iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059745

UUCD1 version

UUC-MeG-00382

Ensembl Protein ID

ENSMGAP00000008472.2

UniProt Accession

G1N870; G1N870_MELGA

Protein Name

Ribosome biogenesis protein WDR12; WD repeat-containing protein 12

Gene Name

WDR12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000008240.2	ENSMGAT00000009269.2	ENSMGAP00000008472.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.10e-42	139.5	343	378
UBD/Beta-Prp	1.20e-44	152.4	248	414

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd..tllvsGsdDgtikvWDlrtgv 34
           Ht++vt++++ ++  + l+sGs D+ +k+WD+r+++
   Q: 343  HTGWVTSVKWsPTheHQLISGSLDNIVKLWDTRSCK 378
           **********9444577**************99876 PP

UBD/Beta-Prp

   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl..ktg 169
           t++++ tl+gh++ + s+ +s   + + s+s+d ti+ wd etg   + tl+g++ v n+++++p ++ l+sGs+Dr +rlWd   k g
   Q: 248  TRTPLATLSGHTEAISSVLWSD-AEEICSASWDHTIKFWDAETGGLKS-TLTGNK-VFNSISYSPLCRRLASGSTDRHIRLWDPrgKDG 333
           577899***************9.99**********************9.***987.99*************************976555 PP
   S: 170  kll.rtltgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           +l+   lt+ ht+ v+s++++++   +l+sgsld+ vklwd +  +  ++ l +h+d v++v+ + +  +l+sg++D+ ++++
   Q: 334  SLVlLSLTS-HTGWVTSVKWSPTHeHQLISGSLDNIVKLWDTRsCKAPLYDLAAHEDKVLCVDWT-EAGLLLSGGADNKLYCY 414
           554156677.************99788****************54566****************9.999**********9997 PP

Organism

Meleagris gallopavo

Functional Description
(View)

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Protein Sequence
(Fasta)

LAAPRLTFNI ETTAWIVEDV PFSVPAASET ADLSHLINKL LAARGADHKY VEFDFLIQGQ 60
FLRVPLVTHM EMENISTEEV VEIEYVEKYM APQPEECIFH DDWISSVQAT EEWILTGCYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTGCAGCCC CACGTCTAAC TTTTAACATT GAGACAACAG CGTGGATGTC AGTCCTAGAA 60
AGAAAGCTAA AGCGTTACAA AAACAAAAGA GATGAACTCA CAGTGACAAG AAGCGTGTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0070545--C:PeBoW complex
GO:0030687--C:preribosome, large subunit precursor
GO:0008283--P:cell proliferation
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0007219--P:Notch signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000532	Aegilops tauschii	33.67	1.00e-58	219.00
IUUC-Aml-001997	Ailuropoda melanoleuca	84.67	0.00e+00	657.00
IUUC-Atr-002544	Amborella trichopoda	31.85	1.00e-52	199.00
IUUC-Apl-003981	Anas platyrhynchos	96.58	0.00e+00	711.00
IUUC-Aca-004370	Anolis carolinensis	82.35	0.00e+00	701.00
IUUC-Aly-006455	Arabidopsis lyrata	33.09	8.00e-55	207.00
IUUC-Ath-006669	Arabidopsis thaliana	33.24	3.00e-51	195.00
IUUC-Ago-007864	Ashbya gossypii	29.79	3.00e-37	148.00
IUUC-Acl-008177	Aspergillus clavatus	29.85	5.00e-36	144.00
IUUC-Afl-008617	Aspergillus flavus	30.71	2.00e-36	146.00
IUUC-Afu-008752	Aspergillus fumigatus	29.49	8.00e-34	137.00
IUUC-Ani-009136	Aspergillus nidulans	29.82	4.00e-36	145.00
IUUC-Ang-009701	Aspergillus niger	29.67	2.00e-34	139.00
IUUC-Aor-009884	Aspergillus oryzae	29.98	2.00e-35	143.00
IUUC-Ate-010472	Aspergillus terreus	31.50	1.00e-21	96.70
IUUC-Ame-011432	Astyanax mexicanus	76.79	0.00e+00	649.00
IUUC-Bgr-012218	Blumeria graminis	28.37	8.00e-34	137.00
IUUC-Bta-012829	Bos taurus	82.35	0.00e+00	662.00
IUUC-Bci-013953	Botrytis cinerea	30.16	4.00e-34	139.00
IUUC-Bdi-014351	Brachypodium distachyon	35.15	4.00e-54	204.00
IUUC-Bol-015618	Brassica oleracea	34.28	1.00e-52	200.00
IUUC-Bra-017876	Brassica rapa	34.23	3.00e-54	205.00
IUUC-Cel-018569	Caenorhabditis elegans	33.50	4.00e-48	185.00
IUUC-Cja-019468	Callithrix jacchus	81.18	0.00e+00	637.00
IUUC-Cfa-020471	Canis familiaris	81.41	0.00e+00	653.00
IUUC-Cpo-022260	Cavia porcellus	81.65	0.00e+00	644.00
IUUC-Cre-022614	Chlamydomonas reinhardtii	30.53	9.00e-37	147.00
IUUC-Csa-023989	Chlorocebus sabaeus	81.65	0.00e+00	642.00
IUUC-Cho-024426	Choloepus hoffmanni	84.54	5.00e-145	506.00
IUUC-Cin-025789	Ciona intestinalis	42.15	2.00e-93	335.00
IUUC-Cne-027063	Cryptococcus neoformans	24.40	6.00e-18	85.10
IUUC-Dre-027907	Danio rerio	77.99	0.00e+00	656.00
IUUC-Dno-029225	Dasypus novemcinctus	82.12	0.00e+00	659.00
IUUC-Dor-031082	Dipodomys ordii	66.82	2.00e-140	491.00
IUUC-Dse-031308	Dothistroma septosporum	29.08	2.00e-36	145.00
IUUC-Dme-032189	Drosophila melanogaster	41.65	2.00e-90	325.00
IUUC-Ete-032247	Echinops telfairi	75.76	6.00e-174	603.00
IUUC-Eca-034285	Equus caballus	81.65	0.00e+00	657.00
IUUC-Eeu-035322	Erinaceus europaeus	73.75	1.00e-161	561.00
IUUC-Fca-036114	Felis catus	81.65	0.00e+00	657.00
IUUC-Fal-036891	Ficedula albicollis	97.19	0.00e+00	664.00
IUUC-Fox-037965	Fusarium oxysporum	26.14	1.00e-31	130.00
IUUC-Fso-038244	Fusarium solani	25.90	8.00e-32	130.00
IUUC-Gmo-039040	Gadus morhua	74.40	0.00e+00	631.00
IUUC-Gga-040610	Gallus gallus	97.13	0.00e+00	786.00
IUUC-Gac-042117	Gasterosteus aculeatus	75.12	5.00e-175	606.00
IUUC-Gma-043146	Glycine max	35.64	4.00e-60	224.00
IUUC-Ggo-045179	Gorilla gorilla	81.18	0.00e+00	632.00
IUUC-Hsa-046114	Homo sapiens	81.88	0.00e+00	637.00
IUUC-Hvu-047331	Hordeum vulgare	33.59	2.00e-54	206.00
IUUC-Itr-048275	Ictidomys tridecemlineatus	82.12	0.00e+00	663.00
IUUC-Kpa-049304	Komagataella pastoris	30.88	1.00e-43	169.00
IUUC-Lch-050655	Latimeria chalumnae	72.57	1.00e-138	485.00
IUUC-Lpe-051675	Leersia perrieri	35.59	1.00e-58	220.00
IUUC-Loc-052868	Lepisosteus oculatus	77.27	0.00e+00	652.00
IUUC-Lma-053258	Leptosphaeria maculans	28.88	5.00e-34	139.00
IUUC-Laf-053993	Loxodonta africana	81.18	0.00e+00	656.00
IUUC-Mcc-055128	Macaca mulatta	66.12	7.00e-141	493.00
IUUC-Meu-056501	Macropus eugenii	82.32	2.00e-149	521.00
IUUC-Mor-057114	Magnaporthe oryzae	25.53	1.00e-25	110.00
IUUC-Mtr-058367	Medicago truncatula	36.12	2.00e-57	216.00
IUUC-Mla-059107	Melampsora laricipopulina	27.13	5.00e-27	115.00
IUUC-Mvi-060362	Microbotryum violaceum	29.16	2.00e-28	120.00
IUUC-Mdo-062257	Monodelphis domestica	79.28	0.00e+00	659.00
IUUC-Mmu-063546	Mus musculus	81.88	0.00e+00	657.00
IUUC-Mac-065540	Musa acuminata	32.43	5.00e-54	204.00
IUUC-Mpu-066284	Mustela putorius furo	81.88	0.00e+00	659.00
IUUC-Mlu-067241	Myotis lucifugus	81.18	0.00e+00	655.00
IUUC-Nfi-068260	Neosartorya fischeri	29.92	6.00e-34	138.00
IUUC-Ncr-068719	Neurospora crassa	26.56	1.00e-25	110.00
IUUC-Nle-068981	Nomascus leucogenys	81.18	0.00e+00	635.00
IUUC-Opr-071218	Ochotona princeps	74.25	6.00e-169	586.00
IUUC-Ont-071646	Oreochromis niloticus	75.42	0.00e+00	631.00
IUUC-Oan-073453	Ornithorhynchus anatinus	83.76	0.00e+00	702.00
IUUC-Ocu-074008	Oryctolagus cuniculus	82.12	0.00e+00	660.00
IUUC-Oba-075712	Oryza barthii	29.87	1.00e-42	166.00
IUUC-Obr-076721	Oryza brachyantha	34.16	3.00e-58	218.00
IUUC-Ogl-077229	Oryza glaberrima	34.42	6.00e-59	221.00
IUUC-Ogu-078977	Oryza glumaepatula	29.87	7.00e-43	167.00
IUUC-Oin-079683	Oryza indica	34.42	3.00e-59	221.00
IUUC-Olo-080291	Oryza longistaminata	28.72	2.00e-28	119.00
IUUC-Ome-081834	Oryza meridionalis	34.67	4.00e-60	225.00
IUUC-Oni-082507	Oryza nivara	32.75	9.00e-54	203.00
IUUC-Opu-083396	Oryza punctata	34.42	7.00e-59	221.00
IUUC-Oru-085220	Oryza rufipogon	32.75	2.00e-53	202.00
IUUC-Osa-085767	Oryza sativa	34.42	3.00e-59	221.00
IUUC-Ola-087420	Oryzias latipes	75.36	0.00e+00	634.00
IUUC-Olu-087740	Ostreococcus lucimarinus	29.61	9.00e-38	150.00
IUUC-Oga-088264	Otolemur garnettii	80.47	0.00e+00	652.00
IUUC-Oar-089335	Ovis aries	81.41	0.00e+00	655.00
IUUC-Ptr-091320	Pan troglodytes	81.88	0.00e+00	637.00
IUUC-Pan-092833	Papio anubis	82.12	0.00e+00	644.00
IUUC-Psi-093504	Pelodiscus sinensis	85.41	0.00e+00	692.00
IUUC-Pma-094189	Petromyzon marinus	65.73	2.00e-160	558.00
IUUC-Pno-094929	Phaeosphaeria nodorum	27.13	2.00e-36	146.00
IUUC-Ppa-095429	Physcomitrella patens	34.56	2.00e-59	222.00
IUUC-Pfo-096337	Poecilia formosa	74.40	0.00e+00	636.00
IUUC-Pab-097571	Pongo abelii	81.65	0.00e+00	637.00
IUUC-Pop-099977	Populus trichocarpa	34.49	2.00e-59	222.00
IUUC-Pca-100394	Procavia capensis	78.35	2.00e-175	607.00
IUUC-Ppe-101848	Prunus persica	35.29	4.00e-60	224.00
IUUC-Pva-102921	Pteropus vampyrus	77.51	1.00e-96	346.00
IUUC-Pgr-103637	Puccinia graminis	29.27	9.00e-32	130.00
IUUC-Ptt-103781	Puccinia triticina	28.85	2.00e-31	130.00
IUUC-Pte-104135	Pyrenophora teres	28.44	8.00e-38	152.00
IUUC-Pyt-104609	Pyrenophora triticirepentis	28.44	1.00e-35	143.00
IUUC-Rno-105114	Rattus norvegicus	79.76	0.00e+00	652.00
IUUC-Sce-106401	Saccharomyces cerevisiae	29.45	2.00e-40	159.00
IUUC-Sha-107122	Sarcophilus harrisii	79.18	0.00e+00	630.00
IUUC-Sja-107766	Schizosaccharomyces japonicus	29.13	1.00e-42	167.00
IUUC-Spo-108134	Schizosaccharomyces pombe	29.49	3.00e-38	152.00
IUUC-Ssl-108398	Sclerotinia sclerotiorum	29.32	8.00e-35	140.00
IUUC-Smo-108761	Selaginella moellendorffii	33.01	1.00e-51	197.00
IUUC-Sit-110311	Setaria italica	35.46	8.00e-59	220.00
IUUC-Sly-111023	Solanum lycopersicum	32.03	3.00e-52	199.00
IUUC-Stu-112778	Solanum tuberosum	34.91	5.00e-58	218.00
IUUC-Sar-113596	Sorex araneus	76.72	8.00e-149	519.00
IUUC-Sbi-114193	Sorghum bicolor	35.38	8.00e-58	217.00
IUUC-Ssc-116066	Sus scrofa	81.41	0.00e+00	653.00
IUUC-Tgu-117048	Taeniopygia guttata	96.05	0.00e+00	707.00
IUUC-Tsy-119573	Tarsius syrichta	52.63	7.00e-112	396.00
IUUC-Tni-119820	Tetraodon nigroviridis	73.40	0.00e+00	627.00
IUUC-Tca-121605	Theobroma cacao	34.37	1.00e-57	216.00
IUUC-Tre-121947	Trichoderma reesei	27.10	5.00e-32	131.00
IUUC-Tvi-122481	Trichoderma virens	27.58	5.00e-34	138.00
IUUC-Tae-125861	Triticum aestivum	33.92	6.00e-59	221.00
IUUC-Tur-126586	Triticum urartu	33.59	9.00e-57	213.00
IUUC-Tme-126900	Tuber melanosporum	30.46	2.00e-43	169.00
IUUC-Tbe-127736	Tupaia belangeri	60.50	6.00e-118	416.00
IUUC-Ttr-129041	Tursiops truncatus	70.59	1.00e-162	565.00
IUUC-Uma-129628	Ustilago maydis	24.54	2.00e-14	73.60
IUUC-Vpa-130260	Vicugna pacos	81.41	0.00e+00	657.00
IUUC-Vvi-131009	Vitis vinifera	34.08	6.00e-57	214.00
IUUC-Xtr-132083	Xenopus tropicalis	76.24	0.00e+00	647.00
IUUC-Xma-133094	Xiphophorus maculatus	74.16	0.00e+00	632.00
IUUC-Yli-134531	Yarrowia lipolytica	25.10	5.00e-19	88.60
IUUC-Zma-135509	Zea mays	34.66	1.00e-57	216.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence