iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Csv-026149

UUCD1 version

UUC-CiS-00461

Ensembl Protein ID

ENSCSAVP00000017046.1

UniProt Accession

H2ZHI0; H2ZHI0_CIOSA

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAVG00000010026.1	ENSCSAVT00000017229.1	ENSCSAVP00000017046.1
ENSCSAVG00000010026.1	ENSCSAVT00000017230.1	ENSCSAVP00000017047.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	3.70e-71	240.2	3	313

Active Site

Position(s)	Description	Evidence
87	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
162	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 4    qvkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffa 91
            + ew+ +esdPg+f  l++dfgv++  qvee+ sLd+++++ + +pv+gl++lFk+ ++ +++           v ++   + iffa
   Q: 3    SAGEWCLIESDPGVFSALIKDFGVQGI-QVEEICSLDSDSFKDL-KPVHGLIFLFKYDQEIQTEG---------TVLEDTLQSDIFFA 79
           5679**********************9.****************.**************999999.........56777888899*** PP
   S: 92   kqvigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafh 179
           kqvi+N+Cat+A++  lln ++  + lG+tl+ +k++t+ +++ +++lal+n++v++++hns+ar++ ++ +e+ +     + ++ +h
   Q: 80   KQVISNACATQAIINILLNTKHDDVILGSTLDAFKNFTQYFDAGMRGLALSNSKVIQQVHNSFARQQVFEYDEKAS-----KSEDSYH 162
           ***********************99***********************************************9984.....45899** PP
   S: 180  fvsyvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid........ 259
           fv yv++ng++ eldglk  P+d+g+  e +++ + ++ ++   +ri+ ++s+ei fnl+a+ +d+++  +++++ l +         
   Q: 163  FVGYVPVNGHVLELDGLKGGPVDHGA-IEGDDWIETVRPII--QKRIQRYTSGEIHFNLMAVISDKKMLLEKKIEKLTTCidgynedi 247
           *************************9.78899*********..*****************************9988776566999888 PP
   S: 260  ..keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklve 323
             ++    l+ +  e e+ +  ld+e+ kr++  +++irR++ny  fi++ i+ la e+ l  lve
   Q: 248  tdQDEKVPLEVLHNELEQCKRVLDEENLKRQRNQVENIRRKHNYLPFIIEMIRILAAEKKLLPLVE 313
           88555566788899999****************************************999988876 PP

Organism

Ciona savignyi

Protein Sequence
(Fasta)

MSSAGEWCLI ESDPGVFSAL IKDFGVQGIQ VEEICSLDSD SFKDLKPVHG LIFLFKYDQE 60
IQTEGTVLED TLQSDIFFAK QVISNACATQ AIINILLNTK HDDVILGSTL DAFKNFTQYF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGAACGATA CCCCTGCATT GCAAGTTTCA GAAGCGTTTG TTTTTGTATA ATAATGAGCT 60
CTGCCGGTGA ATGGTGCCTT ATTGAAAGTG ATCCAGGTGT GTTTTCCGCT TTGATCAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005622--C:intracellular
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	44.21	1.00e-72	264.00
IUUC-Aml-001866	Ailuropoda melanoleuca	57.88	9.00e-106	374.00
IUUC-Atr-002966	Amborella trichopoda	41.26	3.00e-61	227.00
IUUC-Apl-003306	Anas platyrhynchos	51.90	9.00e-97	345.00
IUUC-Aca-004763	Anolis carolinensis	57.56	1.00e-106	377.00
IUUC-Aly-005581	Arabidopsis lyrata	43.90	1.00e-67	248.00
IUUC-Ath-007283	Arabidopsis thaliana	44.95	2.00e-69	254.00
IUUC-Ago-007999	Ashbya gossypii	34.47	2.00e-34	137.00
IUUC-Acl-008231	Aspergillus clavatus	42.98	2.00e-53	201.00
IUUC-Afl-008557	Aspergillus flavus	41.28	1.00e-56	211.00
IUUC-Afu-008988	Aspergillus fumigatus	43.39	6.00e-54	202.00
IUUC-Ani-009420	Aspergillus nidulans	36.99	5.00e-55	206.00
IUUC-Ang-009859	Aspergillus niger	40.73	1.00e-51	194.00
IUUC-Aor-010145	Aspergillus oryzae	41.28	1.00e-56	211.00
IUUC-Ate-010347	Aspergillus terreus	42.80	2.00e-54	204.00
IUUC-Ame-010791	Astyanax mexicanus	57.32	3.00e-107	379.00
IUUC-Bgr-012298	Blumeria graminis	37.46	4.00e-48	183.00
IUUC-Bta-013251	Bos taurus	58.20	6.00e-106	375.00
IUUC-Bci-013786	Botrytis cinerea	38.14	3.00e-56	210.00
IUUC-Bdi-014132	Brachypodium distachyon	43.60	5.00e-71	259.00
IUUC-Bol-015611	Brassica oleracea	43.96	1.00e-69	254.00
IUUC-Bra-017769	Brassica rapa	44.21	1.00e-69	254.00
IUUC-Cel-018604	Caenorhabditis elegans	45.94	3.00e-77	280.00
IUUC-Cja-019768	Callithrix jacchus	52.80	9.00e-101	358.00
IUUC-Cfa-020207	Canis familiaris	57.88	9.00e-106	374.00
IUUC-Cpo-021925	Cavia porcellus	55.31	2.00e-99	353.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	42.68	8.00e-66	242.00
IUUC-Csa-023958	Chlorocebus sabaeus	58.20	1.00e-105	374.00
IUUC-Cho-024928	Choloepus hoffmanni	59.74	1.00e-22	99.00
IUUC-Cin-025771	Ciona intestinalis	83.81	2.00e-152	529.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	33.88	5.00e-46	176.00
IUUC-Cne-026955	Cryptococcus neoformans	38.10	3.00e-54	203.00
IUUC-Cme-027104	Cyanidioschyzon merolae	33.23	2.00e-45	174.00
IUUC-Dre-027409	Danio rerio	57.32	2.00e-106	377.00
IUUC-Dno-028921	Dasypus novemcinctus	57.56	3.00e-105	372.00
IUUC-Dse-031170	Dothistroma septosporum	37.85	1.00e-53	201.00
IUUC-Dme-031677	Drosophila melanogaster	53.33	6.00e-94	335.00
IUUC-Ete-032707	Echinops telfairi	42.27	4.00e-64	236.00
IUUC-Eca-033776	Equus caballus	56.40	6.00e-94	335.00
IUUC-Eeu-035305	Erinaceus europaeus	54.59	2.00e-53	201.00
IUUC-Fca-035846	Felis catus	53.10	5.00e-101	359.00
IUUC-Fal-037597	Ficedula albicollis	56.06	2.00e-94	337.00
IUUC-Fox-037670	Fusarium oxysporum	46.29	3.00e-51	193.00
IUUC-Fso-038243	Fusarium solani	46.29	4.00e-51	193.00
IUUC-Gmo-038499	Gadus morhua	54.34	2.00e-99	353.00
IUUC-Ggr-039975	Gaeumannomyces graminis	39.11	8.00e-46	175.00
IUUC-Gga-040904	Gallus gallus	57.78	6.00e-109	385.00
IUUC-Gac-042058	Gasterosteus aculeatus	56.59	6.00e-106	375.00
IUUC-Gma-043030	Glycine max	43.98	3.00e-70	256.00
IUUC-Ggo-044699	Gorilla gorilla	53.95	4.00e-92	329.00
IUUC-Hsa-046227	Homo sapiens	57.88	8.00e-106	375.00
IUUC-Hvu-047359	Hordeum vulgare	43.90	3.00e-71	259.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	52.77	3.00e-101	359.00
IUUC-Kpa-049123	Komagataella pastoris	26.51	6.00e-12	62.40
IUUC-Lch-049829	Latimeria chalumnae	57.23	2.00e-105	373.00
IUUC-Lpe-050899	Leersia perrieri	43.44	9.00e-69	251.00
IUUC-Loc-052264	Lepisosteus oculatus	56.73	3.00e-103	366.00
IUUC-Lma-053110	Leptosphaeria maculans	41.13	4.00e-44	170.00
IUUC-Laf-053639	Loxodonta africana	57.88	9.00e-106	374.00
IUUC-Mcc-055506	Macaca mulatta	58.20	1.00e-105	374.00
IUUC-Mor-057001	Magnaporthe oryzae	42.86	2.00e-51	194.00
IUUC-Mpo-057608	Magnaporthe poae	41.08	4.00e-31	126.00
IUUC-Mtr-057731	Medicago truncatula	41.59	4.00e-69	253.00
IUUC-Mla-059016	Melampsora laricipopulina	44.23	3.00e-44	169.00
IUUC-Mga-060178	Meleagris gallopavo	55.82	5.00e-96	342.00
IUUC-Mvi-060353	Microbotryum violaceum	34.89	7.00e-47	179.00
IUUC-Mmr-060738	Microcebus murinus	57.88	7.00e-106	375.00
IUUC-Mdo-062266	Monodelphis domestica	63.73	1.00e-76	277.00
IUUC-Mmu-063619	Mus musculus	58.33	8.00e-107	378.00
IUUC-Mac-065301	Musa acuminata	44.48	8.00e-73	265.00
IUUC-Mpu-066058	Mustela putorius furo	57.88	7.00e-106	375.00
IUUC-Mlu-067292	Myotis lucifugus	58.01	3.00e-107	379.00
IUUC-Nfi-068275	Neosartorya fischeri	37.89	8.00e-56	208.00
IUUC-Ncr-068713	Neurospora crassa	35.83	1.00e-51	194.00
IUUC-Nle-069013	Nomascus leucogenys	57.88	6.00e-105	372.00
IUUC-Opr-070628	Ochotona princeps	50.15	1.00e-91	328.00
IUUC-Ont-072688	Oreochromis niloticus	57.19	1.00e-105	374.00
IUUC-Oan-073004	Ornithorhynchus anatinus	61.64	3.00e-79	286.00
IUUC-Ocu-074303	Oryctolagus cuniculus	57.88	6.00e-106	376.00
IUUC-Oba-075002	Oryza barthii	43.57	7.00e-69	252.00
IUUC-Obr-076392	Oryza brachyantha	43.85	9.00e-70	255.00
IUUC-Ogl-077271	Oryza glaberrima	43.57	7.00e-69	252.00
IUUC-Ogu-078493	Oryza glumaepatula	43.89	4.00e-70	256.00
IUUC-Oin-080084	Oryza indica	43.89	4.00e-70	256.00
IUUC-Olo-080803	Oryza longistaminata	43.57	1.00e-69	254.00
IUUC-Ome-081146	Oryza meridionalis	44.20	4.00e-71	259.00
IUUC-Oni-082146	Oryza nivara	43.89	4.00e-70	256.00
IUUC-Opu-083633	Oryza punctata	43.85	2.00e-68	251.00
IUUC-Oru-084789	Oryza rufipogon	43.89	4.00e-70	256.00
IUUC-Osa-086196	Oryza sativa	43.89	4.00e-70	256.00
IUUC-Ola-087126	Oryzias latipes	57.23	6.00e-106	375.00
IUUC-Olu-087665	Ostreococcus lucimarinus	40.83	1.00e-63	234.00
IUUC-Oga-089140	Otolemur garnettii	53.25	4.00e-101	359.00
IUUC-Oar-090296	Ovis aries	57.23	5.00e-104	369.00
IUUC-Ptr-090566	Pan troglodytes	57.88	8.00e-106	375.00
IUUC-Pan-092052	Papio anubis	58.20	1.00e-105	374.00
IUUC-Psi-093723	Pelodiscus sinensis	56.40	4.00e-95	339.00
IUUC-Pma-094568	Petromyzon marinus	47.32	5.00e-80	288.00
IUUC-Pno-095120	Phaeosphaeria nodorum	41.99	2.00e-45	174.00
IUUC-Ppa-095761	Physcomitrella patens	41.89	4.00e-67	246.00
IUUC-Pfo-096210	Poecilia formosa	57.23	1.00e-106	377.00
IUUC-Pab-098463	Pongo abelii	57.69	8.00e-106	375.00
IUUC-Pop-099423	Populus trichocarpa	42.77	9.00e-68	248.00
IUUC-Pca-100108	Procavia capensis	63.03	1.00e-87	314.00
IUUC-Ppe-101176	Prunus persica	43.50	4.00e-67	246.00
IUUC-Pva-102629	Pteropus vampyrus	63.56	2.00e-88	317.00
IUUC-Pgr-103419	Puccinia graminis	46.72	3.00e-59	219.00
IUUC-Ptt-103955	Puccinia triticina	28.39	4.00e-15	73.20
IUUC-Pte-104207	Pyrenophora teres	40.24	2.00e-27	113.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	34.84	4.00e-48	183.00
IUUC-Rno-105579	Rattus norvegicus	50.93	5.00e-89	319.00
IUUC-Sce-106412	Saccharomyces cerevisiae	24.88	1.00e-07	48.10
IUUC-Sha-106894	Sarcophilus harrisii	55.76	2.00e-87	313.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	35.02	3.00e-50	190.00
IUUC-Spo-108371	Schizosaccharomyces pombe	38.28	2.00e-56	210.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	36.30	1.00e-44	171.00
IUUC-Smo-109396	Selaginella moellendorffii	43.03	4.00e-65	239.00
IUUC-Sit-110630	Setaria italica	43.73	7.00e-71	258.00
IUUC-Sly-110972	Solanum lycopersicum	42.95	7.00e-65	238.00
IUUC-Stu-112185	Solanum tuberosum	44.11	6.00e-74	269.00
IUUC-Sar-113294	Sorex araneus	48.97	1.00e-88	318.00
IUUC-Sbi-113951	Sorghum bicolor	44.41	2.00e-71	260.00
IUUC-Sre-114961	Sporisorium reilianum	27.04	6.00e-10	56.20
IUUC-Ssc-115501	Sus scrofa	56.38	1.00e-96	344.00
IUUC-Tgu-117152	Taeniopygia guttata	56.06	2.00e-94	337.00
IUUC-Tru-118388	Takifugu rubripes	57.23	3.00e-106	376.00
IUUC-Tsy-119109	Tarsius syrichta	57.69	8.00e-106	375.00
IUUC-Tni-120048	Tetraodon nigroviridis	57.23	1.00e-106	377.00
IUUC-Tca-121750	Theobroma cacao	44.14	1.00e-72	265.00
IUUC-Tre-122130	Trichoderma reesei	36.00	4.00e-50	189.00
IUUC-Tvi-122284	Trichoderma virens	37.46	4.00e-49	186.00
IUUC-Tae-124082	Triticum aestivum	43.90	7.00e-71	259.00
IUUC-Tur-126366	Triticum urartu	35.49	8.00e-51	192.00
IUUC-Tme-127187	Tuber melanosporum	38.19	8.00e-56	208.00
IUUC-Tbe-127619	Tupaia belangeri	48.60	4.00e-71	259.00
IUUC-Ttr-128867	Tursiops truncatus	55.88	4.00e-73	266.00
IUUC-Uma-129382	Ustilago maydis	29.18	1.00e-14	71.60
IUUC-Vda-129912	Verticillium dahliae	34.80	6.00e-49	186.00
IUUC-Vpa-130552	Vicugna pacos	64.73	2.00e-78	284.00
IUUC-Vvi-130881	Vitis vinifera	43.98	4.00e-67	246.00
IUUC-Xtr-131934	Xenopus tropicalis	57.32	1.00e-105	374.00
IUUC-Xma-133312	Xiphophorus maculatus	57.56	5.00e-108	382.00
IUUC-Yli-134487	Yarrowia lipolytica	39.75	3.00e-47	180.00
IUUC-Zma-135462	Zea mays	35.85	1.00e-58	218.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence