iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000022667.3	ENSMMUT00000031894.3	ENSMMUP00000029841.3
ENSMMUG00000022667.3	ENSMMUT00000079183.1	ENSMMUP00000056917.1
ENSMMUG00000022667.3	ENSMMUT00000069099.1	ENSMMUP00000052808.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	2.70e-54	183.8	80	214

Active Site

Position(s)	Description	Evidence
160	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkee 89
           Rl++++k+l++dpp+g+s  p+++ +++ w+++i+Gpe+tp+e+g+Fkl+ief+e+YP kPP+v+f++k+fhPnvy++G++Cl+il+  
   Q: 80   RLMRDFKRLQEDPPAGVSGAPSEN-NIMVWNAVIFGPEGTPFEDGTFKLTIEFTEEYPNKPPTVRFVSKMFHPNVYADGSICLDILQ-- 165
           9**********************9.9************************************************************9.. PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           ++Wsp+++v+s+l+siqsll+epnp+sp+n++aa+l+++n++ey+k+v+
   Q: 166  NRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVS 214
           **********************************************996 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MWFQSQIVGS APVYTGVVLS RRQTDPRLRR GSAVPLGASA SPSPASPASS ASSPAAGTRD 60
PSVCPTPDPA RDMSTPARRR LMRDFKRLQE DPPAGVSGAP SENNIMVWNA VIFGPEGTPF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGAGACTTG CCTTAACTGA TATATTGGAG TTAATGGGAG ATAGAAATCC TTGACCATGA 60
AAGTACCTGT TATTAAACAG CAGCTAGAAT TACTACCATT GTCAAGTGCC TCCTGCTTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0033503--C:HULC complex
GO:0000790--C:nuclear chromatin
GO:0001741--C:XY body
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0006281--P:DNA repair
GO:0033522--P:histone H2A ubiquitination
GO:0016574--P:histone ubiquitination
GO:0001701--P:in utero embryonic development
GO:0060135--P:maternal process involved in female pregnancy
GO:0008284--P:positive regulation of cell proliferation
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0009411--P:response to UV

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001001	Aegilops tauschii	75.84	1.00e-69	254.00
IUUC-Atr-002862	Amborella trichopoda	79.19	1.00e-71	261.00
IUUC-Aly-005584	Arabidopsis lyrata	77.18	2.00e-70	257.00
IUUC-Ath-007149	Arabidopsis thaliana	77.18	2.00e-70	257.00
IUUC-Ame-011594	Astyanax mexicanus	100.00	4.00e-89	319.00
IUUC-Bgr-012039	Blumeria graminis	66.91	2.00e-56	210.00
IUUC-Bdi-014308	Brachypodium distachyon	78.52	5.00e-71	259.00
IUUC-Bol-016084	Brassica oleracea	78.52	3.00e-71	259.00
IUUC-Bra-016643	Brassica rapa	78.52	3.00e-71	259.00
IUUC-Cel-018244	Caenorhabditis elegans	85.91	1.00e-77	282.00
IUUC-Cja-018783	Callithrix jacchus	100.00	4.00e-89	319.00
IUUC-Cfa-020646	Canis familiaris	94.91	2.00e-110	391.00
IUUC-Cpo-021323	Cavia porcellus	99.34	6.00e-89	318.00
IUUC-Csa-023588	Chlorocebus sabaeus	100.00	4.00e-89	319.00
IUUC-Cin-025537	Ciona intestinalis	82.89	8.00e-63	232.00
IUUC-Csv-025846	Ciona savignyi	83.89	2.00e-67	247.00
IUUC-Cne-026864	Cryptococcus neoformans	71.81	5.00e-65	239.00
IUUC-Dre-028358	Danio rerio	100.00	4.00e-89	319.00
IUUC-Dme-031863	Drosophila melanogaster	88.08	7.00e-78	282.00
IUUC-Eca-033562	Equus caballus	98.05	8.00e-87	311.00
IUUC-Eeu-035191	Erinaceus europaeus	79.22	2.00e-64	237.00
IUUC-Fca-036581	Felis catus	100.00	4.00e-89	319.00
IUUC-Fal-037474	Ficedula albicollis	100.00	3.00e-69	253.00
IUUC-Gmo-038517	Gadus morhua	100.00	4.00e-89	319.00
IUUC-Gga-040588	Gallus gallus	100.00	4.00e-89	319.00
IUUC-Gac-041504	Gasterosteus aculeatus	99.34	1.00e-88	318.00
IUUC-Gma-043883	Glycine max	79.19	1.00e-71	261.00
IUUC-Ggo-044896	Gorilla gorilla	100.00	4.00e-89	319.00
IUUC-Hsa-046383	Homo sapiens	100.00	4.00e-89	319.00
IUUC-Hvu-047054	Hordeum vulgare	75.84	1.00e-69	254.00
IUUC-Itr-048507	Ictidomys tridecemlineatus	100.00	4.00e-89	319.00
IUUC-Lch-049964	Latimeria chalumnae	100.00	4.00e-89	319.00
IUUC-Lpe-051301	Leersia perrieri	79.19	1.00e-71	261.00
IUUC-Loc-051731	Lepisosteus oculatus	100.00	4.00e-89	319.00
IUUC-Laf-053680	Loxodonta africana	100.00	4.00e-89	319.00
IUUC-Meu-056231	Macropus eugenii	100.00	4.00e-89	319.00
IUUC-Mtr-058305	Medicago truncatula	79.19	9.00e-72	262.00
IUUC-Mvi-060330	Microbotryum violaceum	74.17	3.00e-59	220.00
IUUC-Mmr-060956	Microcebus murinus	98.03	6.00e-85	305.00
IUUC-Mdo-062292	Monodelphis domestica	100.00	4.00e-89	319.00
IUUC-Mmu-063680	Mus musculus	100.00	4.00e-89	319.00
IUUC-Mac-064774	Musa acuminata	79.19	2.00e-71	260.00
IUUC-Nle-069121	Nomascus leucogenys	100.00	4.00e-89	319.00
IUUC-Ont-071335	Oreochromis niloticus	98.68	2.00e-87	313.00
IUUC-Ocu-074550	Oryctolagus cuniculus	94.50	6.00e-107	379.00
IUUC-Oba-075896	Oryza barthii	78.52	5.00e-71	259.00
IUUC-Obr-076713	Oryza brachyantha	79.19	1.00e-71	261.00
IUUC-Ogl-077116	Oryza glaberrima	79.19	1.00e-71	261.00
IUUC-Ogu-078696	Oryza glumaepatula	79.19	1.00e-71	261.00
IUUC-Oin-079099	Oryza indica	79.19	1.00e-71	261.00
IUUC-Olo-081018	Oryza longistaminata	67.27	4.00e-62	230.00
IUUC-Ome-081285	Oryza meridionalis	79.19	1.00e-71	261.00
IUUC-Oni-082088	Oryza nivara	79.19	1.00e-71	261.00
IUUC-Opu-083310	Oryza punctata	79.19	1.00e-71	261.00
IUUC-Oru-084449	Oryza rufipogon	79.19	1.00e-71	261.00
IUUC-Osa-085923	Oryza sativa	79.19	1.00e-71	261.00
IUUC-Ola-086407	Oryzias latipes	100.00	4.00e-89	319.00
IUUC-Olu-087830	Ostreococcus lucimarinus	79.87	3.00e-62	229.00
IUUC-Oga-088659	Otolemur garnettii	100.00	4.00e-89	319.00
IUUC-Ptr-091305	Pan troglodytes	100.00	4.00e-89	319.00
IUUC-Pan-092740	Papio anubis	99.55	4.00e-118	416.00
IUUC-Psi-094094	Pelodiscus sinensis	100.00	4.00e-89	319.00
IUUC-Pma-094376	Petromyzon marinus	96.03	2.00e-85	307.00
IUUC-Ppa-095689	Physcomitrella patens	79.19	2.00e-62	231.00
IUUC-Pfo-096656	Poecilia formosa	99.34	6.00e-89	318.00
IUUC-Pab-097972	Pongo abelii	100.00	4.00e-89	319.00
IUUC-Pop-099517	Populus trichocarpa	79.19	1.00e-71	261.00
IUUC-Pca-100906	Procavia capensis	93.42	8.00e-81	291.00
IUUC-Ppe-101949	Prunus persica	79.19	3.00e-71	261.00
IUUC-Pva-102380	Pteropus vampyrus	98.68	2.00e-85	307.00
IUUC-Rno-105577	Rattus norvegicus	93.83	3.00e-86	310.00
IUUC-Sja-107790	Schizosaccharomyces japonicus	72.48	8.00e-59	219.00
IUUC-Spo-108073	Schizosaccharomyces pombe	72.48	6.00e-59	219.00
IUUC-Smo-109512	Selaginella moellendorffii	79.19	5.00e-72	262.00
IUUC-Sit-110731	Setaria italica	79.19	1.00e-71	261.00
IUUC-Sly-111506	Solanum lycopersicum	78.52	3.00e-71	259.00
IUUC-Stu-112080	Solanum tuberosum	78.52	3.00e-71	259.00
IUUC-Sbi-114289	Sorghum bicolor	79.19	1.00e-71	261.00
IUUC-Ssc-116265	Sus scrofa	100.00	4.00e-89	319.00
IUUC-Tgu-117383	Taeniopygia guttata	100.00	4.00e-89	319.00
IUUC-Tru-117924	Takifugu rubripes	90.74	6.00e-81	292.00
IUUC-Tni-119743	Tetraodon nigroviridis	96.05	3.00e-84	303.00
IUUC-Tca-121827	Theobroma cacao	78.52	2.00e-71	261.00
IUUC-Tae-124461	Triticum aestivum	77.85	5.00e-71	260.00
IUUC-Tur-126866	Triticum urartu	77.85	7.00e-71	259.00
IUUC-Tme-127148	Tuber melanosporum	70.39	3.00e-65	239.00
IUUC-Ttr-129050	Tursiops truncatus	99.34	2.00e-85	307.00
IUUC-Vvi-131547	Vitis vinifera	79.19	1.00e-71	262.00
IUUC-Xtr-132301	Xenopus tropicalis	100.00	4.00e-89	319.00
IUUC-Xma-133937	Xiphophorus maculatus	100.00	4.00e-89	319.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence