iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Cel-018527

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Probable ubiquitin-conjugating enzyme E2 21; E2 ubiquitin-conjugating enzyme 21; Ubiquitin carrier protein 21; Ubiquitin-protein ligase 21

Genbank Nucleotide ID

FO080381

Gene Name

ubc-21; C06E2.3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
WBGene00006716	C06E2.3	C06E2.3

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	2.00e-39	134.8	28	158

Active Site

Position(s)	Description	Evidence
106	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 4    kelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkeeekWspalsvesvlls 104
           ke+++ ++ + +gi+++ +++ +l++++  i Gpe+tpY+gg+F++++++pe+YPf+PPk kf+t+i+hPn++++ G++Cl+ilk  +kW++ l++++vlls
   Q: 28   KEVANASDITEAGIHVEIKEN-NLMDIKGFIKGPEGTPYAGGTFEIKVDIPEHYPFEPPKAKFVTRIWHPNISSQtGTICLDILK--DKWTASLTLRTVLLS 126
           6777777777899****9999.9***************************************************99********9..*************** PP
   S: 105  iqsllaepnpesplneeaaellkknreeykkk 136
           +q++l++p+p++p+++ +a+++ +n  ++  +
   Q: 127  LQAMLCSPEPSDPQDAVVAKQFINNYPMFTAT 158
           **********************9999888765 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins.

Protein Sequence
(Fasta)

MSVSKLNKMQ FSDKMSNLAL ARVTRKCKEV ANASDITEAG IHVEIKENNL MDIKGFIKGP 60
EGTPYAGGTF EIKVDIPEHY PFEPPKAKFV TRIWHPNISS QTGTICLDIL KDKWTASLTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCGTAT CGAAATTGAA TAAAATGCAA TTTTCAGATA AAATGTCAAA TCTCGCATTG 60
GCACGGGTCA CACGGAAGTG TAAAGAGGTG GCAAATGCTT CTGATATCAC GGAAGCGGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR015940--UBA
IPR009060--UBA-like
IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50030--UBA
PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination

KEGG

cel:CELE_C06E2.3

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-003063	Amborella trichopoda	49.43	2.00e-38	150.00
IUUC-Bol-015985	Brassica oleracea	52.33	6.00e-51	192.00
IUUC-Bra-016805	Brassica rapa	50.57	2.00e-51	193.00
IUUC-Cre-022987	Chlamydomonas reinhardtii	46.37	2.00e-37	147.00
IUUC-Gma-043630	Glycine max	52.30	5.00e-50	189.00
IUUC-Mtr-058002	Medicago truncatula	53.22	6.00e-51	192.00
IUUC-Ppa-095326	Physcomitrella patens	50.28	8.00e-43	165.00
IUUC-Ppe-101789	Prunus persica	50.00	9.00e-45	172.00
IUUC-Sja-107866	Schizosaccharomyces japonicus	49.67	3.00e-43	166.00
IUUC-Spo-108209	Schizosaccharomyces pombe	49.68	6.00e-45	172.00
IUUC-Stu-112088	Solanum tuberosum	47.94	1.00e-52	197.00
IUUC-Sre-115046	Sporisorium reilianum	45.83	8.00e-44	168.00
IUUC-Tca-121446	Theobroma cacao	54.44	4.00e-53	199.00
IUUC-Tvi-122533	Trichoderma virens	43.48	1.00e-35	141.00
IUUC-Uma-129512	Ustilago maydis	47.47	5.00e-44	169.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence