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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046335
UUCD1 version UUC-HoS-00920
Ensembl Protein ID ENSP00000476117.2
UniProt Accession Q9BV38; O60390; Q9BWR2; WDR18_HUMAN
Genbank Protein ID AAC12679.1; AAH00040.2; AAH01648.1
Protein Name WD repeat-containing protein 18
Genbank Nucleotide ID AC004528; BC000040; BC001648
Gene Name WDR18
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000065268.10 ENST00000585809.5 ENSP00000476117.2
ENSG00000065268.10 ENST00000587001.6 ENSP00000464855.1
ENSG00000065268.10 ENST00000590397.5 ENSP00000465826.3
ENSG00000065268.10 ENST00000591985.6 ENSP00000466551.1
ENSG00000065268.10 ENST00000251289.9 ENSP00000251289.4
ENSG00000065268.10 ENST00000607440.5 ENSP00000475744.1
ENSG00000065268.10 ENST00000590354.3 ENSP00000475953.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 5.70e-18 65.9 267 305
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH + vtcl+  +d   l+sGs+D t+++WD+ +  +++
   Q: 267  GHRNQVTCLSVsTDgSVLLSGSHDETVRLWDVQSKQCIR 305
           8**********988899***************9998876 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May play a role during development (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
 May play a role during development (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
Protein Sequence
(Fasta)
MAAPMEVAVC TDSAAPMWSC IVWELHSGAN LLTYRGGQAG PRGLALLNGE YLLAAQLGKN 60
YISAWELQRK DQLQQKIMCP GPVTCLTASP NGLYVLAGVA ESIHLWEVST GNLLVILSRH 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046335|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGGCCGCCG CTCTGGCCCG CGTGGGGCAG TCGTCCGCGT CTCGCTCATG ATGACGCACG 60
TCCGGGGCGG TGGGGAAGGC AAGATGGCGG CGCCCATGGA GGTGGCCGTG TGTACGGACT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046335|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR026987--Wdr18_C_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PF14077--WD40_alt
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0007275--P:multicellular organism development
GO:0006364--P:rRNA processing
KEGG hsa:57418
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001040 Aegilops tauschii 32.13 6.00e-28 118.00
IUUC-Aml-001819 Ailuropoda melanoleuca 90.28 0.00e+00 754.00
IUUC-Atr-002688 Amborella trichopoda 36.62 1.00e-40 160.00
IUUC-Apl-004023 Anas platyrhynchos 56.94 5.00e-108 384.00
IUUC-Aca-004879 Anolis carolinensis 69.05 1.00e-58 218.00
IUUC-Aly-006061 Arabidopsis lyrata 30.84 1.00e-36 147.00
IUUC-Ath-007111 Arabidopsis thaliana 30.77 5.00e-34 139.00
IUUC-Acl-008357 Aspergillus clavatus 26.28 5.00e-19 89.40
IUUC-Afl-008564 Aspergillus flavus 26.06 2.00e-18 87.80
IUUC-Afu-009113 Aspergillus fumigatus 26.52 3.00e-19 90.50
IUUC-Ani-009132 Aspergillus nidulans 24.62 4.00e-17 83.20
IUUC-Aor-009882 Aspergillus oryzae 26.06 2.00e-18 87.80
IUUC-Ate-010249 Aspergillus terreus 26.59 1.00e-20 94.40
IUUC-Ame-010912 Astyanax mexicanus 63.26 1.00e-168 586.00
IUUC-Bta-013402 Bos taurus 90.05 0.00e+00 753.00
IUUC-Bci-013791 Botrytis cinerea 24.91 3.00e-12 66.20
IUUC-Bdi-015054 Brachypodium distachyon 33.23 1.00e-35 144.00
IUUC-Bol-016342 Brassica oleracea 28.92 6.00e-31 128.00
IUUC-Bra-016967 Brassica rapa 29.22 1.00e-31 130.00
IUUC-Cja-019758 Callithrix jacchus 92.79 0.00e+00 730.00
IUUC-Cfa-020495 Canis familiaris 89.81 0.00e+00 651.00
IUUC-Cpo-021438 Cavia porcellus 86.93 2.00e-171 595.00
IUUC-Csa-023416 Chlorocebus sabaeus 98.38 0.00e+00 809.00
IUUC-Csv-025918 Ciona savignyi 33.18 2.00e-60 226.00
IUUC-Cne-026843 Cryptococcus neoformans 28.63 4.00e-18 86.30
IUUC-Dre-027560 Danio rerio 61.16 2.00e-165 575.00
IUUC-Dno-029315 Dasypus novemcinctus 86.51 0.00e+00 755.00
IUUC-Dor-030935 Dipodomys ordii 86.87 0.00e+00 757.00
IUUC-Dme-032059 Drosophila melanogaster 34.20 7.00e-56 211.00
IUUC-Fca-036068 Felis catus 86.17 0.00e+00 715.00
IUUC-Fal-037467 Ficedula albicollis 72.24 4.00e-164 570.00
IUUC-Gmo-039323 Gadus morhua 53.27 4.00e-115 408.00
IUUC-Gga-040563 Gallus gallus 72.80 6.00e-156 543.00
IUUC-Gac-042641 Gasterosteus aculeatus 59.95 3.00e-150 524.00
IUUC-Gma-043856 Glycine max 29.30 8.00e-40 158.00
IUUC-Ggo-045137 Gorilla gorilla 99.54 0.00e+00 790.00
IUUC-Hvu-047685 Hordeum vulgare 32.42 6.00e-31 128.00
IUUC-Itr-048032 Ictidomys tridecemlineatus 89.35 0.00e+00 806.00
IUUC-Kpa-049129 Komagataella pastoris 31.00 4.00e-31 129.00
IUUC-Lch-049532 Latimeria chalumnae 64.04 5.00e-178 617.00
IUUC-Lpe-051321 Leersia perrieri 32.50 2.00e-28 120.00
IUUC-Loc-052471 Lepisosteus oculatus 60.05 9.00e-159 553.00
IUUC-Lma-053091 Leptosphaeria maculans 25.99 7.00e-24 105.00
IUUC-Laf-054331 Loxodonta africana 87.50 0.00e+00 710.00
IUUC-Mcc-055803 Macaca mulatta 98.38 0.00e+00 809.00
IUUC-Meu-056090 Macropus eugenii 74.54 0.00e+00 691.00
IUUC-Mor-057160 Magnaporthe oryzae 27.69 3.00e-18 86.70
IUUC-Mtr-057827 Medicago truncatula 33.22 7.00e-38 151.00
IUUC-Mla-058943 Melampsora laricipopulina 36.60 2.00e-23 104.00
IUUC-Mga-059282 Meleagris gallopavo 64.56 7.00e-140 490.00
IUUC-Mvi-060315 Microbotryum violaceum 35.67 4.00e-26 112.00
IUUC-Mmr-061127 Microcebus murinus 93.29 0.00e+00 789.00
IUUC-Mdo-062350 Monodelphis domestica 74.07 0.00e+00 686.00
IUUC-Mmu-063706 Mus musculus 83.33 0.00e+00 726.00
IUUC-Mac-065554 Musa acuminata 30.33 5.00e-27 115.00
IUUC-Mpu-066711 Mustela putorius furo 90.28 0.00e+00 817.00
IUUC-Mlu-068121 Myotis lucifugus 89.50 3.00e-178 617.00
IUUC-Ncr-068914 Neurospora crassa 27.40 7.00e-17 81.60
IUUC-Nle-069518 Nomascus leucogenys 97.71 0.00e+00 722.00
IUUC-Ont-071435 Oreochromis niloticus 60.88 4.00e-152 531.00
IUUC-Oan-073532 Ornithorhynchus anatinus 67.31 9.00e-41 157.00
IUUC-Oba-075873 Oryza barthii 32.23 2.00e-38 153.00
IUUC-Obr-076097 Oryza brachyantha 29.73 5.00e-27 115.00
IUUC-Ogl-077840 Oryza glaberrima 31.96 2.00e-38 153.00
IUUC-Ogu-077988 Oryza glumaepatula 32.23 2.00e-38 153.00
IUUC-Oin-079237 Oryza indica 34.39 9.00e-27 114.00
IUUC-Olo-080415 Oryza longistaminata 33.93 1.00e-30 129.00
IUUC-Ome-081952 Oryza meridionalis 31.40 3.00e-36 145.00
IUUC-Oni-082300 Oryza nivara 32.23 2.00e-38 153.00
IUUC-Opu-083436 Oryza punctata 34.29 7.00e-25 108.00
IUUC-Oru-085164 Oryza rufipogon 32.78 2.00e-38 153.00
IUUC-Osa-086129 Oryza sativa 31.96 8.00e-39 154.00
IUUC-Ola-086571 Oryzias latipes 57.77 6.00e-142 497.00
IUUC-Oga-088561 Otolemur garnettii 93.06 0.00e+00 808.00
IUUC-Oar-090131 Ovis aries 78.29 5.00e-178 617.00
IUUC-Ptr-091301 Pan troglodytes 98.63 7.00e-116 410.00
IUUC-Pan-092810 Papio anubis 98.15 0.00e+00 806.00
IUUC-Psi-093091 Pelodiscus sinensis 63.04 3.00e-126 445.00
IUUC-Pno-095047 Phaeosphaeria nodorum 24.25 1.00e-18 88.20
IUUC-Ppa-095317 Physcomitrella patens 36.12 4.00e-35 142.00
IUUC-Pfo-096996 Poecilia formosa 58.37 2.00e-142 499.00
IUUC-Pab-097747 Pongo abelii 98.32 0.00e+00 775.00
IUUC-Pop-099609 Populus trichocarpa 30.00 3.00e-40 159.00
IUUC-Pca-100972 Procavia capensis 83.10 0.00e+00 632.00
IUUC-Ppe-101904 Prunus persica 33.95 4.00e-43 169.00
IUUC-Pva-102700 Pteropus vampyrus 76.60 5.00e-161 560.00
IUUC-Pgr-103616 Puccinia graminis 36.36 9.00e-22 98.60
IUUC-Ptt-103954 Puccinia triticina 36.91 2.00e-20 94.00
IUUC-Pte-104120 Pyrenophora teres 26.32 1.00e-24 108.00
IUUC-Pyt-104558 Pyrenophora triticirepentis 26.64 4.00e-25 109.00
IUUC-Rno-104933 Rattus norvegicus 83.33 0.00e+00 725.00
IUUC-Sce-106403 Saccharomyces cerevisiae 24.13 8.00e-15 75.50
IUUC-Sha-107636 Sarcophilus harrisii 74.77 0.00e+00 692.00
IUUC-Sja-107783 Schizosaccharomyces japonicus 33.86 3.00e-35 142.00
IUUC-Spo-108192 Schizosaccharomyces pombe 24.88 3.00e-23 102.00
IUUC-Ssl-108384 Sclerotinia sclerotiorum 27.08 3.00e-17 82.80
IUUC-Smo-109498 Selaginella moellendorffii 36.60 4.00e-39 155.00
IUUC-Sit-110770 Setaria italica 33.76 5.00e-37 149.00
IUUC-Sly-111453 Solanum lycopersicum 33.03 4.00e-42 165.00
IUUC-Stu-112384 Solanum tuberosum 32.73 8.00e-42 165.00
IUUC-Sbi-113952 Sorghum bicolor 33.44 4.00e-37 149.00
IUUC-Sre-115223 Sporisorium reilianum 31.88 1.00e-24 108.00
IUUC-Ssc-115627 Sus scrofa 91.90 0.00e+00 773.00
IUUC-Tgu-117404 Taeniopygia guttata 72.39 3.00e-156 544.00
IUUC-Tru-117629 Takifugu rubripes 60.20 1.00e-130 459.00
IUUC-Tni-119839 Tetraodon nigroviridis 56.91 5.00e-128 451.00
IUUC-Tca-121766 Theobroma cacao 34.23 7.00e-42 164.00
IUUC-Tae-125634 Triticum aestivum 32.52 3.00e-31 129.00
IUUC-Tur-126673 Triticum urartu 29.49 2.00e-23 103.00
IUUC-Tme-127070 Tuber melanosporum 25.53 2.00e-18 87.00
IUUC-Tbe-127452 Tupaia belangeri 86.70 2.00e-115 409.00
IUUC-Ttr-128735 Tursiops truncatus 89.35 0.00e+00 728.00
IUUC-Uma-129521 Ustilago maydis 27.14 7.00e-24 105.00
IUUC-Vvi-130872 Vitis vinifera 30.96 5.00e-40 158.00
IUUC-Xtr-131838 Xenopus tropicalis 64.57 5.00e-146 510.00
IUUC-Xma-134106 Xiphophorus maculatus 65.27 9.00e-116 409.00
IUUC-Yli-134551 Yarrowia lipolytica 25.24 2.00e-21 97.10
IUUC-Zma-134703 Zea mays 33.12 4.00e-36 145.00
Created Date 25-Jun-2017

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