iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Yli-134467

Ensembl Protein ID

CAG80740

UniProt Accession

Q6C9W0; UBC12_YARLI

Genbank Protein ID

CAG80740.1

Protein Name

NEDD8-conjugating enzyme UBC12; RUB1-conjugating enzyme; RUB1-protein ligase; Ubiquitin carrier protein 12

Genbank Nucleotide ID

CR382130

Gene Name

UBC12; YALI0D07890g

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YALI0_D07890g	CAG80740	CAG80740

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	5.10e-39	131.6	28	160

Active Site

Position(s)	Description	Evidence
106	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsvesv 101
           R++k+l+el  + p++++ ++ + +d++++e+++  p++  Y+gg F++++++++++P +PPkvk+l+k++hPn++ +G+vCl+il+  e+W+p+ls++ v
   Q: 28   RVQKDLSEL--SLPSTMKTHFPSAEDIMNFELTVR-PDEGFYQGGEFRFSFYVNPNFPHEPPKVKCLQKVYHPNIDLEGNVCLNILR--EDWKPVLSLNAV 123
           899999999..78999999999999*********9.**************************************************9..************ PP
   S: 102  llsiqsllaepnpesplneeaaellkknreeykkkvr 138
           ++++q l+ epn ++pln++aa+++++nree+k++v+
   Q: 124  MIGLQYLFLEPNASDPLNKDAAHQMTANREEFKRNVK 160
           ***********************************97 PP

Organism

Yarrowia lipolytica

Functional Description
(View)

Accepts the ubiquitin-like protein NEDD8/RUB1 from the UBA3-ULA1 E1 complex and catalyzes its covalent attachment to other proteins.

Protein Sequence
(Fasta)

MLKIWSMKEK QAAEGGSAKK KVTAAQLRVQ KDLSELSLPS TMKTHFPSAE DIMNFELTVR 60
PDEGFYQGGE FRFSFYVNPN FPHEPPKVKC LQKVYHPNID LEGNVCLNIL REDWKPVLSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTGAAAA TCTGGAGCAT GAAGGAGAAG CAGGCGGCCG AGGGCGGCAG TGCCAAGAAG 60
AAGGTGACTG CTGCTCAGTT GCGGGTCCAG AAGGATCTGT CTGAGCTGTC GCTTCCTTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0016874--F:ligase activity
GO:0019788--F:NEDD8 transferase activity
GO:0045116--P:protein neddylation

KEGG

yli:YALI0D07890g

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000196	Aegilops tauschii	59.03	5.00e-50	187.00
IUUC-Aml-002007	Ailuropoda melanoleuca	58.22	3.00e-50	188.00
IUUC-Atr-003170	Amborella trichopoda	54.75	3.00e-55	205.00
IUUC-Aca-005037	Anolis carolinensis	56.04	8.00e-60	220.00
IUUC-Aly-005638	Arabidopsis lyrata	53.89	3.00e-55	205.00
IUUC-Ath-006876	Arabidopsis thaliana	53.89	3.00e-55	205.00
IUUC-Ago-007910	Ashbya gossypii	50.00	2.00e-42	162.00
IUUC-Acl-008364	Aspergillus clavatus	63.39	3.00e-66	242.00
IUUC-Afl-008463	Aspergillus flavus	62.30	9.00e-65	237.00
IUUC-Afu-008803	Aspergillus fumigatus	63.93	1.00e-66	243.00
IUUC-Ani-009422	Aspergillus nidulans	63.93	5.00e-66	241.00
IUUC-Ang-009728	Aspergillus niger	69.85	8.00e-58	213.00
IUUC-Aor-009962	Aspergillus oryzae	62.30	9.00e-65	237.00
IUUC-Ate-010430	Aspergillus terreus	65.00	5.00e-59	218.00
IUUC-Ame-011382	Astyanax mexicanus	55.43	2.00e-60	223.00
IUUC-Bgr-012306	Blumeria graminis	67.76	2.00e-74	269.00
IUUC-Bta-012818	Bos taurus	55.49	7.00e-59	217.00
IUUC-Bci-013626	Botrytis cinerea	66.12	2.00e-71	259.00
IUUC-Bdi-014091	Brachypodium distachyon	55.11	1.00e-54	203.00
IUUC-Bol-016135	Brassica oleracea	52.75	4.00e-55	204.00
IUUC-Bra-017161	Brassica rapa	58.02	4.00e-53	198.00
IUUC-Cel-018579	Caenorhabditis elegans	42.40	3.00e-20	89.40
IUUC-Cja-019213	Callithrix jacchus	54.01	8.00e-57	210.00
IUUC-Cfa-020242	Canis familiaris	54.89	3.00e-57	212.00
IUUC-Cpo-022405	Cavia porcellus	53.85	5.00e-54	201.00
IUUC-Cre-022865	Chlamydomonas reinhardtii	54.05	2.00e-48	182.00
IUUC-Csa-023269	Chlorocebus sabaeus	55.49	7.00e-59	217.00
IUUC-Cin-025333	Ciona intestinalis	57.69	7.00e-60	220.00
IUUC-Csv-025898	Ciona savignyi	47.64	2.00e-52	196.00
IUUC-Cgl-026477	Colletotrichum gloeosporioides	69.23	3.00e-67	245.00
IUUC-Cne-027097	Cryptococcus neoformans	67.80	6.00e-73	264.00
IUUC-Cme-027287	Cyanidioschyzon merolae	51.28	8.00e-22	94.70
IUUC-Dre-028514	Danio rerio	55.43	2.00e-56	209.00
IUUC-Dno-029678	Dasypus novemcinctus	50.00	9.00e-52	194.00
IUUC-Dor-030940	Dipodomys ordii	43.48	9.00e-28	114.00
IUUC-Dse-031265	Dothistroma septosporum	73.48	4.00e-79	285.00
IUUC-Dme-032076	Drosophila melanogaster	56.91	3.00e-63	231.00
IUUC-Eca-034075	Equus caballus	54.95	1.00e-57	213.00
IUUC-Fca-035654	Felis catus	58.22	3.00e-50	188.00
IUUC-Fal-036808	Ficedula albicollis	37.42	4.00e-27	112.00
IUUC-Fox-037877	Fusarium oxysporum	63.59	4.00e-66	241.00
IUUC-Fso-038428	Fusarium solani	69.57	1.00e-73	266.00
IUUC-Gmo-039402	Gadus morhua	54.89	2.00e-60	222.00
IUUC-Ggr-039731	Gaeumannomyces graminis	69.40	1.00e-67	246.00
IUUC-Gga-041122	Gallus gallus	53.41	1.00e-54	203.00
IUUC-Gac-041480	Gasterosteus aculeatus	37.65	1.00e-28	117.00
IUUC-Gma-043805	Glycine max	56.42	2.00e-56	209.00
IUUC-Ggo-044436	Gorilla gorilla	55.49	7.00e-59	217.00
IUUC-Hsa-046026	Homo sapiens	55.49	7.00e-59	217.00
IUUC-Hvu-047288	Hordeum vulgare	55.11	4.00e-55	205.00
IUUC-Itr-047889	Ictidomys tridecemlineatus	55.49	7.00e-59	217.00
IUUC-Kpa-049315	Komagataella pastoris	56.42	3.00e-55	205.00
IUUC-Lch-050360	Latimeria chalumnae	65.45	6.00e-41	158.00
IUUC-Lpe-050743	Leersia perrieri	57.99	2.00e-55	206.00
IUUC-Loc-052137	Lepisosteus oculatus	37.80	8.00e-27	110.00
IUUC-Lma-053001	Leptosphaeria maculans	68.68	8.00e-71	257.00
IUUC-Laf-053463	Loxodonta africana	58.22	2.00e-50	189.00
IUUC-Mcc-054966	Macaca mulatta	70.51	8.00e-32	126.00
IUUC-Meu-056085	Macropus eugenii	58.45	6.00e-50	187.00
IUUC-Mor-057250	Magnaporthe oryzae	64.48	2.00e-65	239.00
IUUC-Mpo-057481	Magnaporthe poae	64.48	6.00e-65	237.00
IUUC-Mtr-058251	Medicago truncatula	55.31	9.00e-55	203.00
IUUC-Mla-059119	Melampsora laricipopulina	67.80	6.00e-74	267.00
IUUC-Mga-059881	Meleagris gallopavo	63.21	3.00e-39	150.00
IUUC-Mvi-060449	Microbotryum violaceum	65.73	3.00e-67	245.00
IUUC-Mmr-061511	Microcebus murinus	70.51	5.00e-32	126.00
IUUC-Mdo-061993	Monodelphis domestica	37.50	3.00e-27	113.00
IUUC-Mmu-063962	Mus musculus	55.49	7.00e-59	217.00
IUUC-Mac-064435	Musa acuminata	54.75	2.00e-56	209.00
IUUC-Mpu-066423	Mustela putorius furo	42.96	3.00e-28	115.00
IUUC-Mlu-066955	Myotis lucifugus	57.33	7.00e-51	190.00
IUUC-Nfi-068300	Neosartorya fischeri	63.93	1.00e-66	243.00
IUUC-Ncr-068944	Neurospora crassa	67.93	4.00e-70	254.00
IUUC-Nle-069051	Nomascus leucogenys	58.22	3.00e-50	188.00
IUUC-Opr-070635	Ochotona princeps	58.45	1.00e-49	186.00
IUUC-Ont-072348	Oreochromis niloticus	55.43	3.00e-60	222.00
IUUC-Ocu-074905	Oryctolagus cuniculus	55.49	7.00e-59	217.00
IUUC-Oba-075825	Oryza barthii	56.82	9.00e-56	207.00
IUUC-Obr-076067	Oryza brachyantha	56.82	1.00e-55	207.00
IUUC-Ogl-077594	Oryza glaberrima	56.82	9.00e-56	207.00
IUUC-Ogu-078073	Oryza glumaepatula	56.82	9.00e-56	207.00
IUUC-Oin-080060	Oryza indica	58.55	5.00e-53	199.00
IUUC-Olo-080314	Oryza longistaminata	56.82	8.00e-56	207.00
IUUC-Ome-081713	Oryza meridionalis	56.82	8.00e-56	207.00
IUUC-Oni-082426	Oryza nivara	56.82	9.00e-56	207.00
IUUC-Opu-083942	Oryza punctata	57.99	3.00e-55	205.00
IUUC-Oru-085104	Oryza rufipogon	56.82	9.00e-56	207.00
IUUC-Osa-086168	Oryza sativa	56.82	1.00e-55	206.00
IUUC-Olu-087854	Ostreococcus lucimarinus	53.99	1.00e-52	196.00
IUUC-Oga-088580	Otolemur garnettii	55.49	7.00e-59	217.00
IUUC-Oar-089623	Ovis aries	55.56	7.00e-45	170.00
IUUC-Ptr-091161	Pan troglodytes	49.72	4.00e-50	188.00
IUUC-Pan-092119	Papio anubis	58.22	3.00e-50	188.00
IUUC-Psi-093494	Pelodiscus sinensis	58.90	3.00e-51	191.00
IUUC-Pma-094321	Petromyzon marinus	41.53	3.00e-22	95.10
IUUC-Pno-094972	Phaeosphaeria nodorum	64.21	5.00e-68	248.00
IUUC-Ppa-095751	Physcomitrella patens	58.43	1.00e-60	223.00
IUUC-Pfo-097205	Poecilia formosa	54.84	1.00e-54	203.00
IUUC-Pab-098434	Pongo abelii	55.49	7.00e-59	217.00
IUUC-Pop-099226	Populus trichocarpa	55.87	5.00e-56	207.00
IUUC-Pca-100300	Procavia capensis	58.45	9.00e-50	186.00
IUUC-Ppe-101216	Prunus persica	56.98	3.00e-49	185.00
IUUC-Pva-102143	Pteropus vampyrus	55.49	7.00e-59	217.00
IUUC-Pgr-103675	Puccinia graminis	63.13	5.00e-69	251.00
IUUC-Ptt-103997	Puccinia triticina	64.09	5.00e-70	254.00
IUUC-Pte-104042	Pyrenophora teres	67.58	6.00e-71	257.00
IUUC-Pyt-104616	Pyrenophora triticirepentis	72.60	5.00e-65	237.00
IUUC-Rno-105107	Rattus norvegicus	55.49	7.00e-59	217.00
IUUC-Sce-106385	Saccharomyces cerevisiae	44.97	2.00e-43	166.00
IUUC-Sha-106899	Sarcophilus harrisii	58.22	2.00e-50	189.00
IUUC-Sja-107789	Schizosaccharomyces japonicus	54.80	4.00e-57	211.00
IUUC-Spo-108143	Schizosaccharomyces pombe	51.98	9.00e-57	210.00
IUUC-Ssl-108427	Sclerotinia sclerotiorum	65.75	2.00e-70	256.00
IUUC-Smo-109440	Selaginella moellendorffii	57.07	2.00e-58	216.00
IUUC-Sit-109702	Setaria italica	59.87	4.00e-53	198.00
IUUC-Sly-111045	Solanum lycopersicum	55.31	3.00e-55	205.00
IUUC-Stu-112655	Solanum tuberosum	54.75	8.00e-55	204.00
IUUC-Sar-113632	Sorex araneus	54.95	9.00e-58	213.00
IUUC-Sbi-114357	Sorghum bicolor	59.21	9.00e-53	197.00
IUUC-Sre-114912	Sporisorium reilianum	62.57	2.00e-65	239.00
IUUC-Ssc-115597	Sus scrofa	43.17	6.00e-28	114.00
IUUC-Tgu-117397	Taeniopygia guttata	37.42	5.00e-27	111.00
IUUC-Tru-118496	Takifugu rubripes	36.93	1.00e-27	113.00
IUUC-Tsy-119639	Tarsius syrichta	50.34	6.00e-39	150.00
IUUC-Tni-119674	Tetraodon nigroviridis	48.91	3.00e-47	179.00
IUUC-Tca-121359	Theobroma cacao	56.42	4.00e-56	208.00
IUUC-Tre-122115	Trichoderma reesei	66.85	9.00e-69	250.00
IUUC-Tvi-122656	Trichoderma virens	65.76	3.00e-68	248.00
IUUC-Tae-124489	Triticum aestivum	55.11	3.00e-55	205.00
IUUC-Tur-126045	Triticum urartu	55.11	3.00e-55	205.00
IUUC-Tme-126950	Tuber melanosporum	66.30	3.00e-67	245.00
IUUC-Tbe-127874	Tupaia belangeri	40.66	8.00e-32	127.00
IUUC-Ttr-128213	Tursiops truncatus	57.76	1.00e-54	203.00
IUUC-Uma-129329	Ustilago maydis	60.89	5.00e-65	238.00
IUUC-Vda-129754	Verticillium dahliae	64.67	6.00e-67	244.00
IUUC-Vvi-131182	Vitis vinifera	55.87	3.00e-55	206.00
IUUC-Xtr-132742	Xenopus tropicalis	56.04	1.00e-59	220.00
IUUC-Xma-133558	Xiphophorus maculatus	55.43	3.00e-56	208.00
IUUC-Zma-135527	Zea mays	59.21	1.00e-52	197.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence