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Tag Content
UUCD2 ID IUUC-Xtr-131985
UUCD1 version UUC-XeT-00963
Ensembl Protein ID ENSXETP00000042100.3
UniProt Accession Q6NZH4; LIS1_XENTR
Genbank Protein ID CAJ83045.1; AAH66132.1
Protein Name Lissencephaly-1 homolog
Genbank Nucleotide ID CR760201; BC066132
Gene Name pafah1b1; lis1; TNeu059p06.1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSXETG00000019410.3 ENSXETT00000042100.3 ENSXETP00000042100.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 9.80e-60 196.0 336 374
UBD/Beta-Prp 4.60e-96 321.7 107 410
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
    gH ++v++++f ++ ++++s++dD+ti++WD++ ++ k
   Q: 336 GHDNWVRGVQFhPGgKFILSCADDKTIRIWDYKNKRCMK 374
    8***********999****************99998876 PP
   


   UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
    h s++t v f+p s+++t+s+d+tikvwd++tg++ r+l+gh++ v++++f+++gk+l+++s D+tik+wd++ ++c++t++gh+++v
   Q: 107 HRSPVTRVIFHPVFSVMVTASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNV 195
    5668888********************************************************************************** PP
   S: 98 lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
    s++++p+gd++vs+s+d+ti++w+++tg+c++ t++gh+++v++v+ ++dg l++s+s+D+tvr+W ++t+++ +l++ h++ v+++
   Q: 196 SSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVK-TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELRE-HEHVVECI 282
    *********************************.*********************************************9.******** PP
   S: 187 sfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
    s+ +++ ++l+sgs+d+t+k+wd++ g c++tl gh+++v+ v+f+p +++++s+++D++iriWd++++
   Q: 283 SWAPESsystisdatgsetkksgkpgPFLLSGSRDKTIKMWDISIGMCLMTLVGHDNWVRGVQFHPGGKFILSCADDKTIRIWDYKNKR 371
    ***************************************************************************************** PP
   S: 256 llktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
    ++ktl+ h++ v+s ++ + + +++v+gs d++v++w+++
   Q: 372 CMKTLNAHEHFVTSLDF-HKTAPYVVTGSVDQTVKVWECR 410
    *****************.99*****************985 PP
   

Organism Xenopus tropicalis
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Protein Sequence
(Fasta)
MVLSQRQRDE LNRAIADYLR SNGYEEAYSV FKKEAELDMN EELDKKYAGL LEKKWTSVIR 60
LQKKVMELES KLNEAKEEFT SGGPIGQKRD PKEWIPRPPE KYALSGHRSP VTRVIFHPVF 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Xtr-131985|E3,WD_repeat;UBD,Beta-Prp|Xenopus tropicalis
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCGGAAACC ACGGAGAAGA AAGGGAGGCA CGGACCCTTA GAAAGGAATA GCTGCAGAGA 60
AGACGGATTC AGTGCAATTT GACAGGAAAC AACGTACATA CAAGCGAGCC CCGCCGACCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Xtr-131985|E3,WD_repeat;UBD,Beta-Prp|Xenopus tropicalis
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:1904115--C:axon cytoplasm
GO:0005938--C:cell cortex
GO:0005813--C:centrosome
GO:0000776--C:kinetochore
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0008017--F:microtubule binding
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007281--P:germ cell development
GO:0031023--P:microtubule organizing center organization
GO:0007067--P:mitotic nuclear division
GO:0022008--P:neurogenesis
GO:0007097--P:nuclear migration
GO:2000574--P:regulation of microtubule motor activity
GO:0008090--P:retrograde axonal transport
GO:0047496--P:vesicle transport along microtubule

KEGG xtr:403097
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 97.49 0.00e+00 821.00
IUUC-Apl-004024 Anas platyrhynchos 97.32 0.00e+00 840.00
IUUC-Aca-004564 Anolis carolinensis 97.07 0.00e+00 834.00
IUUC-Ago-007862 Ashbya gossypii 27.92 5.00e-40 158.00
IUUC-Acl-008360 Aspergillus clavatus 46.53 3.00e-105 375.00
IUUC-Afl-008502 Aspergillus flavus 45.17 4.00e-94 338.00
IUUC-Afu-008848 Aspergillus fumigatus 47.19 6.00e-107 380.00
IUUC-Ani-009173 Aspergillus nidulans 42.79 1.00e-90 326.00
IUUC-Ang-009873 Aspergillus niger 44.56 2.00e-94 339.00
IUUC-Aor-009973 Aspergillus oryzae 43.94 5.00e-92 331.00
IUUC-Ate-010523 Aspergillus terreus 42.07 7.00e-91 327.00
IUUC-Ame-010969 Astyanax mexicanus 94.15 0.00e+00 818.00
IUUC-Bgr-011972 Blumeria graminis 47.26 1.00e-105 376.00
IUUC-Bta-013106 Bos taurus 97.56 0.00e+00 843.00
IUUC-Bci-013615 Botrytis cinerea 44.34 2.00e-98 352.00
IUUC-Cel-018459 Caenorhabditis elegans 56.93 2.00e-148 518.00
IUUC-Cja-018755 Callithrix jacchus 95.12 0.00e+00 824.00
IUUC-Cfa-020749 Canis familiaris 97.56 0.00e+00 843.00
IUUC-Cpo-022371 Cavia porcellus 97.56 0.00e+00 843.00
IUUC-Cre-022578 Chlamydomonas reinhardtii 34.81 4.00e-50 191.00
IUUC-Csa-023524 Chlorocebus sabaeus 96.52 0.00e+00 707.00
IUUC-Cho-024764 Choloepus hoffmanni 87.06 0.00e+00 668.00
IUUC-Cin-025753 Ciona intestinalis 70.07 1.00e-179 621.00
IUUC-Csv-025817 Ciona savignyi 68.54 0.00e+00 630.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 46.57 2.00e-97 349.00
IUUC-Cne-027087 Cryptococcus neoformans 50.13 9.00e-110 389.00
IUUC-Dre-027554 Danio rerio 94.63 0.00e+00 816.00
IUUC-Dno-029050 Dasypus novemcinctus 97.80 0.00e+00 843.00
IUUC-Dor-030222 Dipodomys ordii 89.76 0.00e+00 762.00
IUUC-Dse-031164 Dothistroma septosporum 43.83 4.00e-102 364.00
IUUC-Dme-031745 Drosophila melanogaster 69.59 5.00e-173 600.00
IUUC-Ete-032508 Echinops telfairi 80.73 0.00e+00 675.00
IUUC-Eca-034288 Equus caballus 96.99 0.00e+00 817.00
IUUC-Eeu-034984 Erinaceus europaeus 89.51 0.00e+00 759.00
IUUC-Fca-036498 Felis catus 97.56 0.00e+00 843.00
IUUC-Fal-036920 Ficedula albicollis 97.32 0.00e+00 840.00
IUUC-Fox-037996 Fusarium oxysporum 46.17 1.00e-104 373.00
IUUC-Fso-038160 Fusarium solani 44.58 1.00e-99 356.00
IUUC-Gmo-038983 Gadus morhua 93.17 0.00e+00 808.00
IUUC-Ggr-040051 Gaeumannomyces graminis 44.63 1.00e-97 349.00
IUUC-Gga-040623 Gallus gallus 97.32 0.00e+00 840.00
IUUC-Gac-041613 Gasterosteus aculeatus 93.17 0.00e+00 810.00
IUUC-Ggo-045410 Gorilla gorilla 86.72 0.00e+00 713.00
IUUC-Hsa-046358 Homo sapiens 97.32 0.00e+00 840.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 97.56 0.00e+00 843.00
IUUC-Kpa-049351 Komagataella pastoris 30.30 2.00e-45 176.00
IUUC-Lch-049936 Latimeria chalumnae 95.61 0.00e+00 827.00
IUUC-Loc-052476 Lepisosteus oculatus 94.99 0.00e+00 800.00
IUUC-Lma-053170 Leptosphaeria maculans 46.67 4.00e-101 361.00
IUUC-Laf-053713 Loxodonta africana 95.60 0.00e+00 825.00
IUUC-Mcc-054628 Macaca mulatta 97.07 0.00e+00 840.00
IUUC-Meu-055927 Macropus eugenii 83.39 5.00e-137 479.00
IUUC-Mor-056962 Magnaporthe oryzae 44.60 9.00e-98 350.00
IUUC-Mpo-057583 Magnaporthe poae 44.58 9.00e-94 337.00
IUUC-Mla-058819 Melampsora laricipopulina 48.54 9.00e-119 420.00
IUUC-Mga-059945 Meleagris gallopavo 97.07 0.00e+00 840.00
IUUC-Mvi-060403 Microbotryum violaceum 50.11 2.00e-128 451.00
IUUC-Mmr-061289 Microcebus murinus 97.49 0.00e+00 821.00
IUUC-Mdo-061912 Monodelphis domestica 96.83 0.00e+00 836.00
IUUC-Mmu-063253 Mus musculus 97.56 0.00e+00 843.00
IUUC-Mpu-066638 Mustela putorius furo 97.56 0.00e+00 843.00
IUUC-Mlu-067267 Myotis lucifugus 95.83 0.00e+00 825.00
IUUC-Nfi-068571 Neosartorya fischeri 45.81 2.00e-99 355.00
IUUC-Ncr-068895 Neurospora crassa 48.17 2.00e-105 375.00
IUUC-Nle-069087 Nomascus leucogenys 97.91 0.00e+00 690.00
IUUC-Opr-070579 Ochotona princeps 97.80 0.00e+00 843.00
IUUC-Ont-072432 Oreochromis niloticus 94.39 0.00e+00 820.00
IUUC-Oan-073072 Ornithorhynchus anatinus 97.56 0.00e+00 843.00
IUUC-Ocu-074180 Oryctolagus cuniculus 97.80 0.00e+00 843.00
IUUC-Ola-086772 Oryzias latipes 93.41 0.00e+00 810.00
IUUC-Oga-088219 Otolemur garnettii 95.35 0.00e+00 823.00
IUUC-Oar-090394 Ovis aries 97.56 0.00e+00 843.00
IUUC-Ptr-091517 Pan troglodytes 97.56 0.00e+00 843.00
IUUC-Pan-092421 Papio anubis 97.07 0.00e+00 840.00
IUUC-Psi-093370 Pelodiscus sinensis 97.56 0.00e+00 841.00
IUUC-Pma-094319 Petromyzon marinus 87.39 0.00e+00 637.00
IUUC-Pno-094815 Phaeosphaeria nodorum 47.26 1.00e-104 373.00
IUUC-Pfo-097089 Poecilia formosa 93.41 0.00e+00 814.00
IUUC-Pab-098421 Pongo abelii 97.56 0.00e+00 843.00
IUUC-Pca-100120 Procavia capensis 71.53 4.00e-162 563.00
IUUC-Pva-102960 Pteropus vampyrus 97.32 0.00e+00 839.00
IUUC-Pgr-103538 Puccinia graminis 47.65 3.00e-118 418.00
IUUC-Ptt-103990 Puccinia triticina 42.06 1.00e-44 174.00
IUUC-Pte-104261 Pyrenophora teres 47.49 1.00e-104 373.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 47.73 6.00e-105 374.00
IUUC-Rno-105123 Rattus norvegicus 97.56 0.00e+00 843.00
IUUC-Sce-106208 Saccharomyces cerevisiae 27.45 4.00e-37 149.00
IUUC-Sha-107010 Sarcophilus harrisii 96.59 0.00e+00 835.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 32.34 6.00e-65 241.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 44.47 8.00e-99 353.00
IUUC-Sar-113309 Sorex araneus 96.74 0.00e+00 812.00
IUUC-Sre-115003 Sporisorium reilianum 50.00 5.00e-126 444.00
IUUC-Ssc-116148 Sus scrofa 97.56 0.00e+00 843.00
IUUC-Tgu-117299 Taeniopygia guttata 97.07 0.00e+00 837.00
IUUC-Tru-118179 Takifugu rubripes 92.44 0.00e+00 810.00
IUUC-Tsy-119493 Tarsius syrichta 96.34 0.00e+00 827.00
IUUC-Tni-120355 Tetraodon nigroviridis 92.93 0.00e+00 781.00
IUUC-Tre-121977 Trichoderma reesei 42.80 1.00e-100 360.00
IUUC-Tvi-122661 Trichoderma virens 43.23 1.00e-99 356.00
IUUC-Tme-127031 Tuber melanosporum 48.64 2.00e-104 372.00
IUUC-Tbe-127492 Tupaia belangeri 62.34 8.00e-124 436.00
IUUC-Ttr-128929 Tursiops truncatus 97.56 0.00e+00 842.00
IUUC-Uma-129347 Ustilago maydis 47.95 5.00e-123 434.00
IUUC-Vda-129837 Verticillium dahliae 45.19 2.00e-99 355.00
IUUC-Vpa-130532 Vicugna pacos 83.42 0.00e+00 654.00
IUUC-Xma-133314 Xiphophorus maculatus 93.90 0.00e+00 816.00
IUUC-Yli-134403 Yarrowia lipolytica 37.89 2.00e-73 269.00
Created Date 25-Jun-2017

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