iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120218

UUCD1 version

UUC-TeN-01179

Ensembl Protein ID

ENSTNIP00000015506.1

UniProt Accession

H3D4R7; H3D4R7_TETNG

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Gene Name

pan2; PAN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000012537.1	ENSTNIT00000015712.1	ENSTNIP00000015506.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.60e-19	68.5	533	923

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.gyeqqDaqEfl 96
             Y+N+++Q+L++++++r+l+ +   + +++      + +l+++l  lf+ l  s+    + +++l+a++++ e    g    D+ E +
   Q: 533  NAYCNCMIQVLYFLEPIRCLVQN---HLCQK------EFCLACELGFLFHMLDLSRGDPCQASNFLRAFRTIPEASAlGLILADSDEQT 612
           56*********************...55654......57*******************************9999855655555665554 PP
   S: 97   a.flldqleeelkk....eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgke 180
               l +l ++ ++    + +++++e+e+ +  +    ++++  ++++s+i +lF+ +++++  c +c+++++r +  l ++++ p+++
   Q: 613  GkAKLGRLIQSWNRfilaQLHQETQEQEGPQ--AYRGASSSSLGSSGESVIGKLFGCEVENSSLC-RCGKETVRSSLTLLFTMHYPEHN 698
           3133555555555544333333334443333..4555578999**********************.8*******************999 PP
   S: 181  etkke...slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfct 266
           + +k    ++ ++L    +   le++ + +ce+c+k+q ++++  ++ lP+vL+++    s +e++  r  ++ ++ f++  + +   t
   Q: 699  SPEKVreyDFAEIL---KRSICLEQSTQAWCENCEKYQPTVQTRNIRCLPDVLVINCEVNSAKEAEFWR--VQAEYAFNKAAQKE--AT 780
           87666333444444...44455667778*****************************999777766665..44444444332222..22 PP
   S: 267  s............................................................peekqke............kkkYeLiav 283
           +                                                            p     e            +  Y+L+  
   Q: 781  EpvkpkepppmpsewcldseemssmegftldtrvedlrhvwiplslkmsisksqgleisswP-----EaqelseaeeaegTSLYDLVVT 864
           21223344444444444455555556666666666666666666665555555555555550.....05555555566669******** PP
   S: 284  vvHsG.slssGHYvayvkn...........ekgkWllfdDskVtevkeeevleetg..s 328
           v H      +G  v+++k            ++++W+lf+D  +++++++e +++    +
   Q: 865  VPHVQdARTGGNLVTHIKVgetyhqrkegvTHQQWYLFNDFLIEPIDKTEAVQFDVswK 923
           *****99999*********999988877777888*************999888654554 PP

Organism

Tetraodon nigroviridis

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

LAASMMNFDG LDPGMGEYPP SLHGTLDAGM EPSLDPHLNP GLLQGVELDP EGLAVTVPEP 60
VHLMEGMFSE LHSVVSEVGV PVTATHFDLQ EEMLWMGNHR GHVTSFFGPT MDRYSSFQVH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTAGCCGCAT CTATGATGAA CTTTGACGGT CTCGACCCTG GGATGGGTGA GTACCCACCC 60
AGCCTTCACG GAACCTTGGA TGCGGGGATG GAGCCCTCCC TGGACCCCCA TCTCAACCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	75.37	0.00e+00	1814.00
IUUC-Apl-003500	Anas platyrhynchos	77.21	0.00e+00	1715.00
IUUC-Aca-004930	Anolis carolinensis	75.94	0.00e+00	1862.00
IUUC-Acl-008214	Aspergillus clavatus	29.55	8.00e-86	311.00
IUUC-Afu-009112	Aspergillus fumigatus	30.65	3.00e-142	499.00
IUUC-Ang-009531	Aspergillus niger	29.26	1.00e-77	285.00
IUUC-Ame-011259	Astyanax mexicanus	87.18	0.00e+00	2125.00
IUUC-Bta-012371	Bos taurus	75.43	0.00e+00	1808.00
IUUC-Bci-013684	Botrytis cinerea	42.63	7.00e-70	259.00
IUUC-Cja-019297	Callithrix jacchus	73.44	0.00e+00	1763.00
IUUC-Cfa-020489	Canis familiaris	75.43	0.00e+00	1806.00
IUUC-Cpo-022392	Cavia porcellus	75.53	0.00e+00	1839.00
IUUC-Csa-023220	Chlorocebus sabaeus	74.88	0.00e+00	1806.00
IUUC-Csv-025841	Ciona savignyi	48.47	5.00e-140	491.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	28.49	5.00e-87	316.00
IUUC-Cne-026932	Cryptococcus neoformans	43.02	1.00e-71	265.00
IUUC-Dre-028482	Danio rerio	85.30	0.00e+00	2053.00
IUUC-Dno-029398	Dasypus novemcinctus	75.64	0.00e+00	1818.00
IUUC-Dor-030307	Dipodomys ordii	70.10	0.00e+00	1008.00
IUUC-Dme-032111	Drosophila melanogaster	40.55	0.00e+00	881.00
IUUC-Eca-033985	Equus caballus	75.60	0.00e+00	1812.00
IUUC-Eeu-034928	Erinaceus europaeus	76.81	7.00e-178	617.00
IUUC-Fca-035587	Felis catus	75.45	0.00e+00	1831.00
IUUC-Fal-037587	Ficedula albicollis	76.43	0.00e+00	1824.00
IUUC-Fso-038133	Fusarium solani	42.65	6.00e-76	279.00
IUUC-Gmo-039076	Gadus morhua	86.73	0.00e+00	2082.00
IUUC-Ggr-039957	Gaeumannomyces graminis	28.67	6.00e-74	272.00
IUUC-Gga-040948	Gallus gallus	77.23	0.00e+00	1858.00
IUUC-Gac-042396	Gasterosteus aculeatus	90.37	0.00e+00	2203.00
IUUC-Ggo-045412	Gorilla gorilla	75.04	0.00e+00	1808.00
IUUC-Hsa-046076	Homo sapiens	75.04	0.00e+00	1808.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	70.12	0.00e+00	1632.00
IUUC-Kpa-049178	Komagataella pastoris	27.32	2.00e-104	374.00
IUUC-Lch-050279	Latimeria chalumnae	71.33	0.00e+00	874.00
IUUC-Loc-052872	Lepisosteus oculatus	85.15	0.00e+00	2044.00
IUUC-Lma-052986	Leptosphaeria maculans	31.24	5.00e-92	332.00
IUUC-Laf-054181	Loxodonta africana	72.77	0.00e+00	1768.00
IUUC-Mcc-054812	Macaca mulatta	74.94	0.00e+00	1801.00
IUUC-Meu-056325	Macropus eugenii	76.73	0.00e+00	1843.00
IUUC-Mor-057246	Magnaporthe oryzae	29.27	4.00e-116	412.00
IUUC-Mpo-057464	Magnaporthe poae	29.01	7.00e-70	259.00
IUUC-Mla-058911	Melampsora laricipopulina	32.28	5.00e-102	366.00
IUUC-Mga-059335	Meleagris gallopavo	77.92	0.00e+00	1818.00
IUUC-Mvi-060461	Microbotryum violaceum	33.63	2.00e-140	493.00
IUUC-Mmr-060636	Microcebus murinus	75.18	0.00e+00	1807.00
IUUC-Mmu-063503	Mus musculus	74.59	0.00e+00	1810.00
IUUC-Mpu-066670	Mustela putorius furo	75.60	0.00e+00	1815.00
IUUC-Mlu-068119	Myotis lucifugus	75.33	0.00e+00	1870.00
IUUC-Nfi-068398	Neosartorya fischeri	31.33	2.00e-151	530.00
IUUC-Ncr-068927	Neurospora crassa	40.11	1.00e-70	261.00
IUUC-Nle-069651	Nomascus leucogenys	72.03	0.00e+00	1718.00
IUUC-Opr-070614	Ochotona princeps	75.02	0.00e+00	1784.00
IUUC-Ont-072433	Oreochromis niloticus	89.96	0.00e+00	2216.00
IUUC-Oan-073283	Ornithorhynchus anatinus	67.50	0.00e+00	1285.00
IUUC-Ocu-074401	Oryctolagus cuniculus	74.92	0.00e+00	1807.00
IUUC-Ola-087522	Oryzias latipes	90.33	0.00e+00	2174.00
IUUC-Oga-088226	Otolemur garnettii	74.25	0.00e+00	1816.00
IUUC-Oar-089241	Ovis aries	75.37	0.00e+00	1833.00
IUUC-Pan-092297	Papio anubis	76.33	0.00e+00	1635.00
IUUC-Psi-094043	Pelodiscus sinensis	74.22	0.00e+00	1745.00
IUUC-Pma-094394	Petromyzon marinus	66.67	0.00e+00	1513.00
IUUC-Pno-095053	Phaeosphaeria nodorum	30.32	1.00e-76	281.00
IUUC-Ppa-095188	Physcomitrella patens	32.03	2.00e-162	566.00
IUUC-Pfo-097517	Poecilia formosa	91.82	0.00e+00	2251.00
IUUC-Pca-100471	Procavia capensis	76.19	0.00e+00	1722.00
IUUC-Pva-102805	Pteropus vampyrus	73.39	0.00e+00	1421.00
IUUC-Pte-104021	Pyrenophora teres	30.90	3.00e-93	337.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	30.48	3.00e-92	333.00
IUUC-Rno-105471	Rattus norvegicus	75.06	0.00e+00	1822.00
IUUC-Sce-106235	Saccharomyces cerevisiae	26.31	6.00e-85	309.00
IUUC-Sha-106883	Sarcophilus harrisii	76.22	0.00e+00	1705.00
IUUC-Spo-108169	Schizosaccharomyces pombe	50.00	5.00e-76	279.00
IUUC-Sar-113323	Sorex araneus	75.72	0.00e+00	1346.00
IUUC-Sre-115075	Sporisorium reilianum	47.75	3.00e-58	220.00
IUUC-Ssc-116363	Sus scrofa	74.29	0.00e+00	1816.00
IUUC-Tru-118427	Takifugu rubripes	95.98	0.00e+00	2367.00
IUUC-Tre-122177	Trichoderma reesei	28.79	2.00e-78	287.00
IUUC-Tme-127176	Tuber melanosporum	31.86	8.00e-132	464.00
IUUC-Tbe-127641	Tupaia belangeri	67.33	1.00e-179	623.00
IUUC-Ttr-128888	Tursiops truncatus	74.84	0.00e+00	1128.00
IUUC-Uma-129361	Ustilago maydis	38.60	9.00e-61	229.00
IUUC-Xtr-132811	Xenopus tropicalis	73.79	0.00e+00	1791.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence