iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mcc-054747

Ensembl Protein ID

ENSMMUP00000051983.1

UniProt Accession

A0A1D5QVA3; A0A1D5QVA3_MACMU

Genbank Protein ID

ENSMMUP00000051983

Protein Name

tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; WD repeat-containing protein 4

Genbank Nucleotide ID

JSUE03027042

Gene Name

WDR4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000038918.1	ENSMMUT00000071623.1	ENSMMUP00000051983.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.70e-07	30.8	186	225

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHt+ v+ ++   +  +ll+s+s+Dgt+++W++r+g++l+
   Q: 186  GHTEFVSRISVvpTQpGLLLSSSGDGTLRLWEYRSGRQLH 225
           67777777776853369*******************9986 PP

Organism

Macaca mulatta

Functional Description
(View)

Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

Protein Sequence
(Fasta)

MAGSVGLALC GQTLVVRGGS RFLATSTASS DDDSLFIYDC SDAEKKSQEN KGEDAPLDQG 60
SGVILASTFS KSGSYFALTD DSKRLILFRT KPWQCLSVRT VARRCTALTF IASEEKVLVA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCTCTAGGC GGGCACATGT GTATGGCGGC GAGGCGGGCG GGTACATGGC GGGCTCTGTG 60
GGACTGGCGT TGTGCGGGCA GACGCTGGTG GTGCGGGGCG GCAGCCGATT CCTGGCCACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0819--tRNA processing
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR028884--Trm82
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0036265--P:RNA (guanine-N7)-methylation
GO:0030488--P:tRNA methylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000556	Aegilops tauschii	33.13	1.00e-10	60.80
IUUC-Apl-003975	Anas platyrhynchos	60.27	2.00e-122	432.00
IUUC-Aca-005170	Anolis carolinensis	54.71	2.00e-105	375.00
IUUC-Aly-005769	Arabidopsis lyrata	30.77	2.00e-24	106.00
IUUC-Ath-006733	Arabidopsis thaliana	35.38	1.00e-23	103.00
IUUC-Acl-008151	Aspergillus clavatus	35.37	4.00e-16	79.70
IUUC-Afl-008518	Aspergillus flavus	39.46	5.00e-17	82.00
IUUC-Afu-009102	Aspergillus fumigatus	38.82	3.00e-14	73.20
IUUC-Ani-009442	Aspergillus nidulans	27.37	7.00e-15	75.10
IUUC-Aor-010133	Aspergillus oryzae	31.01	3.00e-20	93.20
IUUC-Ate-010465	Aspergillus terreus	37.29	3.00e-14	73.20
IUUC-Ame-010613	Astyanax mexicanus	46.60	3.00e-89	322.00
IUUC-Bgr-012067	Blumeria graminis	44.12	2.00e-18	87.00
IUUC-Bta-012788	Bos taurus	77.24	3.00e-180	624.00
IUUC-Bdi-014458	Brachypodium distachyon	37.11	4.00e-19	89.40
IUUC-Bol-015373	Brassica oleracea	36.61	2.00e-23	105.00
IUUC-Bra-016644	Brassica rapa	38.33	2.00e-23	105.00
IUUC-Cpo-021963	Cavia porcellus	78.57	6.00e-169	586.00
IUUC-Csa-024148	Chlorocebus sabaeus	97.82	0.00e+00	697.00
IUUC-Cne-026834	Cryptococcus neoformans	35.10	4.00e-19	89.70
IUUC-Dre-028427	Danio rerio	47.20	5.00e-91	328.00
IUUC-Dno-028881	Dasypus novemcinctus	69.62	2.00e-157	548.00
IUUC-Dor-030522	Dipodomys ordii	74.56	9.00e-165	572.00
IUUC-Dme-032136	Drosophila melanogaster	32.83	1.00e-23	104.00
IUUC-Fca-035833	Felis catus	73.21	7.00e-165	573.00
IUUC-Fal-037497	Ficedula albicollis	58.07	1.00e-120	426.00
IUUC-Gga-040547	Gallus gallus	57.25	2.00e-125	442.00
IUUC-Gac-041761	Gasterosteus aculeatus	44.41	8.00e-83	300.00
IUUC-Gma-043941	Glycine max	35.94	8.00e-26	111.00
IUUC-Ggo-045340	Gorilla gorilla	96.84	0.00e+00	744.00
IUUC-Hsa-046403	Homo sapiens	96.12	0.00e+00	740.00
IUUC-Hvu-047643	Hordeum vulgare	39.33	5.00e-20	92.00
IUUC-Itr-048103	Ictidomys tridecemlineatus	80.63	2.00e-180	624.00
IUUC-Kpa-049283	Komagataella pastoris	33.96	6.00e-18	85.10
IUUC-Lch-050682	Latimeria chalumnae	49.14	2.00e-106	379.00
IUUC-Lpe-050712	Leersia perrieri	31.15	3.00e-23	102.00
IUUC-Loc-052599	Lepisosteus oculatus	51.84	1.00e-114	406.00
IUUC-Laf-054390	Loxodonta africana	77.24	4.00e-175	607.00
IUUC-Mtr-058600	Medicago truncatula	39.23	9.00e-25	107.00
IUUC-Mla-059129	Melampsora laricipopulina	27.08	5.00e-13	68.20
IUUC-Mga-059876	Meleagris gallopavo	57.74	7.00e-125	440.00
IUUC-Mvi-060359	Microbotryum violaceum	29.35	5.00e-13	69.70
IUUC-Mmr-061518	Microcebus murinus	83.29	0.00e+00	659.00
IUUC-Mac-065625	Musa acuminata	32.29	1.00e-19	91.30
IUUC-Nfi-068402	Neosartorya fischeri	37.25	9.00e-15	75.10
IUUC-Nle-069914	Nomascus leucogenys	94.17	0.00e+00	697.00
IUUC-Ont-071555	Oreochromis niloticus	41.51	2.00e-78	286.00
IUUC-Oan-072951	Ornithorhynchus anatinus	67.10	5.00e-151	527.00
IUUC-Ocu-074679	Oryctolagus cuniculus	81.18	3.00e-169	587.00
IUUC-Oba-075355	Oryza barthii	27.75	2.00e-10	60.50
IUUC-Obr-076769	Oryza brachyantha	32.06	1.00e-24	107.00
IUUC-Ogl-077168	Oryza glaberrima	34.48	2.00e-24	107.00
IUUC-Ogu-078275	Oryza glumaepatula	26.99	8.00e-11	61.60
IUUC-Oin-079207	Oryza indica	34.48	2.00e-24	107.00
IUUC-Oni-082437	Oryza nivara	29.15	4.00e-11	63.20
IUUC-Opu-084031	Oryza punctata	34.48	2.00e-22	100.00
IUUC-Oru-084380	Oryza rufipogon	28.35	2.00e-10	60.80
IUUC-Osa-085327	Oryza sativa	36.18	3.00e-24	106.00
IUUC-Ola-086716	Oryzias latipes	44.21	9.00e-79	286.00
IUUC-Olu-087708	Ostreococcus lucimarinus	29.10	3.00e-13	69.70
IUUC-Oar-090239	Ovis aries	80.32	1.00e-170	592.00
IUUC-Ptr-090851	Pan troglodytes	96.36	0.00e+00	740.00
IUUC-Pan-092558	Papio anubis	97.58	0.00e+00	697.00
IUUC-Psi-093792	Pelodiscus sinensis	59.24	4.00e-129	454.00
IUUC-Ppa-095757	Physcomitrella patens	39.64	1.00e-20	94.40
IUUC-Pfo-096465	Poecilia formosa	41.60	1.00e-83	303.00
IUUC-Pab-097722	Pongo abelii	95.15	0.00e+00	724.00
IUUC-Pop-098979	Populus trichocarpa	35.33	8.00e-20	91.70
IUUC-Pca-100753	Procavia capensis	73.70	6.00e-115	407.00
IUUC-Ppe-101515	Prunus persica	34.50	3.00e-20	93.20
IUUC-Sja-107780	Schizosaccharomyces japonicus	26.69	4.00e-15	75.90
IUUC-Spo-108251	Schizosaccharomyces pombe	30.93	5.00e-13	68.90
IUUC-Smo-108938	Selaginella moellendorffii	37.82	8.00e-25	108.00
IUUC-Sit-110020	Setaria italica	35.57	1.00e-22	100.00
IUUC-Sly-111543	Solanum lycopersicum	34.43	2.00e-22	100.00
IUUC-Stu-111925	Solanum tuberosum	32.99	2.00e-22	100.00
IUUC-Sbi-114061	Sorghum bicolor	36.00	1.00e-22	100.00
IUUC-Tgu-117321	Taeniopygia guttata	59.30	2.00e-113	401.00
IUUC-Tru-118454	Takifugu rubripes	44.77	6.00e-81	294.00
IUUC-Tni-119894	Tetraodon nigroviridis	44.42	2.00e-78	286.00
IUUC-Tca-121746	Theobroma cacao	36.02	2.00e-21	97.10
IUUC-Tae-124114	Triticum aestivum	38.76	2.00e-19	90.10
IUUC-Tur-126254	Triticum urartu	26.86	2.00e-12	66.60
IUUC-Tbe-127683	Tupaia belangeri	52.08	9.00e-59	220.00
IUUC-Ttr-129056	Tursiops truncatus	73.37	2.00e-160	558.00
IUUC-Vvi-131428	Vitis vinifera	35.75	2.00e-21	97.10
IUUC-Xma-133605	Xiphophorus maculatus	42.16	4.00e-85	308.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence