGRCDKILTS-HTQSVTCVKWGGDG-LLYSSSQDRTIKVWRSQDGILCRTLQGHAHWVNTMALS- 176
           2278999**************************9.************98.9************************************9. PP
   S: 233  nder 236
            +++
   Q: 177  -TDY 179
           .333 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

AFSPTGKYLA SGSGDTTVRF WDLSTETPQF TAKGHRHWVL SIAWSPDGKK LASGCKNSQI 60
FLWDPATGNQ IGRVLTGHSK WITCLCWEPL HINPECRYLA SASKDGSIRI WDTLMGRCDK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCTTCAGCC CCACGGGAAA GTACGAGGCT CCGGCTGCGG GTGGGGCACG TCTCCATGGA 60
GCAGCCACCG GGGCCCCGTG CTGATCCTGC TGTCCCTCCT GTCCCAGGTA CCTGGCGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0001822--P:kidney development
GO:2001268--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0045930--P:negative regulation of mitotic cell cycle
GO:0007219--P:Notch signaling pathway
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0042273--P:ribosomal large subunit biogenesis
GO:0048705--P:skeletal system morphogenesis
GO:0001756--P:somitogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000437	Aegilops tauschii	61.98	2.00e-136	478.00
IUUC-Aml-001793	Ailuropoda melanoleuca	83.56	0.00e+00	657.00
IUUC-Atr-002507	Amborella trichopoda	61.16	4.00e-133	467.00
IUUC-Apl-003964	Anas platyrhynchos	96.16	0.00e+00	734.00
IUUC-Aly-006396	Arabidopsis lyrata	59.07	2.00e-131	461.00
IUUC-Ath-007278	Arabidopsis thaliana	59.89	3.00e-132	464.00
IUUC-Ago-007951	Ashbya gossypii	52.83	3.00e-110	392.00
IUUC-Acl-008298	Aspergillus clavatus	55.49	4.00e-109	387.00
IUUC-Afl-008581	Aspergillus flavus	53.61	2.00e-110	391.00
IUUC-Afu-008906	Aspergillus fumigatus	54.73	5.00e-109	387.00
IUUC-Ani-009189	Aspergillus nidulans	53.71	4.00e-107	381.00
IUUC-Ang-009630	Aspergillus niger	53.12	1.00e-111	396.00
IUUC-Aor-010038	Aspergillus oryzae	53.39	5.00e-112	397.00
IUUC-Ate-010278	Aspergillus terreus	53.28	2.00e-107	382.00
IUUC-Ame-011890	Astyanax mexicanus	83.84	0.00e+00	660.00
IUUC-Bgr-012011	Blumeria graminis	53.39	8.00e-115	406.00
IUUC-Bta-012964	Bos taurus	83.29	0.00e+00	655.00
IUUC-Bci-013592	Botrytis cinerea	50.70	5.00e-107	381.00
IUUC-Bdi-015035	Brachypodium distachyon	62.53	2.00e-137	481.00
IUUC-Bol-015501	Brassica oleracea	60.44	2.00e-132	464.00
IUUC-Bra-017642	Brassica rapa	60.16	4.00e-132	464.00
IUUC-Cel-018430	Caenorhabditis elegans	61.37	5.00e-137	480.00
IUUC-Cja-019125	Callithrix jacchus	84.93	0.00e+00	665.00
IUUC-Cfa-021013	Canis familiaris	84.53	0.00e+00	657.00
IUUC-Cpo-021743	Cavia porcellus	84.38	0.00e+00	662.00
IUUC-Cre-022973	Chlamydomonas reinhardtii	45.63	8.00e-86	310.00
IUUC-Csa-024270	Chlorocebus sabaeus	84.38	0.00e+00	659.00
IUUC-Cin-025795	Ciona intestinalis	69.51	1.00e-158	552.00
IUUC-Csv-025953	Ciona savignyi	69.78	1.00e-159	555.00
IUUC-Cgl-026517	Colletotrichum gloeosporioides	52.16	1.00e-106	379.00
IUUC-Cne-026901	Cryptococcus neoformans	52.39	3.00e-114	404.00
IUUC-Cme-027281	Cyanidioschyzon merolae	48.70	1.00e-100	359.00
IUUC-Dre-028515	Danio rerio	83.01	0.00e+00	648.00
IUUC-Dno-029596	Dasypus novemcinctus	84.11	0.00e+00	655.00
IUUC-Dor-030494	Dipodomys ordii	84.53	0.00e+00	655.00
IUUC-Dse-031538	Dothistroma septosporum	55.43	7.00e-115	407.00
IUUC-Dme-031974	Drosophila melanogaster	61.88	2.00e-135	475.00
IUUC-Ete-032948	Echinops telfairi	85.65	1.00e-106	379.00
IUUC-Eca-033399	Equus caballus	84.66	0.00e+00	660.00
IUUC-Eeu-035013	Erinaceus europaeus	86.12	1.00e-106	379.00
IUUC-Fca-035860	Felis catus	84.11	0.00e+00	657.00
IUUC-Fal-037069	Ficedula albicollis	94.42	2.00e-140	490.00
IUUC-Fox-038059	Fusarium oxysporum	51.78	2.00e-111	395.00
IUUC-Fso-038445	Fusarium solani	53.15	2.00e-111	395.00
IUUC-Gmo-039319	Gadus morhua	78.39	3.00e-166	577.00
IUUC-Ggr-040095	Gaeumannomyces graminis	52.69	2.00e-109	389.00
IUUC-Gga-040303	Gallus gallus	99.20	3.00e-146	509.00
IUUC-Gac-042267	Gasterosteus aculeatus	81.10	0.00e+00	630.00
IUUC-Gma-044360	Glycine max	61.98	4.00e-136	477.00
IUUC-Ggo-044637	Gorilla gorilla	84.38	0.00e+00	660.00
IUUC-Hsa-046128	Homo sapiens	84.66	0.00e+00	664.00
IUUC-Hvu-047373	Hordeum vulgare	62.26	5.00e-137	480.00
IUUC-Itr-048070	Ictidomys tridecemlineatus	82.97	0.00e+00	652.00
IUUC-Kpa-049274	Komagataella pastoris	51.61	2.00e-110	392.00
IUUC-Lch-049907	Latimeria chalumnae	83.97	0.00e+00	645.00
IUUC-Lpe-050778	Leersia perrieri	57.30	1.00e-119	423.00
IUUC-Loc-051889	Lepisosteus oculatus	83.01	0.00e+00	654.00
IUUC-Lma-053041	Leptosphaeria maculans	52.11	5.00e-103	368.00
IUUC-Laf-053598	Loxodonta africana	84.38	0.00e+00	657.00
IUUC-Mcc-055660	Macaca mulatta	84.38	0.00e+00	658.00
IUUC-Meu-056197	Macropus eugenii	83.33	0.00e+00	637.00
IUUC-Mor-056949	Magnaporthe oryzae	50.95	4.00e-104	371.00
IUUC-Mpo-057571	Magnaporthe poae	44.44	8.00e-64	237.00
IUUC-Mtr-058530	Medicago truncatula	62.53	2.00e-136	478.00
IUUC-Mla-059133	Melampsora laricipopulina	52.03	1.00e-108	386.00
IUUC-Mvi-060522	Microbotryum violaceum	52.86	3.00e-112	398.00
IUUC-Mmr-061117	Microcebus murinus	83.84	0.00e+00	660.00
IUUC-Mdo-062892	Monodelphis domestica	85.21	0.00e+00	662.00
IUUC-Mmu-064108	Mus musculus	84.66	0.00e+00	662.00
IUUC-Mac-064430	Musa acuminata	61.16	1.00e-133	469.00
IUUC-Mpu-065882	Mustela putorius furo	84.93	0.00e+00	663.00
IUUC-Mlu-068123	Myotis lucifugus	84.38	0.00e+00	662.00
IUUC-Nfi-068484	Neosartorya fischeri	55.01	2.00e-109	389.00
IUUC-Ncr-068649	Neurospora crassa	48.09	8.00e-100	357.00
IUUC-Nle-069140	Nomascus leucogenys	84.38	0.00e+00	661.00
IUUC-Opr-070220	Ochotona princeps	84.23	0.00e+00	636.00
IUUC-Ont-072643	Oreochromis niloticus	83.56	0.00e+00	657.00
IUUC-Ocu-074007	Oryctolagus cuniculus	84.11	0.00e+00	658.00
IUUC-Oba-075904	Oryza barthii	62.81	6.00e-138	483.00
IUUC-Obr-076618	Oryza brachyantha	62.81	3.00e-137	481.00
IUUC-Ogl-077425	Oryza glaberrima	63.09	2.00e-138	484.00
IUUC-Ogu-078586	Oryza glumaepatula	62.81	6.00e-138	483.00
IUUC-Oin-079489	Oryza indica	60.61	2.00e-129	455.00
IUUC-Olo-080587	Oryza longistaminata	62.81	1.00e-138	487.00
IUUC-Ome-081905	Oryza meridionalis	63.09	5.00e-138	483.00
IUUC-Oni-083022	Oryza nivara	62.81	6.00e-138	483.00
IUUC-Opu-083615	Oryza punctata	63.09	4.00e-138	484.00
IUUC-Oru-085076	Oryza rufipogon	62.81	6.00e-138	483.00
IUUC-Osa-085516	Oryza sativa	62.81	6.00e-138	483.00
IUUC-Ola-087290	Oryzias latipes	83.56	0.00e+00	655.00
IUUC-Olu-087898	Ostreococcus lucimarinus	56.20	1.00e-120	426.00
IUUC-Oga-088980	Otolemur garnettii	83.56	0.00e+00	658.00
IUUC-Oar-089580	Ovis aries	83.72	8.00e-157	546.00
IUUC-Ptr-090845	Pan troglodytes	84.11	0.00e+00	658.00
IUUC-Pan-092836	Papio anubis	84.38	0.00e+00	661.00
IUUC-Pno-095052	Phaeosphaeria nodorum	52.72	7.00e-108	383.00
IUUC-Ppa-095432	Physcomitrella patens	61.60	4.00e-132	464.00
IUUC-Pfo-096963	Poecilia formosa	73.15	4.00e-156	543.00
IUUC-Pab-097716	Pongo abelii	80.00	5.00e-179	620.00
IUUC-Pop-099224	Populus trichocarpa	61.43	9.00e-134	469.00
IUUC-Pca-100682	Procavia capensis	81.13	1.00e-176	611.00
IUUC-Ppe-101819	Prunus persica	60.88	1.00e-131	462.00
IUUC-Pva-102338	Pteropus vampyrus	81.93	7.00e-127	446.00
IUUC-Pgr-103583	Puccinia graminis	53.26	1.00e-114	406.00
IUUC-Ptt-103737	Puccinia triticina	45.03	4.00e-89	321.00
IUUC-Pte-104150	Pyrenophora teres	53.41	1.00e-108	386.00
IUUC-Pyt-104606	Pyrenophora triticirepentis	53.13	2.00e-108	385.00
IUUC-Rno-105987	Rattus norvegicus	84.66	0.00e+00	663.00
IUUC-Sce-106315	Saccharomyces cerevisiae	53.24	4.00e-115	407.00
IUUC-Sha-107273	Sarcophilus harrisii	84.93	0.00e+00	671.00
IUUC-Sja-107677	Schizosaccharomyces japonicus	50.41	1.00e-100	359.00
IUUC-Spo-108092	Schizosaccharomyces pombe	51.51	3.00e-108	385.00
IUUC-Ssl-108442	Sclerotinia sclerotiorum	50.00	2.00e-101	362.00
IUUC-Smo-108855	Selaginella moellendorffii	59.47	4.00e-131	461.00
IUUC-Sit-110329	Setaria italica	62.81	9.00e-137	480.00
IUUC-Sly-111830	Solanum lycopersicum	62.81	2.00e-136	478.00
IUUC-Stu-112603	Solanum tuberosum	62.81	2.00e-136	478.00
IUUC-Sbi-114560	Sorghum bicolor	62.81	2.00e-138	485.00
IUUC-Sre-115133	Sporisorium reilianum	50.98	7.00e-90	324.00
IUUC-Ssc-115903	Sus scrofa	83.84	0.00e+00	654.00
IUUC-Tgu-116798	Taeniopygia guttata	95.07	0.00e+00	727.00
IUUC-Tru-118361	Takifugu rubripes	84.66	0.00e+00	669.00
IUUC-Tsy-118849	Tarsius syrichta	83.66	0.00e+00	649.00
IUUC-Tni-120094	Tetraodon nigroviridis	84.38	0.00e+00	663.00
IUUC-Tca-121634	Theobroma cacao	61.81	8.00e-133	466.00
IUUC-Tre-122051	Trichoderma reesei	53.55	1.00e-106	379.00
IUUC-Tvi-122322	Trichoderma virens	54.47	1.00e-111	396.00
IUUC-Tae-123133	Triticum aestivum	61.98	1.00e-136	479.00
IUUC-Tur-126766	Triticum urartu	57.69	4.00e-132	464.00
IUUC-Tme-127175	Tuber melanosporum	53.26	1.00e-107	383.00
IUUC-Tbe-127779	Tupaia belangeri	83.93	0.00e+00	642.00
IUUC-Ttr-128224	Tursiops truncatus	80.11	4.00e-179	620.00
IUUC-Uma-129537	Ustilago maydis	44.47	3.00e-103	369.00
IUUC-Vda-129927	Verticillium dahliae	51.10	5.00e-97	347.00
IUUC-Vpa-130658	Vicugna pacos	70.44	2.00e-150	525.00
IUUC-Vvi-131659	Vitis vinifera	60.88	4.00e-133	467.00
IUUC-Xtr-132918	Xenopus tropicalis	80.60	0.00e+00	627.00
IUUC-Xma-133700	Xiphophorus maculatus	84.11	0.00e+00	656.00
IUUC-Yli-134478	Yarrowia lipolytica	55.71	3.00e-117	415.00
IUUC-Zma-135835	Zea mays	58.87	5.00e-134	470.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence