iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Csa-024270

Ensembl Protein ID

ENSCSAP00000002600.1

UniProt Accession

A0A0D9R1W1; A0A0D9R1W1_CHLSB

Genbank Protein ID

ENSCSAP00000002600

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AQIB01146960

Gene Name

NLE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAG00000006308.1	ENSCSAT00000004346.1	ENSCSAP00000002600.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.10e-67	219.0	199	242
UBD/Beta-Prp	1.90e-79	266.9	108	303

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf......sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH+ ++t+l++      ++ ++++s+s Dg++++WD++ g++++
   Q: 199  GHSKWITGLSWeplhanPEcRYVASSSKDGSVRIWDTTAGRCER 242
           8***************9889**********************86 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           + +sl gh+++v +v fsp+gk+l++gs D t++ wdlst ++  + kgh + vls+s+sp+g+kl+sG +   i +wd +tg+ +  t
   Q: 108  CTSSLDGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFICKGHRHWVLSISWSPDGKKLASGCKNGQILLWDPSTGKQVGRT 196
           5799************************************************************************************* PP
   S: 133  lsghdgvvncvvv.....hpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+gh+++++++++     +p++++++s+s+D+ vr+Wd   g++ r ltg ht+sv++l +  +g  l s+s+d+t+k+w  + g   r
   Q: 197  LAGHSKWITGLSWeplhaNPECRYVASSSKDGSVRIWDTTAGRCERILTG-HTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCR 283
           **********9873332257889**************************9.************98.*********************** PP
   S: 217  tlnghtdnvksvrfspnderl 237
           tl+gh  +v+ +++s  d  l
   Q: 284  TLQGHGHWVNTMALS-TDYAL 303
           **************9.44444 PP

Organism

Chlorocebus sabaeus

Protein Sequence
(Fasta)

LPPRFLAQDE SVARDVQRLL VQFQDEGGQL LGSPFDVPVD ITPDRLQLVC NALLAQEDPL 60
PLAFFVHDAE IVSSLGKTLE SQAVETEKVL DIIYQPQAVF RVRAVTRCTS SLDGHSEAVI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGGAAACGA AGTGGGGCTC TTCCGGGCGG GCGACGAGAC TGACTCCCGC CCCGCTTTCT 60
CGCGCAGGAC GAGTCGGTGG CGCGCGATGT GCAGCGGTTG CTAGTGCAGT TCCAGGATGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0001826--P:inner cell mass cell differentiation
GO:0001822--P:kidney development
GO:2001268--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0045930--P:negative regulation of mitotic cell cycle
GO:0007219--P:Notch signaling pathway
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0042273--P:ribosomal large subunit biogenesis
GO:0048705--P:skeletal system morphogenesis
GO:0001756--P:somitogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000437	Aegilops tauschii	58.37	1.00e-168	585.00
IUUC-Aml-001793	Ailuropoda melanoleuca	96.62	0.00e+00	944.00
IUUC-Atr-002507	Amborella trichopoda	57.71	4.00e-167	581.00
IUUC-Apl-003964	Anas platyrhynchos	84.80	0.00e+00	812.00
IUUC-Aly-006396	Arabidopsis lyrata	54.47	7.00e-161	560.00
IUUC-Ath-007278	Arabidopsis thaliana	55.11	8.00e-161	560.00
IUUC-Ago-007951	Ashbya gossypii	47.21	2.00e-128	452.00
IUUC-Acl-008298	Aspergillus clavatus	46.28	3.00e-121	428.00
IUUC-Afl-008581	Aspergillus flavus	51.67	5.00e-109	387.00
IUUC-Afu-008906	Aspergillus fumigatus	45.58	5.00e-121	427.00
IUUC-Ani-009189	Aspergillus nidulans	43.45	2.00e-115	409.00
IUUC-Ang-009630	Aspergillus niger	45.53	3.00e-122	432.00
IUUC-Aor-010038	Aspergillus oryzae	46.20	6.00e-128	450.00
IUUC-Ate-010278	Aspergillus terreus	45.99	4.00e-122	431.00
IUUC-Ame-011890	Astyanax mexicanus	80.97	0.00e+00	822.00
IUUC-Bgr-012011	Blumeria graminis	46.96	2.00e-129	456.00
IUUC-Bta-012964	Bos taurus	95.78	0.00e+00	941.00
IUUC-Bci-013592	Botrytis cinerea	43.89	2.00e-119	422.00
IUUC-Bdi-015035	Brachypodium distachyon	58.46	6.00e-170	590.00
IUUC-Bol-015501	Brassica oleracea	55.77	7.00e-161	560.00
IUUC-Bra-017642	Brassica rapa	55.56	4.00e-160	557.00
IUUC-Cel-018430	Caenorhabditis elegans	58.58	5.00e-168	583.00
IUUC-Cja-019125	Callithrix jacchus	98.10	0.00e+00	952.00
IUUC-Cfa-021013	Canis familiaris	95.38	0.00e+00	857.00
IUUC-Cpo-021743	Cavia porcellus	95.35	0.00e+00	937.00
IUUC-Cre-022973	Chlamydomonas reinhardtii	45.86	3.00e-122	431.00
IUUC-Cin-025795	Ciona intestinalis	65.48	0.00e+00	683.00
IUUC-Csv-025953	Ciona savignyi	66.95	0.00e+00	681.00
IUUC-Cgl-026517	Colletotrichum gloeosporioides	50.66	2.00e-107	382.00
IUUC-Cne-026901	Cryptococcus neoformans	48.34	2.00e-138	486.00
IUUC-Cme-027281	Cyanidioschyzon merolae	47.67	1.00e-114	406.00
IUUC-Dre-028515	Danio rerio	77.31	0.00e+00	799.00
IUUC-Dno-029596	Dasypus novemcinctus	96.24	0.00e+00	949.00
IUUC-Dor-030494	Dipodomys ordii	94.86	0.00e+00	946.00
IUUC-Dse-031538	Dothistroma septosporum	47.83	7.00e-129	454.00
IUUC-Dme-031974	Drosophila melanogaster	58.16	1.00e-168	586.00
IUUC-Ete-032948	Echinops telfairi	97.13	1.00e-117	416.00
IUUC-Eca-033399	Equus caballus	97.66	0.00e+00	949.00
IUUC-Eeu-035013	Erinaceus europaeus	94.74	5.00e-116	411.00
IUUC-Fca-035860	Felis catus	96.41	0.00e+00	942.00
IUUC-Fal-037069	Ficedula albicollis	87.60	5.00e-132	462.00
IUUC-Fox-038059	Fusarium oxysporum	46.14	5.00e-124	437.00
IUUC-Fso-038445	Fusarium solani	46.35	2.00e-124	439.00
IUUC-Gmo-039319	Gadus morhua	75.74	0.00e+00	733.00
IUUC-Ggr-040095	Gaeumannomyces graminis	46.79	1.00e-121	429.00
IUUC-Gga-040303	Gallus gallus	85.60	3.00e-130	457.00
IUUC-Gac-042267	Gasterosteus aculeatus	78.36	0.00e+00	766.00
IUUC-Gma-043974	Glycine max	57.45	6.00e-170	590.00
IUUC-Ggo-044637	Gorilla gorilla	98.51	0.00e+00	949.00
IUUC-Hsa-046128	Homo sapiens	98.75	0.00e+00	970.00
IUUC-Hvu-047373	Hordeum vulgare	57.82	4.00e-168	583.00
IUUC-Itr-048070	Ictidomys tridecemlineatus	95.87	0.00e+00	951.00
IUUC-Kpa-049274	Komagataella pastoris	43.90	3.00e-126	445.00
IUUC-Lch-049907	Latimeria chalumnae	81.57	0.00e+00	819.00
IUUC-Lpe-050778	Leersia perrieri	53.25	1.00e-151	529.00
IUUC-Loc-051889	Lepisosteus oculatus	79.87	0.00e+00	822.00
IUUC-Lma-053041	Leptosphaeria maculans	49.53	7.00e-117	414.00
IUUC-Laf-053598	Loxodonta africana	96.08	0.00e+00	959.00
IUUC-Mcc-055660	Macaca mulatta	99.38	0.00e+00	988.00
IUUC-Meu-056197	Macropus eugenii	79.09	0.00e+00	785.00
IUUC-Mor-056949	Magnaporthe oryzae	46.17	9.00e-119	420.00
IUUC-Mpo-057571	Magnaporthe poae	44.75	2.00e-63	236.00
IUUC-Mtr-058530	Medicago truncatula	58.30	2.00e-166	578.00
IUUC-Mla-059133	Melampsora laricipopulina	46.08	5.00e-124	437.00
IUUC-Mga-059252	Meleagris gallopavo	84.38	0.00e+00	659.00
IUUC-Mvi-060522	Microbotryum violaceum	49.80	1.00e-135	476.00
IUUC-Mmr-061117	Microcebus murinus	95.07	0.00e+00	951.00
IUUC-Mdo-062892	Monodelphis domestica	88.77	0.00e+00	893.00
IUUC-Mmu-064108	Mus musculus	96.19	0.00e+00	913.00
IUUC-Mac-064430	Musa acuminata	59.10	5.00e-172	597.00
IUUC-Mpu-065882	Mustela putorius furo	95.98	0.00e+00	934.00
IUUC-Mlu-068123	Myotis lucifugus	95.99	0.00e+00	946.00
IUUC-Nfi-068484	Neosartorya fischeri	46.17	5.00e-121	427.00
IUUC-Ncr-068649	Neurospora crassa	43.38	7.00e-116	410.00
IUUC-Nle-069140	Nomascus leucogenys	98.51	0.00e+00	951.00
IUUC-Opr-070220	Ochotona princeps	88.82	0.00e+00	836.00
IUUC-Ont-072643	Oreochromis niloticus	80.25	0.00e+00	818.00
IUUC-Ocu-074007	Oryctolagus cuniculus	96.19	0.00e+00	912.00
IUUC-Oba-075904	Oryza barthii	58.89	2.00e-171	594.00
IUUC-Obr-076280	Oryza brachyantha	58.46	3.00e-170	591.00
IUUC-Ogl-077425	Oryza glaberrima	58.89	2.00e-171	595.00
IUUC-Ogu-078586	Oryza glumaepatula	58.89	3.00e-171	594.00
IUUC-Oin-079489	Oryza indica	56.75	3.00e-162	565.00
IUUC-Olo-080766	Oryza longistaminata	58.76	4.00e-171	594.00
IUUC-Ome-081905	Oryza meridionalis	58.89	3.00e-171	594.00
IUUC-Oni-083022	Oryza nivara	58.89	1.00e-171	595.00
IUUC-Opu-083615	Oryza punctata	58.89	2.00e-171	595.00
IUUC-Oru-085076	Oryza rufipogon	58.89	1.00e-171	595.00
IUUC-Osa-085516	Oryza sativa	58.89	1.00e-171	595.00
IUUC-Ola-087290	Oryzias latipes	78.15	0.00e+00	802.00
IUUC-Olu-087898	Ostreococcus lucimarinus	53.14	3.00e-143	501.00
IUUC-Oga-088980	Otolemur garnettii	95.75	0.00e+00	934.00
IUUC-Oar-089580	Ovis aries	95.85	0.00e+00	818.00
IUUC-Ptr-090845	Pan troglodytes	98.30	0.00e+00	946.00
IUUC-Pan-092836	Papio anubis	99.16	0.00e+00	970.00
IUUC-Psi-093965	Pelodiscus sinensis	82.46	8.00e-56	208.00
IUUC-Pno-095052	Phaeosphaeria nodorum	47.23	2.00e-122	432.00
IUUC-Ppa-095432	Physcomitrella patens	57.32	2.00e-169	588.00
IUUC-Pfo-096963	Poecilia formosa	72.06	0.00e+00	702.00
IUUC-Pab-097716	Pongo abelii	94.90	0.00e+00	905.00
IUUC-Pop-099224	Populus trichocarpa	58.72	2.00e-171	595.00
IUUC-Pca-100682	Procavia capensis	92.96	0.00e+00	681.00
IUUC-Ppe-101819	Prunus persica	58.02	3.00e-169	587.00
IUUC-Pva-102338	Pteropus vampyrus	94.86	0.00e+00	731.00
IUUC-Pgr-103583	Puccinia graminis	54.26	6.00e-131	461.00
IUUC-Ptt-103737	Puccinia triticina	44.34	5.00e-99	355.00
IUUC-Pte-104150	Pyrenophora teres	50.00	1.00e-121	429.00
IUUC-Pyt-104606	Pyrenophora triticirepentis	49.77	2.00e-121	429.00
IUUC-Rno-105987	Rattus norvegicus	95.97	0.00e+00	936.00
IUUC-Sce-106315	Saccharomyces cerevisiae	46.87	3.00e-129	455.00
IUUC-Sha-107273	Sarcophilus harrisii	89.81	0.00e+00	904.00
IUUC-Sja-107677	Schizosaccharomyces japonicus	44.55	6.00e-118	417.00
IUUC-Spo-108092	Schizosaccharomyces pombe	48.97	2.00e-123	436.00
IUUC-Ssl-108442	Sclerotinia sclerotiorum	43.53	2.00e-114	406.00
IUUC-Smo-108855	Selaginella moellendorffii	55.85	3.00e-163	568.00
IUUC-Sit-110329	Setaria italica	59.10	4.00e-171	594.00
IUUC-Sly-111830	Solanum lycopersicum	59.96	4.00e-174	603.00
IUUC-Stu-112603	Solanum tuberosum	59.96	5.00e-174	603.00
IUUC-Sar-113504	Sorex araneus	85.62	2.00e-74	272.00
IUUC-Sbi-114560	Sorghum bicolor	58.24	1.00e-168	585.00
IUUC-Sre-115133	Sporisorium reilianum	41.46	8.00e-123	434.00
IUUC-Ssc-115903	Sus scrofa	96.84	0.00e+00	944.00
IUUC-Tgu-116798	Taeniopygia guttata	85.20	0.00e+00	854.00
IUUC-Tru-118361	Takifugu rubripes	77.99	0.00e+00	801.00
IUUC-Tsy-118849	Tarsius syrichta	96.26	0.00e+00	955.00
IUUC-Tni-120094	Tetraodon nigroviridis	77.32	0.00e+00	802.00
IUUC-Tca-121634	Theobroma cacao	58.30	8.00e-168	583.00
IUUC-Tre-122051	Trichoderma reesei	45.62	2.00e-118	419.00
IUUC-Tvi-122322	Trichoderma virens	46.88	4.00e-122	431.00
IUUC-Tae-125822	Triticum aestivum	58.24	9.00e-169	586.00
IUUC-Tur-126766	Triticum urartu	52.00	2.00e-160	558.00
IUUC-Tme-127175	Tuber melanosporum	50.41	1.00e-131	463.00
IUUC-Tbe-127779	Tupaia belangeri	95.55	0.00e+00	834.00
IUUC-Ttr-128224	Tursiops truncatus	91.36	0.00e+00	809.00
IUUC-Uma-129537	Ustilago maydis	41.82	4.00e-124	438.00
IUUC-Vda-129927	Verticillium dahliae	45.40	1.00e-109	389.00
IUUC-Vpa-130658	Vicugna pacos	83.44	0.00e+00	808.00
IUUC-Vvi-131659	Vitis vinifera	58.85	6.00e-171	593.00
IUUC-Xtr-132918	Xenopus tropicalis	77.15	0.00e+00	787.00
IUUC-Xma-133700	Xiphophorus maculatus	80.25	0.00e+00	815.00
IUUC-Yli-134478	Yarrowia lipolytica	49.32	5.00e-139	487.00
IUUC-Zma-135835	Zea mays	55.78	1.00e-165	575.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence