iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pab-097586

Ensembl Protein ID

ENSPPYP00000015661.1

UniProt Accession

Q5RAW8; WDR48_PONAB

Genbank Protein ID

CAH91092.1

Protein Name

WD repeat-containing protein 48; USP1-associated factor 1

Genbank Nucleotide ID

CR858893

Gene Name

WDR48; UAF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000014001.1	ENSPPYT00000016282.1	ENSPPYP00000015661.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.50e-33	111.9	208	245
UBD/Beta-Prp	1.90e-47	162.0	30	294
ULD/UBL/SUMO	2.60e-63	210.8	559	666
ULD/UDP/UFD/RAWUL	1.10e-23	83.6	568	673

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gHtd v +l +  d t  +sGs Dgti++W+l +++++
   Q: 208  GHTDNVKALLLnRDgTQCLSGSSDGTIRLWSLGQQRCI 245
           8********88*888*****************999997 PP

UBD/Beta-Prp

   S: 10   ksvitcvkfspdksllatgsrdgtikvwdvttgkl...lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghed 95
            + +++++  p  + l+t++rd+ i++w+v + k    ++s++ h++ v+++ +  +gk+l+++s+D t+kvw+  +g c++tl+ h+d
   Q: 30   RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKD 118
           556677888899999*****************999999*************************************************** PP
   S: 96   svlslsfspsgdklvsGshdrtirvwdletgqclee........tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtlt 176
           +v +l++ ++++ ++s++ dr i +wd++t + l +         lsg+++++ ++++++ g ++vsGs+ +++r+Wd +t   l +l+
   Q: 119  YVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTAsnntvttsSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLK 207
           **********************************999********************************************99999**9 PP
   S: 177  gghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhn 264
           g htd v+ l ++++g++++sgs dgt++lw+l +++c+ t++ h++ v+ +++ +  ++++sg+ D+ i++ dlr+ d+   +  ++
   Q: 208  G-HTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEK 294
           9.************************************************************************99988766665555 PP

ULD/UBL/SUMO

   S: 1    eskffkapvslkvagqdGsevlfklklsa....qlkklmeavYvkrinldensvrfv.fngqkireqetpeelevededkiellcq... 81
           ++kf+k+p++l++++++G+++l+k++lsa    q++k+me+vY+k+inld++s++++ +n++k++eqe++e+++v++e+kiellcq   
   Q: 559  MPKFNKIPFYLQPHASSGAKTLKKDRLSAsdmlQVRKVMEHVYEKIINLDNESQTTSsSNNEKPGEQEKEEDIAVLAEEKIELLCQdqv 647
           8********************************************************9****************************777 PP
   S: 82   ...............ksGG 85
                          ksGG
   Q: 648  ldpnmdlrtvkhfiwKSGG 666
           7777777777777777776 PP

ULD/UDP/UFD/RAWUL

   S: 4    sLeplesnkakddsklkkkylrcsarltVkhlkkflaeklkl........sssy.....................evdllcedevLedn 63
            L+p++s++ak+   lkk++l++s++l+V++++++++ek+++        s                        +++llc+d+vL++n
   Q: 568  YLQPHASSGAKT---LKKDRLSASDMLQVRKVMEHVYEKIINldnesqttS--SsnnekpgeqekeediavlaeeKIELLCQDQVLDPN 651
           69**********...*************************99988766653..045799999999************************ PP
   S: 64   etLeeikyifiwkkegpLvLqYr 86
           ++L+++ ++fiwk++g+L+L+Yr
   Q: 652  MDLRTV-KHFIWKSGGDLTLHYR 673
           ******.***************9 PP

Organism

Pongo abelii

Functional Description
(View)

Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes.

Protein Sequence
(Fasta)

MAAHHRQNTA GRRKVQVSYV IRDEVEKYNR NGVNALQLDP ALNRLFTAGR DSIIRIWSVN 60
QHKQDPYIAS MEHHTDWVND IVLCCNGKTL ISASSDTTVK VWNAHKGFCM STLRTHKDYV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGTGTCAA CATGCAAGAT GGCGGCCCAT CACCGGCAGA ACACAGCAGG GCGGAGGAAA 60
GTGCAGGTAT GGAAGCCCGG TTCCTCGGTC TTCCGGACGC GGTTGGCAGC TCCGGGCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0458--Lysosome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR021772--DUF3337
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF11816--DUF3337
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005770--C:late endosome
GO:0005764--C:lysosome
GO:0005634--C:nucleus
GO:0000724--P:double-strand break repair via homologous recombination
GO:0048568--P:embryonic organ development
GO:0048872--P:homeostasis of number of cells
GO:0035264--P:multicellular organism growth
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0016579--P:protein deubiquitination
GO:1902525--P:regulation of protein monoubiquitination
GO:0072520--P:seminiferous tubule development
GO:0007338--P:single fertilization
GO:0048705--P:skeletal system morphogenesis
GO:0043588--P:skin development
GO:0007283--P:spermatogenesis

KEGG

pon:100172554

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001160	Aegilops tauschii	40.24	2.00e-97	350.00
IUUC-Aml-001533	Ailuropoda melanoleuca	99.41	0.00e+00	1272.00
IUUC-Atr-003009	Amborella trichopoda	33.73	2.00e-110	393.00
IUUC-Apl-003709	Anas platyrhynchos	97.96	0.00e+00	662.00
IUUC-Aca-004875	Anolis carolinensis	97.93	0.00e+00	1297.00
IUUC-Aly-005464	Arabidopsis lyrata	39.57	1.00e-93	337.00
IUUC-Ath-006969	Arabidopsis thaliana	38.98	6.00e-90	325.00
IUUC-Acl-008203	Aspergillus clavatus	35.40	2.00e-47	184.00
IUUC-Afl-008571	Aspergillus flavus	35.33	4.00e-46	180.00
IUUC-Afu-009072	Aspergillus fumigatus	34.73	8.00e-45	176.00
IUUC-Ani-009413	Aspergillus nidulans	35.85	3.00e-47	183.00
IUUC-Ang-009571	Aspergillus niger	35.02	6.00e-45	176.00
IUUC-Aor-010064	Aspergillus oryzae	35.33	2.00e-46	181.00
IUUC-Ate-010463	Aspergillus terreus	34.73	6.00e-46	179.00
IUUC-Ame-010875	Astyanax mexicanus	94.56	0.00e+00	1094.00
IUUC-Bgr-012288	Blumeria graminis	34.31	5.00e-42	166.00
IUUC-Bta-013379	Bos taurus	99.70	0.00e+00	1275.00
IUUC-Bci-013859	Botrytis cinerea	32.39	2.00e-41	164.00
IUUC-Bdi-014645	Brachypodium distachyon	34.98	2.00e-112	400.00
IUUC-Bol-015551	Brassica oleracea	34.53	2.00e-105	377.00
IUUC-Bra-017237	Brassica rapa	33.92	9.00e-102	364.00
IUUC-Cel-018656	Caenorhabditis elegans	44.46	8.00e-155	540.00
IUUC-Cja-018804	Callithrix jacchus	99.41	0.00e+00	1271.00
IUUC-Cfa-020076	Canis familiaris	99.85	0.00e+00	1277.00
IUUC-Cpo-021721	Cavia porcellus	98.19	0.00e+00	1220.00
IUUC-Cre-022779	Chlamydomonas reinhardtii	31.28	5.00e-41	163.00
IUUC-Csa-023188	Chlorocebus sabaeus	99.85	0.00e+00	1277.00
IUUC-Cho-024932	Choloepus hoffmanni	98.67	0.00e+00	1281.00
IUUC-Cin-025591	Ciona intestinalis	56.71	0.00e+00	724.00
IUUC-Cgl-026540	Colletotrichum gloeosporioides	27.64	2.00e-20	94.70
IUUC-Cne-026819	Cryptococcus neoformans	35.53	2.00e-34	141.00
IUUC-Cme-027188	Cyanidioschyzon merolae	32.72	6.00e-72	265.00
IUUC-Dre-027926	Danio rerio	92.61	0.00e+00	1270.00
IUUC-Dno-029960	Dasypus novemcinctus	98.97	0.00e+00	1266.00
IUUC-Dor-030933	Dipodomys ordii	94.76	0.00e+00	710.00
IUUC-Dse-031532	Dothistroma septosporum	35.07	8.00e-46	179.00
IUUC-Dme-032168	Drosophila melanogaster	56.68	0.00e+00	683.00
IUUC-Ete-033107	Echinops telfairi	95.27	0.00e+00	1202.00
IUUC-Eca-034028	Equus caballus	99.70	0.00e+00	1276.00
IUUC-Eeu-034894	Erinaceus europaeus	96.61	0.00e+00	847.00
IUUC-Fca-035619	Felis catus	99.80	0.00e+00	952.00
IUUC-Fal-036869	Ficedula albicollis	98.04	0.00e+00	1265.00
IUUC-Fox-037907	Fusarium oxysporum	32.77	2.00e-41	164.00
IUUC-Fso-038101	Fusarium solani	33.05	8.00e-41	162.00
IUUC-Gmo-038627	Gadus morhua	94.98	0.00e+00	1291.00
IUUC-Ggr-039995	Gaeumannomyces graminis	31.09	5.00e-42	166.00
IUUC-Gga-040555	Gallus gallus	98.23	0.00e+00	1296.00
IUUC-Gac-042497	Gasterosteus aculeatus	94.68	0.00e+00	1261.00
IUUC-Gma-043089	Glycine max	34.16	3.00e-110	392.00
IUUC-Ggo-045561	Gorilla gorilla	99.85	0.00e+00	1277.00
IUUC-Hsa-045710	Homo sapiens	99.85	0.00e+00	1277.00
IUUC-Hvu-047730	Hordeum vulgare	35.65	2.00e-84	306.00
IUUC-Itr-049030	Ictidomys tridecemlineatus	99.79	0.00e+00	903.00
IUUC-Kpa-049237	Komagataella pastoris	30.98	2.00e-30	127.00
IUUC-Lch-049507	Latimeria chalumnae	97.05	0.00e+00	1266.00
IUUC-Lpe-051608	Leersia perrieri	35.24	5.00e-110	392.00
IUUC-Loc-052373	Lepisosteus oculatus	93.67	0.00e+00	1251.00
IUUC-Lma-053025	Leptosphaeria maculans	36.45	2.00e-48	188.00
IUUC-Laf-053706	Loxodonta africana	99.09	0.00e+00	1240.00
IUUC-Mcc-055046	Macaca mulatta	99.85	0.00e+00	1277.00
IUUC-Meu-056840	Macropus eugenii	80.12	3.00e-149	521.00
IUUC-Mor-057284	Magnaporthe oryzae	31.74	1.00e-43	171.00
IUUC-Mpo-057418	Magnaporthe poae	30.81	8.00e-41	162.00
IUUC-Mtr-058571	Medicago truncatula	34.82	2.00e-109	390.00
IUUC-Mla-059101	Melampsora laricipopulina	45.10	2.00e-45	178.00
IUUC-Mga-059297	Meleagris gallopavo	98.23	0.00e+00	1296.00
IUUC-Mvi-060419	Microbotryum violaceum	37.01	3.00e-38	154.00
IUUC-Mmr-061196	Microcebus murinus	92.93	0.00e+00	1148.00
IUUC-Mdo-062762	Monodelphis domestica	94.60	0.00e+00	1282.00
IUUC-Mmu-063915	Mus musculus	98.67	0.00e+00	1295.00
IUUC-Mac-065434	Musa acuminata	34.71	4.00e-106	379.00
IUUC-Mpu-065999	Mustela putorius furo	99.30	0.00e+00	845.00
IUUC-Mlu-068226	Myotis lucifugus	99.41	0.00e+00	1269.00
IUUC-Nfi-068416	Neosartorya fischeri	29.56	3.00e-55	210.00
IUUC-Ncr-068825	Neurospora crassa	31.34	1.00e-39	158.00
IUUC-Nle-069416	Nomascus leucogenys	99.85	0.00e+00	1277.00
IUUC-Opr-070515	Ochotona princeps	95.13	0.00e+00	1199.00
IUUC-Ont-072052	Oreochromis niloticus	92.36	0.00e+00	1200.00
IUUC-Oan-073636	Ornithorhynchus anatinus	94.71	0.00e+00	1254.00
IUUC-Ocu-074799	Oryctolagus cuniculus	99.70	0.00e+00	1274.00
IUUC-Oba-075146	Oryza barthii	35.37	7.00e-111	394.00
IUUC-Obr-076699	Oryza brachyantha	35.09	1.00e-111	397.00
IUUC-Ogl-077883	Oryza glaberrima	33.67	3.00e-67	249.00
IUUC-Ogu-078114	Oryza glumaepatula	35.38	5.00e-110	391.00
IUUC-Oin-079575	Oryza indica	35.39	9.00e-114	404.00
IUUC-Olo-080531	Oryza longistaminata	32.95	6.00e-100	358.00
IUUC-Ome-081368	Oryza meridionalis	40.87	2.00e-98	353.00
IUUC-Oni-082457	Oryza nivara	35.37	5.00e-111	395.00
IUUC-Opu-084050	Oryza punctata	35.24	7.00e-110	391.00
IUUC-Oru-084330	Oryza rufipogon	35.37	8.00e-111	394.00
IUUC-Osa-085408	Oryza sativa	35.39	9.00e-114	404.00
IUUC-Ola-087546	Oryzias latipes	94.30	0.00e+00	1263.00
IUUC-Olu-087710	Ostreococcus lucimarinus	31.39	3.00e-80	293.00
IUUC-Oga-087998	Otolemur garnettii	98.37	0.00e+00	1249.00
IUUC-Oar-090303	Ovis aries	99.70	0.00e+00	1275.00
IUUC-Ptr-090588	Pan troglodytes	99.85	0.00e+00	1277.00
IUUC-Pan-092722	Papio anubis	99.85	0.00e+00	1277.00
IUUC-Psi-093911	Pelodiscus sinensis	97.65	0.00e+00	1296.00
IUUC-Pma-094580	Petromyzon marinus	88.04	0.00e+00	1183.00
IUUC-Pno-095085	Phaeosphaeria nodorum	35.03	2.00e-43	171.00
IUUC-Ppa-095594	Physcomitrella patens	35.71	3.00e-113	402.00
IUUC-Pfo-096994	Poecilia formosa	94.43	0.00e+00	1258.00
IUUC-Pop-099740	Populus trichocarpa	34.51	2.00e-103	369.00
IUUC-Pca-100458	Procavia capensis	98.56	1.00e-106	380.00
IUUC-Ppe-102060	Prunus persica	34.11	2.00e-108	386.00
IUUC-Pva-102698	Pteropus vampyrus	94.98	0.00e+00	1258.00
IUUC-Pgr-103649	Puccinia graminis	34.42	4.00e-48	187.00
IUUC-Ptt-103910	Puccinia triticina	43.90	3.00e-53	204.00
IUUC-Pte-104181	Pyrenophora teres	36.45	2.00e-48	188.00
IUUC-Pyt-104439	Pyrenophora triticirepentis	36.14	5.00e-48	186.00
IUUC-Rno-104978	Rattus norvegicus	98.79	0.00e+00	1264.00
IUUC-Sha-107079	Sarcophilus harrisii	96.88	0.00e+00	1205.00
IUUC-Sja-107716	Schizosaccharomyces japonicus	30.36	2.00e-58	221.00
IUUC-Spo-108325	Schizosaccharomyces pombe	30.06	2.00e-51	197.00
IUUC-Ssl-108542	Sclerotinia sclerotiorum	29.04	2.00e-45	177.00
IUUC-Smo-109427	Selaginella moellendorffii	35.18	6.00e-110	391.00
IUUC-Sit-110755	Setaria italica	36.80	2.00e-115	409.00
IUUC-Sly-111099	Solanum lycopersicum	35.16	5.00e-98	352.00
IUUC-Sar-113408	Sorex araneus	99.49	0.00e+00	768.00
IUUC-Sbi-113789	Sorghum bicolor	35.40	6.00e-112	398.00
IUUC-Sre-114998	Sporisorium reilianum	39.93	4.00e-52	200.00
IUUC-Ssc-115434	Sus scrofa	99.85	0.00e+00	1277.00
IUUC-Tgu-116517	Taeniopygia guttata	98.23	0.00e+00	1300.00
IUUC-Tru-118174	Takifugu rubripes	94.85	0.00e+00	1266.00
IUUC-Tsy-118935	Tarsius syrichta	99.56	0.00e+00	1303.00
IUUC-Tni-119744	Tetraodon nigroviridis	95.27	0.00e+00	1234.00
IUUC-Tca-121360	Theobroma cacao	34.11	3.00e-112	399.00
IUUC-Tre-122198	Trichoderma reesei	32.57	3.00e-43	170.00
IUUC-Tvi-122389	Trichoderma virens	32.57	3.00e-43	170.00
IUUC-Tae-125576	Triticum aestivum	35.51	3.00e-113	402.00
IUUC-Tur-126699	Triticum urartu	35.28	1.00e-110	394.00
IUUC-Tme-126932	Tuber melanosporum	31.09	3.00e-54	207.00
IUUC-Tbe-127267	Tupaia belangeri	85.21	0.00e+00	736.00
IUUC-Ttr-129153	Tursiops truncatus	99.26	0.00e+00	1306.00
IUUC-Uma-129604	Ustilago maydis	41.26	5.00e-50	193.00
IUUC-Vda-129925	Verticillium dahliae	34.78	6.00e-46	179.00
IUUC-Vpa-130553	Vicugna pacos	99.24	0.00e+00	983.00
IUUC-Vvi-130995	Vitis vinifera	33.98	1.00e-107	384.00
IUUC-Xtr-132346	Xenopus tropicalis	94.25	0.00e+00	1237.00
IUUC-Xma-134266	Xiphophorus maculatus	93.18	0.00e+00	671.00
IUUC-Yli-134451	Yarrowia lipolytica	31.19	2.00e-35	144.00
IUUC-Zma-135647	Zea mays	35.66	2.00e-113	402.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence