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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045659
UUCD1 version UUC-HoS-01209
Ensembl Protein ID ENSP00000360739.3
UniProt Accession Q13404; E1P629; Q13403; Q13532; Q5TGE0; Q5TGE3; Q96H34; Q9GZT0; Q9GZW1; Q9H4J3; Q9H4J4; Q9UKL1; Q9UM48; Q9UM49; Q9UM50; UB2V1_HUMAN
Genbank Protein ID AAB72015.1; AAB72016.1; AAC02757.1; AAC02780.1; AAC02755.1; AAC02756.1; AAG24229.1; AAP36046.1; CAB76864.1; CAB76865.1; CAC16954.1; CAC16955.2; CAI19382.1; CAI19383.1; EAW75635.1; EAW75634.1; EAW75636.1; AAH00468.1; AAH08944.2
Protein Name Ubiquitin-conjugating enzyme E2 variant 1; CROC-1; TRAF6-regulated IKK activator 1 beta Uev1A
Genbank Nucleotide ID U39360; U39361; U49278; U97279; U97280; U97281; AY008273; BT007382; DA580976; AL034423; AL034423; AL034423; AL034423; AL034423; CH471077; CH471077; CH471077; BC000468; BC008944
Gene Name UBE2V1; CROC1; UBE2V; UEV1; P/OKcl.19
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000244687.11 ENST00000371657.9 ENSP00000360720.5
ENSG00000244687.11 ENST00000371674.7 ENSP00000360739.3
ENSG00000244687.11 ENST00000340309.7 ENSP00000340305.3
ENSG00000244687.11 ENST00000415862.6 ENSP00000407770.2
ENSG00000244687.11 ENST00000483534.5 ENSP00000421351.1
ENSG00000244687.11 ENST00000420027.3 ENSP00000395264.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
AREsiteCircNetmiRTarBasemicroRNA
TRANSFACRepTarmiRNAMapmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Drug and target
Manually
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E2/UEV E2_UEV 19264966; 18326498; 21143188
UBD/UBC-like/UBD_UEV UBD_UEV 20420830
Classification
Family E-value Score Start End
E2/UBC 3.00e-19 70.8 32 138
E2/UEV 2.20e-67 227.1 4 145
UBD/UBC-like/UBD_UEV 3.50e-51 174.4 2 139
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E2/UBC
   S: 16   gisakpvdesd..ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.Gkv...ClsilkeeekWspalsvesv 101
           ++s +++d++d  lt+w  +i+Gp++t+Ye+++++l+ie+ ++YP  PP v+f+tki    v+++ G v    +s+l    kW+  +s++ v
   Q: 32   TVSWGLEDDEDmtLTRWTGMIIGPPRTIYENRIYSLKIECGPKYPEAPPFVRFVTKINMNGVNSSnGVVdprAISVL---AKWQNSYSIKVV 120
           456667777776689*****************************************999999988798866668888...5*********** PP
   S: 102  llsiqsll.aepnpespl 118
           l ++ +l+ ++ n++ p+
   Q: 121  LQELRRLMmSKENMKLPQ 138
           ******996667777665 PP
   

   E2/UEV
   S: 4    eselkvvvprnfrlleeleegekglgdgtvsygldDgddilllsltgtIigpertayegrIyqlklfvgkkYPekPPtvrfsskinmaevnd 95
           ++++ v+vprnfrlleeleeg+kg+gdgtvs+gl+D++d++l+++tg+Iigp+rt ye+rIy+lk+++g+kYPe+PP+vrf++kinm++vn+
   Q: 4    TTGSGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTIYENRIYSLKIECGPKYPEAPPFVRFVTKINMNGVNS 95
           67899*************************************************************************************** PP
   S: 96   snGvvdpralpvLanWkreysievvlvqlkkellskenrklqqPpeGnlf 145
           snGvvdpra++vLa+W+++ysi+vvl++l++ ++sken+kl+qPpeG+++
   Q: 96   SNGVVDPRAISVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQCY 145
           ************************************************98 PP
   

   UBD/UBC-like/UBD_UEV
   S: 1    AvsesslkkvpskykdkrltvrellnliesykslkpktasfvlnDgesreLlrltGtipvpergitynipiilwllet...YPekPPfvsvk 89
           A++++s++kvp+++       r l++l+e++k+++++t+s++l+D+e+++L+r+tG+i++p+r+i y+++i+++++e+   YPe+PPfv+++
   Q: 2    AATTGSGVKVPRNF-------RLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTI-YENRIYSLKIECgpkYPEAPPFVRFV 85
           7999**********.......********************************************.************************** PP
   S: 90   ekidmntikssnehvdpnGkialpvLhkWknpasnlvelvqelivllskeppklsrp 146
           +ki+mn+++ssn++vdp+   a++vL+kW+n++s++v+l++++++++ske++kl++p
   Q: 86   TKINMNGVNSSNGVVDPR---AISVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQP 139
           ******************...**********************************98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.
 Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.
Protein Sequence
(Fasta)
MAATTGSGVK VPRNFRLLEE LEEGQKGVGD GTVSWGLEDD EDMTLTRWTG MIIGPPRTIY 60
ENRIYSLKIE CGPKYPEAPP FVRFVTKINM NGVNSSNGVV DPRAISVLAK WQNSYSIKVV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045659|E2,E2/UEV;UBD,UBD_UEV|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTCCCGCCTA ACCTCTTCCT GCGATGAGCT CGGCACGGGA ATTATTATTG TCAATTTTAC 60
TTGCAAGAAG TTTCCTACAA GAGCCAAGGA ATCCATGCGA GTAAACATTT ACGGGCACCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045659|E2,E2/UEV;UBD,UBD_UEV|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD
PROSITE

PS50127--UBIQUITIN_CONJUGAT_2
Pfam

PF00179--UQ_con
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0035370--C:UBC13-UEV1A complex
GO:0031371--C:ubiquitin conjugating enzyme complex
GO:0000151--C:ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0000187--P:activation of MAPK activity
GO:0030154--P:cell differentiation
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0007254--P:JNK cascade
GO:0070423--P:nucleotide-binding oligomerization domain containing signaling pathway
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006301--P:postreplication repair
GO:0070534--P:protein K63-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0006282--P:regulation of DNA repair
GO:0006355--P:regulation of transcription, DNA-templated
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0050852--P:T cell receptor signaling pathway
KEGG hsa:387522; hsa:7335
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000910 Aegilops tauschii 54.23 4.00e-40 156.00
IUUC-Atr-003005 Amborella trichopoda 51.75 2.00e-38 150.00
IUUC-Aly-005402 Arabidopsis lyrata 53.47 7.00e-40 155.00
IUUC-Ath-007596 Arabidopsis thaliana 52.74 8.00e-39 152.00
IUUC-Ago-007810 Ashbya gossypii 52.21 2.00e-34 137.00
IUUC-Acl-008375 Aspergillus clavatus 49.28 1.00e-32 132.00
IUUC-Afl-008598 Aspergillus flavus 51.11 3.00e-34 137.00
IUUC-Afu-008838 Aspergillus fumigatus 49.63 3.00e-34 137.00
IUUC-Aor-010051 Aspergillus oryzae 51.11 3.00e-34 137.00
IUUC-Ame-010710 Astyanax mexicanus 89.12 3.00e-76 276.00
IUUC-Bgr-012010 Blumeria graminis 51.45 5.00e-33 133.00
IUUC-Bta-013403 Bos taurus 100.00 1.00e-77 281.00
IUUC-Bci-013649 Botrytis cinerea 51.82 6.00e-33 132.00
IUUC-Bdi-014636 Brachypodium distachyon 53.73 6.00e-38 149.00
IUUC-Bol-015323 Brassica oleracea 53.15 8.00e-41 159.00
IUUC-Bra-018041 Brassica rapa 53.15 8.00e-41 159.00
IUUC-Cel-018398 Caenorhabditis elegans 66.67 6.00e-48 182.00
IUUC-Cja-019316 Callithrix jacchus 100.00 1.00e-77 281.00
IUUC-Cfa-021118 Canis familiaris 100.00 2.00e-73 268.00
IUUC-Cre-022629 Chlamydomonas reinhardtii 49.64 8.00e-38 149.00
IUUC-Cgl-026596 Colletotrichum gloeosporioides 53.62 7.00e-37 145.00
IUUC-Cne-026817 Cryptococcus neoformans 50.00 3.00e-37 147.00
IUUC-Cme-027257 Cyanidioschyzon merolae 55.47 1.00e-28 119.00
IUUC-Dre-028019 Danio rerio 88.44 3.00e-76 276.00
IUUC-Dno-029762 Dasypus novemcinctus 100.00 5.00e-74 269.00
IUUC-Dme-031635 Drosophila melanogaster 66.90 2.00e-59 221.00
IUUC-Eca-034422 Equus caballus 100.00 6.00e-73 266.00
IUUC-Fox-037803 Fusarium oxysporum 52.17 6.00e-37 145.00
IUUC-Fso-038147 Fusarium solani 53.96 4.00e-38 150.00
IUUC-Gmo-039237 Gadus morhua 81.63 1.00e-70 258.00
IUUC-Gma-043736 Glycine max 54.29 4.00e-43 166.00
IUUC-Hvu-047368 Hordeum vulgare 54.48 4.00e-38 150.00
IUUC-Kpa-049337 Komagataella pastoris 51.11 6.00e-32 129.00
IUUC-Lpe-050874 Leersia perrieri 54.48 2.00e-38 150.00
IUUC-Laf-054176 Loxodonta africana 100.00 1.00e-77 281.00
IUUC-Mor-056915 Magnaporthe oryzae 38.67 3.00e-21 94.40
IUUC-Mpo-057437 Magnaporthe poae 46.71 1.00e-29 122.00
IUUC-Mtr-058655 Medicago truncatula 53.79 6.00e-39 153.00
IUUC-Mvi-060260 Microbotryum violaceum 54.01 7.00e-37 145.00
IUUC-Mmr-061374 Microcebus murinus 93.88 2.00e-64 237.00
IUUC-Mac-065220 Musa acuminata 51.72 1.00e-39 155.00
IUUC-Mpu-065775 Mustela putorius furo 100.00 1.00e-77 281.00
IUUC-Nfi-068400 Neosartorya fischeri 44.21 2.00e-26 110.00
IUUC-Ncr-068946 Neurospora crassa 46.36 1.00e-36 145.00
IUUC-Nle-069245 Nomascus leucogenys 100.00 1.00e-77 281.00
IUUC-Ocu-074447 Oryctolagus cuniculus 97.86 1.00e-72 265.00
IUUC-Obr-076191 Oryza brachyantha 53.47 2.00e-40 157.00
IUUC-Olo-080528 Oryza longistaminata 48.63 3.00e-35 140.00
IUUC-Ptr-090866 Pan troglodytes 100.00 1.00e-77 281.00
IUUC-Pan-092804 Papio anubis 97.28 3.00e-75 273.00
IUUC-Pma-094142 Petromyzon marinus 85.71 2.00e-21 93.60
IUUC-Ppa-095500 Physcomitrella patens 53.19 5.00e-40 156.00
IUUC-Pop-099786 Populus trichocarpa 53.15 6.00e-40 155.00
IUUC-Ppe-101725 Prunus persica 55.71 4.00e-40 157.00
IUUC-Rno-106065 Rattus norvegicus 93.88 6.00e-73 266.00
IUUC-Sja-107722 Schizosaccharomyces japonicus 54.01 7.00e-35 139.00
IUUC-Spo-108027 Schizosaccharomyces pombe 51.09 2.00e-33 134.00
IUUC-Ssl-108493 Sclerotinia sclerotiorum 52.82 1.00e-34 138.00
IUUC-Smo-109006 Selaginella moellendorffii 46.72 2.00e-29 120.00
IUUC-Sit-110302 Setaria italica 54.86 9.00e-42 162.00
IUUC-Sly-111205 Solanum lycopersicum 52.45 2.00e-40 157.00
IUUC-Stu-112459 Solanum tuberosum 51.75 6.00e-40 155.00
IUUC-Sar-113197 Sorex araneus 100.00 3.00e-50 192.00
IUUC-Sbi-114210 Sorghum bicolor 54.17 3.00e-41 160.00
IUUC-Sre-114909 Sporisorium reilianum 51.82 1.00e-33 135.00
IUUC-Ssc-115939 Sus scrofa 100.00 1.00e-77 281.00
IUUC-Tca-121025 Theobroma cacao 56.43 2.00e-40 159.00
IUUC-Tre-121971 Trichoderma reesei 53.96 6.00e-37 146.00
IUUC-Tvi-122622 Trichoderma virens 54.68 2.00e-37 147.00
IUUC-Tae-123220 Triticum aestivum 54.48 4.00e-38 150.00
IUUC-Tur-126236 Triticum urartu 54.01 9.00e-39 152.00
IUUC-Tme-127171 Tuber melanosporum 48.18 7.00e-30 122.00
IUUC-Vda-129776 Verticillium dahliae 52.86 1.00e-36 145.00
IUUC-Vpa-130575 Vicugna pacos 99.28 8.00e-72 263.00
IUUC-Vvi-130831 Vitis vinifera 55.71 5.00e-41 159.00
IUUC-Xtr-132359 Xenopus tropicalis 95.24 4.00e-74 269.00
IUUC-Xma-134032 Xiphophorus maculatus 82.99 1.00e-64 238.00
Created Date 25-Jun-2017

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