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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Cel-018494
Ensembl Protein ID C09G4.5
UniProt Accession Q9GYS1; O16187; MES6_CAEEL
Genbank Protein ID AAC27121.1; CCD64001.1
Protein Name Polycomb protein mes-6; ESC homolog; Maternal-effect sterile protein 6
Genbank Nucleotide ID AF016224; FO080478
Gene Name mes-6; C09G4.5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00003224 C09G4.5 C09G4.5
Annotation
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
PINAMentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.20e-10 41.6 193 223
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDl 30
    H++ + ++++ +d ++++s++ D++++ WDl
   Q: 193 HAGTILSVDWsTDgDFILSCGFDHQLMEWDL 223
    99*********889***********998886 PP
   

Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description



     Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X chromosomes in germline cells. The complex may act via methylation of histone H3 'Lys-27', rendering chromatin heritably changed in its expressibility. This complex is required to exclude mes-4 from the inactivated X-chromosomes in germline cells (PubMed:12077420, PubMed:15380065). Required for small-RNA-induced H3K27 trimethylation (PubMed:26365259).
Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X chromosomes in germline cells. The complex may act via methylation of histone H3 'Lys-27', rendering chromatin heritably changed in its expressibility. This complex is required to exclude mes-4 from the inactivated X-chromosomes in germline cells (PubMed:12077420, PubMed:15380065). Required for small-RNA-induced H3K27 trimethylation (PubMed:26365259).
Protein Sequence
(Fasta)
MEHTKKFKSL NLHGFDRSTE DYGKRPFVLT AKLLEDQKKA IYGCAFNQYA GIDEEQAVAT 60
VGGSFLHMYS VPIDINNIEL QWSCNFPTDK SSKVEREESL FTVTWCYDTY EAENDRNPFK 120
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Protein Fasta Sequence



>IUUC-Cel-018494|E3,WD_repeat|Caenorhabditis elegans
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Nucleotide Sequence
(Fasta)
GCGAGCGGCC ATATTTTAGT TTTTCTGTTG TTTTTATTGT CATTTTTTTC CTTTTTCACT 60
GCAAATTTGA TAGTTAATCG ACTTTTTTAT GTTTTTACTG TGAAGTTTTT ATTTTGTTAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Cel-018494|E3,WD_repeat|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0000786--C:nucleosome
GO:0031519--C:PcG protein complex
GO:0070734--P:histone H3-K27 methylation
GO:0016571--P:histone methylation
GO:0007275--P:multicellular organism development
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG cel:CELE_C09G4.5
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000689 Aegilops tauschii 25.41 5.00e-21 94.40
IUUC-Aml-001510 Ailuropoda melanoleuca 24.06 1.00e-26 112.00
IUUC-Atr-002496 Amborella trichopoda 26.37 5.00e-23 100.00
IUUC-Apl-003768 Anas platyrhynchos 24.70 2.00e-29 122.00
IUUC-Aca-004382 Anolis carolinensis 24.64 3.00e-29 121.00
IUUC-Aly-005980 Arabidopsis lyrata 24.59 5.00e-22 97.40
IUUC-Ath-006579 Arabidopsis thaliana 25.06 1.00e-22 99.00
IUUC-Ame-010987 Astyanax mexicanus 23.87 5.00e-29 120.00
IUUC-Bta-013432 Bos taurus 24.41 1.00e-29 122.00
IUUC-Bdi-014553 Brachypodium distachyon 26.29 1.00e-22 99.80
IUUC-Bol-016522 Brassica oleracea 25.23 3.00e-23 101.00
IUUC-Bra-017137 Brassica rapa 25.23 5.00e-23 100.00
IUUC-Cja-019066 Callithrix jacchus 24.41 1.00e-29 122.00
IUUC-Cfa-021261 Canis familiaris 24.41 1.00e-29 122.00
IUUC-Cpo-022375 Cavia porcellus 23.70 4.00e-28 117.00
IUUC-Csa-024005 Chlorocebus sabaeus 24.41 1.00e-29 122.00
IUUC-Cho-024881 Choloepus hoffmanni 24.47 8.00e-20 90.10
IUUC-Cin-025697 Ciona intestinalis 25.12 3.00e-27 114.00
IUUC-Csv-026221 Ciona savignyi 24.59 5.00e-27 114.00
IUUC-Cgl-026519 Colletotrichum gloeosporioides 22.02 5.00e-08 51.20
IUUC-Cme-027353 Cyanidioschyzon merolae 26.20 5.00e-13 68.20
IUUC-Dre-028346 Danio rerio 24.64 6.00e-29 120.00
IUUC-Dno-029319 Dasypus novemcinctus 24.94 3.00e-30 124.00
IUUC-Dor-030746 Dipodomys ordii 19.27 2.00e-08 52.40
IUUC-Dme-031874 Drosophila melanogaster 26.51 3.00e-31 127.00
IUUC-Ete-032880 Echinops telfairi 25.00 5.00e-11 60.80
IUUC-Eca-034272 Equus caballus 24.41 8.00e-30 123.00
IUUC-Eeu-035303 Erinaceus europaeus 22.47 3.00e-25 108.00
IUUC-Fca-036008 Felis catus 24.41 9.00e-30 123.00
IUUC-Fal-037577 Ficedula albicollis 24.70 2.00e-29 121.00
IUUC-Gmo-039008 Gadus morhua 24.81 3.00e-27 114.00
IUUC-Gga-040859 Gallus gallus 24.70 1.00e-29 122.00
IUUC-Gac-041667 Gasterosteus aculeatus 25.68 9.00e-28 116.00
IUUC-Gma-043832 Glycine max 25.64 2.00e-22 98.60
IUUC-Ggo-045624 Gorilla gorilla 22.70 4.00e-26 111.00
IUUC-Hsa-046505 Homo sapiens 24.41 1.00e-29 122.00
IUUC-Hvu-047228 Hordeum vulgare 27.08 4.00e-08 49.70
IUUC-Itr-048381 Ictidomys tridecemlineatus 24.41 1.00e-29 122.00
IUUC-Lch-050492 Latimeria chalumnae 23.99 4.00e-28 117.00
IUUC-Lpe-050807 Leersia perrieri 25.36 8.00e-24 103.00
IUUC-Loc-052361 Lepisosteus oculatus 24.70 9.00e-30 123.00
IUUC-Laf-053941 Loxodonta africana 24.30 3.00e-30 125.00
IUUC-Mcc-055518 Macaca mulatta 22.70 4.00e-26 111.00
IUUC-Mtr-058716 Medicago truncatula 25.12 9.00e-17 79.70
IUUC-Mga-059469 Meleagris gallopavo 24.70 1.00e-29 122.00
IUUC-Mmr-061026 Microcebus murinus 23.22 6.00e-26 110.00
IUUC-Mdo-062346 Monodelphis domestica 24.70 8.00e-30 123.00
IUUC-Mmu-063785 Mus musculus 24.41 1.00e-29 122.00
IUUC-Mac-064681 Musa acuminata 25.06 1.00e-23 102.00
IUUC-Mpu-066862 Mustela putorius furo 24.41 1.00e-29 122.00
IUUC-Mlu-067103 Myotis lucifugus 25.14 7.00e-27 113.00
IUUC-Nle-069472 Nomascus leucogenys 24.41 1.00e-29 122.00
IUUC-Opr-070376 Ochotona princeps 22.97 4.00e-15 74.70
IUUC-Ont-071513 Oreochromis niloticus 24.82 1.00e-29 123.00
IUUC-Oan-073202 Ornithorhynchus anatinus 24.64 3.00e-29 121.00
IUUC-Ocu-074012 Oryctolagus cuniculus 24.41 9.00e-30 123.00
IUUC-Oba-075030 Oryza barthii 26.45 1.00e-23 102.00
IUUC-Obr-076895 Oryza brachyantha 26.91 3.00e-24 104.00
IUUC-Ogl-077522 Oryza glaberrima 26.13 3.00e-23 101.00
IUUC-Ogu-078250 Oryza glumaepatula 26.90 1.00e-20 92.80
IUUC-Oin-079886 Oryza indica 26.45 2.00e-23 102.00
IUUC-Olo-080238 Oryza longistaminata 26.45 2.00e-23 102.00
IUUC-Ome-081204 Oryza meridionalis 24.65 1.00e-17 82.80
IUUC-Oni-082388 Oryza nivara 30.96 5.00e-16 77.80
IUUC-Opu-083142 Oryza punctata 26.42 4.00e-24 104.00
IUUC-Oru-084863 Oryza rufipogon 25.75 1.00e-19 89.70
IUUC-Osa-085622 Oryza sativa 26.45 3.00e-23 101.00
IUUC-Ola-087426 Oryzias latipes 24.69 2.00e-25 110.00
IUUC-Olu-087788 Ostreococcus lucimarinus 20.04 2.00e-08 52.00
IUUC-Oga-088228 Otolemur garnettii 24.41 1.00e-29 122.00
IUUC-Oar-090139 Ovis aries 24.41 1.00e-29 122.00
IUUC-Pan-092874 Papio anubis 25.33 1.00e-23 101.00
IUUC-Psi-093927 Pelodiscus sinensis 24.47 8.00e-29 120.00
IUUC-Pma-094740 Petromyzon marinus 24.57 6.00e-18 83.20
IUUC-Ppa-095871 Physcomitrella patens 22.80 5.00e-15 73.90
IUUC-Pfo-097208 Poecilia formosa 25.00 5.00e-30 124.00
IUUC-Pab-097658 Pongo abelii 24.41 1.00e-29 122.00
IUUC-Pop-098930 Populus trichocarpa 26.17 1.00e-22 99.00
IUUC-Ppe-101807 Prunus persica 25.75 1.00e-23 102.00
IUUC-Pva-103191 Pteropus vampyrus 23.64 1.00e-19 89.40
IUUC-Rno-105854 Rattus norvegicus 24.41 1.00e-29 122.00
IUUC-Sha-107426 Sarcophilus harrisii 24.70 9.00e-30 123.00
IUUC-Smo-109638 Selaginella moellendorffii 25.00 5.00e-21 94.00
IUUC-Sit-110481 Setaria italica 24.64 2.00e-20 92.00
IUUC-Sly-111464 Solanum lycopersicum 25.65 1.00e-23 102.00
IUUC-Stu-112910 Solanum tuberosum 25.42 4.00e-23 100.00
IUUC-Sar-113754 Sorex araneus 23.56 4.00e-24 103.00
IUUC-Sbi-114023 Sorghum bicolor 24.27 3.00e-21 94.70
IUUC-Ssc-115386 Sus scrofa 24.41 1.00e-29 122.00
IUUC-Tgu-117123 Taeniopygia guttata 24.70 2.00e-29 122.00
IUUC-Tru-117720 Takifugu rubripes 23.96 4.00e-28 117.00
IUUC-Tsy-119584 Tarsius syrichta 22.70 4.00e-26 111.00
IUUC-Tni-119695 Tetraodon nigroviridis 25.30 2.00e-30 125.00
IUUC-Tca-121787 Theobroma cacao 26.87 3.00e-24 104.00
IUUC-Tvi-122409 Trichoderma virens 25.91 3.00e-08 52.00
IUUC-Tae-124808 Triticum aestivum 26.70 2.00e-22 98.60
IUUC-Tme-126906 Tuber melanosporum 23.76 1.00e-13 69.70
IUUC-Tbe-127557 Tupaia belangeri 22.92 1.00e-23 103.00
IUUC-Vpa-130256 Vicugna pacos 20.98 2.00e-18 85.50
IUUC-Vvi-131201 Vitis vinifera 25.64 5.00e-23 100.00
IUUC-Xtr-132206 Xenopus tropicalis 25.18 9.00e-29 119.00
IUUC-Xma-134102 Xiphophorus maculatus 25.24 3.00e-30 124.00
Created Date 25-Jun-2017

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