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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046519
Ensembl Protein ID ENSP00000350708.3
UniProt Accession P54727; B3KWK8; G5E9P0; Q7Z5K8; Q8WUB0; RD23B_HUMAN
Genbank Protein ID BAA04652.1; AAP81008.1; AAN47194.1; BAG54170.1; CAD13275.1; EAW59016.1; EAW59017.1; AAH20973.1
Protein Name UV excision repair protein RAD23 homolog B; XP-C repair-complementing complex 58 kDa protein
Genbank Nucleotide ID D21090; AY313777; AY165178; AK125226; AL137852; CH471105; CH471105; BC020973
Gene Name RAD23B; Hhr23B
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000119318.12 ENST00000358015.7 ENSP00000350708.3
ENSG00000119318.12 ENST00000442587.1 ENSP00000415821.1
ENSG00000119318.12 ENST00000457811.1 ENSP00000396975.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 12832454
ULD/UDP/UBQ/UBQ_PIM UBQ_PIM 16020535; 10915768; 11677784; 14585839
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 4.80e-19 69.5 190 227
ULD/UDP/UBQ/UBQ_PIM 7.30e-27 94.8 1 78
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLld 40
           +e ++ ++++MG++re+++ aLra++nn+++AveyLl 
   Q: 190  YENMVTEIMSMGYEREQVIAALRASFNNPDRAVEYLLM 227
           5789********************************95 PP
   

   ULD/UDP/UBQ/UBQ_PIM
   S: 1    mkltvktlkgkefelevseddtveelKekiakesg...vppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkksk 75
           m++t+ktl++++f++++++++tv++lKeki++e+g   +p++ qkLIyaGkiL+Ddt L+e++i+++++v+++v+k+k
   Q: 1    MQVTLKTLQQQTFKIDIDPEETVKALKEKIESEKGkdaFPVAGQKLIYAGKILNDDTALKEYKIDEKNFVVVMVTKPK 78
           99*************************************************************************997 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the XPC complex composed of XPC, RAD23B and CETN2. Interacts with NGLY1 and PSMC1. Interacts with ATXN3. Interacts with PSMD4 and PSMC5. Interacts with AMFR. Interacts with VCP; the interaction is indirect and mediated by NGLY1 (By similarity).
 Component of the XPC complex composed of XPC, RAD23B and CETN2. Interacts with NGLY1 and PSMC1. Interacts with ATXN3. Interacts with PSMD4 and PSMC5. Interacts with AMFR. Interacts with VCP; the interaction is indirect and mediated by NGLY1 (By similarity).
Protein Sequence
(Fasta)
MQVTLKTLQQ QTFKIDIDPE ETVKALKEKI ESEKGKDAFP VAGQKLIYAG KILNDDTALK 60
EYKIDEKNFV VVMVTKPKAV STPAPATTQQ SAPASTTAVT SSTTTTVAQA PTPVPALAPT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046519|UBD,UBA;ULD,UBQ_PIM|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCCTTCCGCC CCGCCCCCAA TTCTGGGGCG GAGTCCTCGG CCGCGCCGGC GCAAAGCGTC 60
GCCGCACCCC ACGCCTGCGC GCTTCGCCCG CCCGGCCCCA TCCCCCCAGG TTTTTCGCGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046519|UBD,UBA;ULD,UBQ_PIM|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0227--DNA damage
KW-0234--DNA repair
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR004806--Rad23
IPR006636--STI1_HS-bd
IPR015940--UBA
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR015360--XPC-bd
PROSITE

PS50030--UBA
PS50053--UBIQUITIN_2
Pfam

PF00627--UBA
PF00240--ubiquitin
PF09280--XPC-binding
PRINTS

PR01839--RAD23PROTEIN
SMART

SM00727--STI1
SM00165--UBA
SM00213--UBQ
Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000502--C:proteasome complex
GO:0071942--C:XPC complex
GO:0003684--F:damaged DNA binding
GO:0031593--F:polyubiquitin binding
GO:0003697--F:single-stranded DNA binding
GO:0048568--P:embryonic organ development
GO:0070911--P:global genome nucleotide-excision repair
GO:0006289--P:nucleotide-excision repair
GO:0000715--P:nucleotide-excision repair, DNA damage recognition
GO:0000717--P:nucleotide-excision repair, DNA duplex unwinding
GO:0006294--P:nucleotide-excision repair, preincision complex assembly
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0006457--P:protein folding
GO:0032434--P:regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0007283--P:spermatogenesis
KEGG hsa:5887
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001195 Ailuropoda melanoleuca 94.40 3.00e-95 342.00
IUUC-Atr-003116 Amborella trichopoda 36.58 5.00e-31 128.00
IUUC-Apl-003371 Anas platyrhynchos 72.75 4.00e-122 431.00
IUUC-Aca-004599 Anolis carolinensis 81.66 6.00e-94 337.00
IUUC-Aly-006159 Arabidopsis lyrata 34.53 2.00e-54 206.00
IUUC-Ath-006676 Arabidopsis thaliana 39.84 2.00e-40 160.00
IUUC-Ago-007830 Ashbya gossypii 31.12 4.00e-19 89.00
IUUC-Acl-008212 Aspergillus clavatus 47.01 5.00e-19 89.00
IUUC-Afl-008605 Aspergillus flavus 44.12 1.00e-19 90.90
IUUC-Afu-008877 Aspergillus fumigatus 46.27 1.00e-18 87.40
IUUC-Aor-010032 Aspergillus oryzae 44.12 3.00e-19 89.70
IUUC-Ate-010458 Aspergillus terreus 40.73 7.00e-30 124.00
IUUC-Ame-011107 Astyanax mexicanus 67.96 1.00e-33 137.00
IUUC-Bta-012922 Bos taurus 92.91 1.00e-131 462.00
IUUC-Bdi-014253 Brachypodium distachyon 36.65 2.00e-32 133.00
IUUC-Bol-016493 Brassica oleracea 36.29 2.00e-35 143.00
IUUC-Cja-018772 Callithrix jacchus 97.07 2.00e-142 499.00
IUUC-Cfa-020683 Canis familiaris 82.64 3.00e-137 481.00
IUUC-Cpo-022145 Cavia porcellus 92.67 2.00e-140 492.00
IUUC-Cre-022810 Chlamydomonas reinhardtii 36.87 9.00e-30 124.00
IUUC-Csa-023714 Chlorocebus sabaeus 99.27 4.00e-160 557.00
IUUC-Cho-024814 Choloepus hoffmanni 73.33 3.00e-84 305.00
IUUC-Cin-025741 Ciona intestinalis 41.28 5.00e-36 144.00
IUUC-Csv-025823 Ciona savignyi 40.89 2.00e-42 165.00
IUUC-Cne-027056 Cryptococcus neoformans 47.44 2.00e-15 77.40
IUUC-Cme-027260 Cyanidioschyzon merolae 29.16 3.00e-27 115.00
IUUC-Dre-028369 Danio rerio 72.40 6.00e-83 300.00
IUUC-Dno-029543 Dasypus novemcinctus 91.20 1.00e-137 482.00
IUUC-Dse-031336 Dothistroma septosporum 47.41 1.00e-17 84.30
IUUC-Dme-032027 Drosophila melanogaster 37.19 3.00e-64 239.00
IUUC-Ete-032583 Echinops telfairi 84.84 1.00e-98 353.00
IUUC-Eca-034243 Equus caballus 98.72 8.00e-94 337.00
IUUC-Eeu-034721 Erinaceus europaeus 88.99 1.00e-73 269.00
IUUC-Fca-035679 Felis catus 93.40 4.00e-135 474.00
IUUC-Fal-037148 Ficedula albicollis 72.21 7.00e-119 420.00
IUUC-Fox-037960 Fusarium oxysporum 44.19 1.00e-15 77.40
IUUC-Fso-038107 Fusarium solani 52.63 9.00e-17 81.30
IUUC-Ggr-040116 Gaeumannomyces graminis 46.27 5.00e-16 79.00
IUUC-Gga-040544 Gallus gallus 72.19 9.00e-126 443.00
IUUC-Gac-042239 Gasterosteus aculeatus 56.87 2.00e-100 359.00
IUUC-Gma-043835 Glycine max 35.85 4.00e-39 155.00
IUUC-Ggo-045125 Gorilla gorilla 100.00 3.00e-105 375.00
IUUC-Hvu-047832 Hordeum vulgare 37.05 2.00e-32 133.00
IUUC-Itr-048295 Ictidomys tridecemlineatus 92.18 5.00e-130 457.00
IUUC-Kpa-049314 Komagataella pastoris 37.66 3.00e-30 125.00
IUUC-Lch-050553 Latimeria chalumnae 67.50 3.00e-101 362.00
IUUC-Lpe-050801 Leersia perrieri 36.78 2.00e-34 140.00
IUUC-Loc-051748 Lepisosteus oculatus 68.52 3.00e-75 275.00
IUUC-Lma-053328 Leptosphaeria maculans 48.68 1.00e-13 67.40
IUUC-Laf-054293 Loxodonta africana 94.83 1.00e-124 439.00
IUUC-Mcc-055600 Macaca mulatta 100.00 1.00e-113 402.00
IUUC-Meu-056082 Macropus eugenii 66.55 2.00e-70 259.00
IUUC-Mor-057287 Magnaporthe oryzae 50.00 2.00e-16 80.10
IUUC-Mpo-057609 Magnaporthe poae 46.51 3.00e-15 75.90
IUUC-Mtr-058148 Medicago truncatula 38.22 2.00e-40 159.00
IUUC-Mla-058961 Melampsora laricipopulina 46.62 4.00e-26 112.00
IUUC-Mga-060060 Meleagris gallopavo 45.29 4.00e-30 125.00
IUUC-Mvi-060220 Microbotryum violaceum 43.61 2.00e-21 97.40
IUUC-Mmr-061159 Microcebus murinus 97.52 1.00e-98 353.00
IUUC-Mdo-061967 Monodelphis domestica 80.10 6.00e-124 437.00
IUUC-Mmu-063258 Mus musculus 87.77 7.00e-149 520.00
IUUC-Mpu-066389 Mustela putorius furo 94.80 8.00e-96 343.00
IUUC-Mlu-067999 Myotis lucifugus 90.23 2.00e-119 422.00
IUUC-Nfi-068390 Neosartorya fischeri 46.27 1.00e-18 87.40
IUUC-Ncr-068685 Neurospora crassa 44.78 3.00e-24 105.00
IUUC-Nle-069655 Nomascus leucogenys 98.53 1.00e-153 535.00
IUUC-Opr-070234 Ochotona princeps 83.95 7.00e-30 124.00
IUUC-Ont-072484 Oreochromis niloticus 57.62 4.00e-103 368.00
IUUC-Ocu-074831 Oryctolagus cuniculus 83.90 8.00e-134 470.00
IUUC-Ogl-077067 Oryza glaberrima 33.56 2.00e-52 199.00
IUUC-Oin-079203 Oryza indica 33.64 2.00e-52 199.00
IUUC-Osa-085951 Oryza sativa 33.64 2.00e-52 199.00
IUUC-Ola-086540 Oryzias latipes 61.94 6.00e-64 238.00
IUUC-Olu-087843 Ostreococcus lucimarinus 42.79 9.00e-39 154.00
IUUC-Oga-088023 Otolemur garnettii 88.86 9.00e-138 483.00
IUUC-Oar-089964 Ovis aries 92.51 8.00e-118 417.00
IUUC-Ptr-091165 Pan troglodytes 99.48 2.00e-133 468.00
IUUC-Pan-092009 Papio anubis 98.54 1.00e-153 535.00
IUUC-Psi-093477 Pelodiscus sinensis 77.47 7.00e-111 394.00
IUUC-Ppa-095964 Physcomitrella patens 43.61 1.00e-27 117.00
IUUC-Pfo-097385 Poecilia formosa 58.84 1.00e-101 363.00
IUUC-Pab-097868 Pongo abelii 100.00 2.00e-104 372.00
IUUC-Pop-099642 Populus trichocarpa 35.68 1.00e-55 210.00
IUUC-Pca-100652 Procavia capensis 97.00 2.00e-70 259.00
IUUC-Pva-102137 Pteropus vampyrus 98.77 5.00e-99 354.00
IUUC-Ptt-103717 Puccinia triticina 45.93 2.00e-25 110.00
IUUC-Pte-104303 Pyrenophora teres 50.00 8.00e-20 91.30
IUUC-Pyt-104580 Pyrenophora triticirepentis 50.00 1.00e-19 90.90
IUUC-Rno-104844 Rattus norvegicus 88.46 1.00e-150 526.00
IUUC-Sce-106214 Saccharomyces cerevisiae 35.77 5.00e-13 68.90
IUUC-Sha-107073 Sarcophilus harrisii 84.36 2.00e-109 389.00
IUUC-Spo-108298 Schizosaccharomyces pombe 42.04 6.00e-38 151.00
IUUC-Ssl-108382 Sclerotinia sclerotiorum 43.75 6.00e-17 81.60
IUUC-Stu-112054 Solanum tuberosum 34.02 2.00e-55 209.00
IUUC-Sar-112925 Sorex araneus 88.76 3.00e-90 325.00
IUUC-Sre-114894 Sporisorium reilianum 51.61 4.00e-11 62.80
IUUC-Ssc-116329 Sus scrofa 95.11 1.00e-137 483.00
IUUC-Tgu-116918 Taeniopygia guttata 75.43 4.00e-133 468.00
IUUC-Tru-118651 Takifugu rubripes 53.40 9.00e-97 347.00
IUUC-Tsy-118836 Tarsius syrichta 99.26 5.00e-49 188.00
IUUC-Tca-121594 Theobroma cacao 34.99 2.00e-51 196.00
IUUC-Tvi-122617 Trichoderma virens 52.56 2.00e-18 86.70
IUUC-Tme-127092 Tuber melanosporum 37.66 2.00e-27 116.00
IUUC-Tbe-127493 Tupaia belangeri 83.70 3.00e-72 265.00
IUUC-Ttr-128464 Tursiops truncatus 97.74 5.00e-101 361.00
IUUC-Uma-129484 Ustilago maydis 47.54 1.00e-11 64.70
IUUC-Vpa-130357 Vicugna pacos 88.00 3.00e-89 322.00
IUUC-Vvi-131039 Vitis vinifera 37.65 8.00e-40 157.00
IUUC-Xtr-132679 Xenopus tropicalis 71.90 4.00e-108 385.00
IUUC-Xma-133503 Xiphophorus maculatus 56.42 4.00e-104 371.00
IUUC-Yli-134615 Yarrowia lipolytica 41.67 4.00e-36 145.00
IUUC-Zma-135929 Zea mays 30.34 4.00e-50 192.00
Created Date 25-Jun-2017

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