iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-045963

Ensembl Protein ID

ENSP00000490618.1

UniProt Accession

Q9NYJ8; B2RCC4; E1P5A0; O94838; Q6I9W8; Q76N06; Q9UFP7; TAB2_HUMAN

Genbank Protein ID

AAF67176.1; BAA34453.2; BAG37521.1; CAG33668.1; ABC40736.1; CAB55907.1; CAI20026.1; CAI20026.1; CAI20026.1; CAI20971.1; CAI20971.1; CAI20971.1; CAI19581.1; CAI19581.1; CAI19581.1; EAW47805.1; EAW47806.1; EAW47807.1; AAH35910.1

Protein Name

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TAK1-binding protein 2; TGF-beta-activated kinase 1-binding protein 2

Genbank Nucleotide ID

AF241230; AB018276; AK315038; CR457387; DQ314877; AL117407; AL031133; AL138727; AL139103; AL139103; AL031133; AL138727; AL138727; AL031133; AL139103; CH471051; CH471051; CH471051; BC035910

Gene Name

TAB2; KIAA0733; MAP3K7IP2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000055208.18	ENST00000637181.1	ENSP00000490618.1
ENSG00000055208.18	ENST00000606797.5	ENSP00000475580.1
ENSG00000055208.18	ENST00000470466.5	ENSP00000432709.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	miRecords	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/ZnF/NZF	NZF	15029239; 15327770
UBD/Alpha-Helix/CUE	CUE	15029239; 15327770; 15836773

Classification

Family	E-value	Score	Start	End
UBD/ZnF/NZF	2.60e-14	54.1	665	692
UBD/Alpha-Helix/CUE	2.50e-07	32.2	11	50

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpRg 29
           +aqW+C+aCTflN+P++++Ce+C++pR+
   Q: 665  GAQWNCTACTFLNHPALIRCEQCEMPRH 692
           79*************************8 PP

UBD/Alpha-Helix/CUE

   S: 4    taleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           + l+ L++ FP++++ v+ +++++n+++l+a++  L ++s
   Q: 11   QVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQES 50
           689**********************************998 PP

Organism

Homo sapiens

Functional Description
(View)

Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.

Protein Sequence
(Fasta)

MAQGSHQIDF QVLHDLRQKF PEVPEVVVSR CMLQNNNNLD ACCAVLSQES TRYLYGEGDL 60
NFSDDSGISG LRNHMTSLNL DLQSQNIYHH GREGSRMNGS RTLTHSISDG QLQGGQSNSE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGAGGTGA ACTCCTTCAG GGCCACAGGC TGTAAAGATC TAAACACCAT CTGATCCAGT 60
TTCAATATGA CTGCCTGGAT GAAGAAGGAT TTGAGACTAA GTTTATTCCT CCAAAGCAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0160--Chromosomal rearrangement
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0472--Membrane
KW-0479--Metal-binding
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003892--CUE
IPR001876--Znf_RanBP2

PROSITE

PS51140--CUE
PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF02845--CUE

SMART

SM00546--CUE
SM00547--ZnF_RBZ

Gene Ontology

GO:0005829--C:cytosol
GO:0010008--C:endosome membrane
GO:0005886--C:plasma membrane
GO:0070530--F:K63-linked polyubiquitin binding
GO:0008270--F:zinc ion binding
GO:0000187--P:activation of MAPK activity
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0007507--P:heart development
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0007254--P:JNK cascade
GO:0002755--P:MyD88-dependent toll-like receptor signaling pathway
GO:0010507--P:negative regulation of autophagy
GO:0070423--P:nucleotide-binding oligomerization domain containing signaling pathway
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045860--P:positive regulation of protein kinase activity
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0050852--P:T cell receptor signaling pathway

KEGG

hsa:23118

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001681	Ailuropoda melanoleuca	96.68	0.00e+00	1266.00
IUUC-Apl-004125	Anas platyrhynchos	73.81	0.00e+00	952.00
IUUC-Aca-005332	Anolis carolinensis	85.14	0.00e+00	1096.00
IUUC-Ame-010937	Astyanax mexicanus	68.82	5.00e-115	408.00
IUUC-Bta-012567	Bos taurus	96.68	0.00e+00	1260.00
IUUC-Cja-020008	Callithrix jacchus	99.13	0.00e+00	1246.00
IUUC-Cfa-020602	Canis familiaris	96.54	0.00e+00	1264.00
IUUC-Cpo-022483	Cavia porcellus	91.27	0.00e+00	1147.00
IUUC-Csa-024196	Chlorocebus sabaeus	99.86	0.00e+00	1278.00
IUUC-Cho-025022	Choloepus hoffmanni	89.52	2.00e-52	199.00
IUUC-Cin-025456	Ciona intestinalis	34.31	4.00e-26	112.00
IUUC-Dre-027773	Danio rerio	52.90	7.00e-150	524.00
IUUC-Dno-029801	Dasypus novemcinctus	92.93	0.00e+00	1224.00
IUUC-Dor-030605	Dipodomys ordii	95.82	0.00e+00	1266.00
IUUC-Ete-032438	Echinops telfairi	92.21	0.00e+00	1219.00
IUUC-Eca-033410	Equus caballus	96.39	0.00e+00	1268.00
IUUC-Eeu-034509	Erinaceus europaeus	92.50	0.00e+00	1217.00
IUUC-Fca-035548	Felis catus	96.68	0.00e+00	1232.00
IUUC-Fal-037250	Ficedula albicollis	86.96	0.00e+00	1128.00
IUUC-Gmo-039053	Gadus morhua	65.00	4.00e-47	180.00
IUUC-Gga-040871	Gallus gallus	86.96	0.00e+00	1118.00
IUUC-Gac-041832	Gasterosteus aculeatus	63.27	0.00e+00	714.00
IUUC-Ggo-044976	Gorilla gorilla	100.00	0.00e+00	1279.00
IUUC-Itr-048861	Ictidomys tridecemlineatus	95.13	0.00e+00	916.00
IUUC-Lch-050144	Latimeria chalumnae	76.10	0.00e+00	969.00
IUUC-Loc-052931	Lepisosteus oculatus	64.54	0.00e+00	825.00
IUUC-Laf-053883	Loxodonta africana	96.25	0.00e+00	1256.00
IUUC-Mcc-054597	Macaca mulatta	99.71	0.00e+00	1274.00
IUUC-Meu-056202	Macropus eugenii	92.61	0.00e+00	813.00
IUUC-Mor-057018	Magnaporthe oryzae	64.00	2.00e-05	43.90
IUUC-Mla-059157	Melampsora laricipopulina	46.15	2.00e-03	36.20
IUUC-Mga-059601	Meleagris gallopavo	70.60	0.00e+00	875.00
IUUC-Mmr-061047	Microcebus murinus	97.40	0.00e+00	1273.00
IUUC-Mdo-061944	Monodelphis domestica	93.60	0.00e+00	1182.00
IUUC-Mmu-063095	Mus musculus	94.66	0.00e+00	1258.00
IUUC-Mpu-066232	Mustela putorius furo	96.39	0.00e+00	1263.00
IUUC-Mlu-067513	Myotis lucifugus	96.25	0.00e+00	1253.00
IUUC-Nle-069405	Nomascus leucogenys	99.57	0.00e+00	1274.00
IUUC-Opr-071184	Ochotona princeps	94.51	2.00e-120	426.00
IUUC-Ont-071678	Oreochromis niloticus	61.79	0.00e+00	687.00
IUUC-Oan-072975	Ornithorhynchus anatinus	78.50	6.00e-149	521.00
IUUC-Ocu-073763	Oryctolagus cuniculus	96.39	0.00e+00	1228.00
IUUC-Ola-087478	Oryzias latipes	55.86	0.00e+00	633.00
IUUC-Oga-088892	Otolemur garnettii	87.96	0.00e+00	1175.00
IUUC-Oar-089573	Ovis aries	97.11	0.00e+00	1264.00
IUUC-Ptr-091270	Pan troglodytes	100.00	0.00e+00	1279.00
IUUC-Pan-092250	Papio anubis	99.71	0.00e+00	1276.00
IUUC-Psi-093732	Pelodiscus sinensis	85.96	0.00e+00	1110.00
IUUC-Pma-094397	Petromyzon marinus	43.93	1.00e-30	127.00
IUUC-Pfo-097098	Poecilia formosa	60.64	0.00e+00	660.00
IUUC-Pab-098776	Pongo abelii	99.71	0.00e+00	1276.00
IUUC-Pca-100202	Procavia capensis	90.91	0.00e+00	1145.00
IUUC-Pva-103025	Pteropus vampyrus	96.39	0.00e+00	1233.00
IUUC-Rno-105366	Rattus norvegicus	93.94	0.00e+00	1256.00
IUUC-Sha-107249	Sarcophilus harrisii	92.36	0.00e+00	1199.00
IUUC-Stu-112401	Solanum tuberosum	33.80	8.00e-04	36.60
IUUC-Sar-113207	Sorex araneus	95.32	0.00e+00	924.00
IUUC-Ssc-116409	Sus scrofa	93.80	0.00e+00	1218.00
IUUC-Tgu-116911	Taeniopygia guttata	87.11	0.00e+00	1130.00
IUUC-Tru-118667	Takifugu rubripes	58.52	0.00e+00	650.00
IUUC-Tsy-119562	Tarsius syrichta	96.71	0.00e+00	717.00
IUUC-Tni-120195	Tetraodon nigroviridis	54.88	1.00e-175	609.00
IUUC-Tbe-127934	Tupaia belangeri	94.66	0.00e+00	1253.00
IUUC-Ttr-128519	Tursiops truncatus	94.65	0.00e+00	725.00
IUUC-Vpa-130279	Vicugna pacos	92.53	0.00e+00	1192.00
IUUC-Xtr-131844	Xenopus tropicalis	77.54	0.00e+00	993.00
IUUC-Xma-133854	Xiphophorus maculatus	60.17	0.00e+00	660.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence