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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063947
Ensembl Protein ID ENSMUSP00000038871.7
UniProt Accession Q6P1D7; SLX4_MOUSE
Genbank Protein ID AAH65125.1
Protein Name Structure-specific endonuclease subunit SLX4; BTB/POZ domain-containing protein 12
Genbank Nucleotide ID BC065125
Gene Name Slx4; Btbd12
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000039738.16 ENSMUST00000146569.7 ENSMUSP00000126423.1
ENSMUSG00000039738.16 ENSMUST00000040790.13 ENSMUSP00000038871.7
ENSMUSG00000039738.16 ENSMUST00000156542.7 ENSMUSP00000130007.1
ENSMUSG00000039738.16 ENSMUST00000165830.1 ENSMUSP00000126047.1
ENSMUSG00000039738.16 ENSMUST00000171762.1 ENSMUSP00000131380.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRAID2
Protein-protein Interaction
IIDHINTMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/ZnF/UBZ 2.20e-08 35.3 118 143
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/ZnF/UBZ
   S: 2    lvCPvCqkm...vdqtdfeeHlDeCl 24
           ++C++Cqk    +++t++e+H+++Cl
   Q: 118  FFCQMCQKNlsaMNVTRREQHVNRCL 143
           89***********************8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks (By similarity).
 Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks (By similarity).
Protein Sequence
(Fasta)
MVPESAPNGN SQPLPSCFTT TGVPSPSKPR VSELVLQRMK QFKRADPERL RHASEESPQK 60
TALGDDVPRS PPEETVGENE YKLDATDSDA AMALALQQEF RREEASSHHD SLEEKGLFFC 120
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Protein Fasta Sequence


>IUUC-Mmu-063947|UBD,UBZ|Mus musculus
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Nucleotide Sequence
(Fasta)
GCGGTTCTCC GTTAAGAAGG TGCGGCTGAA GCGCGGGAGG TAGGAGGAGC TCGGCATCGG 60
CCTAGAGTGT CCCGGTGCGG GGGAGTAGTG GTGGGGGTTG TCACTTCCCG CGGTTTCCCC 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063947|UBD,UBZ|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR018574--Structure-sp_endonuc_su_Slx4
PROSITE

PS50097--BTB
Pfam

PF00651--BTB
PF09494--Slx4
SMART

SM00225--BTB
Gene Ontology

GO:0030054--C:cell junction
GO:0000781--C:chromosome, telomeric region
GO:0005829--C:cytosol
GO:0070522--C:ERCC4-ERCC1 complex
GO:0048476--C:Holliday junction resolvase complex
GO:0000790--C:nuclear chromatin
GO:0000784--C:nuclear chromosome, telomeric region
GO:0005654--C:nucleoplasm
GO:0033557--C:Slx1-Slx4 complex
GO:0048257--F:3'-flap endonuclease activity
GO:0017108--F:5'-flap endonuclease activity
GO:0008821--F:crossover junction endodeoxyribonuclease activity
GO:0008047--F:enzyme activator activity
GO:0010792--P:DNA double-strand break processing involved in repair via single-strand annealing
GO:0006281--P:DNA repair
GO:0006260--P:DNA replication
GO:0000724--P:double-strand break repair via homologous recombination
GO:0036297--P:interstrand cross-link repair
GO:0000706--P:meiotic DNA double-strand break processing
GO:1904357--P:negative regulation of telomere maintenance via telomere lengthening
GO:0006289--P:nucleotide-excision repair
GO:1904431--P:positive regulation of t-circle formation
GO:0000712--P:resolution of meiotic recombination intermediates
GO:0072429--P:response to intra-S DNA damage checkpoint signaling
GO:0090656--P:t-circle formation
GO:0061820--P:telomeric D-loop disassembly
GO:0090657--P:telomeric loop disassembly
KEGG mmu:52864
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001225 Ailuropoda melanoleuca 55.78 0.00e+00 1312.00
IUUC-Apl-003261 Anas platyrhynchos 39.54 2.00e-166 580.00
IUUC-Aca-004455 Anolis carolinensis 59.42 5.00e-18 82.00
IUUC-Ame-010993 Astyanax mexicanus 39.86 4.00e-14 71.20
IUUC-Bta-013472 Bos taurus 51.92 0.00e+00 818.00
IUUC-Cja-019406 Callithrix jacchus 56.30 0.00e+00 1249.00
IUUC-Cfa-020129 Canis familiaris 62.85 0.00e+00 789.00
IUUC-Cpo-021944 Cavia porcellus 57.77 0.00e+00 1336.00
IUUC-Csa-023941 Chlorocebus sabaeus 49.57 4.00e-159 555.00
IUUC-Cho-024847 Choloepus hoffmanni 63.59 9.00e-120 425.00
IUUC-Cin-025405 Ciona intestinalis 27.82 1.00e-08 53.90
IUUC-Csv-025916 Ciona savignyi 33.90 2.00e-06 45.80
IUUC-Dre-027764 Danio rerio 33.38 4.00e-73 270.00
IUUC-Dno-030083 Dasypus novemcinctus 50.43 0.00e+00 1082.00
IUUC-Dor-031129 Dipodomys ordii 53.01 0.00e+00 999.00
IUUC-Ete-032536 Echinops telfairi 41.74 6.00e-98 353.00
IUUC-Eca-033407 Equus caballus 57.88 0.00e+00 1206.00
IUUC-Eeu-034473 Erinaceus europaeus 43.84 3.00e-39 157.00
IUUC-Fca-035730 Felis catus 54.03 0.00e+00 1271.00
IUUC-Fal-036850 Ficedula albicollis 46.32 2.00e-132 467.00
IUUC-Gmo-038677 Gadus morhua 42.72 7.00e-30 125.00
IUUC-Gga-041088 Gallus gallus 45.83 1.00e-129 458.00
IUUC-Gac-041824 Gasterosteus aculeatus 44.32 5.00e-16 77.80
IUUC-Ggo-045642 Gorilla gorilla 55.71 0.00e+00 1194.00
IUUC-Hsa-047035 Homo sapiens 56.08 0.00e+00 1279.00
IUUC-Itr-049010 Ictidomys tridecemlineatus 60.77 0.00e+00 1445.00
IUUC-Kpa-049328 Komagataella pastoris 26.03 2.00e-03 38.10
IUUC-Lch-050364 Latimeria chalumnae 37.81 3.00e-70 261.00
IUUC-Loc-052423 Lepisosteus oculatus 40.69 1.00e-39 159.00
IUUC-Laf-053910 Loxodonta africana 53.72 0.00e+00 1247.00
IUUC-Mcc-055883 Macaca mulatta 55.44 0.00e+00 1304.00
IUUC-Meu-056224 Macropus eugenii 49.48 4.00e-80 293.00
IUUC-Mga-059880 Meleagris gallopavo 44.31 1.00e-142 501.00
IUUC-Mvi-060510 Microbotryum violaceum 36.36 1.00e-04 42.40
IUUC-Mmr-061715 Microcebus murinus 59.38 0.00e+00 1434.00
IUUC-Mdo-062426 Monodelphis domestica 42.90 0.00e+00 815.00
IUUC-Mpu-066184 Mustela putorius furo 52.73 0.00e+00 1239.00
IUUC-Mlu-067533 Myotis lucifugus 58.18 0.00e+00 1285.00
IUUC-Nle-069204 Nomascus leucogenys 56.09 0.00e+00 1292.00
IUUC-Opr-070377 Ochotona princeps 63.97 0.00e+00 751.00
IUUC-Ont-072551 Oreochromis niloticus 34.93 2.00e-62 235.00
IUUC-Oan-073350 Ornithorhynchus anatinus 51.80 5.00e-94 338.00
IUUC-Ocu-074915 Oryctolagus cuniculus 62.25 0.00e+00 756.00
IUUC-Ola-087360 Oryzias latipes 47.89 3.00e-36 145.00
IUUC-Oga-089106 Otolemur garnettii 56.50 0.00e+00 1179.00
IUUC-Oar-089289 Ovis aries 54.20 0.00e+00 763.00
IUUC-Ptr-091469 Pan troglodytes 56.99 0.00e+00 1293.00
IUUC-Pan-091841 Papio anubis 53.49 0.00e+00 1044.00
IUUC-Psi-093842 Pelodiscus sinensis 45.26 3.00e-125 444.00
IUUC-Pma-094732 Petromyzon marinus 53.52 3.00e-09 55.10
IUUC-Pfo-097299 Poecilia formosa 38.07 2.00e-28 122.00
IUUC-Pab-098271 Pongo abelii 56.09 0.00e+00 1282.00
IUUC-Pca-100721 Procavia capensis 57.25 0.00e+00 657.00
IUUC-Pva-102276 Pteropus vampyrus 56.32 0.00e+00 1420.00
IUUC-Rno-105619 Rattus norvegicus 77.29 0.00e+00 2159.00
IUUC-Sha-106722 Sarcophilus harrisii 51.71 1.00e-171 597.00
IUUC-Sar-113673 Sorex araneus 55.01 4.00e-65 244.00
IUUC-Sre-115039 Sporisorium reilianum 35.59 7.00e-05 41.20
IUUC-Ssc-115383 Sus scrofa 63.30 0.00e+00 695.00
IUUC-Tgu-117243 Taeniopygia guttata 50.51 2.00e-93 336.00
IUUC-Tru-118092 Takifugu rubripes 45.98 3.00e-33 135.00
IUUC-Tsy-119362 Tarsius syrichta 52.30 5.00e-139 489.00
IUUC-Tni-120380 Tetraodon nigroviridis 40.24 2.00e-34 139.00
IUUC-Tbe-127404 Tupaia belangeri 43.92 3.00e-173 603.00
IUUC-Ttr-128317 Tursiops truncatus 55.47 0.00e+00 1185.00
IUUC-Uma-129640 Ustilago maydis 40.68 7.00e-07 48.10
IUUC-Xtr-132533 Xenopus tropicalis 38.72 5.00e-89 323.00
Created Date 25-Jun-2017

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