iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RAID2
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	3.40e-09	37.7	10	77
E3 activity/RING/RING	1.70e-06	29.6	15	59

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 3    peeflCpIslelMrdPvvlpsGitydrssIekwlasggk.....tcPvtrqplteedlvPnltlrrli 65
            ee  Cp+ l+lM  Pv + +G+++ + +I  +++s +      +cPv+r + ++++l Pnl + +++
   Q: 10   KEEVTCPLCLNLMVKPVSADCGHSFCQGCITVYFESTKCdkemfSCPVCRLSYQSSNLRPNLHVANIV 77
           68999*****************************8888788999*****************9876665 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cl+ + + p++ +CgH f++ C+  ++ + +  +  f+CP+Cr
   Q: 15   CPLCLNLMVK-PVSADCGHSFCQGCITVYFESTKCDKEMFSCPVCR 59
           **********.9*9************999999999**********8 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MASQFMKNLK EEVTCPLCLN LMVKPVSADC GHSFCQGCIT VYFESTKCDK EMFSCPVCRL 60
SYQSSNLRPN LHVANIVERL KEFKPSPEEE QKVFNCARHG EKLQLFCRKD MMAICWLCER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTCTCAAA CTTTCGTTTC TCTAGCTTCG AGTCGGAAAT ACCTTGAAGT TCTGGATTGG 60
TTAGTTAATT CTCCCTGGTT TACAACTTTC TGGCGTCTGA TAACGGGCTG AGCAATTTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR003877--SPRY_dom
IPR032917--TRIM5
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000932--C:P-body
GO:0042802--F:identical protein binding
GO:0030674--F:protein binding, bridging
GO:0042803--F:protein homodimerization activity
GO:0019901--F:protein kinase binding
GO:0008329--F:signaling pattern recognition receptor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0051607--P:defense response to virus
GO:0045087--P:innate immune response

KEGG

mmu:319236

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-005459	Arabidopsis lyrata	37.74	2.00e-07	46.60
IUUC-Dor-030700	Dipodomys ordii	48.89	3.00e-129	455.00
IUUC-Kpa-049392	Komagataella pastoris	30.91	4.00e-09	55.50
IUUC-Ocu-073956	Oryctolagus cuniculus	49.29	6.00e-131	461.00
IUUC-Ptt-103920	Puccinia triticina	36.11	4.00e-06	45.10
IUUC-Rno-105761	Rattus norvegicus	78.67	0.00e+00	790.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence