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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046373
UUCD1 version UUC-HoS-00906
Ensembl Protein ID ENSP00000372499.1
UniProt Accession Q9BQ87; A1L4B3; TBL1Y_HUMAN
Genbank Protein ID AAK13472.1; AAK13473.1; AAK13474.1; EAW59126.1; AAI30472.1; AAI30474.1
Protein Name F-box-like/WD repeat-containing protein TBL1Y; Transducin beta-like protein 1Y; Transducin-beta-like protein 1, Y-linked
Genbank Nucleotide ID AF332220; AF332221; AF332222; CH471163; BC130471; BC130473
Gene Name TBL1Y; TBL1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000092377.13 ENST00000383032.5 ENSP00000372499.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
THPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmicroRNA
TRANSFACTargetScanmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDHINTMenthaInWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
PhosphositePlusdbPTM
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 9.70e-50 166.0 451 489
UBD/Beta-Prp 7.30e-62 210.9 321 494
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           H+++v+++af +d ++l+sGs D+ +++W++ +g l++s
   Q: 451  HQEPVYSVAFsPDgKYLASGSFDKYVHIWNTQSGSLVHS 489
           9**********999******************9999875 PP
   

   UBD/Beta-Prp
   S: 97   vlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsf 188
           +l+++++  + +++s s d  i+v  l  +  ++ t++gh+  vn ++++p+g ll+s+s+D t+++W++k++ ++++l+  h + +y +++
   Q: 321  ALDVDWQN-NMTFASCSTDMCIHVCRLGCDHPVK-TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQA-HSKEIYTIKW 409
           33333333.3444444444444444444444444.4444444444444444444444444444444444444444444443.4444444444 PP
   S: 189  dsng.........kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhn 264
           +++g           l+s+s d+tv+lwd+++g c +tl  h+++v+sv+fsp++++l+sgs D+ + iW+++sg l++++q++ 
   Q: 410  SPTGpatsnpnssIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTG 494
           4444444444444444444444444444444444444444444444444444444444444444444444444444444444432 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity).
 F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity).
Protein Sequence
(Fasta)
MSITSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GTLVPPSALI SILQKGLQYV 60
EAEISINKDG TVFDSRPIES LSLIVAVIPD VVQMRQQAFG EKLTQQQASA AATEASAMAK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046373|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCAGTGCCCC CAATTCGCGC TCGGGAGTGA GGAGCCGCCA ACACCCCAGC TCCGCTGCTG 60
CCGCCACCGC AGTGCTCTCT AGTCGCCATT GGTTACCTAA ACTTTCCAGT ACCCGCGACC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046373|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0010--Activator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08513--LisH
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00667--LisH
SM00320--WD40
Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0005667--C:transcription factor complex
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0045444--P:fat cell differentiation
GO:0016575--P:histone deacetylation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0043627--P:response to estrogen
GO:0048545--P:response to steroid hormone
GO:0006351--P:transcription, DNA-templated
KEGG hsa:90665
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Mcc-055124 Macaca mulatta 91.88 0.00e+00 947.00
IUUC-Olu-087589 Ostreococcus lucimarinus 52.37 5.00e-156 544.00
IUUC-Ptr-090793 Pan troglodytes 96.93 0.00e+00 977.00
IUUC-Stu-112786 Solanum tuberosum 48.31 6.00e-142 497.00
Created Date 25-Jun-2017

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