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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063680
UUCD1 version UUC-MuM-01070
Ensembl Protein ID ENSMUSP00000016452.7
UniProt Accession Q9Z255; UBE2A_MOUSE
Genbank Protein ID AAC64563.1; AAK62984.1; AAH26053.1
Protein Name Ubiquitin-conjugating enzyme E2 A; E2 ubiquitin-conjugating enzyme A; RAD6 homolog A; Ubiquitin carrier protein A; Ubiquitin-protein ligase A
Genbank Nucleotide ID AF089812; AF383148; BC026053
Gene Name Ube2a; Rad6a
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000016308.12 ENSMUST00000016452.10 ENSMUSP00000016452.7
ENSMUSG00000016308.12 ENSMUST00000202991.3 ENSMUSP00000144242.1
ENSMUSG00000016308.12 ENSMUST00000201068.3 ENSMUSP00000143836.1
ENSMUSG00000016308.12 ENSMUST00000200835.3 ENSMUSP00000144306.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
CPLMPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E2/UBC E2_UBC 12525704
Classification
Family E-value Score Start End
E2/UBC 8.40e-55 185.5 8 142
Active Site
Position(s) Description Evidence
88 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00388,
ECO:0000255|PROSITE-ProRule:PRU10133}
Domain Profile

   E2/UBC
   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkee 89
           Rl++++k+l++dpp+g+s  p+++ +++ w+++i+Gpe+tp+e+g+Fkl+ief+e+YP kPP+v+f++k+fhPnvy++G++Cl+il+  
   Q: 8    RLMRDFKRLQEDPPAGVSGAPSEN-NIMVWNAVIFGPEGTPFEDGTFKLTIEFTEEYPNKPPTVRFVSKMFHPNVYADGSICLDILQ-- 93
           9**********************9.9************************************************************9.. PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           ++Wsp+++v+s+l+siqsll+epnp+sp+n++aa+l+++n++ey+k+v+
   Q: 94   NRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVS 142
           **********************************************996 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.
 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.
Protein Sequence
(Fasta)
MSTPARRRLM RDFKRLQEDP PAGVSGAPSE NNIMVWNAVI FGPEGTPFED GTFKLTIEFT 60
EEYPNKPPTV RFVSKMFHPN VYADGSICLD ILQNRWSPTY DVSSILTSIQ SLLDEPNPNS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063680|E2,E2/UBC|Mus musculus
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Nucleotide Sequence
(Fasta)
GGAGAGTCAG GAGTTCAAAA TCATGCTCAA CGACACAGTG AGTTCGAGGT TCTCTGGCCT 60
ATAGGAGACT CTGTCTCAAC AGAGGGGGAA AAAAGATAGA AAAAGAGCCC CTCCTTCCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063680|E2,E2/UBC|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD
PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2
Pfam

PF00179--UQ_con
Gene Ontology

GO:0000785--C:chromatin
GO:0005737--C:cytoplasm
GO:0033503--C:HULC complex
GO:0000790--C:nuclear chromatin
GO:0001741--C:XY body
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006281--P:DNA repair
GO:0033522--P:histone H2A ubiquitination
GO:0016574--P:histone ubiquitination
GO:0001701--P:in utero embryonic development
GO:0060135--P:maternal process involved in female pregnancy
GO:0008284--P:positive regulation of cell proliferation
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0009411--P:response to UV
KEGG mmu:22209
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001001 Aegilops tauschii 75.84 9.00e-70 255.00
IUUC-Atr-002862 Amborella trichopoda 79.19 7.00e-72 262.00
IUUC-Aly-005584 Arabidopsis lyrata 77.18 8.00e-71 258.00
IUUC-Ath-007149 Arabidopsis thaliana 77.18 8.00e-71 258.00
IUUC-Ago-007745 Ashbya gossypii 69.80 9.00e-63 232.00
IUUC-Afl-008551 Aspergillus flavus 68.87 1.00e-63 234.00
IUUC-Afu-008980 Aspergillus fumigatus 68.87 1.00e-63 234.00
IUUC-Ang-009554 Aspergillus niger 68.87 1.00e-63 234.00
IUUC-Aor-010242 Aspergillus oryzae 68.87 1.00e-63 234.00
IUUC-Ate-010390 Aspergillus terreus 68.87 1.00e-63 234.00
IUUC-Ame-011594 Astyanax mexicanus 100.00 1.00e-88 318.00
IUUC-Bgr-012039 Blumeria graminis 66.91 2.00e-56 211.00
IUUC-Bci-013919 Botrytis cinerea 69.54 1.00e-64 238.00
IUUC-Bdi-015010 Brachypodium distachyon 78.52 4.00e-71 259.00
IUUC-Bol-016084 Brassica oleracea 78.52 1.00e-71 261.00
IUUC-Bra-016643 Brassica rapa 78.52 1.00e-71 261.00
IUUC-Cel-018244 Caenorhabditis elegans 85.91 8.00e-78 282.00
IUUC-Cja-018783 Callithrix jacchus 100.00 1.00e-88 318.00
IUUC-Cfa-020646 Canis familiaris 100.00 2.00e-87 314.00
IUUC-Cpo-021323 Cavia porcellus 99.34 2.00e-88 317.00
IUUC-Csa-023588 Chlorocebus sabaeus 100.00 1.00e-88 318.00
IUUC-Cin-025537 Ciona intestinalis 82.89 7.00e-63 232.00
IUUC-Csv-025846 Ciona savignyi 83.89 2.00e-67 247.00
IUUC-Cgl-026381 Colletotrichum gloeosporioides 68.87 3.00e-64 236.00
IUUC-Cne-026864 Cryptococcus neoformans 71.81 4.00e-65 239.00
IUUC-Cme-027284 Cyanidioschyzon merolae 67.33 2.00e-54 205.00
IUUC-Dre-028358 Danio rerio 100.00 1.00e-88 318.00
IUUC-Dse-031487 Dothistroma septosporum 68.87 7.00e-64 235.00
IUUC-Dme-031863 Drosophila melanogaster 88.08 4.00e-78 283.00
IUUC-Eca-033562 Equus caballus 98.05 7.00e-87 311.00
IUUC-Eeu-035191 Erinaceus europaeus 79.22 2.00e-64 238.00
IUUC-Fca-036581 Felis catus 100.00 1.00e-88 318.00
IUUC-Fal-037474 Ficedula albicollis 100.00 1.00e-68 251.00
IUUC-Gmo-038517 Gadus morhua 100.00 1.00e-88 318.00
IUUC-Gga-040588 Gallus gallus 100.00 1.00e-88 318.00
IUUC-Gac-041504 Gasterosteus aculeatus 99.34 3.00e-88 316.00
IUUC-Gma-043883 Glycine max 79.19 6.00e-72 262.00
IUUC-Ggo-044896 Gorilla gorilla 100.00 1.00e-88 318.00
IUUC-Hsa-046383 Homo sapiens 100.00 1.00e-88 318.00
IUUC-Hvu-047054 Hordeum vulgare 75.84 9.00e-70 255.00
IUUC-Itr-048507 Ictidomys tridecemlineatus 100.00 1.00e-88 318.00
IUUC-Lch-049964 Latimeria chalumnae 100.00 1.00e-88 318.00
IUUC-Lpe-051301 Leersia perrieri 79.19 8.00e-72 262.00
IUUC-Loc-051731 Lepisosteus oculatus 100.00 1.00e-88 318.00
IUUC-Laf-053680 Loxodonta africana 100.00 1.00e-88 318.00
IUUC-Mcc-055546 Macaca mulatta 100.00 3.00e-88 317.00
IUUC-Meu-056231 Macropus eugenii 100.00 1.00e-88 318.00
IUUC-Mpo-057498 Magnaporthe poae 69.13 3.00e-63 234.00
IUUC-Mtr-058305 Medicago truncatula 79.19 6.00e-72 263.00
IUUC-Mvi-060330 Microbotryum violaceum 74.17 2.00e-59 221.00
IUUC-Mmr-060956 Microcebus murinus 98.03 5.00e-85 306.00
IUUC-Mdo-062292 Monodelphis domestica 100.00 1.00e-88 318.00
IUUC-Mac-064774 Musa acuminata 79.19 1.00e-71 261.00
IUUC-Nfi-068580 Neosartorya fischeri 68.87 1.00e-63 234.00
IUUC-Ncr-068913 Neurospora crassa 68.87 3.00e-64 236.00
IUUC-Nle-069121 Nomascus leucogenys 100.00 1.00e-88 318.00
IUUC-Ont-071335 Oreochromis niloticus 98.03 8.00e-87 311.00
IUUC-Ocu-074550 Oryctolagus cuniculus 100.00 3.00e-88 317.00
IUUC-Oba-075896 Oryza barthii 78.52 3.00e-71 260.00
IUUC-Obr-076713 Oryza brachyantha 79.19 8.00e-72 262.00
IUUC-Ogl-077116 Oryza glaberrima 79.19 8.00e-72 262.00
IUUC-Ogu-078696 Oryza glumaepatula 79.19 8.00e-72 262.00
IUUC-Oin-079099 Oryza indica 79.19 8.00e-72 262.00
IUUC-Olo-081018 Oryza longistaminata 67.27 3.00e-62 231.00
IUUC-Ome-081285 Oryza meridionalis 79.19 8.00e-72 262.00
IUUC-Oni-082088 Oryza nivara 79.19 8.00e-72 262.00
IUUC-Opu-083310 Oryza punctata 79.19 8.00e-72 262.00
IUUC-Oru-084449 Oryza rufipogon 79.19 8.00e-72 262.00
IUUC-Osa-085923 Oryza sativa 79.19 8.00e-72 262.00
IUUC-Ola-086407 Oryzias latipes 100.00 1.00e-88 318.00
IUUC-Olu-087830 Ostreococcus lucimarinus 79.87 2.00e-62 230.00
IUUC-Oga-088659 Otolemur garnettii 100.00 1.00e-88 318.00
IUUC-Ptr-091305 Pan troglodytes 100.00 1.00e-88 318.00
IUUC-Pan-092740 Papio anubis 100.00 3.00e-88 317.00
IUUC-Psi-094094 Pelodiscus sinensis 100.00 1.00e-88 318.00
IUUC-Pma-094376 Petromyzon marinus 96.03 2.00e-85 307.00
IUUC-Ppa-095689 Physcomitrella patens 79.19 9.00e-63 232.00
IUUC-Pfo-096656 Poecilia formosa 99.34 2.00e-88 317.00
IUUC-Pab-097972 Pongo abelii 100.00 1.00e-88 318.00
IUUC-Pop-099517 Populus trichocarpa 79.19 6.00e-72 262.00
IUUC-Pca-100906 Procavia capensis 93.42 1.00e-80 291.00
IUUC-Ppe-101949 Prunus persica 79.19 1.00e-71 262.00
IUUC-Pva-102380 Pteropus vampyrus 98.68 1.00e-85 307.00
IUUC-Rno-105577 Rattus norvegicus 93.83 2.00e-86 310.00
IUUC-Sja-107790 Schizosaccharomyces japonicus 72.48 7.00e-59 219.00
IUUC-Spo-108073 Schizosaccharomyces pombe 72.48 4.00e-59 219.00
IUUC-Ssl-108432 Sclerotinia sclerotiorum 69.54 1.00e-64 238.00
IUUC-Smo-109512 Selaginella moellendorffii 79.19 3.00e-72 263.00
IUUC-Sit-110731 Setaria italica 79.19 8.00e-72 262.00
IUUC-Sly-111506 Solanum lycopersicum 78.52 2.00e-71 261.00
IUUC-Stu-112080 Solanum tuberosum 78.52 2.00e-71 261.00
IUUC-Sbi-114289 Sorghum bicolor 79.19 8.00e-72 262.00
IUUC-Sre-115106 Sporisorium reilianum 72.85 7.00e-60 223.00
IUUC-Ssc-116265 Sus scrofa 100.00 1.00e-88 318.00
IUUC-Tgu-117383 Taeniopygia guttata 100.00 1.00e-88 318.00
IUUC-Tru-117924 Takifugu rubripes 90.74 4.00e-81 293.00
IUUC-Tni-119743 Tetraodon nigroviridis 96.05 2.00e-84 303.00
IUUC-Tca-121827 Theobroma cacao 78.52 8.00e-72 261.00
IUUC-Tre-122002 Trichoderma reesei 68.87 7.00e-64 235.00
IUUC-Tvi-122331 Trichoderma virens 68.87 7.00e-64 235.00
IUUC-Tae-124461 Triticum aestivum 77.85 3.00e-71 261.00
IUUC-Tur-126866 Triticum urartu 77.85 5.00e-71 259.00
IUUC-Tme-127148 Tuber melanosporum 70.39 2.00e-65 240.00
IUUC-Ttr-129050 Tursiops truncatus 99.34 1.00e-85 308.00
IUUC-Vda-129711 Verticillium dahliae 68.87 3.00e-64 236.00
IUUC-Vvi-131547 Vitis vinifera 79.19 7.00e-72 263.00
IUUC-Xtr-132301 Xenopus tropicalis 100.00 1.00e-88 318.00
IUUC-Xma-133937 Xiphophorus maculatus 100.00 1.00e-88 318.00
Created Date 25-Jun-2017

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