iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mla-058911

Ensembl Protein ID

EGG03974

UniProt Accession

F4RUL3; F4RUL3_MELLP

Genbank Protein ID

EGG03974.1

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

GL883121

Gene Name

PAN2; MELLADRAFT_117197

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MELLADRAFT_117197	EGG03974	EGG03974

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.50e-10	40.5	581	943

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.gyeqqDaqEflaflld 101
           Gl+ +    Y N++LQ+L+++ ++r+l  ++ + +++++       ++l++l  lf+ + + k  + +++++ +a++   + +    + +  q+f+ +   
   Q: 581  GLETHIVNSYTNALLQVLYHTLPIRHLAESHITLTCSAT------SCMLCELGFLFKMMDDAKGVNCQTTNFSRAFSINPRAIAlALMDHHHQDFFLHRPR 675
           566666667*********************888888765......79************9999999**********9777776668899999999999988 PP
   S: 102  qleeelkkeknkpkeeeeeedkselsde..............aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke... 185
           + +++l +++n+p  + ++        +              a++++     +++  ++   ++++ +c++c+++s r      ++l  p++  ++++   
   Q: 676  SDSQSLASSSNNPHRSYSS--L-----IqlchhflleqmtddARKQPGLGIVDPVAVIYATNWRTEQVCPTCQHSSARPTVAKVVELVYPRRALSNESppg 769
           8888886533333333311..1.....0222334444444447888888888************************8877777777777766655555667 PP
   S: 186  .slqdcLesftkeeelegenkyycekckkkqe........aekkl.klkklPevLilhLkRfsfse.eqksrekinkkvefple.Ldlspfcts....... 267
            +l  +L++  ++e+  +     c++c +++         +e  + + + lP +L lh    s+++ + + ++k + +  f +  ++++    +       
   Q: 770  sDLCTILRHSLARETTAK---SPCSQCGQNSHqrwrrvfdSETCVeGREGLPAILALHAGVTSVEQlDFWLDSKQQHSHRFLQPeISIATRAGTaelvigd 867
           7**************995...789999987777778887633333134679********999776513356666666655533334443222223345445 PP
   S: 268  ..peekqke.....kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetg..staYvlfYkr 337
             p     +      ++YeL+++v     + ++ H va+vk  +g+ W lf+D  V++++e+e l + +  + + vl+Y+r
   Q: 868  dyP-----VpapadGVRYELCSMVLQIEaEDEEPHLVALVKVADGSgWHLFNDFLVRKISEDEALGFPAawKIPAVLYYRR 943
           552.....0555559*******9998888*************99989****************998766666666666665 PP

Organism

Melampsora laricipopulina

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.

Protein Sequence
(Fasta)

MPSAPWQPYS STFLGDVSSI LFDPYADLLW TGSSIGTVVS HFLPNGVGGS NDESKCLNRY 60
TSFKSHSNRT PTRQLLISER AVLSLGESSV KSTSRRGLPQ WFSQHAQDAQ SMAFSSTKSN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCTTCAG CTCCTTGGCA GCCTTACTCG AGTACATTCC TGGGCGATGT CTCTTCAATT 60
CTCTTCGATC CATACGCCGA CTTACTTTGG ACCGGGTCTT CGATCGGCAC CGTCGTTTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

KEGG

mlr:MELLADRAFT_117197

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	40.36	2.00e-67	249.00
IUUC-Apl-003500	Anas platyrhynchos	31.80	5.00e-84	304.00
IUUC-Aca-004930	Anolis carolinensis	41.12	1.00e-66	246.00
IUUC-Acl-008214	Aspergillus clavatus	34.90	7.00e-172	596.00
IUUC-Afu-009112	Aspergillus fumigatus	34.44	6.00e-163	566.00
IUUC-Ang-009531	Aspergillus niger	33.33	4.00e-160	557.00
IUUC-Ame-011259	Astyanax mexicanus	43.41	7.00e-68	250.00
IUUC-Bta-012371	Bos taurus	32.42	7.00e-98	350.00
IUUC-Bci-013684	Botrytis cinerea	38.95	6.00e-81	293.00
IUUC-Cja-019297	Callithrix jacchus	32.69	8.00e-101	360.00
IUUC-Cfa-020489	Canis familiaris	40.36	7.00e-68	250.00
IUUC-Cpo-022392	Cavia porcellus	40.36	2.00e-67	249.00
IUUC-Csa-023220	Chlorocebus sabaeus	32.69	2.00e-100	358.00
IUUC-Csv-025841	Ciona savignyi	31.08	1.00e-75	276.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	40.87	1.00e-127	449.00
IUUC-Cne-026932	Cryptococcus neoformans	38.49	0.00e+00	664.00
IUUC-Dre-028482	Danio rerio	41.19	3.00e-70	258.00
IUUC-Dno-029398	Dasypus novemcinctus	32.64	3.00e-98	351.00
IUUC-Dor-030307	Dipodomys ordii	31.67	4.00e-90	324.00
IUUC-Dme-032111	Drosophila melanogaster	38.73	6.00e-64	237.00
IUUC-Eca-033985	Equus caballus	32.42	8.00e-98	350.00
IUUC-Eeu-034928	Erinaceus europaeus	28.78	2.00e-25	109.00
IUUC-Fca-035587	Felis catus	32.29	3.00e-101	361.00
IUUC-Fal-037587	Ficedula albicollis	32.74	9.00e-96	343.00
IUUC-Fso-038133	Fusarium solani	36.88	1.00e-99	355.00
IUUC-Gmo-039076	Gadus morhua	43.43	1.00e-69	256.00
IUUC-Ggr-039957	Gaeumannomyces graminis	39.04	2.00e-116	412.00
IUUC-Gga-040948	Gallus gallus	32.42	2.00e-95	342.00
IUUC-Gac-042396	Gasterosteus aculeatus	41.02	3.00e-69	255.00
IUUC-Ggo-045412	Gorilla gorilla	32.55	2.00e-98	352.00
IUUC-Hsa-046076	Homo sapiens	32.55	2.00e-98	352.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	31.51	5.00e-93	333.00
IUUC-Kpa-049178	Komagataella pastoris	29.35	3.00e-125	441.00
IUUC-Lch-050279	Latimeria chalumnae	40.36	4.00e-66	244.00
IUUC-Loc-052872	Lepisosteus oculatus	41.30	2.00e-64	239.00
IUUC-Lma-052986	Leptosphaeria maculans	39.35	1.00e-120	426.00
IUUC-Laf-054181	Loxodonta africana	40.48	1.00e-69	256.00
IUUC-Mcc-054812	Macaca mulatta	32.42	4.00e-97	347.00
IUUC-Meu-056325	Macropus eugenii	40.95	8.00e-68	250.00
IUUC-Mor-057246	Magnaporthe oryzae	33.38	8.00e-94	336.00
IUUC-Mpo-057464	Magnaporthe poae	39.04	5.00e-120	423.00
IUUC-Mga-059335	Meleagris gallopavo	32.06	1.00e-94	339.00
IUUC-Mvi-060461	Microbotryum violaceum	41.06	0.00e+00	796.00
IUUC-Mmr-060636	Microcebus murinus	32.55	2.00e-97	348.00
IUUC-Mmu-063503	Mus musculus	40.36	3.00e-67	248.00
IUUC-Mpu-066670	Mustela putorius furo	32.28	4.00e-97	347.00
IUUC-Mlu-068119	Myotis lucifugus	31.92	8.00e-103	366.00
IUUC-Nfi-068398	Neosartorya fischeri	35.10	3.00e-171	593.00
IUUC-Ncr-068927	Neurospora crassa	31.19	7.00e-135	473.00
IUUC-Nle-069651	Nomascus leucogenys	31.02	7.00e-90	323.00
IUUC-Opr-070614	Ochotona princeps	32.92	3.00e-99	354.00
IUUC-Ont-072433	Oreochromis niloticus	42.39	2.00e-71	262.00
IUUC-Oan-073283	Ornithorhynchus anatinus	41.23	6.00e-61	227.00
IUUC-Ocu-074401	Oryctolagus cuniculus	40.36	2.00e-67	249.00
IUUC-Ola-087522	Oryzias latipes	32.37	1.00e-102	366.00
IUUC-Oga-088226	Otolemur garnettii	40.36	2.00e-67	249.00
IUUC-Oar-089241	Ovis aries	32.60	4.00e-102	364.00
IUUC-Pan-092297	Papio anubis	32.42	4.00e-97	347.00
IUUC-Psi-094043	Pelodiscus sinensis	39.47	1.00e-54	206.00
IUUC-Pma-094394	Petromyzon marinus	45.76	1.00e-71	263.00
IUUC-Pno-095053	Phaeosphaeria nodorum	39.42	1.00e-123	435.00
IUUC-Ppa-095188	Physcomitrella patens	40.38	8.00e-59	220.00
IUUC-Pfo-097517	Poecilia formosa	33.42	9.00e-106	376.00
IUUC-Pca-100471	Procavia capensis	40.48	2.00e-70	258.00
IUUC-Pva-102805	Pteropus vampyrus	40.36	1.00e-67	249.00
IUUC-Pte-104021	Pyrenophora teres	39.62	1.00e-122	432.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	39.62	1.00e-122	432.00
IUUC-Rno-105471	Rattus norvegicus	32.15	2.00e-99	355.00
IUUC-Sce-106235	Saccharomyces cerevisiae	30.76	2.00e-74	272.00
IUUC-Sha-106883	Sarcophilus harrisii	40.95	7.00e-68	250.00
IUUC-Spo-108169	Schizosaccharomyces pombe	46.87	2.00e-77	282.00
IUUC-Stu-112823	Solanum tuberosum	28.33	1.10e-01	30.40
IUUC-Sar-113323	Sorex araneus	42.76	6.00e-67	247.00
IUUC-Sre-115075	Sporisorium reilianum	42.37	6.00e-87	314.00
IUUC-Ssc-116363	Sus scrofa	40.48	4.00e-70	258.00
IUUC-Tru-118427	Takifugu rubripes	43.41	4.00e-70	258.00
IUUC-Tni-120218	Tetraodon nigroviridis	40.90	2.00e-69	255.00
IUUC-Tre-122177	Trichoderma reesei	39.67	5.00e-123	433.00
IUUC-Tme-127176	Tuber melanosporum	34.04	2.00e-160	557.00
IUUC-Tbe-127641	Tupaia belangeri	31.86	2.00e-19	90.10
IUUC-Ttr-128888	Tursiops truncatus	39.76	2.00e-63	235.00
IUUC-Uma-129361	Ustilago maydis	39.14	1.00e-108	386.00
IUUC-Xtr-132811	Xenopus tropicalis	41.42	2.00e-67	248.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence