iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108367

UUCD1 version

UUC-ScP-00296

Ensembl Protein ID

SPCC188.08c.1:pep

UniProt Accession

Q09879; Q10433; Q9Y7P5; UBP5_SCHPO

Genbank Protein ID

CAB41228.1

Protein Name

Probable ubiquitin carboxyl-terminal hydrolase 5; Deubiquitinating enzyme 5; Ubiquitin thioesterase 5; Ubiquitin-specific-processing protease 5

Genbank Nucleotide ID

CU329672

Gene Name

ubp5; SPCC188.08c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPCC188.08c	SPCC188.08c.1	SPCC188.08c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	Mentha
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-70	236.2	213	527

Active Site

Position(s)	Description	Evidence
222	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
464	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDa 92
           +GlkN+g+tCYmNS+LQ+L+ i+ +r+ + +     ++ ++ ++ k +++ +lq++f +l +  ++ vs++el+k++++ +  +++++q+D+
   Q: 213  VGLKNQGATCYMNSLLQSLYIIHAFRRIVYQ-----IPTDS-PQGKDSIAYALQRCFYNL-QFMNEPVSTTELTKSFGWDS--LDSFMQHDV 295
           6******************************.....44443.356789************.9999*************877..67******* PP
   S: 93   qEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkk 184
           qEf ++l d+le+++                           ++k ++ +++lF g++ks i c + + +s r e+ +d++l+v+g +    
   Q: 296  QEFNRVLQDNLERSM--------------------------RDTKVENALTNLFVGKMKSYIACVNVNFESARSEDYWDIQLNVKGMK---- 357
           ***************..........................6899*******************************************.... PP
   S: 185  eslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekk 276
            +l+d+++s+ + e+leg+n y+ ++  + qea+k + ++++P++L+l+LkRf+++ e+++ +kin+++efple+d + f++ +  +q++++
   Q: 358  -NLEDSFRSYIQVETLEGDNCYFADTY-GFQEAKKGVIFESFPPILHLQLKRFEYDFERDMMIKINDRYEFPLEFDAKAFLSPEA-DQSQNC 446
           .9******************8887775.7999**********************************************9999855.5667** PP
   S: 277  kYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg...................staYvlfYkr 337
           +Y L++v+vHsG l++GHY+a+ k ek++ W+++dD++Vt  +  evlee+                     +aY+l+Y r
   Q: 447  EYVLYGVLVHSGDLHNGHYYALLKTEKDGpWYKYDDTRVTRATLREVLEENYggdyimhppfrspvklkrfMSAYMLLYLR 527
           *************************88888*******************7779**************************76 PP

Organism

Schizosaccharomyces pombe

Protein Sequence
(Fasta)

MVTGETLVDS QKSLINNDTL LNEKLKEDFE ENVSIDVKIH EELRRALPDY EESGFQRFTW 60
HIKSWHELDR RAVSPQFAVG SRQFKITYFP QGTLQSAGFT SIFLEYIPSE EEKLSNKYGC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGATATTCA AATCCATTGT TTTACAGTCA TTACTTGTTC CTTTATTATT TGAAAGCCTC 60
ACAACTAAAA AAATTCTAAG ATTTCATGGT ATTGAAGTTT TTGTTGATAT CTCGGACCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR002083--MATH/TRAF_dom
IPR001394--Peptidase_C19_UCH
IPR008974--TRAF-like
IPR024729--USP7_ICP0-binding_dom
IPR029346--USP_C
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50144--MATH
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF14533--USP7_C2
PF12436--USP7_ICP0_bdg

SMART

SM00061--MATH

Gene Ontology

GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0035871--P:protein K11-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

spo:SPCC188.08c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cre-022708	Chlamydomonas reinhardtii	42.22	5.00e-96	342.00
IUUC-Loc-052234	Lepisosteus oculatus	37.97	7.00e-131	459.00
IUUC-Mtr-058630	Medicago truncatula	36.96	5.00e-152	530.00
IUUC-Olu-087874	Ostreococcus lucimarinus	31.79	1.00e-132	465.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence