iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-034288

UUCD1 version

UUC-EqC-00836

Ensembl Protein ID

ENSECAP00000012312.1

UniProt Accession

F7D3K4; F7D3K4_HORSE

Protein Name

Platelet-activating factor acetylhydrolase IB subunit alpha; Lissencephaly-1 protein; PAF acetylhydrolase 45 kDa subunit; PAF-AH alpha

Gene Name

PAFAH1B1; LIS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000014291.1	ENSECAT00000015329.1	ENSECAP00000012312.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.70e-60	197.3	179	218
UBD/Beta-Prp	7.20e-95	317.8	96	399

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           gH   v+++a  ++ +++vs+s+D+tik+W++ tg ++k+
   Q: 179  GHDHNVSSVAImPNgDHIVSASRDKTIKMWEVQTGYCVKT 218
           899*******99777********************99875 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           h s++t v f+p  s+++++s+d+tikvwd++tg++ r+l+gh++ v++++f+++gk+l+++s D+tik+wd++ ++c++t++gh+++v
   Q: 96   HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNV 184
           5668888********************************************************************************** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
            s++++p+gd++vs+s+d+ti++w+++tg+c++ t++gh+++v++v+ ++dg l++s+s+D+tvr+W ++t+++  +l++ h++ v+++
   Q: 185  SSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVK-TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELRE-HEHVVECI 271
           *********************************.*********************************************9.******** PP
   S: 187  sfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
           s+ +++                    ++l+sgs+d+t+k+wd++tg c++tl gh+++v+ v f++ +++++s+++D+++r+Wd++++ 
   Q: 272  SWAPESsyssiseatgsetkksgkpgPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKR 360
           ***************************************************************************************** PP
   S: 256  llktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
           ++ktl+ h++ v+s ++ + + +++v+gs d++v++w+++
   Q: 361  CMKTLNAHEHFVTSLDF-HKTAPYVVTGSVDQTVKVWECR 399
           *****************.99*****************985 PP

Organism

Equus caballus

Functional Description
(View)

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.

Protein Sequence
(Fasta)

NRAIADYLRS NGYEEAYSVF KKEAELDMNE ELDKKYAGLL EKKWTSVIRL QRVVMELESK 60
LNEAKEEFTS GGPLGQKRDP KEWIPRPPEK YALSGHRSPV TRVIFHPVFS VMVSASEDAT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATCGAGCTA TAGCAGATTA TCTTCGTTCA AATGGCTATG AAGAGGCATA TTCTGTTTTT 60
AAAAAGGAAG CTGAATTAGA TATGGTATGT TTGACTTTTT ACAATTATTC ATAGTACAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0000235--C:astral microtubule
GO:1904115--C:axon cytoplasm
GO:0005938--C:cell cortex
GO:0031252--C:cell leading edge
GO:0005813--C:centrosome
GO:0070062--C:extracellular exosome
GO:0000776--C:kinetochore
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0031514--C:motile cilium
GO:0031965--C:nuclear membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0032420--C:stereocilium
GO:0008017--F:microtubule binding
GO:0001675--P:acrosome assembly
GO:0030036--P:actin cytoskeleton organization
GO:0008344--P:adult locomotory behavior
GO:0001667--P:ameboidal-type cell migration
GO:0060117--P:auditory receptor cell development
GO:0048854--P:brain morphogenesis
GO:0051301--P:cell division
GO:0007268--P:chemical synaptic transmission
GO:0090102--P:cochlea development
GO:0021540--P:corpus callosum morphogenesis
GO:0043622--P:cortical microtubule organization
GO:0000132--P:establishment of mitotic spindle orientation
GO:0042249--P:establishment of planar polarity of embryonic epithelium
GO:0007281--P:germ cell development
GO:0021766--P:hippocampus development
GO:0021819--P:layer formation in cerebral cortex
GO:0007611--P:learning or memory
GO:0016042--P:lipid catabolic process
GO:0051661--P:maintenance of centrosome location
GO:0090176--P:microtubule cytoskeleton organization involved in establishment of planar polarity
GO:0031023--P:microtubule organizing center organization
GO:0007067--P:mitotic nuclear division
GO:0046329--P:negative regulation of JNK cascade
GO:0007405--P:neuroblast proliferation
GO:0022008--P:neurogenesis
GO:0050885--P:neuromuscular process controlling balance
GO:0001764--P:neuron migration
GO:0051081--P:nuclear envelope disassembly
GO:0007097--P:nuclear migration
GO:0036035--P:osteoclast development
GO:0001961--P:positive regulation of cytokine-mediated signaling pathway
GO:0061003--P:positive regulation of dendritic spine morphogenesis
GO:0040019--P:positive regulation of embryonic development
GO:0009306--P:protein secretion
GO:0043087--P:regulation of GTPase activity
GO:0070507--P:regulation of microtubule cytoskeleton organization
GO:2000574--P:regulation of microtubule motor activity
GO:0008090--P:retrograde axonal transport
GO:0019226--P:transmission of nerve impulse
GO:0047496--P:vesicle transport along microtubule

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001589	Ailuropoda melanoleuca	99.50	0.00e+00	829.00
IUUC-Apl-004024	Anas platyrhynchos	98.25	0.00e+00	824.00
IUUC-Aca-004564	Anolis carolinensis	97.99	0.00e+00	818.00
IUUC-Ago-007862	Ashbya gossypii	26.70	3.00e-35	142.00
IUUC-Acl-008360	Aspergillus clavatus	45.94	2.00e-100	359.00
IUUC-Afl-008502	Aspergillus flavus	45.17	2.00e-93	335.00
IUUC-Afu-008848	Aspergillus fumigatus	46.62	4.00e-102	365.00
IUUC-Ani-009173	Aspergillus nidulans	43.11	2.00e-88	318.00
IUUC-Ang-009873	Aspergillus niger	44.16	9.00e-91	327.00
IUUC-Aor-009973	Aspergillus oryzae	43.26	4.00e-88	318.00
IUUC-Ate-010523	Aspergillus terreus	41.86	2.00e-87	316.00
IUUC-Ame-010969	Astyanax mexicanus	94.24	0.00e+00	795.00
IUUC-Bgr-011972	Blumeria graminis	46.94	8.00e-101	360.00
IUUC-Bta-013106	Bos taurus	99.50	0.00e+00	830.00
IUUC-Bci-013615	Botrytis cinerea	43.84	2.00e-94	339.00
IUUC-Cel-018459	Caenorhabditis elegans	57.50	4.00e-144	504.00
IUUC-Cja-018755	Callithrix jacchus	99.50	0.00e+00	830.00
IUUC-Cfa-020749	Canis familiaris	99.50	0.00e+00	830.00
IUUC-Cpo-022371	Cavia porcellus	99.50	0.00e+00	830.00
IUUC-Csa-023524	Chlorocebus sabaeus	99.42	0.00e+00	720.00
IUUC-Cho-024764	Choloepus hoffmanni	88.68	0.00e+00	675.00
IUUC-Cin-025753	Ciona intestinalis	70.50	2.00e-174	604.00
IUUC-Csv-025817	Ciona savignyi	68.92	8.00e-177	612.00
IUUC-Cgl-026529	Colletotrichum gloeosporioides	46.73	2.00e-94	338.00
IUUC-Cne-027087	Cryptococcus neoformans	49.87	6.00e-109	387.00
IUUC-Dre-027554	Danio rerio	93.98	0.00e+00	789.00
IUUC-Dno-029050	Dasypus novemcinctus	99.25	0.00e+00	830.00
IUUC-Dor-030222	Dipodomys ordii	90.98	0.00e+00	747.00
IUUC-Dse-031164	Dothistroma septosporum	42.93	1.00e-97	350.00
IUUC-Dme-031745	Drosophila melanogaster	69.00	1.00e-164	572.00
IUUC-Ete-032508	Echinops telfairi	99.64	1.00e-168	585.00
IUUC-Eeu-034984	Erinaceus europaeus	90.73	0.00e+00	743.00
IUUC-Fca-036498	Felis catus	99.50	0.00e+00	830.00
IUUC-Fal-036920	Ficedula albicollis	98.25	0.00e+00	824.00
IUUC-Fox-037996	Fusarium oxysporum	45.72	2.00e-100	359.00
IUUC-Fso-038160	Fusarium solani	43.41	1.00e-95	343.00
IUUC-Gmo-038983	Gadus morhua	93.23	0.00e+00	784.00
IUUC-Ggr-040051	Gaeumannomyces graminis	45.48	4.00e-95	341.00
IUUC-Gga-040623	Gallus gallus	98.25	0.00e+00	824.00
IUUC-Gac-041613	Gasterosteus aculeatus	92.23	0.00e+00	780.00
IUUC-Ggo-045410	Gorilla gorilla	88.72	0.00e+00	720.00
IUUC-Hsa-046358	Homo sapiens	99.25	0.00e+00	828.00
IUUC-Itr-047890	Ictidomys tridecemlineatus	99.50	0.00e+00	830.00
IUUC-Kpa-049351	Komagataella pastoris	29.19	2.00e-40	160.00
IUUC-Lch-049936	Latimeria chalumnae	96.24	0.00e+00	806.00
IUUC-Loc-052476	Lepisosteus oculatus	95.49	0.00e+00	800.00
IUUC-Lma-053170	Leptosphaeria maculans	47.89	8.00e-98	350.00
IUUC-Laf-053713	Loxodonta africana	99.25	0.00e+00	829.00
IUUC-Mcc-054628	Macaca mulatta	99.00	0.00e+00	827.00
IUUC-Meu-055927	Macropus eugenii	86.28	5.00e-140	489.00
IUUC-Mor-056962	Magnaporthe oryzae	44.47	5.00e-94	337.00
IUUC-Mpo-057583	Magnaporthe poae	45.64	6.00e-91	327.00
IUUC-Mla-058819	Melampsora laricipopulina	47.59	7.00e-114	404.00
IUUC-Mga-059945	Meleagris gallopavo	97.99	0.00e+00	823.00
IUUC-Mvi-060403	Microbotryum violaceum	48.97	9.00e-123	433.00
IUUC-Mmr-061289	Microcebus murinus	99.50	0.00e+00	830.00
IUUC-Mdo-061912	Monodelphis domestica	98.75	0.00e+00	823.00
IUUC-Mmu-063253	Mus musculus	99.50	0.00e+00	830.00
IUUC-Mpu-066638	Mustela putorius furo	99.50	0.00e+00	830.00
IUUC-Mlu-067267	Myotis lucifugus	99.25	0.00e+00	828.00
IUUC-Nfi-068571	Neosartorya fischeri	44.95	6.00e-95	340.00
IUUC-Ncr-068895	Neurospora crassa	49.60	3.00e-102	365.00
IUUC-Nle-069087	Nomascus leucogenys	99.07	0.00e+00	672.00
IUUC-Opr-070579	Ochotona princeps	99.25	0.00e+00	830.00
IUUC-Ont-072432	Oreochromis niloticus	93.98	0.00e+00	795.00
IUUC-Oan-073072	Ornithorhynchus anatinus	99.50	0.00e+00	830.00
IUUC-Ocu-074180	Oryctolagus cuniculus	99.25	0.00e+00	830.00
IUUC-Ola-086772	Oryzias latipes	93.48	0.00e+00	786.00
IUUC-Oga-088219	Otolemur garnettii	99.50	0.00e+00	831.00
IUUC-Oar-090394	Ovis aries	99.50	0.00e+00	830.00
IUUC-Ptr-091517	Pan troglodytes	99.50	0.00e+00	830.00
IUUC-Pan-092421	Papio anubis	99.00	0.00e+00	827.00
IUUC-Psi-093370	Pelodiscus sinensis	98.50	0.00e+00	825.00
IUUC-Pma-094319	Petromyzon marinus	89.08	0.00e+00	641.00
IUUC-Pno-094815	Phaeosphaeria nodorum	46.70	4.00e-100	358.00
IUUC-Pfo-097089	Poecilia formosa	92.98	0.00e+00	788.00
IUUC-Pab-098421	Pongo abelii	99.50	0.00e+00	830.00
IUUC-Pca-100120	Procavia capensis	72.18	5.00e-160	556.00
IUUC-Pva-102960	Pteropus vampyrus	99.25	0.00e+00	826.00
IUUC-Pgr-103538	Puccinia graminis	46.45	6.00e-113	400.00
IUUC-Ptt-103990	Puccinia triticina	40.50	3.00e-39	156.00
IUUC-Pte-104261	Pyrenophora teres	46.94	4.00e-100	358.00
IUUC-Pyt-104780	Pyrenophora triticirepentis	47.19	1.00e-100	359.00
IUUC-Rno-105123	Rattus norvegicus	99.50	0.00e+00	830.00
IUUC-Sha-107010	Sarcophilus harrisii	98.50	0.00e+00	822.00
IUUC-Sja-107899	Schizosaccharomyces japonicus	31.84	3.00e-61	229.00
IUUC-Ssl-108571	Sclerotinia sclerotiorum	44.09	1.00e-94	340.00
IUUC-Sar-113309	Sorex araneus	99.00	0.00e+00	820.00
IUUC-Sre-115003	Sporisorium reilianum	49.07	1.00e-119	422.00
IUUC-Ssc-116148	Sus scrofa	99.50	0.00e+00	830.00
IUUC-Tgu-117299	Taeniopygia guttata	97.99	0.00e+00	821.00
IUUC-Tru-118179	Takifugu rubripes	91.48	0.00e+00	781.00
IUUC-Tsy-119493	Tarsius syrichta	97.99	0.00e+00	814.00
IUUC-Tni-120355	Tetraodon nigroviridis	92.48	0.00e+00	755.00
IUUC-Tre-121977	Trichoderma reesei	42.55	2.00e-97	348.00
IUUC-Tvi-122661	Trichoderma virens	44.32	4.00e-96	345.00
IUUC-Tme-127031	Tuber melanosporum	47.46	4.00e-99	354.00
IUUC-Tbe-127492	Tupaia belangeri	83.08	2.00e-115	409.00
IUUC-Ttr-128929	Tursiops truncatus	99.25	0.00e+00	827.00
IUUC-Uma-129347	Ustilago maydis	46.73	3.00e-116	411.00
IUUC-Vda-129837	Verticillium dahliae	45.05	2.00e-96	345.00
IUUC-Vpa-130532	Vicugna pacos	84.53	0.00e+00	639.00
IUUC-Xtr-131985	Xenopus tropicalis	96.99	0.00e+00	817.00
IUUC-Xma-133314	Xiphophorus maculatus	93.48	0.00e+00	790.00
IUUC-Yli-134403	Yarrowia lipolytica	40.81	5.00e-73	268.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence