iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-070173

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

ADFV01078510

Gene Name

USP5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000004763.2	ENSNLET00000006141.2	ENSNLEP00000005833.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.70e-64	216.4	326	832
UBD/Alpha-Helix/UBA	9.30e-23	79.6	702	739

Active Site

Position(s)	Description	Evidence
335	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
795	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel....................wkskkkavs 69
           tG++NlgN+CY+NSv+Q+L++ip++++ + + k ek+ +++p++p+++++++++kl + l                    +k+ +  ++
   Q: 326  TGIRNLGNSCYLNSVVQVLFSIPDFQRKYVD-KLEKIFQNAPTDPTQDFSTQVAKLGHGLlsgeyskpvpesgdgervpeQKEVQDGIA 413
           7******************************.99999999********************67766666666666655443366666*** PP
   S: 70   prellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikcle 158
           pr++++ ++k ++efs+++qqDaqEf+ +l++ +e+++                             ++++  +++F++ ++++ikcl+
   Q: 414  PRMFKALIGKGHPEFSTNRQQDAQEFFLHLINMVERNC-----------------------------RSSENPNEVFRFLVEEKIKCLA 473
           **************************************.............................6788899*************** PP
   S: 159  cdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeaekk 220
            ++v+ ++   + ++lpvp++   +ke                            +++cLe++ ++e++++   ++++  ++k+ a+k+
   Q: 474  TEKVKYTQRVDYIMQLPVPMDAALNKEelleyeekkrqaeeekmalpelvraqvPFSSCLEAYGAPEQVDD---FWSTALQAKSVAVKT 559
           **********************999989*****************************************97...*************** PP
   S: 221  lklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts.......................................... 267
           +++ ++P++L++++k+f+f  + ++++k++ ++e+p+eLd+s+   +                                          
   Q: 560  TRFASFPDYLVIQIKKFTFGLD-WVPKKLDVSIEMPEELDISQLRGTglqpgeeelpdiapplvtpdepkapmldesviiqlvemgfpm 647
           *******************997.*******************98888788888888888888888888777777777777777777777 PP
   S: 268  ..........................................................peekqke........................ 274
                                                                     +     +                        
   Q: 648  dacrkavyytgnsgaeaamnwvmshmddpdfanplilpgssgpgstsaaadpppedcvT-----Tivsmgfsrdqalkalratnnsler 731
           77777777777777777777766666666666666666666666665555555555550.....0555555555555555566666666 PP
   S: 275  ...........................................kkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevke 319
                                                      + kY+L+a ++H+G s+ +GHYv+++k+ +g+W+ ++D+kV ++  
   Q: 732  avdwifshiddldaeaamdisegrsaadsisesvpvgpkvrdgPGKYQLFAFISHMGtSTMCGHYVCHIKK-EGRWVIYNDQKVCAS-- 817
           6777777777777777777777777777888888888888888****************************.9***********999.. PP
   S: 320  eevleetgstaYvlfYkr 337
           e+  +   + +Y++fY+r
   Q: 818  EKPPK---DLGYIYFYQR 832
           78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ed +  +v+MGF+r++al+aLra+nn+le+Av++++++
   Q: 702  EDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFSH 739
           889999******************************97 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MAELSEEALL SVLPTIRVPK AGDRVHKDEC AFSFDTPESE GGLYICMNTF LGFGKQYVER 60
HFNKTGQRVY LHLRRTRRPK EEDPTTGTGD PPRKKPTRLA IGVEGGFDLS EEKFELDEDV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGAGC TGAGTGAGGA GGCGCTGCTG TCAGTATTAC CGACGATCCG GGTCCCTAAG 60
GCTGGAGACC GGGTCCACAA AGACGAGTGC GCCTTCTCCT TCGACACGCC GGTAAGCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

nle:100596356

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	45.70	0.00e+00	656.00
IUUC-Aml-002104	Ailuropoda melanoleuca	95.17	0.00e+00	1578.00
IUUC-Atr-002580	Amborella trichopoda	47.18	0.00e+00	743.00
IUUC-Apl-003774	Anas platyrhynchos	88.74	0.00e+00	1467.00
IUUC-Aca-005368	Anolis carolinensis	88.62	0.00e+00	1518.00
IUUC-Aly-005727	Arabidopsis lyrata	48.33	0.00e+00	740.00
IUUC-Ath-006974	Arabidopsis thaliana	48.56	0.00e+00	743.00
IUUC-Ago-007890	Ashbya gossypii	29.81	1.00e-84	308.00
IUUC-Acl-008057	Aspergillus clavatus	35.17	1.00e-126	447.00
IUUC-Afl-008547	Aspergillus flavus	37.30	3.00e-121	429.00
IUUC-Afu-008805	Aspergillus fumigatus	34.77	5.00e-116	411.00
IUUC-Ani-009441	Aspergillus nidulans	33.55	2.00e-101	363.00
IUUC-Ang-009720	Aspergillus niger	34.32	5.00e-120	425.00
IUUC-Aor-010111	Aspergillus oryzae	34.76	5.00e-130	458.00
IUUC-Ate-010531	Aspergillus terreus	32.34	7.00e-105	374.00
IUUC-Ame-011893	Astyanax mexicanus	67.36	0.00e+00	1010.00
IUUC-Bgr-012183	Blumeria graminis	34.37	6.00e-124	438.00
IUUC-Bta-013179	Bos taurus	95.40	0.00e+00	1585.00
IUUC-Bci-013858	Botrytis cinerea	35.60	8.00e-132	464.00
IUUC-Bdi-014904	Brachypodium distachyon	48.26	0.00e+00	722.00
IUUC-Bol-015296	Brassica oleracea	48.86	0.00e+00	757.00
IUUC-Bra-017939	Brassica rapa	49.22	0.00e+00	762.00
IUUC-Cel-018625	Caenorhabditis elegans	35.53	6.00e-137	481.00
IUUC-Cja-019063	Callithrix jacchus	95.29	0.00e+00	1575.00
IUUC-Cfa-020976	Canis familiaris	98.67	0.00e+00	1608.00
IUUC-Cpo-022265	Cavia porcellus	98.67	0.00e+00	1603.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	41.01	3.00e-115	409.00
IUUC-Csa-024177	Chlorocebus sabaeus	99.61	0.00e+00	1488.00
IUUC-Cho-024702	Choloepus hoffmanni	85.24	0.00e+00	934.00
IUUC-Cin-025411	Ciona intestinalis	51.39	0.00e+00	838.00
IUUC-Csv-026347	Ciona savignyi	47.09	0.00e+00	801.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	35.35	4.00e-115	409.00
IUUC-Cne-026831	Cryptococcus neoformans	36.34	2.00e-131	462.00
IUUC-Dre-027982	Danio rerio	65.59	0.00e+00	1082.00
IUUC-Dno-029034	Dasypus novemcinctus	95.75	0.00e+00	1607.00
IUUC-Dor-030479	Dipodomys ordii	93.05	0.00e+00	669.00
IUUC-Dse-031467	Dothistroma septosporum	36.82	3.00e-134	472.00
IUUC-Dme-032075	Drosophila melanogaster	50.47	0.00e+00	809.00
IUUC-Ete-032865	Echinops telfairi	84.15	0.00e+00	1397.00
IUUC-Eca-034059	Equus caballus	95.79	0.00e+00	1599.00
IUUC-Eeu-035304	Erinaceus europaeus	89.73	0.00e+00	1435.00
IUUC-Fca-035515	Felis catus	95.75	0.00e+00	1590.00
IUUC-Fal-037271	Ficedula albicollis	90.49	0.00e+00	1439.00
IUUC-Fox-037745	Fusarium oxysporum	36.09	7.00e-131	461.00
IUUC-Fso-038158	Fusarium solani	36.68	1.00e-130	460.00
IUUC-Gmo-039071	Gadus morhua	64.70	0.00e+00	1078.00
IUUC-Ggr-040098	Gaeumannomyces graminis	34.79	2.00e-121	430.00
IUUC-Gga-040635	Gallus gallus	88.34	0.00e+00	1533.00
IUUC-Gac-042528	Gasterosteus aculeatus	65.01	0.00e+00	1099.00
IUUC-Gma-043614	Glycine max	47.78	0.00e+00	708.00
IUUC-Ggo-044602	Gorilla gorilla	97.05	0.00e+00	1608.00
IUUC-Hsa-045959	Homo sapiens	97.05	0.00e+00	1608.00
IUUC-Hvu-047563	Hordeum vulgare	49.02	2.00e-172	598.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	95.40	0.00e+00	1583.00
IUUC-Kpa-049156	Komagataella pastoris	33.96	2.00e-118	419.00
IUUC-Lch-049648	Latimeria chalumnae	84.31	0.00e+00	1389.00
IUUC-Lpe-051523	Leersia perrieri	47.69	0.00e+00	725.00
IUUC-Lma-053216	Leptosphaeria maculans	34.92	3.00e-115	410.00
IUUC-Laf-054327	Loxodonta africana	94.69	0.00e+00	1574.00
IUUC-Mcc-055443	Macaca mulatta	96.69	0.00e+00	1600.00
IUUC-Meu-056298	Macropus eugenii	93.23	0.00e+00	1062.00
IUUC-Mor-057106	Magnaporthe oryzae	36.09	4.00e-132	465.00
IUUC-Mpo-057589	Magnaporthe poae	35.64	8.00e-126	444.00
IUUC-Mtr-058680	Medicago truncatula	49.40	0.00e+00	746.00
IUUC-Mla-058903	Melampsora laricipopulina	33.45	1.00e-122	434.00
IUUC-Mga-059669	Meleagris gallopavo	87.39	0.00e+00	1451.00
IUUC-Mvi-060476	Microbotryum violaceum	35.27	8.00e-122	431.00
IUUC-Mmr-060575	Microcebus murinus	95.75	0.00e+00	1590.00
IUUC-Mdo-062183	Monodelphis domestica	92.23	0.00e+00	1532.00
IUUC-Mmu-063592	Mus musculus	95.51	0.00e+00	1584.00
IUUC-Mac-065634	Musa acuminata	43.90	0.00e+00	696.00
IUUC-Mpu-066082	Mustela putorius furo	97.82	0.00e+00	1594.00
IUUC-Mlu-067345	Myotis lucifugus	93.41	0.00e+00	1548.00
IUUC-Nfi-068558	Neosartorya fischeri	35.57	1.00e-124	440.00
IUUC-Ncr-068960	Neurospora crassa	35.27	3.00e-118	419.00
IUUC-Opr-070556	Ochotona princeps	94.45	0.00e+00	1575.00
IUUC-Ont-071502	Oreochromis niloticus	67.02	0.00e+00	1105.00
IUUC-Ocu-074861	Oryctolagus cuniculus	98.18	0.00e+00	1602.00
IUUC-Oba-075109	Oryza barthii	47.65	0.00e+00	726.00
IUUC-Obr-076292	Oryza brachyantha	49.10	0.00e+00	724.00
IUUC-Ogl-077065	Oryza glaberrima	48.98	0.00e+00	756.00
IUUC-Ogu-078776	Oryza glumaepatula	47.65	0.00e+00	738.00
IUUC-Oin-080048	Oryza indica	48.50	0.00e+00	749.00
IUUC-Olo-080711	Oryza longistaminata	45.80	0.00e+00	668.00
IUUC-Ome-081506	Oryza meridionalis	46.91	0.00e+00	680.00
IUUC-Oni-082320	Oryza nivara	47.06	0.00e+00	724.00
IUUC-Opu-083801	Oryza punctata	47.84	0.00e+00	719.00
IUUC-Oru-085139	Oryza rufipogon	47.06	0.00e+00	725.00
IUUC-Osa-085713	Oryza sativa	49.10	0.00e+00	759.00
IUUC-Ola-086951	Oryzias latipes	64.49	0.00e+00	1062.00
IUUC-Olu-087822	Ostreococcus lucimarinus	41.93	2.00e-180	625.00
IUUC-Oga-088625	Otolemur garnettii	95.05	0.00e+00	1572.00
IUUC-Oar-089995	Ovis aries	94.00	0.00e+00	1553.00
IUUC-Ptr-090640	Pan troglodytes	94.21	0.00e+00	1583.00
IUUC-Pan-091974	Papio anubis	95.76	0.00e+00	1583.00
IUUC-Psi-093957	Pelodiscus sinensis	87.21	0.00e+00	1533.00
IUUC-Pma-094242	Petromyzon marinus	71.65	8.00e-165	572.00
IUUC-Pno-094835	Phaeosphaeria nodorum	35.41	1.00e-108	387.00
IUUC-Ppa-095901	Physcomitrella patens	50.41	0.00e+00	793.00
IUUC-Pfo-097148	Poecilia formosa	68.43	0.00e+00	1116.00
IUUC-Pab-098068	Pongo abelii	89.37	0.00e+00	1427.00
IUUC-Pop-098943	Populus trichocarpa	48.02	0.00e+00	728.00
IUUC-Pca-100738	Procavia capensis	93.84	0.00e+00	1070.00
IUUC-Ppe-101315	Prunus persica	48.51	0.00e+00	734.00
IUUC-Pva-102154	Pteropus vampyrus	93.74	0.00e+00	1555.00
IUUC-Pgr-103343	Puccinia graminis	34.86	3.00e-111	395.00
IUUC-Ptt-103928	Puccinia triticina	31.12	1.00e-108	387.00
IUUC-Pte-104306	Pyrenophora teres	32.79	6.00e-105	375.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	33.69	3.00e-108	386.00
IUUC-Rno-105801	Rattus norvegicus	95.40	0.00e+00	1585.00
IUUC-Sce-106304	Saccharomyces cerevisiae	28.36	1.00e-72	267.00
IUUC-Sha-107635	Sarcophilus harrisii	94.54	0.00e+00	1556.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	33.37	4.00e-113	402.00
IUUC-Spo-108144	Schizosaccharomyces pombe	32.51	4.00e-115	409.00
IUUC-Smo-108848	Selaginella moellendorffii	49.52	0.00e+00	748.00
IUUC-Sit-110728	Setaria italica	49.46	0.00e+00	780.00
IUUC-Sly-111523	Solanum lycopersicum	48.69	0.00e+00	771.00
IUUC-Sbi-114419	Sorghum bicolor	48.68	0.00e+00	759.00
IUUC-Sre-115225	Sporisorium reilianum	35.75	6.00e-129	454.00
IUUC-Ssc-115686	Sus scrofa	94.46	0.00e+00	1575.00
IUUC-Tgu-117346	Taeniopygia guttata	87.89	0.00e+00	1499.00
IUUC-Tru-118350	Takifugu rubripes	63.07	0.00e+00	1091.00
IUUC-Tni-120658	Tetraodon nigroviridis	64.16	0.00e+00	1074.00
IUUC-Tca-121585	Theobroma cacao	48.81	0.00e+00	729.00
IUUC-Tre-122043	Trichoderma reesei	35.32	3.00e-122	432.00
IUUC-Tvi-122303	Trichoderma virens	35.32	1.00e-127	450.00
IUUC-Tae-125686	Triticum aestivum	48.62	0.00e+00	738.00
IUUC-Tur-126732	Triticum urartu	46.08	0.00e+00	693.00
IUUC-Tme-126909	Tuber melanosporum	35.09	4.00e-120	425.00
IUUC-Tbe-127261	Tupaia belangeri	87.19	0.00e+00	973.00
IUUC-Uma-129599	Ustilago maydis	34.84	2.00e-130	459.00
IUUC-Vda-129688	Verticillium dahliae	34.54	1.00e-122	434.00
IUUC-Vvi-131116	Vitis vinifera	48.34	0.00e+00	712.00
IUUC-Xtr-131953	Xenopus tropicalis	76.81	0.00e+00	1291.00
IUUC-Xma-133837	Xiphophorus maculatus	68.55	0.00e+00	1118.00
IUUC-Yli-134510	Yarrowia lipolytica	36.08	1.00e-131	463.00
IUUC-Zma-135786	Zea mays	48.44	0.00e+00	725.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence