iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-133362

Ensembl Protein ID

ENSXMAP00000016370.1

UniProt Accession

M4APH5; M4APH5_XIPMA

Genbank Protein ID

ENSXMAP00000016370

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AGAJ01031063

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000016309.1	ENSXMAT00000016394.1	ENSXMAP00000016370.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.00e-112	374.2	156	686

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tGlkN+gNtCYmN++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++ lw k++ ++v p++l++ +k+++++f+gy+
   Q: 156  TGLKNIGNTCYMNAALQALSNCPPLTQFFLE-----CGGLVKTDKKPALCKSYQKLVSDLWhKNRPSYVVPTNLFQGIKAINPMFRGYS 239
           7******************************.....9999999******************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkk........eknkpkeeeeeedkselsde........................................ 129
           qqD+qEfl++l+dql+eelk+        +++   +++ eed+ ++sd+                                        
   Q: 240  QQDSQEFLRCLMDQLHEELKEsvpepsdlSTSIAMDDSPEEDNHSQSDNdfqscescgsseradnevqggtivmdntneaemlipeqde 328
           *******************9977777766444444444444444444447888899999999*************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 329  iqanrewqkeknmindlyrsgfngvmggnngdidkdvdtttetmpiissqgalkvqgrtsdffsdiqmsnitrpqspvaieghipkiss 417
           ***************************************************************************************** PP
   S: 130  .........................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke........ 185
                                     ++k ++k++s+isd+F+g++ s+++cl+cd+vs++ e+f+d+slp+pgke+ +k+        
   Q: 418  sppkatsgwlslnpahkkavttfspLKNKRQRKYRSVISDVFDGTIVSSVQCLTCDRVSVTLENFQDISLPIPGKEDLAKLhsashqts 506
           ***********************998899999********************************************99888******** PP
   S: 186  .................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfse 241
                                            +lqdcL++f++++el+g+n+y+cekckk+++ +k +k+++lPe+L++hLkRf  ++
   Q: 507  lvkagscgeayaaqgwiafvmeyirswfwgpvvTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKMQNLPEILCIHLKRF--RH 593
           *************************************************************************************..99 PP
   S: 242  eqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgs 328
           e + ++ki ++v+fple Ldl+pf+++++++q  +++Y+L++v++H+G++ssGHY+ay++n+ ++ W++fdD++Vtev+e  v++   +
   Q: 594  ELMYSTKIGTHVSFPLEgLDLQPFLAKDSSAQ--TTSYDLLSVICHHGTASSGHYIAYCRNSVNNlWYEFDDQSVTEVPELCVQN---A 677
           99*************************88877..9**************************88889*******************...* PP
   S: 329  taYvlfYkr 337
           +aYvlfYk+
   Q: 678  EAYVLFYKK 686
           *******98 PP

Organism

Xiphophorus maculatus

Protein Sequence
(Fasta)

MPPASSCDCP HLDCVGEITK EELIQKSNGH CQDCKVRGPN LWACLENGCA YVGCGESHAD 60
HSTVHSQETR HNLTVNLTTL RVWCYACGKE VFLERKLGPH SPNAIVEPLP LPQNDVQDNS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAAAACACA GAAAGTCACT GAACCTTTAA AGCTAATTTT ACCAAACAGT GTTTTTCTTC 60
TTGACTGCAG ACTGGACAGT GAGGGATGCC GCCAGCGTCC AGCTGTGACT GCCCCCACCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

xma:102235512

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001742	Ailuropoda melanoleuca	69.56	0.00e+00	1288.00
IUUC-Apl-003987	Anas platyrhynchos	69.60	0.00e+00	1247.00
IUUC-Aca-004713	Anolis carolinensis	67.61	0.00e+00	1242.00
IUUC-Bta-013132	Bos taurus	70.43	0.00e+00	1303.00
IUUC-Cja-018811	Callithrix jacchus	70.36	0.00e+00	1299.00
IUUC-Cfa-021158	Canis familiaris	70.10	0.00e+00	1292.00
IUUC-Cpo-021910	Cavia porcellus	63.65	0.00e+00	1133.00
IUUC-Csa-023130	Chlorocebus sabaeus	70.58	0.00e+00	1298.00
IUUC-Cho-024383	Choloepus hoffmanni	50.74	1.00e-112	400.00
IUUC-Dre-028639	Danio rerio	81.26	0.00e+00	1460.00
IUUC-Dno-029416	Dasypus novemcinctus	70.51	0.00e+00	1274.00
IUUC-Ete-032994	Echinops telfairi	60.45	3.00e-127	449.00
IUUC-Eca-034248	Equus caballus	70.45	0.00e+00	1309.00
IUUC-Eeu-035357	Erinaceus europaeus	54.68	0.00e+00	884.00
IUUC-Fca-036013	Felis catus	68.07	0.00e+00	1240.00
IUUC-Fal-037509	Ficedula albicollis	69.68	0.00e+00	1276.00
IUUC-Gmo-038944	Gadus morhua	80.61	0.00e+00	1447.00
IUUC-Gga-040647	Gallus gallus	69.71	0.00e+00	1256.00
IUUC-Gac-041752	Gasterosteus aculeatus	87.87	0.00e+00	1619.00
IUUC-Hsa-045694	Homo sapiens	70.36	0.00e+00	1289.00
IUUC-Itr-049041	Ictidomys tridecemlineatus	70.14	0.00e+00	1283.00
IUUC-Kpa-049198	Komagataella pastoris	31.91	4.00e-30	126.00
IUUC-Lch-050400	Latimeria chalumnae	68.32	0.00e+00	1224.00
IUUC-Loc-052616	Lepisosteus oculatus	76.11	0.00e+00	1395.00
IUUC-Laf-053493	Loxodonta africana	70.53	0.00e+00	1299.00
IUUC-Mcc-055542	Macaca mulatta	70.58	0.00e+00	1300.00
IUUC-Meu-056645	Macropus eugenii	62.23	0.00e+00	1066.00
IUUC-Mmr-061241	Microcebus murinus	67.86	0.00e+00	1258.00
IUUC-Mmu-063786	Mus musculus	70.62	0.00e+00	1276.00
IUUC-Mlu-067732	Myotis lucifugus	69.46	0.00e+00	1289.00
IUUC-Nle-069528	Nomascus leucogenys	69.82	0.00e+00	1300.00
IUUC-Opr-070606	Ochotona princeps	65.51	0.00e+00	1150.00
IUUC-Ont-071495	Oreochromis niloticus	89.60	0.00e+00	1631.00
IUUC-Ocu-074457	Oryctolagus cuniculus	67.88	0.00e+00	1279.00
IUUC-Ola-086739	Oryzias latipes	86.12	0.00e+00	1643.00
IUUC-Oga-088720	Otolemur garnettii	70.36	0.00e+00	1305.00
IUUC-Oar-089921	Ovis aries	70.43	0.00e+00	1304.00
IUUC-Ptr-090526	Pan troglodytes	70.14	0.00e+00	1287.00
IUUC-Pan-092396	Papio anubis	70.31	0.00e+00	1295.00
IUUC-Psi-092971	Pelodiscus sinensis	70.10	0.00e+00	1302.00
IUUC-Pfo-097415	Poecilia formosa	95.07	0.00e+00	1725.00
IUUC-Pab-098740	Pongo abelii	70.47	0.00e+00	1311.00
IUUC-Pca-100598	Procavia capensis	64.92	0.00e+00	712.00
IUUC-Pva-102820	Pteropus vampyrus	66.83	0.00e+00	1068.00
IUUC-Rno-104894	Rattus norvegicus	69.90	0.00e+00	1279.00
IUUC-Sha-107244	Sarcophilus harrisii	66.85	0.00e+00	1182.00
IUUC-Sar-113665	Sorex araneus	68.48	0.00e+00	1288.00
IUUC-Ssc-115793	Sus scrofa	70.18	0.00e+00	1277.00
IUUC-Tgu-117487	Taeniopygia guttata	70.95	0.00e+00	1238.00
IUUC-Tru-117694	Takifugu rubripes	81.62	0.00e+00	1579.00
IUUC-Tsy-119598	Tarsius syrichta	61.74	0.00e+00	1053.00
IUUC-Tni-120189	Tetraodon nigroviridis	79.94	0.00e+00	1486.00
IUUC-Tbe-128125	Tupaia belangeri	75.00	2.00e-79	290.00
IUUC-Ttr-128269	Tursiops truncatus	68.18	0.00e+00	1222.00
IUUC-Vpa-130598	Vicugna pacos	68.85	0.00e+00	1265.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence