iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-073660

UUCD1 version

UUC-OrA-00343

Ensembl Protein ID

ENSOANP00000001912.2

UniProt Accession

F6Z7L6; F6Z7L6_ORNAN

Protein Name

Eukaryotic translation initiation factor 3 subunit I; Eukaryotic translation initiation factor 3 subunit 2; eIF-3-beta; eIF3 p36

Gene Name

EIF3I; EIF3S2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000001198.3	ENSOANT00000001913.2	ENSOANP00000001912.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.40e-18	64.2	18	55

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtcl..afsd.tllvsGsdDgtikvWDlrtgvll 36
           gHt+ v+c+  ++ d +++++Gs D+++++WD  tg++l
   Q: 18   GHTGAVWCVdaDW-DtKHVLTGSADNSCRLWDCETGKQL 55
           8*******98679.55*******************9986 PP

Organism

Ornithorhynchus anatinus

Functional Description
(View)

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

Protein Sequence
(Fasta)

IVNVWYSVNG ERLGTYNGHT GAVWCVDADW DTKHVLTGSA DNSCRLWDCE TGKQLALLKT 60
NSAVRTCGFD FGGNIVMFST DKQMGYQCFF VSFFDLRDPS QIESNEPYMK IPCNDSKITS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAGATCGTC AATGTGTGGT ACTCCGTGAA CGGGGAGAGA TTGGGTACCT ACAACGGGCA 60
CACCGGAGCC GTGTGGTGCG TGGATGCCGA CTGTATCCTT TGGCCGGTGG TTTTCTAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0396--Initiation factor
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR027525--eIF3i
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0016282--C:eukaryotic 43S preinitiation complex
GO:0033290--C:eukaryotic 48S preinitiation complex
GO:0071541--C:eukaryotic translation initiation factor 3 complex, eIF3m
GO:0070062--C:extracellular exosome
GO:0003743--F:translation initiation factor activity
GO:0001731--P:formation of translation preinitiation complex
GO:0006446--P:regulation of translational initiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000115	Aegilops tauschii	56.64	2.00e-34	139.00
IUUC-Aml-001321	Ailuropoda melanoleuca	95.58	1.00e-170	591.00
IUUC-Atr-002468	Amborella trichopoda	49.74	5.00e-53	200.00
IUUC-Apl-003841	Anas platyrhynchos	93.54	4.00e-169	586.00
IUUC-Aca-005123	Anolis carolinensis	91.16	1.00e-165	575.00
IUUC-Aly-005473	Arabidopsis lyrata	43.69	1.00e-70	258.00
IUUC-Ath-007094	Arabidopsis thaliana	45.05	2.00e-72	265.00
IUUC-Ago-008000	Ashbya gossypii	41.53	9.00e-67	246.00
IUUC-Acl-008098	Aspergillus clavatus	49.50	2.00e-84	304.00
IUUC-Afl-008494	Aspergillus flavus	49.50	3.00e-84	304.00
IUUC-Afu-009080	Aspergillus fumigatus	49.33	2.00e-84	304.00
IUUC-Ani-009230	Aspergillus nidulans	50.51	2.00e-84	305.00
IUUC-Aor-010114	Aspergillus oryzae	49.50	3.00e-84	304.00
IUUC-Ate-010285	Aspergillus terreus	51.85	2.00e-87	315.00
IUUC-Ame-011534	Astyanax mexicanus	81.02	7.00e-151	525.00
IUUC-Bgr-012121	Blumeria graminis	46.62	5.00e-75	273.00
IUUC-Bta-013143	Bos taurus	95.24	2.00e-170	590.00
IUUC-Bci-013950	Botrytis cinerea	49.66	3.00e-83	300.00
IUUC-Bdi-015019	Brachypodium distachyon	44.71	9.00e-73	266.00
IUUC-Bol-015709	Brassica oleracea	44.75	2.00e-69	256.00
IUUC-Bra-017760	Brassica rapa	44.75	1.00e-69	256.00
IUUC-Cel-018226	Caenorhabditis elegans	42.32	2.00e-68	251.00
IUUC-Cja-019741	Callithrix jacchus	95.58	7.00e-171	592.00
IUUC-Cfa-021204	Canis familiaris	94.90	9.00e-170	588.00
IUUC-Cpo-021661	Cavia porcellus	95.58	7.00e-171	592.00
IUUC-Cre-022952	Chlamydomonas reinhardtii	40.83	3.00e-67	247.00
IUUC-Csa-024038	Chlorocebus sabaeus	95.58	7.00e-171	592.00
IUUC-Cin-025597	Ciona intestinalis	57.19	7.00e-101	359.00
IUUC-Csv-026287	Ciona savignyi	27.11	1.00e-20	92.40
IUUC-Cgl-026583	Colletotrichum gloeosporioides	48.81	3.00e-80	290.00
IUUC-Cne-026838	Cryptococcus neoformans	46.44	5.00e-78	283.00
IUUC-Cme-027304	Cyanidioschyzon merolae	42.21	1.00e-64	239.00
IUUC-Dre-028567	Danio rerio	81.97	8.00e-153	531.00
IUUC-Dno-029171	Dasypus novemcinctus	96.26	6.00e-172	596.00
IUUC-Dor-030257	Dipodomys ordii	79.31	5.00e-63	233.00
IUUC-Dse-031191	Dothistroma septosporum	48.16	8.00e-79	286.00
IUUC-Dme-031879	Drosophila melanogaster	59.04	6.00e-103	366.00
IUUC-Ete-032336	Echinops telfairi	94.42	3.00e-120	422.00
IUUC-Eca-033259	Equus caballus	95.24	4.00e-170	589.00
IUUC-Eeu-035153	Erinaceus europaeus	75.84	3.00e-59	221.00
IUUC-Fca-036489	Felis catus	95.24	4.00e-170	589.00
IUUC-Fal-037485	Ficedula albicollis	92.86	3.00e-168	583.00
IUUC-Fox-037860	Fusarium oxysporum	47.28	6.00e-79	286.00
IUUC-Fso-038188	Fusarium solani	48.30	1.00e-79	289.00
IUUC-Gmo-039311	Gadus morhua	82.99	6.00e-155	539.00
IUUC-Ggr-040045	Gaeumannomyces graminis	48.47	2.00e-80	291.00
IUUC-Gga-040645	Gallus gallus	91.06	4.00e-167	579.00
IUUC-Gac-042086	Gasterosteus aculeatus	82.31	3.00e-151	526.00
IUUC-Gma-043246	Glycine max	44.52	2.00e-73	268.00
IUUC-Ggo-045578	Gorilla gorilla	95.58	7.00e-171	592.00
IUUC-Hsa-046734	Homo sapiens	95.58	7.00e-171	592.00
IUUC-Hvu-047553	Hordeum vulgare	44.18	3.00e-72	264.00
IUUC-Itr-048467	Ictidomys tridecemlineatus	95.24	2.00e-170	590.00
IUUC-Kpa-049325	Komagataella pastoris	42.57	3.00e-69	254.00
IUUC-Lch-049620	Latimeria chalumnae	85.34	2.00e-141	494.00
IUUC-Lpe-051338	Leersia perrieri	43.53	7.00e-66	243.00
IUUC-Loc-052094	Lepisosteus oculatus	78.50	2.00e-141	494.00
IUUC-Lma-053047	Leptosphaeria maculans	47.47	8.00e-80	289.00
IUUC-Laf-053801	Loxodonta africana	95.92	2.00e-171	593.00
IUUC-Mcc-055498	Macaca mulatta	86.88	5.00e-142	496.00
IUUC-Meu-056729	Macropus eugenii	88.14	2.00e-153	534.00
IUUC-Mor-057025	Magnaporthe oryzae	49.15	2.00e-79	288.00
IUUC-Mpo-057511	Magnaporthe poae	50.17	8.00e-82	296.00
IUUC-Mtr-058051	Medicago truncatula	45.55	4.00e-74	270.00
IUUC-Mla-059061	Melampsora laricipopulina	46.90	2.00e-69	255.00
IUUC-Mga-059229	Meleagris gallopavo	92.91	2.00e-167	581.00
IUUC-Mvi-060399	Microbotryum violaceum	44.33	1.00e-67	249.00
IUUC-Mmr-060764	Microcebus murinus	95.58	7.00e-171	592.00
IUUC-Mdo-062088	Monodelphis domestica	95.93	2.00e-171	593.00
IUUC-Mmu-064304	Mus musculus	95.58	5.00e-171	592.00
IUUC-Mac-065520	Musa acuminata	46.58	1.00e-77	282.00
IUUC-Mpu-066340	Mustela putorius furo	95.24	4.00e-170	589.00
IUUC-Mlu-067111	Myotis lucifugus	95.92	2.00e-171	593.00
IUUC-Nfi-068478	Neosartorya fischeri	49.67	1.00e-84	305.00
IUUC-Ncr-068820	Neurospora crassa	49.15	1.00e-80	292.00
IUUC-Nle-069903	Nomascus leucogenys	95.24	3.00e-170	589.00
IUUC-Opr-070221	Ochotona princeps	93.20	4.00e-165	573.00
IUUC-Ont-071765	Oreochromis niloticus	84.69	7.00e-157	545.00
IUUC-Ocu-074039	Oryctolagus cuniculus	95.58	9.00e-171	591.00
IUUC-Oba-075856	Oryza barthii	41.37	2.00e-61	228.00
IUUC-Obr-076334	Oryza brachyantha	43.36	2.00e-67	248.00
IUUC-Ogl-077060	Oryza glaberrima	44.71	7.00e-71	259.00
IUUC-Ogu-078207	Oryza glumaepatula	44.52	7.00e-73	266.00
IUUC-Oin-079878	Oryza indica	44.03	6.00e-72	263.00
IUUC-Olo-080677	Oryza longistaminata	37.18	8.00e-63	233.00
IUUC-Ome-081228	Oryza meridionalis	31.43	5.00e-21	94.00
IUUC-Oni-082411	Oryza nivara	37.37	4.00e-56	210.00
IUUC-Opu-083136	Oryza punctata	43.69	2.00e-71	261.00
IUUC-Oru-084916	Oryza rufipogon	43.05	1.00e-70	258.00
IUUC-Osa-085776	Oryza sativa	44.03	9.00e-72	263.00
IUUC-Ola-087053	Oryzias latipes	83.33	3.00e-154	536.00
IUUC-Olu-087602	Ostreococcus lucimarinus	45.49	2.00e-73	268.00
IUUC-Oga-088154	Otolemur garnettii	95.24	7.00e-170	588.00
IUUC-Oar-089915	Ovis aries	95.24	3.00e-170	590.00
IUUC-Ptr-091124	Pan troglodytes	78.08	4.00e-130	456.00
IUUC-Pan-092035	Papio anubis	95.58	7.00e-171	592.00
IUUC-Psi-094096	Pelodiscus sinensis	90.83	2.00e-119	421.00
IUUC-Pno-094988	Phaeosphaeria nodorum	45.24	3.00e-71	261.00
IUUC-Ppa-095536	Physcomitrella patens	46.92	7.00e-77	280.00
IUUC-Pfo-096101	Poecilia formosa	83.67	4.00e-155	540.00
IUUC-Pab-097726	Pongo abelii	95.58	7.00e-171	592.00
IUUC-Pop-099617	Populus trichocarpa	46.92	4.00e-75	274.00
IUUC-Pca-101014	Procavia capensis	95.92	3.00e-171	593.00
IUUC-Ppe-101320	Prunus persica	46.08	7.00e-72	263.00
IUUC-Pva-102789	Pteropus vampyrus	81.97	7.00e-140	489.00
IUUC-Pgr-103479	Puccinia graminis	44.48	4.00e-67	247.00
IUUC-Ptt-103981	Puccinia triticina	44.83	9.00e-69	253.00
IUUC-Pte-104278	Pyrenophora teres	48.48	7.00e-82	296.00
IUUC-Pyt-104492	Pyrenophora triticirepentis	48.48	7.00e-82	296.00
IUUC-Rno-105867	Rattus norvegicus	71.86	8.00e-115	405.00
IUUC-Sce-106251	Saccharomyces cerevisiae	43.14	8.00e-70	256.00
IUUC-Sha-107039	Sarcophilus harrisii	95.59	3.00e-171	593.00
IUUC-Sja-107758	Schizosaccharomyces japonicus	50.00	7.00e-82	296.00
IUUC-Spo-108314	Schizosaccharomyces pombe	45.24	3.00e-76	277.00
IUUC-Ssl-108478	Sclerotinia sclerotiorum	49.15	6.00e-83	300.00
IUUC-Smo-108728	Selaginella moellendorffii	46.23	4.00e-72	264.00
IUUC-Sit-110801	Setaria italica	43.84	4.00e-71	260.00
IUUC-Sly-111326	Solanum lycopersicum	44.52	7.00e-72	263.00
IUUC-Stu-112458	Solanum tuberosum	45.21	2.00e-72	265.00
IUUC-Sbi-114063	Sorghum bicolor	43.49	3.00e-70	258.00
IUUC-Sre-115096	Sporisorium reilianum	44.97	7.00e-67	246.00
IUUC-Ssc-116080	Sus scrofa	95.58	1.00e-170	591.00
IUUC-Tgu-116988	Taeniopygia guttata	92.86	5.00e-168	582.00
IUUC-Tru-118766	Takifugu rubripes	84.69	3.00e-156	543.00
IUUC-Tsy-119522	Tarsius syrichta	27.37	3.00e-15	75.10
IUUC-Tni-120197	Tetraodon nigroviridis	84.01	7.00e-156	542.00
IUUC-Tca-121316	Theobroma cacao	45.21	1.00e-72	265.00
IUUC-Tre-122097	Trichoderma reesei	48.14	3.00e-80	291.00
IUUC-Tvi-122442	Trichoderma virens	48.14	1.00e-80	292.00
IUUC-Tae-125542	Triticum aestivum	44.59	1.00e-72	265.00
IUUC-Tur-126334	Triticum urartu	41.98	1.00e-58	219.00
IUUC-Tme-127038	Tuber melanosporum	50.68	3.00e-86	310.00
IUUC-Ttr-128659	Tursiops truncatus	88.78	3.00e-145	507.00
IUUC-Uma-129464	Ustilago maydis	45.15	2.00e-66	245.00
IUUC-Vda-129841	Verticillium dahliae	50.68	2.00e-82	298.00
IUUC-Vvi-131076	Vitis vinifera	45.89	7.00e-74	270.00
IUUC-Xtr-132395	Xenopus tropicalis	89.12	6.00e-163	565.00
IUUC-Xma-133383	Xiphophorus maculatus	83.33	2.00e-154	537.00
IUUC-Yli-134586	Yarrowia lipolytica	45.64	3.00e-64	238.00
IUUC-Zma-135904	Zea mays	43.84	6.00e-71	259.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence