iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sly-111283

Ensembl Protein ID

Solyc06g007510.2.1

UniProt Accession

P35135; UBC4_SOLLC

Genbank Protein ID

AAA34125.1

Protein Name

Ubiquitin-conjugating enzyme E2-17 kDa; E2 ubiquitin-conjugating enzyme; Ubiquitin carrier protein; Ubiquitin-protein ligase

Genbank Nucleotide ID

L23762

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Solyc06g007510.2	Solyc06g007510.2.1	Solyc06g007510.2.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.80e-56	190.5	5	139
UBD/UBC-like/UBD_UBC	3.40e-74	248.2	5	142

Active Site

Position(s)	Description	Evidence
85	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeek 91
           R+ kelk+l+kdpp+++sa+pv e d+++w+++i+Gp+d+pY+ggvF ++i+fp+dYPfkPPkv f tk+fhPn+++nG++Cl+ilk  e+
   Q: 5    RILKELKDLQKDPPTSCSAGPVAE-DMFHWQATIMGPTDSPYAGGVFLVSIHFPPDYPFKPPKVAFRTKVFHPNINSNGSICLDILK--EQ 92
           899*********************.9************************************************************9..** PP
   S: 92   Wspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           Wspal++++vllsi+sll++pnp++pl  e+a+++k++r++y++++r
   Q: 93   WSPALTISKVLLSICSLLTDPNPDDPLVPEIAHMYKTDRAKYETTAR 139
           *******************************************9987 PP

UBD/UBC-like/UBD_UBC

   S: 1    rikkelkdllrdeeaqisadlvdddlfelratiagppdspyeggvffltiklptdypfkppkvafitkiyhpninsngsicldilrsqwsa 91
           ri kelkdl++d+++ +sa++v +d+f+++ati+gp+dspy ggvf + i++p dypfkppkvaf tk++hpninsngsicldil++qws+
   Q: 5    RILKELKDLQKDPPTSCSAGPVAEDMFHWQATIMGPTDSPYAGGVFLVSIHFPPDYPFKPPKVAFRTKVFHPNINSNGSICLDILKEQWSP 95
           899**************************************************************************************** PP
   S: 92   altlskvllslcslladaepddplvaeiariyktdkekykriarewt 138
           alt+skvlls+csll+d++pddplv+eia++yktd+ ky+ +ar wt
   Q: 96   ALTISKVLLSICSLLTDPNPDDPLVPEIAHMYKTDRAKYETTARSWT 142
           **********************************************8 PP

Organism

Solanum lycopersicum

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins.

Protein Sequence
(Fasta)

MASKRILKEL KDLQKDPPTS CSAGPVAEDM FHWQATIMGP TDSPYAGGVF LVSIHFPPDY 60
PFKPPKVAFR TKVFHPNINS NGSICLDILK EQWSPALTIS KVLLSICSLL TDPNPDDPLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCATTTTAA TCTCCTCTTC TTCCATTTCT TTCAAAATTA AAGTATTGTT ACTCTGCTAT 60
TGGCTCAAAA CCTCTGCAAT CTCCGTCTCC TTCAATTTCA ACTCAAGCAA ATCCACCTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005524--F:ATP binding
GO:0016740--F:transferase activity
GO:0016567--P:protein ubiquitination

KEGG

sly:100301932; sly:101249087

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002861	Amborella trichopoda	97.97	1.00e-84	304.00
IUUC-Bgr-012238	Blumeria graminis	78.91	2.00e-70	256.00
IUUC-Cne-026957	Cryptococcus neoformans	77.40	5.00e-68	248.00
IUUC-Ggr-039912	Gaeumannomyces graminis	76.32	5.00e-68	248.00
IUUC-Gma-043068	Glycine max	98.65	3.00e-85	305.00
IUUC-Mpo-057596	Magnaporthe poae	76.32	9.00e-68	248.00
IUUC-Mtr-058532	Medicago truncatula	97.97	1.00e-84	303.00
IUUC-Pop-098986	Populus trichocarpa	98.65	3.00e-85	305.00
IUUC-Ppe-101538	Prunus persica	98.65	3.00e-85	305.00
IUUC-Sja-107729	Schizosaccharomyces japonicus	81.63	4.00e-72	262.00
IUUC-Sit-109936	Setaria italica	95.95	3.00e-84	303.00
IUUC-Stu-112825	Solanum tuberosum	100.00	3.00e-86	308.00
IUUC-Tca-121375	Theobroma cacao	97.97	9.00e-85	304.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence