iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000026429.8	ENSMUST00000027687.7	ENSMUSP00000027687.7
ENSMUSG00000026429.8	ENSMUST00000188177.1	ENSMUSP00000139929.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.50e-44	152.2	6	145

Active Site

Position(s)	Description	Evidence
86	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk.. 87
           Rlkkel+ l+ +pp+gi++ ++++ ++ +++++ilG ++tpYe+gvF le+ +pe+YPf+PP+v+flt+i+hPn++++G++Cl+ilk  
   Q: 6    RLKKELHMLAIEPPPGITCWQEKD-QVADLRAQILGGANTPYEKGVFTLEVIIPERYPFEPPQVRFLTPIYHPNIDSSGRICLDILKlp 93
           9***********************.7************************************************************998 PP
   S: 88   eeekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvre 139
           ++ +W+p l++++vl+siq l+aepnp++pl +++++++k n+ ++ kk+++
   Q: 94   PKGAWRPSLNIATVLTSIQLLMAEPNPDDPLMADISSEFKYNKIAFLKKAKQ 145
           99********************************************999875 PP

Organism

Mus musculus

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination.

Protein Sequence
(Fasta)

MQRASRLKKE LHMLAIEPPP GITCWQEKDQ VADLRAQILG GANTPYEKGV FTLEVIIPER 60
YPFEPPQVRF LTPIYHPNID SSGRICLDIL KLPPKGAWRP SLNIATVLTS IQLLMAEPNP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACGGTCTCC GCGGTTCCGC GTGAGCACAG CAGAGGCGCG CCGCGGTAAG TGGGGCTGCT 60
GACGGGTGCT GCGAGTGCCA CCTGAGGGAA CGAGCCCGAG GTCACGGAGA GTCTGGGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-1017--Isopeptide bond
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006281--P:DNA repair
GO:0051865--P:protein autoubiquitination
GO:0070979--P:protein K11-linked ubiquitination
GO:0044314--P:protein K27-linked ubiquitination
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination

KEGG

mmu:67196

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000366	Aegilops tauschii	56.58	3.00e-46	179.00
IUUC-Aml-001392	Ailuropoda melanoleuca	79.19	5.00e-92	329.00
IUUC-Atr-003069	Amborella trichopoda	45.69	4.00e-49	188.00
IUUC-Apl-003914	Anas platyrhynchos	76.92	1.00e-73	268.00
IUUC-Aca-004381	Anolis carolinensis	66.16	1.00e-77	282.00
IUUC-Aly-006059	Arabidopsis lyrata	53.80	2.00e-45	176.00
IUUC-Ath-007669	Arabidopsis thaliana	61.29	9.00e-44	171.00
IUUC-Ame-011372	Astyanax mexicanus	64.02	4.00e-69	253.00
IUUC-Bta-012479	Bos taurus	76.65	4.00e-85	306.00
IUUC-Bdi-014043	Brachypodium distachyon	57.62	2.00e-50	193.00
IUUC-Bol-016011	Brassica oleracea	48.39	3.00e-45	176.00
IUUC-Bra-017419	Brassica rapa	47.85	4.00e-44	172.00
IUUC-Cja-019773	Callithrix jacchus	79.29	1.00e-90	325.00
IUUC-Cfa-020043	Canis familiaris	80.20	7.00e-93	332.00
IUUC-Cpo-021481	Cavia porcellus	83.90	4.00e-100	356.00
IUUC-Csa-024083	Chlorocebus sabaeus	83.76	5.00e-96	343.00
IUUC-Cho-024386	Choloepus hoffmanni	80.43	4.00e-86	310.00
IUUC-Cin-025419	Ciona intestinalis	64.29	5.00e-61	226.00
IUUC-Csv-026224	Ciona savignyi	56.41	1.00e-63	235.00
IUUC-Cme-027179	Cyanidioschyzon merolae	49.03	5.00e-40	156.00
IUUC-Dre-028800	Danio rerio	68.85	2.00e-73	268.00
IUUC-Dno-029833	Dasypus novemcinctus	80.71	1.00e-93	335.00
IUUC-Ete-032625	Echinops telfairi	82.05	6.00e-71	259.00
IUUC-Eca-033821	Equus caballus	85.99	4.00e-81	293.00
IUUC-Eeu-034578	Erinaceus europaeus	79.56	5.00e-61	226.00
IUUC-Fca-036398	Felis catus	82.23	1.00e-94	338.00
IUUC-Fal-037564	Ficedula albicollis	68.88	3.00e-75	273.00
IUUC-Gmo-039142	Gadus morhua	78.06	3.00e-72	263.00
IUUC-Gga-041054	Gallus gallus	67.54	2.00e-73	268.00
IUUC-Gac-041370	Gasterosteus aculeatus	76.13	4.00e-71	259.00
IUUC-Ggo-045370	Gorilla gorilla	84.77	1.00e-96	344.00
IUUC-Hsa-046513	Homo sapiens	85.28	5.00e-97	346.00
IUUC-Hvu-047694	Hordeum vulgare	55.26	1.00e-47	184.00
IUUC-Itr-049076	Ictidomys tridecemlineatus	81.46	1.00e-97	348.00
IUUC-Lch-050484	Latimeria chalumnae	69.59	9.00e-68	249.00
IUUC-Loc-051967	Lepisosteus oculatus	66.30	1.00e-70	258.00
IUUC-Laf-053377	Loxodonta africana	81.22	3.00e-93	333.00
IUUC-Mcc-055453	Macaca mulatta	83.76	4.00e-96	343.00
IUUC-Meu-056745	Macropus eugenii	72.96	2.00e-84	304.00
IUUC-Mga-059729	Meleagris gallopavo	68.06	4.00e-73	267.00
IUUC-Mmr-060581	Microcebus murinus	84.26	7.00e-96	342.00
IUUC-Mdo-062434	Monodelphis domestica	73.10	1.00e-80	293.00
IUUC-Mac-064647	Musa acuminata	53.42	1.00e-46	179.00
IUUC-Mpu-066713	Mustela putorius furo	79.19	6.00e-91	326.00
IUUC-Mlu-067525	Myotis lucifugus	85.06	1.00e-78	285.00
IUUC-Nle-069757	Nomascus leucogenys	84.26	2.00e-96	344.00
IUUC-Opr-070756	Ochotona princeps	79.19	1.00e-90	325.00
IUUC-Ont-071956	Oreochromis niloticus	69.15	4.00e-75	273.00
IUUC-Oan-072745	Ornithorhynchus anatinus	79.88	2.00e-77	281.00
IUUC-Ocu-074423	Oryctolagus cuniculus	78.68	2.00e-89	321.00
IUUC-Oba-075569	Oryza barthii	57.89	1.00e-48	187.00
IUUC-Obr-076131	Oryza brachyantha	56.58	3.00e-48	186.00
IUUC-Ogl-077132	Oryza glaberrima	57.89	1.00e-48	187.00
IUUC-Ogu-078880	Oryza glumaepatula	57.89	6.00e-49	188.00
IUUC-Oin-079748	Oryza indica	57.89	5.00e-49	188.00
IUUC-Olo-080501	Oryza longistaminata	57.89	3.00e-49	189.00
IUUC-Ome-081248	Oryza meridionalis	57.89	1.00e-48	187.00
IUUC-Oni-083033	Oryza nivara	57.89	6.00e-49	188.00
IUUC-Opu-083664	Oryza punctata	57.89	5.00e-49	189.00
IUUC-Oru-084580	Oryza rufipogon	57.89	5.00e-49	188.00
IUUC-Osa-085721	Oryza sativa	57.89	5.00e-49	188.00
IUUC-Ola-087559	Oryzias latipes	75.78	2.00e-72	265.00
IUUC-Oga-088420	Otolemur garnettii	81.55	4.00e-98	350.00
IUUC-Oar-090082	Ovis aries	74.75	2.00e-83	301.00
IUUC-Ptr-091134	Pan troglodytes	84.77	2.00e-96	344.00
IUUC-Pan-091735	Papio anubis	83.76	5.00e-96	343.00
IUUC-Psi-094064	Pelodiscus sinensis	71.35	2.00e-78	285.00
IUUC-Pma-094609	Petromyzon marinus	71.52	2.00e-65	241.00
IUUC-Ppa-095553	Physcomitrella patens	51.60	5.00e-50	191.00
IUUC-Pfo-096710	Poecilia formosa	69.73	2.00e-74	271.00
IUUC-Pab-098126	Pongo abelii	85.28	5.00e-97	346.00
IUUC-Pop-099108	Populus trichocarpa	53.95	4.00e-47	182.00
IUUC-Pca-100338	Procavia capensis	80.71	2.00e-92	331.00
IUUC-Ppe-101239	Prunus persica	47.98	4.00e-44	172.00
IUUC-Pva-102756	Pteropus vampyrus	76.71	7.00e-63	232.00
IUUC-Rno-105211	Rattus norvegicus	91.67	1.00e-102	365.00
IUUC-Sha-106969	Sarcophilus harrisii	67.16	2.00e-71	261.00
IUUC-Smo-109052	Selaginella moellendorffii	56.77	5.00e-45	173.00
IUUC-Sit-110464	Setaria italica	49.46	5.00e-47	182.00
IUUC-Sly-110971	Solanum lycopersicum	58.11	4.00e-46	179.00
IUUC-Stu-112126	Solanum tuberosum	58.78	1.00e-46	181.00
IUUC-Sar-113633	Sorex araneus	73.87	5.00e-84	303.00
IUUC-Sbi-114875	Sorghum bicolor	56.29	8.00e-48	184.00
IUUC-Ssc-116375	Sus scrofa	74.62	3.00e-83	300.00
IUUC-Tgu-117292	Taeniopygia guttata	77.78	5.00e-71	259.00
IUUC-Tru-118157	Takifugu rubripes	66.67	7.00e-59	219.00
IUUC-Tsy-119260	Tarsius syrichta	82.23	4.00e-91	327.00
IUUC-Tni-120162	Tetraodon nigroviridis	74.52	2.00e-71	261.00
IUUC-Tca-121255	Theobroma cacao	55.28	1.00e-36	147.00
IUUC-Tae-123184	Triticum aestivum	56.58	3.00e-46	179.00
IUUC-Tbe-127296	Tupaia belangeri	84.26	4.00e-96	343.00
IUUC-Ttr-128443	Tursiops truncatus	78.39	3.00e-89	320.00
IUUC-Vpa-130689	Vicugna pacos	76.14	3.00e-87	313.00
IUUC-Vvi-130925	Vitis vinifera	55.84	9.00e-46	176.00
IUUC-Xma-133779	Xiphophorus maculatus	69.95	3.00e-73	267.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence