iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027560

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

WD repeat-containing protein 18

Genbank Nucleotide ID

BX640454

Gene Name

wdr18

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000041113.4	ENSDART00000060251.3	ENSDARP00000060250.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.20e-17	63.3	267	304
UBD/Beta-Prp	3.90e-46	158.5	82	315

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvll 36
           gH + vtcl+   ++t l+sGs+D t+++WD+ +  ++
   Q: 267  GHRNLVTCLSVsmDGTVLLSGSNDETVRMWDVQSKQCI 304
           8*******9998555****************9887775 PP

UBD/Beta-Prp

   S: 12   vitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdls.........tgkcvhtlk 91
            +tc++ spd+ ++++g   + i +w+v+tg+ll+ ls h +  +++kf +d++ +v+g++D+++ +w+ls         t+++ h+l+
   Q: 82   IVTCLCASPDGLYVLAGI-AEAIYLWEVSTGNLLAILSRHFQDLSCIKFTDDSSHFVSGGKDNLAFIWNLSsvvqldssrTPEPRHILS 169
           6899999*********98.899******************************99**************999999999999********* PP
   S: 92   ghedsvlslsfsp..sgdklvsGshdrtirvwdletgqclee............................................... 131
           +h+  +++++      + +++++s d+t++vw++++g+ l +                                               
   Q: 170  RHSLPITDIHCGLmgPQARVATASLDQTVKVWEISSGEMLLSvlfdvgimsvtfdpceyflfcggsdgnifqvslcstslsrdktfqsd 258
           *******9998884455999*******************99966666666666666666666666666666666666666666666666 PP
   S: 132  .....tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvys 185
                +++gh+ +v+c++v+ dg +l sGs+D+tvr+Wd+++++++ t   +h ++v+ 
   Q: 259  segnqVFKGHRNLVTCLSVSMDGTVLLSGSNDETVRMWDVQSKQCIWTI--NHRGPVTN 315
           6666666666666666666666666666666666666666666666555..35555554 PP

Organism

Danio rerio

Functional Description
(View)

Involved in left-right determination through controlling the correct clustering and migration of dorsal forerunner cells (DFCs) and Kupffer's vesicle formation.

Protein Sequence
(Fasta)

MSAPVEVVLS ADSAGQLFNC AVYDPHTGSE FLSYRGGNTS SRSLTILNGE YILGAQLGKN 60
YINVWEIQRK DQLQQKIVCP GIVTCLCASP DGLYVLAGIA EAIYLWEVST GNLLAILSRH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAATACTCGC GCTTTGTGTA TCCAACATGT CGGCGCCCGT GGAAGTAGTT CTGTCTGCAG 60
ATTCAGCGGG TCAGCTGTTT AACTGTGCGG TTTATGACCC ACATACCGGG TCAGAATTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0217--Developmental protein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR026987--Wdr18_C_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40
PF14077--WD40_alt

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0007368--P:determination of left/right symmetry
GO:0070121--P:Kupffer's vesicle development

KEGG

dre:445819

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001040	Aegilops tauschii	29.81	8.00e-27	114.00
IUUC-Aml-001819	Ailuropoda melanoleuca	62.33	9.00e-155	540.00
IUUC-Atr-002688	Amborella trichopoda	31.96	4.00e-40	159.00
IUUC-Apl-004023	Anas platyrhynchos	52.60	1.00e-101	362.00
IUUC-Aca-004879	Anolis carolinensis	57.74	1.00e-48	185.00
IUUC-Aly-006061	Arabidopsis lyrata	29.68	3.00e-33	135.00
IUUC-Ath-007111	Arabidopsis thaliana	29.49	1.00e-31	131.00
IUUC-Acl-008357	Aspergillus clavatus	24.02	2.00e-19	90.90
IUUC-Aor-009882	Aspergillus oryzae	25.36	5.00e-17	82.80
IUUC-Ame-010912	Astyanax mexicanus	87.01	0.00e+00	794.00
IUUC-Bgr-012242	Blumeria graminis	26.49	2.00e-18	87.00
IUUC-Bta-013402	Bos taurus	62.18	3.00e-153	534.00
IUUC-Bci-013791	Botrytis cinerea	25.00	6.00e-17	82.00
IUUC-Bdi-015054	Brachypodium distachyon	31.45	3.00e-35	142.00
IUUC-Bol-016342	Brassica oleracea	27.81	3.00e-30	126.00
IUUC-Bra-016967	Brassica rapa	28.48	2.00e-31	130.00
IUUC-Cja-019758	Callithrix jacchus	59.62	2.00e-138	485.00
IUUC-Cfa-020495	Canis familiaris	63.43	5.00e-133	467.00
IUUC-Cpo-021438	Cavia porcellus	65.43	2.00e-132	465.00
IUUC-Csa-023416	Chlorocebus sabaeus	60.93	2.00e-149	521.00
IUUC-Csv-025918	Ciona savignyi	33.49	2.00e-65	243.00
IUUC-Cgl-026618	Colletotrichum gloeosporioides	27.17	2.00e-21	97.10
IUUC-Cne-026843	Cryptococcus neoformans	29.53	2.00e-21	97.40
IUUC-Dno-029315	Dasypus novemcinctus	61.02	4.00e-162	564.00
IUUC-Dor-030935	Dipodomys ordii	60.98	2.00e-157	548.00
IUUC-Dse-031492	Dothistroma septosporum	22.15	4.00e-19	89.70
IUUC-Dme-032059	Drosophila melanogaster	33.98	4.00e-60	225.00
IUUC-Fca-036068	Felis catus	60.27	4.00e-146	511.00
IUUC-Fal-037467	Ficedula albicollis	66.40	2.00e-152	531.00
IUUC-Fox-037903	Fusarium oxysporum	26.32	8.00e-20	91.70
IUUC-Gmo-039323	Gadus morhua	63.55	1.00e-147	516.00
IUUC-Ggr-040050	Gaeumannomyces graminis	24.58	1.00e-12	68.20
IUUC-Gga-040563	Gallus gallus	65.55	1.00e-141	496.00
IUUC-Gac-042641	Gasterosteus aculeatus	75.88	0.00e+00	670.00
IUUC-Gma-043856	Glycine max	31.00	5.00e-40	158.00
IUUC-Ggo-045137	Gorilla gorilla	60.93	8.00e-146	510.00
IUUC-Hsa-046335	Homo sapiens	61.16	2.00e-146	512.00
IUUC-Hvu-047685	Hordeum vulgare	30.99	8.00e-31	128.00
IUUC-Itr-048032	Ictidomys tridecemlineatus	62.79	2.00e-169	588.00
IUUC-Kpa-049129	Komagataella pastoris	30.00	1.00e-31	130.00
IUUC-Lch-049532	Latimeria chalumnae	67.37	0.00e+00	634.00
IUUC-Lpe-051321	Leersia perrieri	27.47	7.00e-27	114.00
IUUC-Loc-052471	Lepisosteus oculatus	74.60	0.00e+00	674.00
IUUC-Lma-053091	Leptosphaeria maculans	25.17	7.00e-23	102.00
IUUC-Laf-054331	Loxodonta africana	59.63	3.00e-144	504.00
IUUC-Mcc-055803	Macaca mulatta	60.93	2.00e-149	521.00
IUUC-Meu-056090	Macropus eugenii	65.81	1.00e-176	612.00
IUUC-Mor-057160	Magnaporthe oryzae	27.49	7.00e-20	92.00
IUUC-Mtr-058800	Medicago truncatula	27.42	2.00e-41	163.00
IUUC-Mla-058943	Melampsora laricipopulina	34.25	5.00e-27	116.00
IUUC-Mga-059282	Meleagris gallopavo	59.09	1.00e-129	456.00
IUUC-Mvi-060315	Microbotryum violaceum	34.62	1.00e-27	118.00
IUUC-Mmr-061127	Microcebus murinus	62.56	1.00e-157	549.00
IUUC-Mdo-062350	Monodelphis domestica	65.27	2.00e-175	608.00
IUUC-Mmu-063706	Mus musculus	59.86	2.00e-152	532.00
IUUC-Mac-065554	Musa acuminata	27.51	6.00e-24	105.00
IUUC-Mpu-066711	Mustela putorius furo	63.02	2.00e-169	588.00
IUUC-Mlu-068121	Myotis lucifugus	63.71	3.00e-131	461.00
IUUC-Nfi-068454	Neosartorya fischeri	22.83	2.00e-16	80.90
IUUC-Ncr-068914	Neurospora crassa	27.21	4.00e-18	85.90
IUUC-Nle-069518	Nomascus leucogenys	62.72	3.00e-136	478.00
IUUC-Ont-071435	Oreochromis niloticus	76.51	0.00e+00	681.00
IUUC-Oan-073532	Ornithorhynchus anatinus	55.77	1.00e-32	130.00
IUUC-Oba-075873	Oryza barthii	31.14	1.00e-38	154.00
IUUC-Obr-076097	Oryza brachyantha	27.93	4.00e-30	125.00
IUUC-Ogl-077840	Oryza glaberrima	31.14	1.00e-38	154.00
IUUC-Ogu-077988	Oryza glumaepatula	31.14	1.00e-38	154.00
IUUC-Oin-079237	Oryza indica	32.59	5.00e-27	115.00
IUUC-Olo-080415	Oryza longistaminata	29.08	2.00e-30	127.00
IUUC-Ome-081952	Oryza meridionalis	30.84	4.00e-36	145.00
IUUC-Oni-082300	Oryza nivara	31.14	1.00e-38	154.00
IUUC-Opu-083436	Oryza punctata	33.18	9.00e-25	108.00
IUUC-Oru-085164	Oryza rufipogon	31.14	3.00e-38	152.00
IUUC-Osa-086129	Oryza sativa	32.04	2.00e-39	157.00
IUUC-Ola-086571	Oryzias latipes	72.85	0.00e+00	647.00
IUUC-Oga-088561	Otolemur garnettii	62.09	7.00e-160	556.00
IUUC-Oar-090131	Ovis aries	54.86	4.00e-124	438.00
IUUC-Ptr-091301	Pan troglodytes	49.08	7.00e-108	384.00
IUUC-Pan-092810	Papio anubis	60.70	7.00e-149	520.00
IUUC-Psi-093091	Pelodiscus sinensis	57.81	5.00e-119	421.00
IUUC-Pno-095047	Phaeosphaeria nodorum	25.65	3.00e-18	86.70
IUUC-Ppa-095317	Physcomitrella patens	35.22	9.00e-35	141.00
IUUC-Pfo-096996	Poecilia formosa	72.56	0.00e+00	638.00
IUUC-Pab-097747	Pongo abelii	61.35	6.00e-145	507.00
IUUC-Pop-099609	Populus trichocarpa	31.72	1.00e-38	154.00
IUUC-Pca-100972	Procavia capensis	58.37	3.00e-127	448.00
IUUC-Ppe-101904	Prunus persica	32.21	1.00e-41	164.00
IUUC-Pva-102700	Pteropus vampyrus	70.21	3.00e-88	318.00
IUUC-Pgr-103616	Puccinia graminis	34.62	2.00e-24	107.00
IUUC-Ptt-103954	Puccinia triticina	35.16	2.00e-24	107.00
IUUC-Pte-104120	Pyrenophora teres	26.73	5.00e-25	109.00
IUUC-Pyt-104558	Pyrenophora triticirepentis	27.06	4.00e-25	109.00
IUUC-Rno-104933	Rattus norvegicus	59.86	3.00e-152	531.00
IUUC-Sce-106403	Saccharomyces cerevisiae	23.06	1.00e-17	85.10
IUUC-Sha-107636	Sarcophilus harrisii	64.88	6.00e-174	603.00
IUUC-Sja-107783	Schizosaccharomyces japonicus	29.52	3.00e-34	139.00
IUUC-Spo-108192	Schizosaccharomyces pombe	25.67	1.00e-24	107.00
IUUC-Ssl-108384	Sclerotinia sclerotiorum	28.57	5.00e-22	99.00
IUUC-Smo-109066	Selaginella moellendorffii	35.66	5.00e-40	159.00
IUUC-Sit-110770	Setaria italica	31.78	2.00e-36	146.00
IUUC-Sly-111453	Solanum lycopersicum	30.79	4.00e-40	159.00
IUUC-Stu-112384	Solanum tuberosum	30.54	5.00e-40	159.00
IUUC-Sbi-113952	Sorghum bicolor	31.83	2.00e-35	143.00
IUUC-Sre-115223	Sporisorium reilianum	31.13	6.00e-25	109.00
IUUC-Ssc-115627	Sus scrofa	63.26	1.00e-157	549.00
IUUC-Tgu-117404	Taeniopygia guttata	65.63	6.00e-142	496.00
IUUC-Tru-117629	Takifugu rubripes	74.23	8.00e-169	586.00
IUUC-Tni-119839	Tetraodon nigroviridis	72.75	9.00e-170	589.00
IUUC-Tca-121766	Theobroma cacao	30.21	1.00e-38	154.00
IUUC-Tre-122047	Trichoderma reesei	24.91	1.00e-17	84.30
IUUC-Tae-125258	Triticum aestivum	31.58	3.00e-28	119.00
IUUC-Tur-126673	Triticum urartu	29.22	7.00e-23	101.00
IUUC-Tme-127070	Tuber melanosporum	23.96	5.00e-22	99.40
IUUC-Tbe-127452	Tupaia belangeri	56.28	9.00e-76	277.00
IUUC-Ttr-128735	Tursiops truncatus	61.40	4.00e-148	517.00
IUUC-Uma-129521	Ustilago maydis	28.40	8.00e-24	105.00
IUUC-Vvi-130872	Vitis vinifera	31.42	2.00e-38	153.00
IUUC-Xtr-131838	Xenopus tropicalis	61.31	6.00e-144	504.00
IUUC-Xma-134106	Xiphophorus maculatus	75.88	2.00e-141	494.00
IUUC-Yli-134551	Yarrowia lipolytica	27.41	7.00e-18	85.10

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence