iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046513

UUCD1 version

UUC-HoS-01077

Ensembl Protein ID

ENSP00000356243.4

UniProt Accession

Q9NPD8; Q2TU36; UBE2T_HUMAN

Genbank Protein ID

BAA93711.1; AAF67016.1; AAF29114.1; BAA91211.1; AAT08178.1; CAI15933.1; EAW91411.1; AAH04152.1; AAH19284.1

Protein Name

Ubiquitin-conjugating enzyme E2 T; Cell proliferation-inducing gene 50 protein; E2 ubiquitin-conjugating enzyme T; Ubiquitin carrier protein T; Ubiquitin-protein ligase T

Genbank Nucleotide ID

AB032931; AF160215; AF161499; AK000504; AY542309; AL356953; CH471067; BC004152; BC019284

Gene Name

UBE2T; HSPC150; PIG50

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000077152.9	ENST00000367274.8	ENSP00000356243.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	20675655; 19589784

Classification

Family	E-value	Score	Start	End
E2/UBC	1.40e-45	156.2	6	145

Active Site

Position(s)	Description	Evidence
86	Glycyl thioester intermediate	N/A

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk..eee 90
           Rlk+el+ l+++pp+gi++ ++++ ++++++++ilG ++tpYe+gvFkle+ +pe+YPf+PP+++flt+i+hPn++++G++Cl++lk  ++ 
   Q: 6    RLKRELHMLATEPPPGITCWQDKD-QMDDLRAQILGGANTPYEKGVFKLEVIIPERYPFEPPQIRFLTPIYHPNIDSAGRICLDVLKlpPKG 96
           99**********************.7************************************************************99899* PP
   S: 91   kWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvre 139
           +W+p l++++vl+siq l++epnp++pl +++++++k n+ ++ k++r+
   Q: 97   AWRPSLNIATVLTSIQLLMSEPNPDDPLMADISSEFKYNKPAFLKNARQ 145
           *******************************************999985 PP

Organism

Homo sapiens

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination.

Protein Sequence
(Fasta)

MQRASRLKRE LHMLATEPPP GITCWQDKDQ MDDLRAQILG GANTPYEKGV FKLEVIIPER 60
YPFEPPQIRF LTPIYHPNID SAGRICLDVL KLPPKGAWRP SLNIATVLTS IQLLMSEPNP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGCCACGC CAACAGTCAG AGGTCGCGCA GGCGCTGGTA CCCCGTTGGT CCGCGCGTTG 60
CTGCGTTGTG AGGGGTGTCA GCTCAGGTAA GCAAGGAGAG TATTCCGGTT CCCCATCTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0227--DNA damage
KW-0234--DNA repair
KW-0923--Fanconi anemia
KW-1017--Isopeptide bond
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006281--P:DNA repair
GO:0036297--P:interstrand cross-link repair
GO:0051865--P:protein autoubiquitination
GO:0070979--P:protein K11-linked ubiquitination
GO:0044314--P:protein K27-linked ubiquitination
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0006513--P:protein monoubiquitination
GO:0016567--P:protein ubiquitination

KEGG

hsa:29089

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000366	Aegilops tauschii	55.63	3.00e-47	183.00
IUUC-Aml-001392	Ailuropoda melanoleuca	88.32	8.00e-103	365.00
IUUC-Atr-003069	Amborella trichopoda	47.64	7.00e-52	197.00
IUUC-Apl-003914	Anas platyrhynchos	80.77	4.00e-77	279.00
IUUC-Aca-004381	Anolis carolinensis	73.58	4.00e-83	300.00
IUUC-Aly-006059	Arabidopsis lyrata	53.16	4.00e-46	179.00
IUUC-Ath-007669	Arabidopsis thaliana	61.48	1.00e-43	170.00
IUUC-Ame-011372	Astyanax mexicanus	65.57	1.00e-70	258.00
IUUC-Bta-012479	Bos taurus	82.23	2.00e-92	331.00
IUUC-Bdi-014043	Brachypodium distachyon	48.08	7.00e-54	205.00
IUUC-Bol-016011	Brassica oleracea	50.93	3.00e-44	172.00
IUUC-Bra-017419	Brassica rapa	50.93	9.00e-44	171.00
IUUC-Cja-019773	Callithrix jacchus	94.44	1.00e-108	385.00
IUUC-Cfa-020043	Canis familiaris	89.85	1.00e-102	365.00
IUUC-Cpo-021481	Cavia porcellus	89.85	2.00e-103	368.00
IUUC-Csa-024083	Chlorocebus sabaeus	96.95	3.00e-114	403.00
IUUC-Cho-024386	Choloepus hoffmanni	89.62	2.00e-97	347.00
IUUC-Cin-025419	Ciona intestinalis	66.23	4.00e-63	233.00
IUUC-Csv-026224	Ciona savignyi	67.53	3.00e-64	237.00
IUUC-Cme-027179	Cyanidioschyzon merolae	50.32	8.00e-42	162.00
IUUC-Dre-028800	Danio rerio	76.43	8.00e-74	269.00
IUUC-Dno-029833	Dasypus novemcinctus	89.85	2.00e-105	374.00
IUUC-Ete-032625	Echinops telfairi	87.82	2.00e-75	273.00
IUUC-Eca-033821	Equus caballus	94.27	3.00e-87	313.00
IUUC-Eeu-034578	Erinaceus europaeus	87.59	1.00e-67	248.00
IUUC-Fca-036398	Felis catus	90.36	1.00e-103	368.00
IUUC-Fal-037564	Ficedula albicollis	71.72	7.00e-79	286.00
IUUC-Gmo-039142	Gadus morhua	81.82	8.00e-75	272.00
IUUC-Gga-041054	Gallus gallus	70.41	6.00e-77	280.00
IUUC-Gac-041370	Gasterosteus aculeatus	78.57	7.00e-74	269.00
IUUC-Ggo-045370	Gorilla gorilla	99.49	1.00e-115	408.00
IUUC-Hvu-047694	Hordeum vulgare	54.97	9.00e-49	188.00
IUUC-Itr-049076	Ictidomys tridecemlineatus	88.83	5.00e-104	369.00
IUUC-Lch-050484	Latimeria chalumnae	72.09	7.00e-71	259.00
IUUC-Loc-051967	Lepisosteus oculatus	75.80	5.00e-73	266.00
IUUC-Laf-053377	Loxodonta africana	90.86	1.00e-106	378.00
IUUC-Mcc-055453	Macaca mulatta	96.45	8.00e-114	402.00
IUUC-Meu-056745	Macropus eugenii	79.19	2.00e-91	328.00
IUUC-Mga-059729	Meleagris gallopavo	70.41	5.00e-77	280.00
IUUC-Mmr-060581	Microcebus murinus	94.42	4.00e-110	390.00
IUUC-Mdo-062434	Monodelphis domestica	80.71	2.00e-88	319.00
IUUC-Mmu-064379	Mus musculus	85.28	6.00e-97	346.00
IUUC-Mac-064647	Musa acuminata	56.25	5.00e-46	177.00
IUUC-Mpu-066713	Mustela putorius furo	89.34	2.00e-102	364.00
IUUC-Mlu-067525	Myotis lucifugus	90.26	1.00e-82	298.00
IUUC-Nle-069757	Nomascus leucogenys	98.48	1.00e-114	405.00
IUUC-Opr-070756	Ochotona princeps	85.79	3.00e-100	357.00
IUUC-Ont-071956	Oreochromis niloticus	71.51	2.00e-76	278.00
IUUC-Oan-072745	Ornithorhynchus anatinus	84.34	3.00e-83	300.00
IUUC-Ocu-074423	Oryctolagus cuniculus	89.34	1.00e-103	368.00
IUUC-Oba-075569	Oryza barthii	58.28	2.00e-49	190.00
IUUC-Obr-076131	Oryza brachyantha	57.62	2.00e-49	190.00
IUUC-Ogl-077132	Oryza glaberrima	58.28	2.00e-49	190.00
IUUC-Ogu-078880	Oryza glumaepatula	58.28	9.00e-50	191.00
IUUC-Oin-079748	Oryza indica	58.28	8.00e-50	191.00
IUUC-Olo-080501	Oryza longistaminata	58.28	4.00e-50	192.00
IUUC-Ome-081248	Oryza meridionalis	58.28	2.00e-49	190.00
IUUC-Oni-083033	Oryza nivara	58.28	9.00e-50	191.00
IUUC-Opu-083664	Oryza punctata	58.28	8.00e-50	191.00
IUUC-Oru-084580	Oryza rufipogon	58.28	8.00e-50	191.00
IUUC-Osa-085721	Oryza sativa	58.28	8.00e-50	191.00
IUUC-Ola-087559	Oryzias latipes	75.76	7.00e-74	269.00
IUUC-Oga-088420	Otolemur garnettii	93.43	6.00e-107	379.00
IUUC-Oar-090082	Ovis aries	79.90	8.00e-90	322.00
IUUC-Ptr-091134	Pan troglodytes	99.49	1.00e-115	408.00
IUUC-Pan-091735	Papio anubis	96.95	3.00e-114	403.00
IUUC-Psi-094064	Pelodiscus sinensis	73.80	5.00e-81	293.00
IUUC-Pma-094609	Petromyzon marinus	72.19	1.00e-67	248.00
IUUC-Ppa-095553	Physcomitrella patens	58.94	8.00e-50	191.00
IUUC-Pfo-096710	Poecilia formosa	68.06	6.00e-73	266.00
IUUC-Pab-098126	Pongo abelii	100.00	4.00e-116	410.00
IUUC-Pop-099108	Populus trichocarpa	53.95	4.00e-47	182.00
IUUC-Pca-100338	Procavia capensis	88.32	5.00e-102	363.00
IUUC-Ppe-101239	Prunus persica	58.70	7.00e-45	175.00
IUUC-Pva-102756	Pteropus vampyrus	81.51	1.00e-67	248.00
IUUC-Rno-105211	Rattus norvegicus	80.71	2.00e-90	324.00
IUUC-Sha-106969	Sarcophilus harrisii	75.62	2.00e-82	298.00
IUUC-Smo-109052	Selaginella moellendorffii	56.13	9.00e-46	175.00
IUUC-Sit-110464	Setaria italica	57.82	1.00e-47	184.00
IUUC-Sly-110971	Solanum lycopersicum	60.14	3.00e-48	186.00
IUUC-Stu-112126	Solanum tuberosum	60.81	1.00e-48	187.00
IUUC-Sar-113633	Sorex araneus	80.90	6.00e-91	326.00
IUUC-Sbi-114875	Sorghum bicolor	57.62	3.00e-49	189.00
IUUC-Ssc-116375	Sus scrofa	83.25	2.00e-90	324.00
IUUC-Tgu-117292	Taeniopygia guttata	81.70	2.00e-74	271.00
IUUC-Tru-118157	Takifugu rubripes	67.31	3.00e-59	220.00
IUUC-Tsy-119260	Tarsius syrichta	91.88	9.00e-105	372.00
IUUC-Tni-120162	Tetraodon nigroviridis	71.43	2.00e-73	267.00
IUUC-Tca-121255	Theobroma cacao	55.90	2.00e-37	150.00
IUUC-Tae-123184	Triticum aestivum	55.63	3.00e-47	183.00
IUUC-Tbe-127296	Tupaia belangeri	91.88	5.00e-107	379.00
IUUC-Ttr-128443	Tursiops truncatus	83.92	1.00e-94	338.00
IUUC-Vpa-130689	Vicugna pacos	81.73	3.00e-92	330.00
IUUC-Vvi-130925	Vitis vinifera	53.33	1.00e-47	182.00
IUUC-Xma-133779	Xiphophorus maculatus	74.40	4.00e-74	270.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence