iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bra-017685

Ensembl Protein ID

Bra022779.1-P

UniProt Accession

M4E1X9; M4E1X9_BRARP

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Bra022779	Bra022779.1	Bra022779.1-P

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.50e-166	555.7	413	900

Active Site

Position(s)	Description	Evidence
594	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnve 91
           YD Qi ++G++ q+kl+ akv+ vG g+lGcE+lKn++l+Gv     g++tv+D+d +e+snl+rqFLfr++++g+ K+ vaa a++ +np+ n+e
   Q: 413  YDAQISVFGAKFQQKLEDAKVFTVGSGALGCEFLKNMALMGVscgseGKLTVTDDDIIEKSNLSRQFLFRDWNIGQAKSTVAASAAAAINPKFNIE 508
           ************************************************************************************************ PP
   S: 92   aheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketpnaae 184
           a ++++ +++e+++   F ++++vVv+aldn+ ar++v+++cl+ ++pl+esgtlG + +++ +i++lte y +s+dpp+k++P+ct+ ++p +++
   Q: 509  ALQNRVGAETENVFddaFWENLTVVVNALDNVNARLYVDSRCLYFQKPLLESGTLGAKCNTQMVIPHLTENYGASRDPPEKQAPMCTVHSFPHNID 604
           ************99********************************************************************************** PP
   S: 185  htiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqllksfecdivtks 268
           h+++wa            + +n +l+   + ++       ++ +++++++ + l++e+ e+f+++ ++a+  f+ ++ n +kql+  f+ d  t+ 
   Q: 605  HCLTWArsefegllektpAEVNAYLSSPVEYTNSMMSAGDAQARDTLERIVECLEKEKCEDFQDCLTWARLRFEDYFVNRVKQLIYTFPEDAATST 700
           *************99999777777777777777777788899999999999999****************************************** PP
   S: 269  kspfwv.........................................................sfcsnaealqvpekvekdeevvkasap..lyll 305
           ++pfw+                                                          f++ ++a+ v +  +   ++ +++++  +  l
   Q: 701  GAPFWSapkrfprplqysssdpsllnfitatailraetfgipvpewtkspkeaaeaidrvivpDFEPRKDAKIVTDEKATTLTTASVDDAavINDL 796
           ************************************************999999999999999888877777766666666565666655685555 PP
   S: 306  lrale..rfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsg..kfepl 395
           +++le  r +  ++  ++ ++fekddd   ++d+++ +an+ra +++i++ +d+ + k iag+iipaiat +a+  Gl+++E++Kv++g  k e++
   Q: 797  IAKLEqcRQNLSPDFRMKPIQFEKDDDTnyHMDVIAGLANMRARNYSIPE-VDKLKAKFIAGRIIPAIATSTAMATGLVCLELYKVLDGghKVEAY 891
           555550055567899999********************************.***************************************9***** PP
   S: 396  knfflfdae 404
           +n+f ++a+
   Q: 892  RNTFANLAL 900
           ****99875 PP

Organism

Brassica rapa

Protein Sequence
(Fasta)

MAFGNSNRHE IDEDLHSRQL AVYGRETMRR LFASNVLISG MHGLGAEIAK NLILAGVKSV 60
TLHDESVVEL WDLSSNFVFS EGDIGKNRAD ASVNKLQDLN NAVAVSSLTT GLTKEQLSGF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGTTTG GCAATTCGAA CCGTCACGAG ATCGATGAAG ATCTCCACAG CAGGCAGCTC 60
GCCGTCTACG GACGCGAGAC CATGAGGCGT CTCTTCGCTT CCAACGTCCT CATCTCCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0008641--F:small protein activating enzyme activity
GO:0006464--P:cellular protein modification process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bol-015786	Brassica oleracea	99.02	0.00e+00	2077.00
IUUC-Fso-038339	Fusarium solani	46.91	0.00e+00	820.00
IUUC-Kpa-049112	Komagataella pastoris	45.64	0.00e+00	861.00
IUUC-Lma-053315	Leptosphaeria maculans	45.64	0.00e+00	873.00
IUUC-Mor-057269	Magnaporthe oryzae	45.67	0.00e+00	854.00
IUUC-Mpo-057435	Magnaporthe poae	45.80	0.00e+00	842.00
IUUC-Ncr-068698	Neurospora crassa	45.91	0.00e+00	850.00
IUUC-Pte-104200	Pyrenophora teres	46.21	0.00e+00	890.00
IUUC-Pyt-104441	Pyrenophora triticirepentis	45.60	0.00e+00	883.00
IUUC-Sce-106245	Saccharomyces cerevisiae	45.41	0.00e+00	877.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence