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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106147
UUCD1 version UUC-SaC-00099
Ensembl Protein ID YLL036C
UniProt Accession P32523; D6VXW9; Q07870; PRP19_YEAST
Genbank Protein ID AAA34912.1; CAA68103.1; CAA97487.1; DAA09285.1
Protein Name Pre-mRNA-processing factor 19; RING-type E3 ubiquitin transferase PRP19
Genbank Nucleotide ID L09721; X99770; Z73142; BK006945
Gene Name PRP19; PSO4; YLL036C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YLL036C YLL036C YLL036C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFdbPTMBioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/U-box 1.30e-08 33.3 1 51
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 6    flCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlv 56
           +lC+Is++++r Pv +p s+  +++s +e+++++ g+ +P+t++pl+ e++v
   Q: 1    MLCAISGKVPRRPVLSPkSRTIFEKSLLEQYVKDTGN-DPITNEPLSIEEIV 51
           58**********************************9.********998876 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Probable ubiquitin-protein ligase involved in pre-mRNA splicing. Acts as a central component of the NTC complex (or PRP19-associated complex) that associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation. It is also probably involved in DNA repair.
 Probable ubiquitin-protein ligase involved in pre-mRNA splicing. Acts as a central component of the NTC complex (or PRP19-associated complex) that associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation. It is also probably involved in DNA repair.
Protein Sequence
(Fasta)
MLCAISGKVP RRPVLSPKSR TIFEKSLLEQ YVKDTGNDPI TNEPLSIEEI VEIVPSAQQA 60
SLTESTNSAT LKANYSIPNL LTSLQNEWDA IMLENFKLRS TLDSLTKKLS TVMYERDAAK 120
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Protein Fasta Sequence


>IUUC-Sce-106147|E3,U-box|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGCTTTGTG CTATTAGTGG GAAAGTTCCT AGAAGGCCAG TTCTATCACC TAAATCCAGG 60
ACTATTTTTG AAAAGTCGCT CCTTGAACAG TATGTTAAAG ATACGGGGAA TGATCCGATA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106147|E3,U-box|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR013915--Pre-mRNA_splic_Prp19
IPR011047--Quinoprotein_ADH-like_supfam
IPR003613--Ubox_domain
IPR015943--WD40/YVTN_repeat-like_dom
PROSITE

PS51698--U_BOX
Pfam

PF08606--Prp19
SMART

SM00504--Ubox
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0000974--C:Prp19 complex
GO:0071006--C:U2-type catalytic step 1 spliceosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006281--P:DNA repair
GO:0000349--P:generation of catalytic spliceosome for first transesterification step
GO:0070534--P:protein K63-linked ubiquitination
KEGG sce:YLL036C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000890 Aegilops tauschii 38.73 1.00e-21 94.70
IUUC-Atr-002594 Amborella trichopoda 39.16 1.00e-24 105.00
IUUC-Aly-006002 Arabidopsis lyrata 43.18 4.00e-25 107.00
IUUC-Ath-007696 Arabidopsis thaliana 43.18 7.00e-25 106.00
IUUC-Ago-007879 Ashbya gossypii 53.79 1.00e-36 145.00
IUUC-Acl-008335 Aspergillus clavatus 34.31 5.00e-17 80.50
IUUC-Afl-008527 Aspergillus flavus 40.51 2.00e-27 114.00
IUUC-Afu-008957 Aspergillus fumigatus 24.54 9.00e-32 129.00
IUUC-Ani-009280 Aspergillus nidulans 41.96 5.00e-27 113.00
IUUC-Ang-009746 Aspergillus niger 40.56 5.00e-26 110.00
IUUC-Aor-009905 Aspergillus oryzae 40.51 2.00e-27 115.00
IUUC-Ate-010412 Aspergillus terreus 43.88 1.00e-27 115.00
IUUC-Ame-011561 Astyanax mexicanus 42.64 5.00e-22 96.30
IUUC-Bgr-012283 Blumeria graminis 35.92 3.00e-20 90.90
IUUC-Bci-013901 Botrytis cinerea 25.98 5.00e-33 133.00
IUUC-Bdi-014896 Brachypodium distachyon 38.46 3.00e-24 104.00
IUUC-Bol-016207 Brassica oleracea 40.91 5.00e-24 103.00
IUUC-Bra-017650 Brassica rapa 26.18 6.00e-27 113.00
IUUC-Cre-022993 Chlamydomonas reinhardtii 42.66 2.00e-25 108.00
IUUC-Cho-025065 Choloepus hoffmanni 40.31 3.00e-21 93.60
IUUC-Cin-025699 Ciona intestinalis 45.22 7.00e-23 99.40
IUUC-Cgl-026507 Colletotrichum gloeosporioides 40.00 7.00e-26 109.00
IUUC-Cne-026860 Cryptococcus neoformans 36.50 3.00e-22 97.80
IUUC-Dse-031220 Dothistroma septosporum 25.10 2.00e-30 124.00
IUUC-Ete-033035 Echinops telfairi 36.09 2.00e-21 95.50
IUUC-Fox-037922 Fusarium oxysporum 25.21 2.00e-29 121.00
IUUC-Fso-038256 Fusarium solani 37.25 2.00e-23 101.00
IUUC-Ggr-039854 Gaeumannomyces graminis 37.41 1.00e-18 85.90
IUUC-Gma-043635 Glycine max 24.51 3.00e-24 104.00
IUUC-Hvu-047442 Hordeum vulgare 40.41 2.00e-24 104.00
IUUC-Kpa-049195 Komagataella pastoris 41.55 5.00e-19 87.00
IUUC-Lpe-050976 Leersia perrieri 39.86 3.00e-24 104.00
IUUC-Lma-053143 Leptosphaeria maculans 41.84 2.00e-25 109.00
IUUC-Mor-057215 Magnaporthe oryzae 38.64 6.00e-20 90.10
IUUC-Mpo-057419 Magnaporthe poae 36.36 6.00e-18 83.20
IUUC-Mtr-057756 Medicago truncatula 25.42 3.00e-22 97.80
IUUC-Mla-059085 Melampsora laricipopulina 31.72 6.00e-16 76.60
IUUC-Mvi-060441 Microbotryum violaceum 39.86 9.00e-22 96.30
IUUC-Mac-064972 Musa acuminata 38.51 1.00e-23 102.00
IUUC-Nfi-068504 Neosartorya fischeri 24.75 3.00e-32 130.00
IUUC-Ncr-068729 Neurospora crassa 24.63 5.00e-27 113.00
IUUC-Oba-075509 Oryza barthii 40.41 8.00e-25 106.00
IUUC-Obr-076480 Oryza brachyantha 39.73 2.00e-24 104.00
IUUC-Ogl-077052 Oryza glaberrima 40.41 7.00e-25 106.00
IUUC-Ogu-078919 Oryza glumaepatula 40.41 8.00e-25 106.00
IUUC-Oin-079357 Oryza indica 40.56 8.00e-25 106.00
IUUC-Oni-082849 Oryza nivara 40.41 7.00e-25 106.00
IUUC-Opu-083243 Oryza punctata 39.73 2.00e-24 105.00
IUUC-Oru-084613 Oryza rufipogon 40.14 5.00e-25 107.00
IUUC-Osa-085407 Oryza sativa 40.41 7.00e-25 106.00
IUUC-Olu-087757 Ostreococcus lucimarinus 24.82 3.00e-23 100.00
IUUC-Pno-095115 Phaeosphaeria nodorum 40.43 2.00e-25 108.00
IUUC-Ppa-095841 Physcomitrella patens 38.46 3.00e-23 100.00
IUUC-Pop-099854 Populus trichocarpa 38.46 4.00e-24 103.00
IUUC-Ppe-101383 Prunus persica 36.91 1.00e-21 96.30
IUUC-Pgr-103304 Puccinia graminis 40.30 5.00e-22 97.10
IUUC-Ptt-103984 Puccinia triticina 38.67 2.00e-22 98.20
IUUC-Pte-104385 Pyrenophora teres 41.73 9.00e-26 109.00
IUUC-Pyt-104697 Pyrenophora triticirepentis 41.73 9.00e-26 109.00
IUUC-Sja-107697 Schizosaccharomyces japonicus 23.67 2.00e-25 108.00
IUUC-Spo-108315 Schizosaccharomyces pombe 34.51 9.00e-19 86.30
IUUC-Ssl-108628 Sclerotinia sclerotiorum 27.01 1.00e-31 128.00
IUUC-Smo-108803 Selaginella moellendorffii 24.21 2.00e-21 95.10
IUUC-Sit-109873 Setaria italica 40.56 1.00e-24 105.00
IUUC-Sly-111673 Solanum lycopersicum 37.58 6.00e-23 100.00
IUUC-Stu-112125 Solanum tuberosum 37.58 6.00e-23 100.00
IUUC-Sbi-114696 Sorghum bicolor 43.65 1.00e-23 102.00
IUUC-Sre-115134 Sporisorium reilianum 40.88 7.00e-26 110.00
IUUC-Tca-121807 Theobroma cacao 39.73 3.00e-25 107.00
IUUC-Tre-121920 Trichoderma reesei 37.06 6.00e-22 96.70
IUUC-Tvi-122294 Trichoderma virens 34.53 6.00e-18 83.60
IUUC-Tae-124231 Triticum aestivum 38.93 7.00e-25 106.00
IUUC-Tur-126664 Triticum urartu 38.73 1.00e-21 96.30
IUUC-Tme-127026 Tuber melanosporum 42.45 9.00e-26 109.00
IUUC-Uma-129626 Ustilago maydis 40.88 2.00e-25 108.00
IUUC-Vda-129699 Verticillium dahliae 37.59 4.00e-21 94.00
IUUC-Vvi-131668 Vitis vinifera 38.93 1.00e-23 102.00
IUUC-Yli-134607 Yarrowia lipolytica 43.57 1.00e-25 106.00
IUUC-Zma-135662 Zea mays 40.56 7.00e-25 106.00
Created Date 25-Jun-2017

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