iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Olu-087625

Ensembl Protein ID

ABO94034

UniProt Accession

A4RQJ4; A4RQJ4_OSTLU

Genbank Protein ID

ABO94034.1

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

CP000581

Gene Name

OSTLU_13599

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
OSTLU_13599	ABO94034	ABO94034

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E1	32.42	2.00e-62	237.00	IUUC-Ath-006692
E1	27.23	9.00e-46	181.00	IUUC-Cel-018456
E1	30.85	4.00e-59	227.00	IUUC-Hsa-046563
E1	28.50	4.00e-23	104.00	IUUC-Sce-106397

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ostreococcus lucimarinus

Functional Description
(View)

Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.

Protein Sequence
(Fasta)

MASPAPADAR YDRQLRLWGA EGQRRLARCR VLALGASPAT CETMKNLILG GIRAFELVDD 60
GAWRRGARSA GETFELTCED VERGARERGG KTMVETVVER LAALNPGVDG AATTANARAT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGTCGC CCGCGCCCGC GGACGCGCGC TACGACCGCC AGCTCCGCCT GTGGGGCGCC 60
GAGGGCCAGC GTCGACTCGC GCGATGCCGC GTCCTCGCGC TCGGCGCGTC GCCGGCGACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

KEGG

olu:OSTLU_13599

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	29.74	2.00e-61	228.00
IUUC-Aml-002333	Ailuropoda melanoleuca	30.19	5.00e-62	229.00
IUUC-Atr-002644	Amborella trichopoda	28.55	2.00e-54	204.00
IUUC-Apl-003446	Anas platyrhynchos	30.47	2.00e-57	214.00
IUUC-Aca-004450	Anolis carolinensis	29.61	1.00e-59	221.00
IUUC-Aly-006187	Arabidopsis lyrata	31.42	1.00e-66	244.00
IUUC-Ath-006692	Arabidopsis thaliana	32.42	4.00e-66	243.00
IUUC-Ago-007900	Ashbya gossypii	26.13	2.00e-19	88.20
IUUC-Acl-008333	Aspergillus clavatus	23.56	3.00e-34	137.00
IUUC-Afl-008529	Aspergillus flavus	25.74	4.00e-45	173.00
IUUC-Afu-009071	Aspergillus fumigatus	25.30	1.00e-38	151.00
IUUC-Ani-009443	Aspergillus nidulans	26.30	7.00e-33	132.00
IUUC-Ang-009669	Aspergillus niger	27.93	5.00e-39	153.00
IUUC-Aor-009914	Aspergillus oryzae	25.95	4.00e-44	170.00
IUUC-Ate-010450	Aspergillus terreus	25.52	4.00e-44	170.00
IUUC-Ame-011183	Astyanax mexicanus	30.02	1.00e-65	241.00
IUUC-Bgr-012111	Blumeria graminis	27.36	2.00e-33	134.00
IUUC-Bta-012583	Bos taurus	31.06	4.00e-64	236.00
IUUC-Bci-013892	Botrytis cinerea	27.43	3.00e-34	137.00
IUUC-Bdi-014592	Brachypodium distachyon	30.47	2.00e-61	227.00
IUUC-Bol-015487	Brassica oleracea	31.66	2.00e-66	243.00
IUUC-Bra-017506	Brassica rapa	32.02	8.00e-66	241.00
IUUC-Cel-018456	Caenorhabditis elegans	27.23	1.00e-48	185.00
IUUC-Cja-020007	Callithrix jacchus	30.56	5.00e-62	229.00
IUUC-Cfa-020324	Canis familiaris	30.89	1.00e-63	234.00
IUUC-Cpo-022248	Cavia porcellus	27.79	4.00e-27	113.00
IUUC-Csa-023149	Chlorocebus sabaeus	30.35	3.00e-49	187.00
IUUC-Cho-024537	Choloepus hoffmanni	32.72	1.00e-36	145.00
IUUC-Cin-025763	Ciona intestinalis	28.42	4.00e-58	216.00
IUUC-Csv-026113	Ciona savignyi	27.65	4.00e-49	186.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	24.83	1.00e-37	148.00
IUUC-Cne-026884	Cryptococcus neoformans	23.35	1.00e-28	118.00
IUUC-Dre-028140	Danio rerio	31.00	6.00e-67	246.00
IUUC-Dno-030033	Dasypus novemcinctus	31.25	8.00e-52	195.00
IUUC-Dor-030513	Dipodomys ordii	33.91	1.00e-09	55.50
IUUC-Dse-031536	Dothistroma septosporum	25.65	1.00e-43	168.00
IUUC-Dme-031683	Drosophila melanogaster	29.29	4.00e-52	196.00
IUUC-Ete-032420	Echinops telfairi	25.71	1.00e-40	158.00
IUUC-Eca-033992	Equus caballus	30.17	1.00e-48	184.00
IUUC-Eeu-034713	Erinaceus europaeus	26.91	2.00e-23	101.00
IUUC-Fca-036548	Felis catus	30.63	1.00e-60	225.00
IUUC-Fal-037600	Ficedula albicollis	31.14	2.00e-59	221.00
IUUC-Fox-038037	Fusarium oxysporum	24.26	3.00e-39	154.00
IUUC-Fso-038387	Fusarium solani	24.36	1.00e-39	155.00
IUUC-Gmo-038562	Gadus morhua	29.60	4.00e-63	233.00
IUUC-Ggr-040005	Gaeumannomyces graminis	27.95	7.00e-34	136.00
IUUC-Gga-041129	Gallus gallus	31.71	2.00e-62	231.00
IUUC-Gac-042558	Gasterosteus aculeatus	29.77	1.00e-64	238.00
IUUC-Gma-043610	Glycine max	31.78	4.00e-62	229.00
IUUC-Ggo-045611	Gorilla gorilla	30.86	8.00e-62	228.00
IUUC-Hsa-046563	Homo sapiens	30.85	2.00e-62	231.00
IUUC-Hvu-047790	Hordeum vulgare	31.11	4.00e-47	179.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	31.24	2.00e-63	234.00
IUUC-Kpa-049309	Komagataella pastoris	27.79	4.00e-41	160.00
IUUC-Lch-050038	Latimeria chalumnae	29.72	1.00e-59	221.00
IUUC-Lpe-051535	Leersia perrieri	29.62	1.00e-51	194.00
IUUC-Loc-051917	Lepisosteus oculatus	29.60	4.00e-61	226.00
IUUC-Lma-053112	Leptosphaeria maculans	29.22	1.00e-48	185.00
IUUC-Laf-053690	Loxodonta africana	31.41	2.00e-64	237.00
IUUC-Mcc-055117	Macaca mulatta	30.72	7.00e-62	229.00
IUUC-Meu-056761	Macropus eugenii	33.67	4.00e-40	156.00
IUUC-Mor-057230	Magnaporthe oryzae	26.42	2.00e-42	164.00
IUUC-Mpo-057514	Magnaporthe poae	27.27	7.00e-39	152.00
IUUC-Mtr-058551	Medicago truncatula	31.94	4.00e-58	216.00
IUUC-Mla-059183	Melampsora laricipopulina	28.03	3.00e-50	190.00
IUUC-Mga-060144	Meleagris gallopavo	30.66	1.00e-57	214.00
IUUC-Mvi-060221	Microbotryum violaceum	31.30	5.00e-32	130.00
IUUC-Mmr-061325	Microcebus murinus	30.19	2.00e-59	221.00
IUUC-Mdo-062532	Monodelphis domestica	31.34	3.00e-63	233.00
IUUC-Mmu-063956	Mus musculus	31.76	7.00e-64	235.00
IUUC-Mac-064521	Musa acuminata	30.81	3.00e-62	230.00
IUUC-Mpu-066716	Mustela putorius furo	29.83	1.00e-53	201.00
IUUC-Mlu-067459	Myotis lucifugus	30.88	5.00e-62	229.00
IUUC-Nfi-068245	Neosartorya fischeri	24.70	3.00e-39	153.00
IUUC-Ncr-068910	Neurospora crassa	27.35	2.00e-46	177.00
IUUC-Nle-070034	Nomascus leucogenys	29.86	4.00e-58	216.00
IUUC-Opr-070552	Ochotona princeps	31.40	3.00e-38	150.00
IUUC-Ont-071426	Oreochromis niloticus	30.23	1.00e-68	251.00
IUUC-Oan-073389	Ornithorhynchus anatinus	29.54	7.00e-43	165.00
IUUC-Ocu-074911	Oryctolagus cuniculus	31.06	3.00e-63	233.00
IUUC-Oba-075437	Oryza barthii	30.27	1.00e-53	201.00
IUUC-Obr-076684	Oryza brachyantha	27.93	6.00e-45	172.00
IUUC-Ogl-077170	Oryza glaberrima	30.27	1.00e-53	201.00
IUUC-Ogu-078844	Oryza glumaepatula	30.58	3.00e-49	187.00
IUUC-Oin-079105	Oryza indica	30.27	9.00e-54	202.00
IUUC-Olo-080943	Oryza longistaminata	30.00	1.00e-47	182.00
IUUC-Oni-082891	Oryza nivara	29.55	4.00e-52	196.00
IUUC-Opu-083457	Oryza punctata	29.73	2.00e-52	197.00
IUUC-Oru-084960	Oryza rufipogon	29.93	9.00e-48	182.00
IUUC-Osa-085358	Oryza sativa	30.27	7.00e-54	202.00
IUUC-Ola-086420	Oryzias latipes	32.63	5.00e-49	185.00
IUUC-Oga-088810	Otolemur garnettii	31.06	3.00e-64	236.00
IUUC-Oar-089196	Ovis aries	30.90	1.00e-62	231.00
IUUC-Ptr-090617	Pan troglodytes	30.85	1.00e-62	231.00
IUUC-Pan-092761	Papio anubis	31.06	8.00e-64	235.00
IUUC-Psi-093191	Pelodiscus sinensis	29.50	1.00e-56	211.00
IUUC-Pma-094380	Petromyzon marinus	30.02	8.00e-49	185.00
IUUC-Pno-095084	Phaeosphaeria nodorum	26.63	1.00e-27	116.00
IUUC-Ppa-095798	Physcomitrella patens	29.73	2.00e-59	221.00
IUUC-Pfo-096467	Poecilia formosa	29.46	2.00e-63	233.00
IUUC-Pab-098255	Pongo abelii	31.62	4.00e-51	193.00
IUUC-Pop-099722	Populus trichocarpa	31.06	4.00e-63	233.00
IUUC-Pca-100807	Procavia capensis	28.64	3.00e-11	60.80
IUUC-Ppe-101280	Prunus persica	31.72	1.00e-64	238.00
IUUC-Pva-102333	Pteropus vampyrus	29.36	2.00e-52	197.00
IUUC-Pgr-103401	Puccinia graminis	25.84	1.00e-40	158.00
IUUC-Ptt-103889	Puccinia triticina	23.04	2.00e-27	114.00
IUUC-Pte-104355	Pyrenophora teres	29.02	2.00e-49	187.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	29.10	3.00e-51	193.00
IUUC-Rno-105810	Rattus norvegicus	31.56	6.00e-63	232.00
IUUC-Sce-106397	Saccharomyces cerevisiae	28.50	2.00e-24	104.00
IUUC-Sha-106770	Sarcophilus harrisii	30.46	2.00e-24	103.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	26.87	9.00e-44	168.00
IUUC-Spo-108276	Schizosaccharomyces pombe	26.92	3.00e-44	170.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	28.26	8.00e-35	139.00
IUUC-Smo-109296	Selaginella moellendorffii	31.84	7.00e-60	222.00
IUUC-Sit-110157	Setaria italica	30.56	4.00e-63	233.00
IUUC-Sly-111105	Solanum lycopersicum	29.51	3.00e-59	220.00
IUUC-Stu-112469	Solanum tuberosum	29.86	6.00e-61	226.00
IUUC-Sar-113083	Sorex araneus	30.43	1.00e-30	125.00
IUUC-Sbi-113813	Sorghum bicolor	30.56	1.00e-63	234.00
IUUC-Sre-115058	Sporisorium reilianum	29.47	8.00e-35	139.00
IUUC-Tgu-116772	Taeniopygia guttata	31.56	1.00e-59	221.00
IUUC-Tru-118686	Takifugu rubripes	30.58	2.00e-66	244.00
IUUC-Tsy-119111	Tarsius syrichta	30.33	2.00e-21	94.40
IUUC-Tni-120231	Tetraodon nigroviridis	28.84	3.00e-56	210.00
IUUC-Tca-121491	Theobroma cacao	29.75	2.00e-57	214.00
IUUC-Tre-122103	Trichoderma reesei	25.69	2.00e-40	157.00
IUUC-Tvi-122672	Trichoderma virens	27.70	6.00e-35	139.00
IUUC-Tae-125455	Triticum aestivum	30.11	1.00e-61	228.00
IUUC-Tur-126487	Triticum urartu	28.73	7.00e-57	212.00
IUUC-Tme-127097	Tuber melanosporum	28.06	5.00e-50	189.00
IUUC-Ttr-128465	Tursiops truncatus	28.87	7.00e-54	202.00
IUUC-Uma-129645	Ustilago maydis	28.09	5.00e-42	163.00
IUUC-Vda-129989	Verticillium dahliae	31.58	3.00e-14	70.90
IUUC-Vpa-130529	Vicugna pacos	30.21	2.00e-59	221.00
IUUC-Vvi-131059	Vitis vinifera	31.42	1.00e-62	231.00
IUUC-Xtr-132002	Xenopus tropicalis	30.04	7.00e-62	229.00
IUUC-Xma-133930	Xiphophorus maculatus	29.05	1.00e-62	231.00
IUUC-Yli-134505	Yarrowia lipolytica	28.16	2.00e-48	184.00
IUUC-Zma-135895	Zea mays	30.11	4.00e-63	233.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence