iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000121236.20	ENST00000380107.5	ENSP00000369450.1
ENSG00000121236.20	ENST00000380097.7	ENSP00000369440.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	8.70e-06	27.4	37	106
E3 activity/RING/RING	1.00e-07	34.0	43	88

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwl......asggktcPvtrqplteedlvPnltlrrli 65
           + ee  CpI lel ++P  + +G+++ +++I          ++g+++cPv++++ ++ +l Pn  l +++
   Q: 37   IREEVTCPICLELLTEPLSIDCGHSFCQACITPNGresvigQEGERSCPVCQTSYQPGNLRPNRHLANIV 106
           678999*************************874433334666666*****************9987765 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.....qkwpglknssskefrCPlCr 46
           C+iCle + + pl+ +CgH f++ C+     + +      + +e +CP+C+
   Q: 43   CPICLELLTE-PLSIDCGHSFCQACItpngrESV----IGQEGERSCPVCQ 88
           ********99.***************87655555....999*********7 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase which ubiquitinates MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (By similarity). Involved in the synthesis of unanchored K48-linked polyubiquitin chains which interact with and activate the serine/threonine kinase IKBKE, leading to phosphorylation of STAT1 and stimulation of an antiviral response (PubMed:24882218).

Protein Sequence
(Fasta)

MCGSERILQA GNILEIRVGQ AGARRVATMT SPVLVDIREE VTCPICLELL TEPLSIDCGH 60
SFCQACITPN GRESVIGQEG ERSCPVCQTS YQPGNLRPNR HLANIVRRLR EVVLGPGKQL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGAGTCTTT CGGCCTGGGT GGAGGACGCG GCTGCTTCAA GTCCTTGGCT CTGATCCAGG 60
CCACAGATTC CAGGTTAGTG AGCAAGTTTA TTTTCTGGCC AGCTACCGCT GTCCCCACTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR010908--Longin_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY
PF00643--zf-B_box
PF13445--zf-RING_UBOX

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0030674--F:protein binding, bridging
GO:0019901--F:protein kinase binding
GO:1990782--F:protein tyrosine kinase binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0035458--P:cellular response to interferon-beta
GO:0098586--P:cellular response to virus
GO:0010994--P:free ubiquitin chain polymerization
GO:0010629--P:negative regulation of gene expression
GO:2000737--P:negative regulation of stem cell differentiation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045071--P:negative regulation of viral genome replication
GO:0002741--P:positive regulation of cytokine secretion involved in immune response
GO:0002230--P:positive regulation of defense response to virus by host
GO:0010628--P:positive regulation of gene expression
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0010800--P:positive regulation of peptidyl-threonine phosphorylation
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0060340--P:positive regulation of type I interferon-mediated signaling pathway
GO:0000209--P:protein polyubiquitination
GO:0070206--P:protein trimerization
GO:0032496--P:response to lipopolysaccharide

KEGG

hsa:117854

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001965	Ailuropoda melanoleuca	83.40	0.00e+00	811.00
IUUC-Cel-018370	Caenorhabditis elegans	33.75	1.00e-09	57.80
IUUC-Cja-019394	Callithrix jacchus	70.37	4.00e-137	481.00
IUUC-Fca-035533	Felis catus	82.58	0.00e+00	805.00
IUUC-Itr-048069	Ictidomys tridecemlineatus	79.74	0.00e+00	769.00
IUUC-Kpa-049392	Komagataella pastoris	33.01	1.00e-09	57.40
IUUC-Laf-053805	Loxodonta africana	79.51	0.00e+00	733.00
IUUC-Mmr-061023	Microcebus murinus	82.97	0.00e+00	812.00
IUUC-Mmu-063682	Mus musculus	80.12	0.00e+00	803.00
IUUC-Mpu-065842	Mustela putorius furo	81.52	0.00e+00	794.00
IUUC-Oga-088267	Otolemur garnettii	85.07	0.00e+00	824.00
IUUC-Ptr-090573	Pan troglodytes	98.98	0.00e+00	978.00
IUUC-Pan-092745	Papio anubis	97.13	0.00e+00	944.00
IUUC-Rno-105401	Rattus norvegicus	81.15	0.00e+00	815.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence