iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108278

UUCD1 version

UUC-ScP-00023

Ensembl Protein ID

SPBC16E9.11c.1:pep

UniProt Accession

O14326; P79055; PUB3_SCHPO

Genbank Protein ID

CAB16903.1; BAA19217.1

Protein Name

E3 ubiquitin-protein ligase pub3; HECT-type E3 ubiquitin transferase pub3

Genbank Nucleotide ID

CU329671; AB001023

Gene Name

pub3; SPBC16E9.11c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBC16E9.11c	SPBC16E9.11c.1	SPBC16E9.11c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/HECT	HECT	11956316

Classification

Family	E-value	Score	Start	End
E3 activity/HECT	7.30e-126	418.1	454	785

Active Site

Position(s)	Description	Evidence
754	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
           ++dlkkrl+++f gE+gld+gG++ref++lls+++++p ++lf+ys+ d++tlq+np+s + npehl++F+f+Gr++g+a++++r+ld+++
   Q: 454  AHDLKKRLMIRFDGEDGLDYGGLSREFFFLLSHKMFDPIYCLFEYSAVDNYTLQINPHSSI-NPEHLNYFRFIGRVIGLAIFHRRFLDAFF 543
           689*********************************************************9.89*************************** PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlk 183
             s+yk+ll+kk+sl d+e++d+e+y+slk+++en   di+ + ldltfsv+e+++ge++++eL+++Geni+Vt+eNk++Yv+lv+e+r+ 
   Q: 544  VVSLYKKLLRKKVSLADMESIDAEFYRSLKWVLEN---DITGI-LDLTFSVEEDHFGEVRTVELITNGENIEVTEENKKKYVDLVTEWRVS 630
           *********************************99...9***9.*********************************************** PP
   S: 184  egikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrl 274
           +++++q++af++Gf e+++++l+++F+e+elelli G +++dved+k++t+y+  y +++p+i+wFwe++ ++++e+r+++LqF+Tg+sr+
   Q: 631  KRVEQQFNAFYSGFVELVSPDLVNVFDERELELLIGGISDVDVEDWKSHTEYRT-YIATDPVIKWFWEIIAGWKNEDRSKLLQFATGTSRI 720
           ****************************************************99.************************************ PP
   S: 275  PlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           P++Gf++l+    pr+f+i+k++++d+lP ++TCfn+L+LP+Y+sk++l+ekL +A+e+t gF+ 
   Q: 721  PVNGFRDLQgsdgPRKFTIEKAGTPDQLPVAHTCFNRLDLPDYPSKDTLHEKLSLAVENTVGFGN 785
           ***************************************************************85 PP

Organism

Schizosaccharomyces pombe

Protein Sequence
(Fasta)

MEQGAKRVRF YIVAADGLSK RDLFRQPDPF AILTVDGEQT HTTKVIKKSV NPYWNEGFEV 60
TVKPSSVISI RLFDQKKFKK KDQGFLGLVS FRMREVGSFR SNREVSLTRP LKKSSTTNLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCGTTGCGTA GTGAACTACA GCGTTCTTCA TACTACCACC AAACTCCCCC ACCTTCCTAC 60
TGGCTCGGAA CCCCCGCTTC AATATTGAAA CCTTTTGTGG TATACGTATC CGCTTTTACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005543--F:phospholipid binding
GO:0061630--F:ubiquitin protein ligase activity

KEGG

spo:SPBC16E9.11c

Orthology

iUUCD ID

Species

Identity

E-value

Score

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence