iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000078923.10	ENSMUST00000109207.9	ENSMUSP00000104830.3
ENSMUSG00000078923.10	ENSMUST00000060645.12	ENSMUSP00000053109.6
ENSMUSG00000078923.10	ENSMUST00000151365.7	ENSMUSP00000114764.1
ENSMUSG00000078923.10	ENSMUST00000140216.1	ENSMUSP00000116578.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Post-translational Modifications (PTMs)
CPLM	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UEV	1.70e-63	213.9	32	171
E2/UBC	2.30e-17	64.2	58	164

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E2/UEV

   S: 6    elkvvvprnfrlleeleegekglgdgtvsygldDgddilllsltgtIigpertayegrIyqlklfvgkkYPekPPtvrfsskinmaevn 94
              v+vprnfrlleeleeg+kg+gdgtvs+gl+D++d++l+++tg+Iigp+rt ye+rIy+lk+++g+kYPe+PP vrf++++nm++v 
   Q: 32   LPGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTIYENRIYSLKIECGPKYPEAPPSVRFVTRVNMSGVS 120
           5679************************************************************************************* PP
   S: 95   dsnGvvdpralpvLanWkreysievvlvqlkkellskenrklqqPpeGnlf 145
           +snGvvdpra +vLa+W+++ si+v+l++l++ ++sken+kl+qPpeG+++
   Q: 121  SSNGVVDPRATAVLAKWQNSHSIKVILQELRRLMMSKENMKLPQPPEGQCY 171
           *************************************************98 PP

E2/UBC

   S: 16   gisakpvdesd..ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkeeekWspalsvesv 101
           ++s +++d++d  lt+w  +i+Gp++t+Ye+++++l+ie+ ++YP  PP+v+f+t++    v+++ G v         kW+  +s++ +
   Q: 58   TVSWGLEDDEDmtLTRWTGMIIGPPRTIYENRIYSLKIECGPKYPEAPPSVRFVTRVNMSGVSSSnGVVDPRATAVLAKWQNSHSIKVI 146
           456667777776689******************************************999999887999766665568*********** PP
   S: 102  llsiqsll.aepnpespl 118
           l ++ +l+ ++ n++ p+
   Q: 147  LQELRRLMmSKENMKLPQ 164
           ******996667777665 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MSPLQPLKMS TIEGTSLLCV QDCRMSDSGP WLPGVKVPRN FRLLEELEEG QKGVGDGTVS 60
WGLEDDEDMT LTRWTGMIIG PPRTIYENRI YSLKIECGPK YPEAPPSVRF VTRVNMSGVS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCTGCGAC CCCGAGCGGG CGTCAGCGGC ACCGTTTGCG GCTGCGCCTA CACCTGCGCC 60
TGCGCACTAG CGCCCGGAGA AAAACTCAAG GGGGGGTGAA GAAGGGGCCG GCCTTCGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0035370--C:UBC13-UEV1A complex
GO:0000151--C:ubiquitin ligase complex
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0070534--P:protein K63-linked ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000910	Aegilops tauschii	52.94	1.00e-38	151.00
IUUC-Atr-003059	Amborella trichopoda	51.13	5.00e-37	147.00
IUUC-Aly-005402	Arabidopsis lyrata	55.07	6.00e-39	152.00
IUUC-Acl-008375	Aspergillus clavatus	51.09	2.00e-32	131.00
IUUC-Afu-008838	Aspergillus fumigatus	51.11	4.00e-34	136.00
IUUC-Ang-009631	Aspergillus niger	52.17	1.00e-34	138.00
IUUC-Bci-013649	Botrytis cinerea	51.09	4.00e-33	133.00
IUUC-Bdi-014636	Brachypodium distachyon	52.24	1.00e-37	148.00
IUUC-Bol-015323	Brassica oleracea	54.74	1.00e-39	155.00
IUUC-Bra-018041	Brassica rapa	54.74	1.00e-39	155.00
IUUC-Cre-022629	Chlamydomonas reinhardtii	50.36	1.00e-37	148.00
IUUC-Cin-025219	Ciona intestinalis	49.04	7.00e-26	108.00
IUUC-Cgl-026596	Colletotrichum gloeosporioides	54.35	6.00e-37	145.00
IUUC-Cme-027257	Cyanidioschyzon merolae	56.30	2.00e-28	118.00
IUUC-Fox-037803	Fusarium oxysporum	52.17	6.00e-37	145.00
IUUC-Fso-038147	Fusarium solani	54.68	6.00e-38	149.00
IUUC-Gma-043736	Glycine max	55.22	2.00e-42	164.00
IUUC-Hvu-047368	Hordeum vulgare	52.24	1.00e-37	148.00
IUUC-Lch-050494	Latimeria chalumnae	82.27	1.00e-69	254.00
IUUC-Lpe-050874	Leersia perrieri	53.73	3.00e-38	150.00
IUUC-Mtr-058655	Medicago truncatula	55.40	2.00e-38	151.00
IUUC-Mga-059951	Meleagris gallopavo	92.96	7.00e-71	259.00
IUUC-Nfi-068400	Neosartorya fischeri	47.31	3.00e-26	110.00
IUUC-Ppa-095557	Physcomitrella patens	54.74	4.00e-40	156.00
IUUC-Pop-099786	Populus trichocarpa	54.01	9.00e-39	152.00
IUUC-Ssl-108493	Sclerotinia sclerotiorum	51.80	2.00e-34	137.00
IUUC-Smo-109006	Selaginella moellendorffii	46.72	9.00e-30	122.00
IUUC-Sit-110302	Setaria italica	55.07	6.00e-40	156.00
IUUC-Sly-111205	Solanum lycopersicum	55.47	1.00e-39	155.00
IUUC-Stu-112459	Solanum tuberosum	54.74	3.00e-39	154.00
IUUC-Sbi-114210	Sorghum bicolor	54.35	2.00e-39	154.00
IUUC-Sre-114909	Sporisorium reilianum	51.09	2.00e-33	134.00
IUUC-Tvi-122622	Trichoderma virens	55.07	3.00e-37	147.00
IUUC-Tae-123220	Triticum aestivum	52.24	1.00e-37	148.00
IUUC-Tur-126236	Triticum urartu	51.82	3.00e-38	150.00
IUUC-Uma-129419	Ustilago maydis	52.55	3.00e-34	137.00
IUUC-Vda-129776	Verticillium dahliae	52.86	1.00e-36	144.00
IUUC-Vpa-130575	Vicugna pacos	92.81	1.00e-68	253.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence