iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mcc-054919

Ensembl Protein ID

ENSMMUP00000049762.1

UniProt Accession

H9ET84; H9ET84_MACMU

Genbank Protein ID

AFE65593.1; AFH28779.1; AFH28780.1; AFH28781.1; AFI34518.1

Protein Name

E3 ubiquitin-protein ligase ARIH2

Genbank Nucleotide ID

JSUE03023746; JU471975; JU471976; JU471977; JV044447

Gene Name

ARIH2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000039597.1	ENSMMUT00000067873.1	ENSMMUP00000049762.1
ENSMMUG00000039597.1	ENSMMUT00000069947.1	ENSMMUP00000047721.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RBR	3.90e-56	190.7	139	326

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RBR

   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpekleeseikellveeelykryekllleevveadaalkw 90
           C+vC+ ++  +e++ +l+C+h+fC++C++q++++ ik+g  + +sc+a++cp +++e+ +  ll++eel ++y+++l++++ve++++l++
   Q: 139  CAVCM-QFVRKENLLSLACQHQFCRSCWEQHCSVLIKDGVGVGVSCMAQDCPLRTPEDFVFPLLPNEELREKYRRYLFRDYVESHYQLQL 227
           9***9.77777888899************************************************************************* PP
   S: 91   cpapdCslvvllekeaeklevecekcgkefCveCkeewHeglsCkelkeklakteeekeeaeskelleanskkCpkCkvyieknegCnhm 180
           cp +dC +v+++++  ++ +v+c++c+++fC++C++++H++++C +++++l+k++   +++e++++++a++k+CpkC+++iekn+gCnhm
   Q: 228  CPGADCPMVIRVQEP-RARRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTKCA---DDSETANYISAHTKDCPKCNICIEKNGGCNHM 313
           **************7.99*************************************...99****************************** PP
   S: 181  tCakCkaefCwlC 193
           +C+kCk++fCw+C
   Q: 314  QCSKCKHDFCWMC 326
           ************* PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MSVDMNSQGS DSNEEDYDPN CEEEEEEEDE DPGDIEDYYV GVASDVEQQG ADAFDPEEYQ 60
FTCLTYKESE GALNEHMTSL ASVLKVSHSV AKLILVNFHW QVSEILDRFK SNSAQLLVEA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCAACGGCG CCAAGTACTT CCGGAGCTGC GGGGACGACT CTTCTGGAGG AAGCAGCACG 60
GGCTTGACCG GCGTCGGCCC GCCGCCTCTG CCGCCGCTTC TCCCCAATCC AGTCCCTCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF01485--IBR

SMART

SM00647--IBR
SM00184--RING

Gene Ontology

GO:0031466--C:Cul5-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0048588--P:developmental cell growth
GO:0071425--P:hematopoietic stem cell proliferation
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001557	Ailuropoda melanoleuca	97.97	0.00e+00	936.00
IUUC-Atr-002495	Amborella trichopoda	31.68	2.00e-50	193.00
IUUC-Apl-003878	Anas platyrhynchos	93.10	0.00e+00	875.00
IUUC-Aca-004865	Anolis carolinensis	92.29	0.00e+00	879.00
IUUC-Bta-012901	Bos taurus	97.77	0.00e+00	931.00
IUUC-Bra-017081	Brassica rapa	29.20	7.00e-58	218.00
IUUC-Cel-018334	Caenorhabditis elegans	48.64	3.00e-127	448.00
IUUC-Cja-019728	Callithrix jacchus	98.99	0.00e+00	939.00
IUUC-Cfa-020953	Canis familiaris	98.17	0.00e+00	936.00
IUUC-Cpo-021445	Cavia porcellus	98.38	0.00e+00	936.00
IUUC-Csa-023769	Chlorocebus sabaeus	100.00	0.00e+00	947.00
IUUC-Cho-024650	Choloepus hoffmanni	87.63	0.00e+00	793.00
IUUC-Cin-025577	Ciona intestinalis	54.09	5.00e-143	501.00
IUUC-Csv-025849	Ciona savignyi	55.58	4.00e-120	424.00
IUUC-Dre-028490	Danio rerio	79.24	0.00e+00	776.00
IUUC-Dno-029942	Dasypus novemcinctus	97.97	0.00e+00	932.00
IUUC-Dor-030134	Dipodomys ordii	84.98	5.00e-151	527.00
IUUC-Dme-031853	Drosophila melanogaster	55.06	3.00e-149	521.00
IUUC-Ete-032355	Echinops telfairi	88.87	0.00e+00	835.00
IUUC-Eca-033440	Equus caballus	98.17	0.00e+00	936.00
IUUC-Eeu-035230	Erinaceus europaeus	89.36	3.00e-115	408.00
IUUC-Fca-036308	Felis catus	91.90	0.00e+00	864.00
IUUC-Fal-036974	Ficedula albicollis	93.10	0.00e+00	875.00
IUUC-Gmo-038642	Gadus morhua	80.91	0.00e+00	777.00
IUUC-Gga-041019	Gallus gallus	93.10	0.00e+00	875.00
IUUC-Gac-042014	Gasterosteus aculeatus	80.08	0.00e+00	801.00
IUUC-Ggo-045329	Gorilla gorilla	99.59	0.00e+00	944.00
IUUC-Hsa-046712	Homo sapiens	99.19	0.00e+00	944.00
IUUC-Hvu-047322	Hordeum vulgare	30.73	4.00e-54	205.00
IUUC-Itr-048370	Ictidomys tridecemlineatus	98.56	0.00e+00	842.00
IUUC-Lch-049584	Latimeria chalumnae	85.63	0.00e+00	816.00
IUUC-Lpe-051492	Leersia perrieri	29.21	8.00e-57	214.00
IUUC-Loc-051826	Lepisosteus oculatus	79.89	7.00e-165	573.00
IUUC-Laf-054567	Loxodonta africana	96.55	0.00e+00	915.00
IUUC-Meu-056332	Macropus eugenii	91.08	0.00e+00	848.00
IUUC-Mga-060132	Meleagris gallopavo	93.13	0.00e+00	880.00
IUUC-Mmr-061599	Microcebus murinus	94.74	0.00e+00	885.00
IUUC-Mdo-062186	Monodelphis domestica	94.69	0.00e+00	799.00
IUUC-Mmu-064271	Mus musculus	97.36	0.00e+00	930.00
IUUC-Mpu-066827	Mustela putorius furo	96.19	0.00e+00	827.00
IUUC-Mlu-067528	Myotis lucifugus	96.96	0.00e+00	890.00
IUUC-Nle-068995	Nomascus leucogenys	99.59	0.00e+00	944.00
IUUC-Opr-070518	Ochotona princeps	98.17	0.00e+00	900.00
IUUC-Ont-071650	Oreochromis niloticus	82.87	0.00e+00	819.00
IUUC-Oan-073676	Ornithorhynchus anatinus	93.63	0.00e+00	752.00
IUUC-Ocu-073761	Oryctolagus cuniculus	99.19	0.00e+00	942.00
IUUC-Obr-076705	Oryza brachyantha	30.28	1.00e-58	221.00
IUUC-Ogu-079025	Oryza glumaepatula	28.74	2.00e-56	213.00
IUUC-Opu-084059	Oryza punctata	29.44	3.00e-57	216.00
IUUC-Oru-084181	Oryza rufipogon	28.74	2.00e-56	214.00
IUUC-Osa-086069	Oryza sativa	28.74	4.00e-56	212.00
IUUC-Ola-087204	Oryzias latipes	79.37	0.00e+00	793.00
IUUC-Olu-087826	Ostreococcus lucimarinus	30.60	4.00e-45	176.00
IUUC-Oga-088098	Otolemur garnettii	98.38	0.00e+00	933.00
IUUC-Oar-089205	Ovis aries	97.77	0.00e+00	931.00
IUUC-Ptr-091514	Pan troglodytes	99.59	0.00e+00	944.00
IUUC-Pan-092493	Papio anubis	95.23	0.00e+00	901.00
IUUC-Psi-093024	Pelodiscus sinensis	87.11	3.00e-117	414.00
IUUC-Ppa-095554	Physcomitrella patens	29.34	3.00e-57	216.00
IUUC-Pfo-097256	Poecilia formosa	81.84	0.00e+00	808.00
IUUC-Pab-098504	Pongo abelii	91.89	0.00e+00	844.00
IUUC-Pop-099547	Populus trichocarpa	31.09	2.00e-55	209.00
IUUC-Pca-100700	Procavia capensis	91.08	0.00e+00	835.00
IUUC-Pva-103105	Pteropus vampyrus	97.16	0.00e+00	920.00
IUUC-Rno-105289	Rattus norvegicus	97.57	0.00e+00	932.00
IUUC-Sha-107417	Sarcophilus harrisii	95.13	0.00e+00	871.00
IUUC-Sit-110645	Setaria italica	31.33	2.00e-55	210.00
IUUC-Sar-113042	Sorex araneus	95.57	0.00e+00	924.00
IUUC-Ssc-115362	Sus scrofa	98.38	0.00e+00	936.00
IUUC-Tgu-117469	Taeniopygia guttata	92.77	0.00e+00	827.00
IUUC-Tru-117976	Takifugu rubripes	80.00	0.00e+00	812.00
IUUC-Tsy-118876	Tarsius syrichta	85.45	7.00e-91	327.00
IUUC-Tni-119831	Tetraodon nigroviridis	79.80	0.00e+00	792.00
IUUC-Tca-121326	Theobroma cacao	29.15	3.00e-59	223.00
IUUC-Tae-123545	Triticum aestivum	29.93	1.00e-56	214.00
IUUC-Tbe-127386	Tupaia belangeri	92.19	6.00e-161	560.00
IUUC-Ttr-128315	Tursiops truncatus	97.97	0.00e+00	934.00
IUUC-Vpa-130383	Vicugna pacos	90.47	0.00e+00	835.00
IUUC-Vvi-131543	Vitis vinifera	29.51	2.00e-56	213.00
IUUC-Xtr-132945	Xenopus tropicalis	90.47	0.00e+00	870.00
IUUC-Xma-134312	Xiphophorus maculatus	80.00	0.00e+00	803.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence