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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046520
Ensembl Protein ID ENSP00000484956.1
UniProt Accession Q9Y2M0; A8K4M2; Q86WU8; FAN1_HUMAN
Genbank Protein ID BAA76862.3; BAF83676.1; AAH47882.1
Protein Name Fanconi-associated nuclease 1; FANCD2/FANCI-associated nuclease 1; Myotubularin-related protein 15
Genbank Nucleotide ID AB023235; AK290987; AC087481
Gene Name FAN1; KIAA1018; MTMR15
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000276787.1 ENST00000621063.1 ENSP00000484956.1
Annotation
DNA & RNA Element
circRNADbCircNet
Protein-protein Interaction
IIDiRefIndexMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
PhosphositePlusUniProt
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/ZnF/UBZ UBZ 20935496
Classification
Family E-value Score Start End
UBD/ZnF/UBZ 6.30e-09 37.5 41 64
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/ZnF/UBZ
   S: 1    llvCPvCqkmvdqtdfeeHlDe.C 23
           +l CPvC+kmv+++d+++HlDe C
   Q: 41   KLACPVCSKMVPRYDLNRHLDEmC 64
           689******************988 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866).
 Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866).
Protein Sequence
(Fasta)
MMSEGKPPDK KRPRRSLSIS KNKKKASNSI ISCFNNAPPA KLACPVCSKM VPRYDLNRHL 60
DEMCANNDFV QVDPGQVGLI NSNVSMVDLT SVTLEDVTPK KSPPPKTNLT PGQSDSAKRE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046520|UBD,UBZ|Homo sapiens
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Nucleotide Sequence
(Fasta)
GGCGCGCGGA GCCAGGTGGG AGGTGCGAGG TGGCCGCGCG GGGATCTTGG GTGACAGGGC 60
ACCGAGGGAA GGAGGACGCG AGGGCAGCCA GGCCCTAGGG AGCAGGGAGA GTGGCTCGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046520|UBD,UBZ|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0227--DNA damage
KW-0234--DNA repair
KW-0255--Endonuclease
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0460--Magnesium
KW-0464--Manganese
KW-0479--Metal-binding
KW-0540--Nuclease
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR033315--Fan1-like
IPR011990--TPR-like_helical_dom
IPR014883--VRR_NUC
IPR006642--Znf_Rad18_put
Pfam

PF08774--VRR_NUC
SMART

SM00990--VRR_NUC
SM00734--ZnF_Rad18
Gene Ontology

GO:0005829--C:cytosol
GO:0045171--C:intercellular bridge
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0008409--F:5'-3' exonuclease activity
GO:0017108--F:5'-flap endonuclease activity
GO:0070336--F:flap-structured DNA binding
GO:0000287--F:magnesium ion binding
GO:0004528--F:phosphodiesterase I activity
GO:0043130--F:ubiquitin binding
GO:0006281--P:DNA repair
GO:0000724--P:double-strand break repair via homologous recombination
GO:0036297--P:interstrand cross-link repair
GO:0006289--P:nucleotide-excision repair
GO:0033683--P:nucleotide-excision repair, DNA incision
KEGG hsa:22909
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000306 Aegilops tauschii 34.78 1.00e-58 220.00
IUUC-Aml-001380 Ailuropoda melanoleuca 78.70 0.00e+00 1585.00
IUUC-Atr-002873 Amborella trichopoda 31.11 1.00e-78 288.00
IUUC-Apl-003430 Anas platyrhynchos 53.75 0.00e+00 949.00
IUUC-Aca-005376 Anolis carolinensis 50.49 0.00e+00 875.00
IUUC-Aly-005463 Arabidopsis lyrata 29.94 4.00e-69 256.00
IUUC-Ath-007392 Arabidopsis thaliana 30.26 5.00e-72 266.00
IUUC-Acl-008285 Aspergillus clavatus 25.87 2.00e-55 210.00
IUUC-Afl-008680 Aspergillus flavus 27.53 2.00e-60 227.00
IUUC-Afu-008795 Aspergillus fumigatus 26.76 2.00e-52 201.00
IUUC-Ani-009329 Aspergillus nidulans 26.67 4.00e-52 199.00
IUUC-Ang-009526 Aspergillus niger 25.75 5.00e-45 176.00
IUUC-Aor-009880 Aspergillus oryzae 27.53 8.00e-60 225.00
IUUC-Ate-010269 Aspergillus terreus 27.14 2.00e-59 224.00
IUUC-Ame-011630 Astyanax mexicanus 60.00 6.00e-176 611.00
IUUC-Bgr-012168 Blumeria graminis 24.36 2.00e-35 144.00
IUUC-Bta-013504 Bos taurus 71.56 0.00e+00 1368.00
IUUC-Bci-013838 Botrytis cinerea 24.31 2.00e-50 194.00
IUUC-Bdi-014522 Brachypodium distachyon 30.78 6.00e-68 253.00
IUUC-Bol-016153 Brassica oleracea 30.88 2.00e-72 267.00
IUUC-Bra-017548 Brassica rapa 29.29 1.00e-61 231.00
IUUC-Cel-018711 Caenorhabditis elegans 29.94 1.00e-64 241.00
IUUC-Cja-018810 Callithrix jacchus 89.81 0.00e+00 1726.00
IUUC-Cfa-020147 Canis familiaris 78.62 0.00e+00 1580.00
IUUC-Cpo-021787 Cavia porcellus 72.51 0.00e+00 1437.00
IUUC-Cre-022863 Chlamydomonas reinhardtii 45.45 6.00e-03 32.70
IUUC-Csa-023730 Chlorocebus sabaeus 95.38 0.00e+00 1877.00
IUUC-Cho-024754 Choloepus hoffmanni 73.27 3.00e-128 452.00
IUUC-Cin-025459 Ciona intestinalis 47.34 2.00e-40 158.00
IUUC-Cgl-026724 Colletotrichum gloeosporioides 25.61 8.00e-42 165.00
IUUC-Cne-026815 Cryptococcus neoformans 26.06 7.00e-35 142.00
IUUC-Cme-027208 Cyanidioschyzon merolae 32.14 4.00e-24 106.00
IUUC-Dre-027725 Danio rerio 60.28 0.00e+00 761.00
IUUC-Dno-029713 Dasypus novemcinctus 75.39 0.00e+00 1531.00
IUUC-Dse-031534 Dothistroma septosporum 24.65 2.00e-39 157.00
IUUC-Dme-032015 Drosophila melanogaster 32.04 5.20e-02 32.30
IUUC-Ete-033004 Echinops telfairi 62.89 0.00e+00 921.00
IUUC-Eca-034119 Equus caballus 80.39 0.00e+00 1583.00
IUUC-Eeu-034618 Erinaceus europaeus 64.62 0.00e+00 1209.00
IUUC-Fca-035411 Felis catus 79.94 0.00e+00 1627.00
IUUC-Fal-037505 Ficedula albicollis 66.62 0.00e+00 847.00
IUUC-Fox-038070 Fusarium oxysporum 25.80 2.00e-50 194.00
IUUC-Fso-038376 Fusarium solani 26.83 2.00e-51 197.00
IUUC-Gmo-039093 Gadus morhua 60.40 0.00e+00 753.00
IUUC-Ggr-040081 Gaeumannomyces graminis 26.35 5.00e-48 186.00
IUUC-Gac-041973 Gasterosteus aculeatus 60.69 0.00e+00 807.00
IUUC-Gma-043421 Glycine max 30.47 4.00e-74 273.00
IUUC-Ggo-044431 Gorilla gorilla 99.02 0.00e+00 1969.00
IUUC-Hvu-047632 Hordeum vulgare 31.67 3.00e-77 283.00
IUUC-Itr-048263 Ictidomys tridecemlineatus 79.24 0.00e+00 1579.00
IUUC-Kpa-049398 Komagataella pastoris 29.23 3.40e-02 30.80
IUUC-Lch-049799 Latimeria chalumnae 52.61 0.00e+00 1009.00
IUUC-Lpe-051149 Leersia perrieri 31.50 1.00e-82 301.00
IUUC-Loc-051964 Lepisosteus oculatus 50.19 0.00e+00 865.00
IUUC-Lma-053161 Leptosphaeria maculans 26.58 1.00e-53 205.00
IUUC-Laf-054446 Loxodonta africana 75.73 0.00e+00 1502.00
IUUC-Mcc-055087 Macaca mulatta 94.89 0.00e+00 1867.00
IUUC-Meu-055930 Macropus eugenii 69.42 0.00e+00 682.00
IUUC-Mor-056966 Magnaporthe oryzae 28.57 2.00e-48 187.00
IUUC-Mpo-057393 Magnaporthe poae 27.34 4.00e-42 166.00
IUUC-Mtr-058315 Medicago truncatula 31.53 1.00e-75 278.00
IUUC-Mla-058859 Melampsora laricipopulina 25.25 5.00e-36 146.00
IUUC-Mga-059870 Meleagris gallopavo 67.45 0.00e+00 898.00
IUUC-Mvi-060226 Microbotryum violaceum 28.10 5.00e-51 196.00
IUUC-Mmr-060892 Microcebus murinus 83.51 0.00e+00 1622.00
IUUC-Mdo-062896 Monodelphis domestica 60.21 0.00e+00 1193.00
IUUC-Mmu-064276 Mus musculus 71.29 0.00e+00 1449.00
IUUC-Mac-064503 Musa acuminata 30.93 1.00e-68 254.00
IUUC-Mpu-066820 Mustela putorius furo 77.10 0.00e+00 1557.00
IUUC-Mlu-068131 Myotis lucifugus 67.80 0.00e+00 1285.00
IUUC-Nfi-068480 Neosartorya fischeri 26.09 1.00e-52 201.00
IUUC-Ncr-068646 Neurospora crassa 26.70 1.00e-55 211.00
IUUC-Nle-069545 Nomascus leucogenys 94.30 0.00e+00 1893.00
IUUC-Opr-070722 Ochotona princeps 84.32 0.00e+00 876.00
IUUC-Ont-072561 Oreochromis niloticus 49.26 0.00e+00 887.00
IUUC-Oan-072811 Ornithorhynchus anatinus 58.95 0.00e+00 1149.00
IUUC-Ocu-073884 Oryctolagus cuniculus 74.54 0.00e+00 1493.00
IUUC-Oba-075112 Oryza barthii 30.16 1.00e-62 235.00
IUUC-Obr-076057 Oryza brachyantha 32.43 6.00e-81 296.00
IUUC-Ogl-077002 Oryza glaberrima 32.24 1.00e-73 271.00
IUUC-Ogu-078683 Oryza glumaepatula 31.01 3.00e-61 230.00
IUUC-Oin-079952 Oryza indica 30.78 2.00e-61 231.00
IUUC-Olo-080278 Oryza longistaminata 31.50 3.00e-61 230.00
IUUC-Ome-081094 Oryza meridionalis 31.62 1.00e-61 231.00
IUUC-Oni-083059 Oryza nivara 31.93 1.00e-61 231.00
IUUC-Opu-084144 Oryza punctata 31.20 5.00e-76 279.00
IUUC-Oru-084897 Oryza rufipogon 31.50 3.00e-61 230.00
IUUC-Osa-085924 Oryza sativa 31.74 2.00e-73 270.00
IUUC-Oga-088979 Otolemur garnettii 80.74 0.00e+00 1589.00
IUUC-Oar-090362 Ovis aries 71.49 0.00e+00 1425.00
IUUC-Ptr-090823 Pan troglodytes 99.02 0.00e+00 1969.00
IUUC-Pan-092863 Papio anubis 95.28 0.00e+00 1882.00
IUUC-Psi-093006 Pelodiscus sinensis 55.54 0.00e+00 1019.00
IUUC-Pma-094523 Petromyzon marinus 50.31 1.00e-132 466.00
IUUC-Pno-094770 Phaeosphaeria nodorum 26.39 6.00e-44 172.00
IUUC-Ppa-095372 Physcomitrella patens 31.88 5.00e-75 276.00
IUUC-Pfo-096875 Poecilia formosa 59.72 0.00e+00 778.00
IUUC-Pab-097665 Pongo abelii 97.42 0.00e+00 1905.00
IUUC-Pop-099082 Populus trichocarpa 30.77 3.00e-78 287.00
IUUC-Pca-100138 Procavia capensis 66.98 1.00e-121 431.00
IUUC-Ppe-101167 Prunus persica 28.02 6.00e-30 126.00
IUUC-Pva-103199 Pteropus vampyrus 62.18 2.00e-120 426.00
IUUC-Pgr-103480 Puccinia graminis 27.57 1.00e-44 176.00
IUUC-Ptt-103783 Puccinia triticina 30.99 2.00e-46 181.00
IUUC-Pte-104357 Pyrenophora teres 25.81 1.00e-39 158.00
IUUC-Pyt-104788 Pyrenophora triticirepentis 26.61 6.00e-46 179.00
IUUC-Rno-104958 Rattus norvegicus 69.88 0.00e+00 1382.00
IUUC-Sha-106828 Sarcophilus harrisii 59.01 0.00e+00 1232.00
IUUC-Sja-107731 Schizosaccharomyces japonicus 28.38 1.00e-45 177.00
IUUC-Spo-108086 Schizosaccharomyces pombe 24.82 3.00e-43 170.00
IUUC-Ssl-108610 Sclerotinia sclerotiorum 25.23 1.00e-47 184.00
IUUC-Smo-108690 Selaginella moellendorffii 34.06 2.00e-80 293.00
IUUC-Sit-110385 Setaria italica 36.18 2.00e-49 191.00
IUUC-Sly-111187 Solanum lycopersicum 32.22 2.00e-76 280.00
IUUC-Stu-112673 Solanum tuberosum 43.90 5.00e-32 130.00
IUUC-Sar-113548 Sorex araneus 56.83 0.00e+00 694.00
IUUC-Sbi-114131 Sorghum bicolor 37.02 9.00e-60 225.00
IUUC-Sre-114921 Sporisorium reilianum 38.46 8.00e-33 135.00
IUUC-Ssc-115484 Sus scrofa 77.17 0.00e+00 1506.00
IUUC-Tgu-116749 Taeniopygia guttata 64.52 0.00e+00 847.00
IUUC-Tru-118772 Takifugu rubripes 59.82 0.00e+00 741.00
IUUC-Tsy-119359 Tarsius syrichta 79.40 0.00e+00 1276.00
IUUC-Tni-120878 Tetraodon nigroviridis 48.49 0.00e+00 799.00
IUUC-Tca-120912 Theobroma cacao 31.66 1.00e-80 294.00
IUUC-Tre-122171 Trichoderma reesei 26.59 4.00e-57 216.00
IUUC-Tvi-122483 Trichoderma virens 27.96 4.00e-56 213.00
IUUC-Tae-125125 Triticum aestivum 31.48 4.00e-74 273.00
IUUC-Tur-126497 Triticum urartu 31.57 1.00e-73 271.00
IUUC-Tbe-127473 Tupaia belangeri 60.75 8.00e-89 321.00
IUUC-Ttr-128458 Tursiops truncatus 70.98 0.00e+00 1368.00
IUUC-Uma-129558 Ustilago maydis 40.00 4.00e-34 140.00
IUUC-Vda-129683 Verticillium dahliae 25.03 2.00e-48 187.00
IUUC-Vvi-131226 Vitis vinifera 35.52 2.00e-63 236.00
IUUC-Xtr-132517 Xenopus tropicalis 53.46 0.00e+00 734.00
IUUC-Xma-133763 Xiphophorus maculatus 59.41 0.00e+00 773.00
IUUC-Zma-135455 Zea mays 32.51 1.00e-80 295.00
Created Date 25-Jun-2017

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