iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cne-026864

Ensembl Protein ID

AAW41362

UniProt Accession

P0CS16; Q55YQ1; Q5KN22; UBC2_CRYNJ

Genbank Protein ID

AAW41362.1

Protein Name

Ubiquitin-conjugating enzyme E2 2; E2 ubiquitin-conjugating enzyme 2; Ubiquitin carrier protein UBC2; Ubiquitin-protein ligase UBC2

Genbank Nucleotide ID

AE017341

Gene Name

UBC2; CNA08010

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CNA08010	AAW41362	AAW41362

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	4.20e-50	167.5	8	142

Active Site

Position(s)	Description	Evidence
88	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsvesv 101
           Rl +++k+l++d p gis +p+ + +++ w+++i+Gp++tp+e+g F+l+++f++ YP kPP+v+f++k+fhPn+y+nG++Cl+il+  ++Wsp+++v+ +
   Q: 8    RLIRDFKRLTSDAPIGISGSPNPD-NIMVWNAVIFGPPETPFEDGSFRLTLTFTDAYPNKPPTVRFISKMFHPNIYANGELCLDILQ--NRWSPTYDVAAI 105
           899*********************.9************************************************************9..************ PP
   S: 102  llsiqsllaepnpesplneeaaellkknreeykkkvr 138
           l+s+qsll++pnp+sp+n++aa+l+k+n +ey+++v+
   Q: 106  LTSVQSLLNDPNPASPANVDAAQLFKENLKEYERRVK 142
           ***********************************98 PP

Organism

Cryptococcus neoformans

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation.

Protein Sequence
(Fasta)

MSTAAKRRLI RDFKRLTSDA PIGISGSPNP DNIMVWNAVI FGPPETPFED GSFRLTLTFT 60
DAYPNKPPTV RFISKMFHPN IYANGELCLD ILQNRWSPTY DVAAILTSVQ SLLNDPNPAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGAGCCACT CAACTCGCAC GACCATCTTC ATTTGCCCTA TCCTAATTTT TGTCTGCCTG 60
AACTAGCTCG CAATGGTAAG TCCAATGCGT CTGTAATACA TCTGCAAAGT CTTCGCTTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0749--Sporulation
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0033503--C:HULC complex
GO:0000790--C:nuclear chromatin
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0006281--P:DNA repair
GO:0016574--P:histone ubiquitination
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0006355--P:regulation of transcription, DNA-templated
GO:0030435--P:sporulation resulting in formation of a cellular spore
GO:0006351--P:transcription, DNA-templated

KEGG

cne:CNA08010

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001001	Aegilops tauschii	67.33	1.00e-61	226.00
IUUC-Aml-002120	Ailuropoda melanoleuca	69.08	4.00e-65	237.00
IUUC-Atr-002862	Amborella trichopoda	69.48	4.00e-63	231.00
IUUC-Apl-004063	Anas platyrhynchos	63.09	2.00e-55	205.00
IUUC-Aca-005001	Anolis carolinensis	69.08	6.00e-65	237.00
IUUC-Aly-006336	Arabidopsis lyrata	67.33	1.00e-55	206.00
IUUC-Ath-007547	Arabidopsis thaliana	67.33	1.00e-55	206.00
IUUC-Ago-007745	Ashbya gossypii	71.14	3.00e-65	238.00
IUUC-Acl-008139	Aspergillus clavatus	70.20	5.00e-65	237.00
IUUC-Afl-008551	Aspergillus flavus	70.20	3.00e-65	238.00
IUUC-Afu-008980	Aspergillus fumigatus	70.20	3.00e-65	238.00
IUUC-Ang-009554	Aspergillus niger	70.20	3.00e-65	238.00
IUUC-Aor-010242	Aspergillus oryzae	70.20	3.00e-65	238.00
IUUC-Ate-010390	Aspergillus terreus	70.20	3.00e-65	238.00
IUUC-Ame-011594	Astyanax mexicanus	71.52	3.00e-66	241.00
IUUC-Bgr-012039	Blumeria graminis	67.65	1.00e-57	212.00
IUUC-Bta-012840	Bos taurus	69.08	4.00e-65	237.00
IUUC-Bci-013919	Botrytis cinerea	71.05	3.00e-67	245.00
IUUC-Bdi-014308	Brachypodium distachyon	69.33	8.00e-63	230.00
IUUC-Bol-016084	Brassica oleracea	69.33	2.00e-62	229.00
IUUC-Bra-016643	Brassica rapa	69.33	2.00e-62	229.00
IUUC-Cel-018244	Caenorhabditis elegans	66.06	6.00e-66	241.00
IUUC-Cja-018783	Callithrix jacchus	71.52	3.00e-66	241.00
IUUC-Cfa-020646	Canis familiaris	71.52	4.00e-66	242.00
IUUC-Cpo-021323	Cavia porcellus	72.19	2.00e-66	242.00
IUUC-Cre-022822	Chlamydomonas reinhardtii	66.45	9.00e-55	203.00
IUUC-Csa-023588	Chlorocebus sabaeus	71.52	3.00e-66	241.00
IUUC-Cho-024773	Choloepus hoffmanni	55.26	1.00e-45	173.00
IUUC-Cin-025537	Ciona intestinalis	65.56	6.00e-51	191.00
IUUC-Csv-025846	Ciona savignyi	67.11	3.00e-55	204.00
IUUC-Cgl-026381	Colletotrichum gloeosporioides	71.52	5.00e-67	244.00
IUUC-Cme-027284	Cyanidioschyzon merolae	60.26	1.00e-47	180.00
IUUC-Dre-028774	Danio rerio	71.05	2.00e-66	242.00
IUUC-Dno-029661	Dasypus novemcinctus	69.08	4.00e-65	237.00
IUUC-Dor-030452	Dipodomys ordii	68.38	2.00e-57	212.00
IUUC-Dse-031487	Dothistroma septosporum	70.86	8.00e-66	240.00
IUUC-Dme-031863	Drosophila melanogaster	72.19	9.00e-67	243.00
IUUC-Ete-032595	Echinops telfairi	68.46	1.00e-63	232.00
IUUC-Eca-033377	Equus caballus	69.08	4.00e-65	237.00
IUUC-Eeu-035191	Erinaceus europaeus	55.56	7.00e-45	170.00
IUUC-Fca-036581	Felis catus	71.52	3.00e-66	241.00
IUUC-Fal-037474	Ficedula albicollis	73.73	5.00e-53	197.00
IUUC-Fox-037808	Fusarium oxysporum	71.52	5.00e-67	244.00
IUUC-Fso-038232	Fusarium solani	71.52	6.00e-67	244.00
IUUC-Gmo-038517	Gadus morhua	71.52	3.00e-66	241.00
IUUC-Ggr-039875	Gaeumannomyces graminis	71.81	1.00e-66	243.00
IUUC-Gga-040588	Gallus gallus	71.52	3.00e-66	241.00
IUUC-Gac-041504	Gasterosteus aculeatus	71.52	8.00e-66	240.00
IUUC-Gma-043883	Glycine max	69.33	5.00e-63	230.00
IUUC-Ggo-044896	Gorilla gorilla	71.52	3.00e-66	241.00
IUUC-Hsa-046383	Homo sapiens	71.52	3.00e-66	241.00
IUUC-Hvu-047054	Hordeum vulgare	67.33	1.00e-61	226.00
IUUC-Itr-048507	Ictidomys tridecemlineatus	71.52	3.00e-66	241.00
IUUC-Kpa-049225	Komagataella pastoris	68.46	8.00e-63	230.00
IUUC-Lch-049964	Latimeria chalumnae	71.52	3.00e-66	241.00
IUUC-Lpe-051301	Leersia perrieri	69.33	7.00e-63	230.00
IUUC-Loc-051731	Lepisosteus oculatus	71.52	3.00e-66	241.00
IUUC-Laf-053680	Loxodonta africana	71.52	3.00e-66	241.00
IUUC-Mcc-055546	Macaca mulatta	71.52	7.00e-66	241.00
IUUC-Meu-056231	Macropus eugenii	71.52	3.00e-66	241.00
IUUC-Mor-057087	Magnaporthe oryzae	70.90	4.00e-58	214.00
IUUC-Mpo-057498	Magnaporthe poae	71.81	1.00e-66	244.00
IUUC-Mtr-058305	Medicago truncatula	69.80	5.00e-63	231.00
IUUC-Mla-058876	Melampsora laricipopulina	77.48	1.00e-64	236.00
IUUC-Mga-059863	Meleagris gallopavo	68.12	4.00e-58	214.00
IUUC-Mvi-060330	Microbotryum violaceum	78.21	5.00e-64	234.00
IUUC-Mmr-060630	Microcebus murinus	69.08	4.00e-65	237.00
IUUC-Mdo-062292	Monodelphis domestica	71.52	3.00e-66	241.00
IUUC-Mmu-063680	Mus musculus	71.52	3.00e-66	241.00
IUUC-Mac-065428	Musa acuminata	68.46	3.00e-62	229.00
IUUC-Mpu-065803	Mustela putorius furo	69.08	4.00e-65	237.00
IUUC-Mlu-067147	Myotis lucifugus	69.08	4.00e-65	237.00
IUUC-Nfi-068580	Neosartorya fischeri	70.20	3.00e-65	238.00
IUUC-Ncr-068913	Neurospora crassa	71.52	3.00e-67	244.00
IUUC-Nle-069121	Nomascus leucogenys	71.52	3.00e-66	241.00
IUUC-Opr-070935	Ochotona princeps	69.08	4.00e-65	237.00
IUUC-Ont-071335	Oreochromis niloticus	70.39	1.00e-65	239.00
IUUC-Oan-072706	Ornithorhynchus anatinus	64.63	2.00e-58	215.00
IUUC-Ocu-074550	Oryctolagus cuniculus	71.52	5.00e-66	241.00
IUUC-Oba-075847	Oryza barthii	69.33	1.00e-62	230.00
IUUC-Obr-076713	Oryza brachyantha	69.33	7.00e-63	230.00
IUUC-Ogl-076956	Oryza glaberrima	69.33	8.00e-63	230.00
IUUC-Ogu-078696	Oryza glumaepatula	69.33	7.00e-63	230.00
IUUC-Oin-080106	Oryza indica	69.33	8.00e-63	230.00
IUUC-Olo-081018	Oryza longistaminata	54.84	4.00e-55	205.00
IUUC-Ome-081285	Oryza meridionalis	69.33	7.00e-63	230.00
IUUC-Oni-082088	Oryza nivara	69.33	7.00e-63	230.00
IUUC-Opu-083310	Oryza punctata	69.33	7.00e-63	230.00
IUUC-Oru-084449	Oryza rufipogon	69.33	7.00e-63	230.00
IUUC-Osa-086191	Oryza sativa	69.33	8.00e-63	230.00
IUUC-Ola-086407	Oryzias latipes	71.52	3.00e-66	241.00
IUUC-Olu-087830	Ostreococcus lucimarinus	63.09	7.00e-51	190.00
IUUC-Oga-088659	Otolemur garnettii	71.52	3.00e-66	241.00
IUUC-Oar-090141	Ovis aries	69.08	4.00e-65	237.00
IUUC-Ptr-091305	Pan troglodytes	71.52	3.00e-66	241.00
IUUC-Pan-092740	Papio anubis	71.52	7.00e-66	241.00
IUUC-Psi-094094	Pelodiscus sinensis	71.52	3.00e-66	241.00
IUUC-Pma-094376	Petromyzon marinus	69.74	4.00e-65	238.00
IUUC-Pno-094935	Phaeosphaeria nodorum	71.52	2.00e-66	242.00
IUUC-Ppa-095689	Physcomitrella patens	72.44	2.00e-54	202.00
IUUC-Pfo-096656	Poecilia formosa	70.86	4.00e-66	241.00
IUUC-Pab-097972	Pongo abelii	71.52	3.00e-66	241.00
IUUC-Pop-099517	Populus trichocarpa	69.33	5.00e-63	230.00
IUUC-Pca-100906	Procavia capensis	66.23	9.00e-60	220.00
IUUC-Ppe-101594	Prunus persica	69.33	7.00e-63	230.00
IUUC-Pva-102380	Pteropus vampyrus	70.86	2.00e-64	235.00
IUUC-Pgr-103611	Puccinia graminis	75.82	8.00e-65	237.00
IUUC-Ptt-103971	Puccinia triticina	75.83	2.00e-49	185.00
IUUC-Pte-104378	Pyrenophora teres	72.19	6.00e-67	244.00
IUUC-Pyt-104757	Pyrenophora triticirepentis	72.19	6.00e-67	244.00
IUUC-Rno-105772	Rattus norvegicus	69.08	2.00e-65	239.00
IUUC-Sce-106283	Saccharomyces cerevisiae	71.14	3.00e-65	238.00
IUUC-Sha-107650	Sarcophilus harrisii	68.42	7.00e-64	233.00
IUUC-Sja-107790	Schizosaccharomyces japonicus	73.83	1.00e-58	216.00
IUUC-Spo-108073	Schizosaccharomyces pombe	73.83	9.00e-59	216.00
IUUC-Ssl-108432	Sclerotinia sclerotiorum	71.05	3.00e-67	245.00
IUUC-Smo-109036	Selaginella moellendorffii	68.67	2.00e-62	229.00
IUUC-Sit-110731	Setaria italica	69.33	7.00e-63	230.00
IUUC-Sly-111506	Solanum lycopersicum	68.67	1.00e-62	229.00
IUUC-Stu-112080	Solanum tuberosum	68.67	1.00e-62	229.00
IUUC-Sar-113429	Sorex araneus	69.08	4.00e-65	237.00
IUUC-Sbi-114289	Sorghum bicolor	69.33	7.00e-63	230.00
IUUC-Sre-115106	Sporisorium reilianum	74.68	5.00e-64	234.00
IUUC-Ssc-116265	Sus scrofa	71.52	3.00e-66	241.00
IUUC-Tgu-117383	Taeniopygia guttata	71.52	3.00e-66	241.00
IUUC-Tru-118576	Takifugu rubripes	69.08	3.00e-65	238.00
IUUC-Tsy-119000	Tarsius syrichta	69.08	4.00e-65	237.00
IUUC-Tni-119745	Tetraodon nigroviridis	68.42	8.00e-65	236.00
IUUC-Tca-121827	Theobroma cacao	70.00	4.00e-63	231.00
IUUC-Tre-122002	Trichoderma reesei	71.52	5.00e-67	244.00
IUUC-Tvi-122331	Trichoderma virens	71.52	5.00e-67	244.00
IUUC-Tae-125400	Triticum aestivum	69.33	7.00e-63	230.00
IUUC-Tur-126866	Triticum urartu	68.00	3.00e-62	228.00
IUUC-Tme-127148	Tuber melanosporum	70.47	3.00e-65	238.00
IUUC-Tbe-127921	Tupaia belangeri	67.11	1.00e-60	223.00
IUUC-Ttr-129050	Tursiops truncatus	71.52	3.00e-65	238.00
IUUC-Uma-129561	Ustilago maydis	73.42	2.00e-64	235.00
IUUC-Vda-129711	Verticillium dahliae	71.52	5.00e-67	244.00
IUUC-Vpa-130570	Vicugna pacos	63.24	8.00e-52	193.00
IUUC-Vvi-131547	Vitis vinifera	69.33	5.00e-63	231.00
IUUC-Xtr-132301	Xenopus tropicalis	71.52	3.00e-66	241.00
IUUC-Xma-133937	Xiphophorus maculatus	71.52	3.00e-66	241.00
IUUC-Yli-134660	Yarrowia lipolytica	68.87	2.00e-65	238.00
IUUC-Zma-135584	Zea mays	68.46	4.00e-62	228.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence