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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Spo-108057
UUCD1 version UUC-ScP-00156
Ensembl Protein ID SPAC57A7.11.1:pep
UniProt Accession P87141; MIP1_SCHPO
Genbank Protein ID BAA84585.1; CAB08769.1
Protein Name Target of rapamycin complex 1 subunit mip1
Genbank Nucleotide ID AB032552; CU329670
Gene Name mip1; SPAC57A7.11
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPAC57A7.11 SPAC57A7.11.1 SPAC57A7.11.1:pep
Annotation
mRNA Expression
GEO
Protein-protein Interaction
iRefIndexHINTMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMUniProt
Protein Expression/Proteomics
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.00e-17 61.6 1177 1215
UBD/Beta-Prp 5.40e-44 148.6 993 1304
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWDlrtgvllk 37
           H++++  ++   s+ + l+s+s Dg +k+WD+r +++l+
   Q: 1177 HSSEIVNVEMqsSGmRELISASSDGEVKLWDIRMNHSLQ 1215
           77888888888655778**************99888877 PP
   

   UBD/Beta-Prp
   S: 13   itcvkfspdksllatgsrdgtikvwdvttgkllrsl.sgheae..vtavkfspdgk..ilvtgseDrtikvw.dls..tgkcvhtlk... 91
            +++ f++++++l+t ++ + i+vwd+++  +l s+  + +a+  vt++++ ++++  +l+tgs+D+tik++ d++  + + v +++   
   Q: 993  PRKLMFHQFEDQLITLGDKDIIQVWDWRRNRCLNSFkTSASATtnVTDMQLLNEDDvaLLMTGSSDGTIKLYrDYEneKVELVTSWNsls 1082
           455999**************************88884333333448888888888899***************88844455666777444 PP
   S: 92   ....ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdl...ktgkllr 173
               g  +  l++s++++  +l++++++r+ir+wd +++ c+ ++    + ++++++++  g n++v+G+ D+++r++d    ++++l +
   Q: 1083 dlvfGDRNASLLMSWQQNCGHLLVAGDVRVIRIWDASKEICYANLPVRSSNSITSLTSDLVGcNIIVAGFSDGVLRVYDKrlpARDSLTD 1172
           444455555555*****9999999999****************988899999***************************9999999**** PP
   S: 174  tltgghtdsvyslsfdsng.kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlql 262
            +++ h + +  ++++s+g +el+s+s dg vklwd++ ++ ++t+   ++  +s+ ++++   +++gss +si+iWd+  +++++  ++
   Q: 1173 VWKE-HSSEIVNVEMQSSGmRELISASSDGEVKLWDIRMNHSLQTFSTDNSGLTSLTVHSHAPVYATGSSNQSIKIWDTLGQNINTFREN 1261
           **99.*********998888**********************************************************776666666667 PP
   S: 263  hn.......ssvisvavlsfgdnvlvlgse.dskvniwklkkne 298
           ++       ss+++ ++ ++ +  l+ g++ ds+vn+++++kne
   Q: 1262 PRflnqpkpSSLMCLKF-HPHHLLLACGDNtDSRVNLYSCTKNE 1304
           77999976666666666.666777777777**********9986 PP
   
Organism Schizosaccharomyces pombe
Functional Description
(View)

Functional Description


     Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Tor2 is essential for growth. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulating ribosomal protein gene expression. TORC1 negatively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Represses mating, meiosis and sporulation efficiency by interfering with the functions of the transcription factor ste11 and the meiosis-promoting RNA-binding protein mei2.
 Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Tor2 is essential for growth. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulating ribosomal protein gene expression. TORC1 negatively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Represses mating, meiosis and sporulation efficiency by interfering with the functions of the transcription factor ste11 and the meiosis-promoting RNA-binding protein mei2.
Protein Sequence
(Fasta)
MNDRISEVSG SSRARRSVLS YGTTETGSDR YTENSNIATE NGVDTASSMI DGIQSGFPQP 60
RHGFEEEYNN AEYINMLEQV FYMYYTDKRH RGVISKKNAE PTETIHDWRM RERLKTVSAA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Spo-108057|E3,WD_repeat;UBD,Beta-Prp|Schizosaccharomyces pombe
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATTTCTCCTA TATCACTTGC GTAATTCGTA TATACATACA GAGTCATCTT AATTTTCTCT 60
TATTTTTTTT TGTTTTGTTA ATTAAGTTTC CCTTGAGTTC CTGATTTACC GACCTTTTGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Spo-108057|E3,WD_repeat;UBD,Beta-Prp|Schizosaccharomyces pombe
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0469--Meiosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0749--Sporulation
KW-0853--WD repeat
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR029030--Caspase-like_dom
IPR004083--Raptor
IPR029347--Raptor_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF14538--Raptor_N
SMART

SM01302--Raptor_N
SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0031931--C:TORC1 complex
GO:0030674--F:protein binding, bridging
GO:0071230--P:cellular response to amino acid stimulus
GO:0009267--P:cellular response to starvation
GO:0051321--P:meiotic cell cycle
GO:0030307--P:positive regulation of cell growth
GO:0031139--P:positive regulation of conjugation with cellular fusion
GO:0071902--P:positive regulation of protein serine/threonine kinase activity
GO:0010506--P:regulation of autophagy
GO:0008361--P:regulation of cell size
GO:0030435--P:sporulation resulting in formation of a cellular spore
GO:0031929--P:TOR signaling
KEGG spo:SPAC57A7.11
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000354 Aegilops tauschii 49.52 3.00e-156 544.00
IUUC-Aml-001499 Ailuropoda melanoleuca 56.94 0.00e+00 770.00
IUUC-Atr-002704 Amborella trichopoda 51.94 1.00e-175 608.00
IUUC-Apl-003540 Anas platyrhynchos 58.61 0.00e+00 768.00
IUUC-Aca-004449 Anolis carolinensis 57.41 0.00e+00 659.00
IUUC-Aly-006524 Arabidopsis lyrata 54.70 0.00e+00 636.00
IUUC-Ath-007688 Arabidopsis thaliana 37.25 0.00e+00 746.00
IUUC-Ago-007709 Ashbya gossypii 55.22 6.00e-135 473.00
IUUC-Acl-008215 Aspergillus clavatus 49.02 0.00e+00 1256.00
IUUC-Afl-008401 Aspergillus flavus 48.60 0.00e+00 1256.00
IUUC-Afu-008797 Aspergillus fumigatus 50.31 0.00e+00 1272.00
IUUC-Ani-009268 Aspergillus nidulans 48.82 0.00e+00 1234.00
IUUC-Ang-009608 Aspergillus niger 50.15 0.00e+00 1245.00
IUUC-Aor-009894 Aspergillus oryzae 49.89 0.00e+00 1274.00
IUUC-Ate-010357 Aspergillus terreus 57.18 0.00e+00 889.00
IUUC-Ame-011186 Astyanax mexicanus 57.72 0.00e+00 693.00
IUUC-Bgr-012085 Blumeria graminis 47.58 0.00e+00 1154.00
IUUC-Bta-013422 Bos taurus 56.94 0.00e+00 769.00
IUUC-Bci-013736 Botrytis cinerea 46.26 0.00e+00 1196.00
IUUC-Bdi-015042 Brachypodium distachyon 50.89 1.00e-164 572.00
IUUC-Bol-016048 Brassica oleracea 54.36 0.00e+00 636.00
IUUC-Bra-016961 Brassica rapa 52.05 0.00e+00 649.00
IUUC-Cel-018321 Caenorhabditis elegans 43.21 2.00e-89 323.00
IUUC-Cja-018939 Callithrix jacchus 57.08 0.00e+00 770.00
IUUC-Cfa-020898 Canis familiaris 57.23 0.00e+00 769.00
IUUC-Cpo-021514 Cavia porcellus 56.93 0.00e+00 766.00
IUUC-Cre-022818 Chlamydomonas reinhardtii 54.86 3.00e-97 345.00
IUUC-Csa-023314 Chlorocebus sabaeus 57.08 0.00e+00 771.00
IUUC-Cin-025701 Ciona intestinalis 40.80 0.00e+00 830.00
IUUC-Csv-026362 Ciona savignyi 53.02 0.00e+00 692.00
IUUC-Cgl-026561 Colletotrichum gloeosporioides 48.46 0.00e+00 1176.00
IUUC-Cne-027009 Cryptococcus neoformans 49.17 0.00e+00 731.00
IUUC-Cme-027253 Cyanidioschyzon merolae 65.34 2.00e-72 266.00
IUUC-Dre-028485 Danio rerio 56.33 0.00e+00 781.00
IUUC-Dno-029901 Dasypus novemcinctus 58.38 0.00e+00 665.00
IUUC-Dor-030140 Dipodomys ordii 52.18 3.00e-172 597.00
IUUC-Dse-031462 Dothistroma septosporum 47.21 0.00e+00 723.00
IUUC-Dme-031670 Drosophila melanogaster 51.52 0.00e+00 640.00
IUUC-Ete-032578 Echinops telfairi 66.67 6.00e-66 244.00
IUUC-Eca-034076 Equus caballus 57.08 0.00e+00 771.00
IUUC-Eeu-035140 Erinaceus europaeus 54.69 0.00e+00 656.00
IUUC-Fca-035651 Felis catus 56.94 0.00e+00 769.00
IUUC-Fal-037244 Ficedula albicollis 57.37 0.00e+00 768.00
IUUC-Fox-037742 Fusarium oxysporum 48.43 0.00e+00 1135.00
IUUC-Fso-038369 Fusarium solani 47.17 0.00e+00 1129.00
IUUC-Gmo-039007 Gadus morhua 55.61 3.00e-127 447.00
IUUC-Ggr-039836 Gaeumannomyces graminis 48.27 0.00e+00 1181.00
IUUC-Gga-041121 Gallus gallus 57.23 0.00e+00 768.00
IUUC-Gac-041430 Gasterosteus aculeatus 55.77 0.00e+00 773.00
IUUC-Gma-043160 Glycine max 53.73 0.00e+00 643.00
IUUC-Ggo-044934 Gorilla gorilla 58.55 0.00e+00 754.00
IUUC-Hsa-045887 Homo sapiens 57.08 0.00e+00 771.00
IUUC-Hvu-047823 Hordeum vulgare 49.12 6.00e-174 603.00
IUUC-Itr-048274 Ictidomys tridecemlineatus 51.43 8.00e-70 255.00
IUUC-Kpa-049399 Komagataella pastoris 39.72 2.00e-174 604.00
IUUC-Lch-050405 Latimeria chalumnae 57.04 0.00e+00 776.00
IUUC-Lpe-050864 Leersia perrieri 51.67 3.00e-125 440.00
IUUC-Loc-051868 Lepisosteus oculatus 52.63 0.00e+00 716.00
IUUC-Lma-052993 Leptosphaeria maculans 49.01 0.00e+00 1241.00
IUUC-Laf-053339 Loxodonta africana 57.08 0.00e+00 766.00
IUUC-Mcc-055591 Macaca mulatta 57.08 0.00e+00 771.00
IUUC-Meu-056642 Macropus eugenii 56.59 1.00e-169 588.00
IUUC-Mor-057204 Magnaporthe oryzae 47.66 0.00e+00 1169.00
IUUC-Mpo-057532 Magnaporthe poae 48.02 0.00e+00 1170.00
IUUC-Mtr-058553 Medicago truncatula 52.17 0.00e+00 629.00
IUUC-Mla-058907 Melampsora laricipopulina 41.60 5.00e-166 577.00
IUUC-Mga-059256 Meleagris gallopavo 57.23 0.00e+00 769.00
IUUC-Mvi-060457 Microbotryum violaceum 51.94 0.00e+00 749.00
IUUC-Mmr-060874 Microcebus murinus 56.14 0.00e+00 738.00
IUUC-Mdo-062436 Monodelphis domestica 57.23 0.00e+00 766.00
IUUC-Mmu-063264 Mus musculus 56.93 0.00e+00 767.00
IUUC-Mac-065524 Musa acuminata 49.54 4.00e-173 600.00
IUUC-Mpu-065899 Mustela putorius furo 58.00 0.00e+00 694.00
IUUC-Mlu-067344 Myotis lucifugus 55.53 9.00e-147 512.00
IUUC-Nfi-068615 Neosartorya fischeri 58.06 0.00e+00 899.00
IUUC-Ncr-068744 Neurospora crassa 47.49 0.00e+00 1169.00
IUUC-Nle-069014 Nomascus leucogenys 57.08 0.00e+00 770.00
IUUC-Opr-070548 Ochotona princeps 62.50 1.00e-108 385.00
IUUC-Ont-072485 Oreochromis niloticus 55.85 0.00e+00 775.00
IUUC-Oan-073253 Ornithorhynchus anatinus 33.46 2.00e-41 160.00
IUUC-Ocu-074290 Oryctolagus cuniculus 24.85 1.00e-20 92.40
IUUC-Oba-075130 Oryza barthii 49.08 1.00e-167 582.00
IUUC-Obr-076161 Oryza brachyantha 51.06 3.00e-176 610.00
IUUC-Ogl-077800 Oryza glaberrima 49.71 1.00e-173 602.00
IUUC-Ogu-078292 Oryza glumaepatula 62.71 1.00e-39 155.00
IUUC-Oin-080126 Oryza indica 45.61 8.00e-150 523.00
IUUC-Olo-080598 Oryza longistaminata 35.65 5.00e-22 97.10
IUUC-Ome-081293 Oryza meridionalis 48.20 3.00e-109 388.00
IUUC-Oni-082236 Oryza nivara 53.95 2.00e-69 256.00
IUUC-Opu-083423 Oryza punctata 48.83 2.00e-172 598.00
IUUC-Oru-085086 Oryza rufipogon 50.34 6.00e-162 563.00
IUUC-Osa-086012 Oryza sativa 51.10 2.00e-166 578.00
IUUC-Ola-086662 Oryzias latipes 55.43 5.00e-168 583.00
IUUC-Olu-087760 Ostreococcus lucimarinus 47.35 1.00e-170 592.00
IUUC-Oga-088053 Otolemur garnettii 58.33 0.00e+00 696.00
IUUC-Oar-089466 Ovis aries 53.59 0.00e+00 754.00
IUUC-Ptr-090868 Pan troglodytes 57.08 0.00e+00 770.00
IUUC-Pan-092259 Papio anubis 57.08 0.00e+00 771.00
IUUC-Psi-093641 Pelodiscus sinensis 57.57 0.00e+00 678.00
IUUC-Pno-094789 Phaeosphaeria nodorum 46.34 0.00e+00 1105.00
IUUC-Ppa-095973 Physcomitrella patens 52.35 0.00e+00 659.00
IUUC-Pfo-096837 Poecilia formosa 55.71 0.00e+00 771.00
IUUC-Pab-097545 Pongo abelii 51.92 6.00e-71 259.00
IUUC-Pop-099059 Populus trichocarpa 52.68 0.00e+00 635.00
IUUC-Pca-100579 Procavia capensis 45.52 5.00e-62 231.00
IUUC-Ppe-101494 Prunus persica 47.85 0.00e+00 649.00
IUUC-Pva-103245 Pteropus vampyrus 50.40 2.00e-130 458.00
IUUC-Pgr-103460 Puccinia graminis 36.36 5.00e-58 218.00
IUUC-Ptt-103797 Puccinia triticina 35.45 3.00e-76 279.00
IUUC-Pte-104367 Pyrenophora teres 48.90 0.00e+00 1226.00
IUUC-Pyt-104771 Pyrenophora triticirepentis 46.70 0.00e+00 1130.00
IUUC-Rno-104965 Rattus norvegicus 56.93 0.00e+00 767.00
IUUC-Sce-106156 Saccharomyces cerevisiae 53.74 3.00e-133 468.00
IUUC-Sha-106474 Sarcophilus harrisii 56.94 7.00e-129 453.00
IUUC-Sja-107888 Schizosaccharomyces japonicus 68.81 0.00e+00 1756.00
IUUC-Ssl-108423 Sclerotinia sclerotiorum 48.25 0.00e+00 1148.00
IUUC-Smo-109425 Selaginella moellendorffii 51.41 0.00e+00 653.00
IUUC-Sit-109752 Setaria italica 48.88 4.00e-177 613.00
IUUC-Sly-110910 Solanum lycopersicum 53.41 0.00e+00 636.00
IUUC-Stu-112814 Solanum tuberosum 53.08 0.00e+00 632.00
IUUC-Sbi-113810 Sorghum bicolor 51.29 3.00e-171 593.00
IUUC-Sre-115168 Sporisorium reilianum 52.01 0.00e+00 776.00
IUUC-Ssc-115398 Sus scrofa 56.10 5.00e-123 433.00
IUUC-Tgu-117361 Taeniopygia guttata 57.37 0.00e+00 768.00
IUUC-Tsy-119587 Tarsius syrichta 61.89 0.00e+00 714.00
IUUC-Tni-119757 Tetraodon nigroviridis 56.21 0.00e+00 766.00
IUUC-Tca-121570 Theobroma cacao 53.00 0.00e+00 633.00
IUUC-Tre-122024 Trichoderma reesei 47.17 0.00e+00 1150.00
IUUC-Tvi-122502 Trichoderma virens 47.83 0.00e+00 1163.00
IUUC-Tae-125799 Triticum aestivum 49.71 3.00e-176 610.00
IUUC-Tme-127001 Tuber melanosporum 52.84 0.00e+00 1080.00
IUUC-Ttr-129128 Tursiops truncatus 55.11 0.00e+00 645.00
IUUC-Uma-129588 Ustilago maydis 51.29 0.00e+00 768.00
IUUC-Vda-129990 Verticillium dahliae 48.70 0.00e+00 1061.00
IUUC-Vvi-131611 Vitis vinifera 49.85 0.00e+00 632.00
IUUC-Xtr-132727 Xenopus tropicalis 57.67 0.00e+00 771.00
IUUC-Xma-133492 Xiphophorus maculatus 55.85 0.00e+00 774.00
IUUC-Yli-134358 Yarrowia lipolytica 47.98 0.00e+00 1142.00
IUUC-Zma-135844 Zea mays 47.01 2.00e-161 561.00
Created Date 25-Jun-2017

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