iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Smo-109213

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

GL377592

Gene Name

AXR1-1; SELMODRAFT_103350

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SELMODRAFT_103350	EFJ23460	EFJ23460

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	8.70e-90	302.6	26	533

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveaheesitele 101
           YDRQ+r+wGe++q +l++a+v+l+++g++G+E lKnLvl+G+g++t vD+  v+ s+l+++FL++ae+ g+++A++ a+ l+e+n++v ++    s++ l 
   Q: 26   YDRQLRIWGEHGQGALEQASVCLLNCGATGSEALKNLVLGGIGNVTAVDGGLVQESDLGNNFLLSAENLGQPRAKSMAALLQEMNDSVLIDHIDASPESLL 126
           ***************************************************************************************************** PP
   S: 102  eeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlketpn.........aaehtiew 189
           ++++ Ff +f++V+++++   +   ++++c+  +v l+ ++++Gl G+vr++++++ +++s++d    ++++  P+++l  ++           ++++i+ 
   Q: 127  DSDPgFFARFTLVIATQMRDRSLVILDEVCRRFSVMLLVARSYGLTGYVRISLREHAVIESKPDntvSDLRLHRPWPELTTFVKefnletedsLVHKHIPF 227
           **********************************************************************************77777888888******** PP
   S: 190  avlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfecdivtkskspfwv............... 274
           a ++ k+ ee+++++ ++ +++++e +e+k +v s+ +++de+n++ea+++a k +++ + +s +k +l++   + v +s+s+fw+               
   Q: 228  AIILLKVCEEWRSKHGGALPSTTKERSEFKSLVASKKQAQDEDNYKEAVAAASKVWSPPSLSSeVKAILED-GAADVDSSSSDFWIlvaalkgfvaseggg 327
           *************************************************************999*******.55677************************ PP
   S: 275  ............................................................sfcsnaealqvp............ekvekdeevvkasap.. 301
                                                                        fc+n++ l+v             e ++k ++++  + +  
   Q: 328  efpldgaipdmhsfteyyillqrcyqakaesdvsaveahvrsilsqlgrdpdsisraaikHFCKNSRNLRVLrysslaeelglkEVGAKLQKYLPFEGDna 428
           ************************************************************99999999995555555554444444455444443333366 PP
   S: 302  ...lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknff 399
              +yl++ra++rf+++ gr pg +  e  +++a +l + +a   a ++g+ + ++++++ e+++++ ++i+ + avvgG+a+qE+iK+v+++f+p   ++
   Q: 429  nyaIYLMFRAVDRFAEEFGRFPGAMADETVEEDAAKLGA-IAHKLAGEIGVDGGVSEEFVYEFSRFGGGEIHCVGAVVGGIASQEAIKLVTKQFTPTAGTL 528
           789*******************87766666665555555.555667****************************************************999 PP
   S: 400  lfdae 404
           +++a+
   Q: 529  IYNAI 533
           99985 PP

Organism

Selaginella moellendorffii

Functional Description
(View)

Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.

Protein Sequence
(Fasta)

MAHANGGSGD EQKKAAAAAA TRSNKYDRQL RIWGEHGQGA LEQASVCLLN CGATGSEALK 60
NLVLGGIGNV TAVDGGLVQE SDLGNNFLLS AENLGQPRAK SMAALLQEMN DSVLIDHIDA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGCACG CCAATGGCGG CAGCGGCGAC GAGCAAAAGA AGGCGGCGGC GGCGGCGGCG 60
ACGAGGAGCA ACAAGTATGA TCGGCAGCTC CGGATTTGGG GTGAGCACGG GCAAGGCGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

KEGG

smo:SELMODRAFT_103350

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007900	Ashbya gossypii	27.37	4.00e-37	148.00
IUUC-Bgr-012111	Blumeria graminis	32.71	2.00e-61	228.00
IUUC-Cpo-022248	Cavia porcellus	35.82	3.00e-63	235.00
IUUC-Dse-031536	Dothistroma septosporum	34.59	9.00e-79	286.00
IUUC-Ggr-040005	Gaeumannomyces graminis	36.96	2.00e-60	226.00
IUUC-Kpa-049309	Komagataella pastoris	35.69	4.00e-77	281.00
IUUC-Mor-057230	Magnaporthe oryzae	32.16	2.00e-65	242.00
IUUC-Mpo-057514	Magnaporthe poae	32.35	1.00e-63	236.00
IUUC-Pno-095084	Phaeosphaeria nodorum	31.37	2.00e-64	240.00
IUUC-Pca-100807	Procavia capensis	49.20	7.00e-51	193.00
IUUC-Sce-106397	Saccharomyces cerevisiae	26.64	2.00e-34	139.00
IUUC-Sha-106770	Sarcophilus harrisii	46.36	4.00e-68	250.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.44	7.00e-74	270.00
IUUC-Tvi-122672	Trichoderma virens	33.82	6.00e-71	260.00
IUUC-Vda-129989	Verticillium dahliae	30.80	1.00e-54	206.00
IUUC-Yli-134505	Yarrowia lipolytica	33.01	8.00e-80	290.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence