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Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Cel-018439
UUCD1 version UUC-CaE-00495
Ensembl Protein ID K04G11.4
UniProt Accession Q93847; WDR52_CAEEL
Genbank Protein ID CAB01760.1
Protein Name WD repeat-containing protein wdr-5.2
Genbank Nucleotide ID Z78544
Gene Name wdr-5.2; swd-3.2; K04G11.4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00010572 K04G11.4 K04G11.4
Annotation
mRNA Expression
GEO
DNA & RNA Element
microRNA
Protein Expression/Proteomics
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 5.40e-52 171.7 230 269
UBD/Beta-Prp 9.80e-79 264.9 101 393
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
    gH+d+v++++f d +l+sGs+Dg +++WD +tg+++k+
   Q: 230 GHEDPVSSVCFnRDgAYLASGSYDGIVRIWDSTTGTCVKT 269
    8***********8889*********************986 PP
   


   UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp 104
    ++ ++hk+ i+ +kfspd++++ +gs+d +ik+w+++ + ++l gh +++ ++s+d+k++v++s+D+++kv+d+s+g cv tlkgh+++v ++ f+p
   Q: 101 EIPNAHKKSISGIKFSPDGRYMGSGSADCSIKIWRMDF-VYEKTLMGHRLGINEFSWSSDSKLIVSCSDDKLVKVFDVSSGRCVKTLKGHTNYVFCCCFNP 200
    56689*******************************99.899*********************************************************** PP
   S: 105 sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvk 205
    sg ++sGs d+tir+w ++g + gh++ v++v+++ dg +l+sGs+D++vr+Wd+ tg++++tl + ++++++++f++ngk++++ l++t+k
   Q: 201 SGTLIASGSFDETIRIWCARNGNTIF-SIPGHEDPVSSVCFNRDGAYLASGSYDGIVRIWDSTTGTCVKTLIDEEHPPITHVKFSPNGKYILASNLNNTLK 300
    *************************9.999*****************************************8889************************** PP
   S: 206 lwdlqtgecvrtlnghtdnvksvrfs...pnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgse..dskvniwkl 294
    lwd+q+ +++++++gh++ ++v++ ++++vsgs+D ++iW+l+++++l+tl +hn+ v++ ++ ++g+n++++++ d +++iw
   Q: 301 LWDYQKLRVLKEYTGHENSKYCVAANfsvTGGKWIVSGSEDHKVYIWNLQTREILQTLDGHNTAVMCTDC-HPGQNIIASAALepDMRIKIWRS 393
    ************************999999****************************************.**********9999*******86 PP
   

Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description



     Sex determining protein required in the germline to promote the spermatogenesis to oogenesis switch during the late larval stages of development. Acts with the sex determining factor tra-1, and redundantly with wdr-5.1, to regulate fog-3 expression, which in turn determines germ cell fate. Not required for methylation of histone H3 'Lys-4'.
Sex determining protein required in the germline to promote the spermatogenesis to oogenesis switch during the late larval stages of development. Acts with the sex determining factor tra-1, and redundantly with wdr-5.1, to regulate fog-3 expression, which in turn determines germ cell fate. Not required for methylation of histone H3 'Lys-4'.
Protein Sequence
(Fasta)
MEQRGRASQD EEQAIVGAET GSQPSLPVSP MRPIIAPSPA MVLPTPGHGM GIPQFGPVGL 60
PAQASTPMLS STPGPSYSSA PTPMPNPSAA NLWPTYKLVA EIPNAHKKSI SGIKFSPDGR 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Cel-018439|E3,WD_repeat;UBD,Beta-Prp|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGAGCAAC GCGGAAGAGC TTCTCAAGAT GAAGAGCAAG CAATAGTTGG TGCGGAAACC 60
GGTAGTCAGC CATCTCTTCC AGTTTCACCA ATGCGTCCTA TTATAGCAGT GAGTATTTTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Cel-018439|E3,WD_repeat;UBD,Beta-Prp|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

KEGG cel:CELE_K04G11.4
Orthology
iUUCD ID Species Identity E-value Score
Created Date 25-Jun-2017

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